Mutagenetix > Incidental Mutation

Incidental Mutation 'R7378:Slc4a7'

572527

Institutional Source

Beutler Lab

Gene Symbol

Slc4a7

Ensembl Gene

ENSMUSG00000021733

Gene Name

solute carrier family 4, sodium bicarbonate cotransporter, member 7

Synonyms

NBC3, NBCn1, E430014N10Rik

MMRRC Submission

045460-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.925) question?

Stock #

R7378 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

7669819-7766808 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 14757421 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 422 (V422D)

Ref Sequence

ENSEMBL: ENSMUSP00000058313 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057015] [ENSMUST00000223607] [ENSMUST00000223695] [ENSMUST00000223740] [ENSMUST00000223761] [ENSMUST00000223981] [ENSMUST00000224049] [ENSMUST00000224222] [ENSMUST00000224333] [ENSMUST00000224672] [ENSMUST00000224752] [ENSMUST00000225175] [ENSMUST00000225232] [ENSMUST00000225238] [ENSMUST00000225630] [ENSMUST00000225979] [ENSMUST00000226079]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000057015
AA Change: V422D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000058313
Gene: ENSMUSG00000021733
AA Change: V422D

Domain	Start	End	E-Value	Type
low complexity region	57	89	N/A	INTRINSIC
Pfam:Band_3_cyto	146	413	1.4e-110	PFAM
Pfam:HCO3_cotransp	456	969	1.6e-242	PFAM
transmembrane domain	977	999	N/A	INTRINSIC
coiled coil region	1021	1050	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000223607
AA Change: V534D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000223695
AA Change: V435D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000223740
AA Change: V428D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000223761
AA Change: V545D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000223771

Predicted Effect

probably damaging
Transcript: ENSMUST00000223981
AA Change: V547D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000224049
AA Change: V415D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000224222
AA Change: V534D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000224333
AA Change: V553D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000224672
AA Change: V538D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000224752
AA Change: V539D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000225175
AA Change: V532D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000225232
AA Change: V409D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000225238
AA Change: V442D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Predicted Effect

probably damaging
Transcript: ENSMUST00000225630
AA Change: V409D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000225979
AA Change: V429D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Predicted Effect

probably damaging
Transcript: ENSMUST00000226079
AA Change: V422D

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

99% (138/140)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
PHENOTYPE: Mice homozygous for a disruption at this locus display defects of the auditory and visual systems similar to those observed in patients with Ushers syndrome. Mice homozygous for a gene trap allele exhibit disruption in sodium/bicarbonate function that impacts vasodilation and hypertension. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 142 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	A	C	6: 128,523,210 (GRCm39)		probably null	Het
Aars1	A	G	8: 111,768,974 (GRCm39)	Y258C	probably damaging	Het
Acaa2	A	T	18: 74,938,943 (GRCm39)	Y376F	probably benign	Het
Adcy1	C	T	11: 7,119,543 (GRCm39)	S1062F	possibly damaging	Het
Adgrb3	A	T	1: 25,571,000 (GRCm39)	C492*	probably null	Het
Adgrg6	A	G	10: 14,411,636 (GRCm39)	F22S	probably benign	Het
Adh1	A	G	3: 137,994,648 (GRCm39)		probably null	Het
Afm	T	A	5: 90,699,259 (GRCm39)	C568S	probably benign	Het
Ago4	C	T	4: 126,405,257 (GRCm39)	E439K	probably benign	Het
Aifm2	T	G	10: 61,563,496 (GRCm39)	V122G	possibly damaging	Het
Akap6	A	G	12: 53,189,357 (GRCm39)	N2257S	probably benign	Het
Ap3m2	A	G	8: 23,294,026 (GRCm39)	I8T	probably benign	Het
Apc2	C	A	10: 80,147,228 (GRCm39)	L761I	probably damaging	Het
Asap2	A	G	12: 21,162,052 (GRCm39)	D3G	probably benign	Het
Asxl1	T	C	2: 153,243,913 (GRCm39)	C1489R	probably damaging	Het
Atm	T	G	9: 53,364,737 (GRCm39)		probably null	Het
Bmal1	C	A	7: 112,898,415 (GRCm39)	T281K	probably benign	Het
Bpifa6	C	A	2: 153,828,353 (GRCm39)	A153E	probably damaging	Het
Cav2	A	G	6: 17,282,059 (GRCm39)	T106A	probably benign	Het
Cavin4	A	G	4: 48,663,631 (GRCm39)	N4D	probably benign	Het
Cenpc1	T	C	5: 86,194,358 (GRCm39)	N136S	probably benign	Het
Cfap45	T	A	1: 172,365,910 (GRCm39)		probably null	Het
Col3a1	G	A	1: 45,366,807 (GRCm39)		probably null	Het
Crocc2	C	T	1: 93,121,809 (GRCm39)	L653F	probably damaging	Het
Cry2	A	G	2: 92,244,009 (GRCm39)	L388P	probably damaging	Het
Cstb	T	C	10: 78,262,822 (GRCm39)	F43S	probably damaging	Het
Ctcfl	A	G	2: 172,954,051 (GRCm39)	Y349H	probably damaging	Het
Ctu2	T	A	8: 123,208,238 (GRCm39)	V485D	probably damaging	Het
Cwc25	A	C	11: 97,638,823 (GRCm39)	L367R	possibly damaging	Het
Dock4	T	A	12: 40,838,243 (GRCm39)	H1061Q	possibly damaging	Het
Dpy19l3	C	A	7: 35,452,067 (GRCm39)	V26L	probably benign	Het
Efcab3	T	C	11: 104,605,528 (GRCm39)	I298T	probably benign	Het
Elmo1	A	T	13: 20,465,105 (GRCm39)	I225F	probably benign	Het
Ep300	T	C	15: 81,534,746 (GRCm39)	S2268P	probably damaging	Het
F2r	C	T	13: 95,754,836 (GRCm39)	C16Y	probably damaging	Het
Fbxo33	C	A	12: 59,251,157 (GRCm39)	E453*	probably null	Het
Flot1	A	T	17: 36,136,405 (GRCm39)	D186V	probably damaging	Het
Fmn2	CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC	CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC	1: 174,436,769 (GRCm39)		probably benign	Het
Fras1	T	C	5: 96,744,644 (GRCm39)	C560R	probably damaging	Het
Get3	A	T	8: 85,746,492 (GRCm39)	F119I	probably benign	Het
Gfi1	A	T	5: 107,871,095 (GRCm39)	S165T	possibly damaging	Het
Gli2	T	C	1: 118,776,222 (GRCm39)	D400G	probably damaging	Het
Gm37240	T	A	3: 84,879,944 (GRCm39)		probably null	Het
Gml	C	T	15: 74,688,970 (GRCm39)	V27I	possibly damaging	Het
Htt	A	T	5: 34,961,143 (GRCm39)	I257F	probably benign	Het
Hycc2	T	C	1: 58,569,193 (GRCm39)	K462R	probably benign	Het
Ier5	C	T	1: 154,974,438 (GRCm39)	V247M	probably damaging	Het
Ift46	C	T	9: 44,689,892 (GRCm39)		probably benign	Het
Il12b	A	G	11: 44,298,721 (GRCm39)	T59A	probably benign	Het
Insr	A	G	8: 3,248,231 (GRCm39)	L438P	probably damaging	Het
Iqgap2	C	T	13: 95,869,398 (GRCm39)		probably null	Het
Irx4	A	T	13: 73,415,672 (GRCm39)	T154S	possibly damaging	Het
Itgbl1	A	G	14: 124,094,901 (GRCm39)	K309E	probably benign	Het
Kcns2	T	A	15: 34,839,849 (GRCm39)	L404*	probably null	Het
Kif2c	T	C	4: 117,019,226 (GRCm39)	E644G	possibly damaging	Het
Klhl22	T	C	16: 17,594,669 (GRCm39)	L266P	probably damaging	Het
Krt71	T	A	15: 101,646,764 (GRCm39)	K315*	probably null	Het
Lca5	T	C	9: 83,277,583 (GRCm39)	N587S	probably benign	Het
Lrp1b	T	A	2: 41,185,681 (GRCm39)	M1459L		Het
Lrrtm2	T	C	18: 35,346,645 (GRCm39)	K219R	probably damaging	Het
Mcmbp	T	C	7: 128,306,241 (GRCm39)	D459G	probably damaging	Het
Megf8	A	G	7: 25,048,367 (GRCm39)	H1680R	probably damaging	Het
Mia3	A	G	1: 183,115,629 (GRCm39)	S301P	probably benign	Het
Mtrr	A	G	13: 68,712,521 (GRCm39)	Y622H	probably damaging	Het
Myo7b	T	A	18: 32,099,292 (GRCm39)	Q1710L	probably damaging	Het
Nab1	T	C	1: 52,520,154 (GRCm39)	N276D	probably damaging	Het
Nalcn	C	T	14: 123,540,302 (GRCm39)	R1127H	probably damaging	Het
Nbas	T	A	12: 13,324,220 (GRCm39)	I110N	probably damaging	Het
Nfe2l3	C	T	6: 51,434,276 (GRCm39)	Q279*	probably null	Het
Nlrp9c	C	T	7: 26,064,440 (GRCm39)	E963K	probably benign	Het
Nsmaf	A	G	4: 6,416,586 (GRCm39)	V569A	probably benign	Het
Or10ak14	T	C	4: 118,611,372 (GRCm39)	Y123C	possibly damaging	Het
Or13c3	C	T	4: 52,856,421 (GRCm39)	V31I	probably benign	Het
Or52a5b	T	A	7: 103,417,137 (GRCm39)	I156F	probably benign	Het
Or52n5	A	T	7: 104,588,638 (GRCm39)	I302F	probably benign	Het
Or5ac17	T	A	16: 59,036,283 (GRCm39)	D231V	probably benign	Het
Or5p4	T	C	7: 107,680,399 (GRCm39)	S133P	not run	Het
Or7e166	A	T	9: 19,624,183 (GRCm39)	D20V	probably damaging	Het
Or7g32	T	A	9: 19,408,398 (GRCm39)	M118K	probably damaging	Het
Or8d1b	T	A	9: 38,887,017 (GRCm39)	V15E	probably benign	Het
Or8k28	T	C	2: 86,286,412 (GRCm39)	T68A	probably benign	Het
Paf1	A	G	7: 28,096,353 (GRCm39)	Y322C	probably damaging	Het
Pcdha2	C	A	18: 37,072,438 (GRCm39)	A23D	possibly damaging	Het
Pcdhb6	G	A	18: 37,468,225 (GRCm39)	C382Y	probably damaging	Het
Pdzd7	C	T	19: 45,034,045 (GRCm39)	G13D	probably damaging	Het
Pik3r2	T	C	8: 71,222,025 (GRCm39)	N586S	probably benign	Het
Pik3r3	T	A	4: 116,128,027 (GRCm39)	D119E	probably benign	Het
Pkd2l1	T	A	19: 44,142,154 (GRCm39)	I535F	probably benign	Het
Ppfia3	T	C	7: 45,010,870 (GRCm39)		probably null	Het
Ppl	T	A	16: 4,930,860 (GRCm39)	Q53L	possibly damaging	Het
Rimbp3	T	G	16: 17,029,068 (GRCm39)	S831A	probably benign	Het
Rnps1	A	G	17: 24,637,504 (GRCm39)	T49A	unknown	Het
Rpl7a	T	A	2: 26,802,019 (GRCm39)		probably null	Het
Rrm2b	T	A	15: 37,931,891 (GRCm39)	E248D	probably benign	Het
Sdhaf4	A	G	1: 24,035,439 (GRCm39)	F70L	probably damaging	Het
Sel1l3	A	T	5: 53,273,751 (GRCm39)	S1038R	probably benign	Het
Selenoo	T	A	15: 88,973,681 (GRCm39)	F124I	probably benign	Het
Setbp1	A	T	18: 78,900,701 (GRCm39)	Y989N	probably damaging	Het
Slc1a7	A	G	4: 107,859,400 (GRCm39)	E163G	possibly damaging	Het
Slc22a2	T	C	17: 12,831,278 (GRCm39)	F356S	probably damaging	Het
Slc24a4	C	T	12: 102,205,435 (GRCm39)	P378L	probably benign	Het
Slc4a1ap	A	G	5: 31,684,871 (GRCm39)	D169G	probably benign	Het
Slitrk6	T	C	14: 110,987,295 (GRCm39)	Y804C	probably damaging	Het
Smarcad1	T	A	6: 65,087,360 (GRCm39)	H906Q	probably benign	Het
Smn1	A	G	13: 100,264,373 (GRCm39)	T109A	probably damaging	Het
Sntb2	A	G	8: 107,707,944 (GRCm39)	N236S	probably damaging	Het
Spag9	T	A	11: 94,005,177 (GRCm39)		probably null	Het
Spg11	C	A	2: 121,888,910 (GRCm39)	G2154W	probably damaging	Het
Srsf6	T	C	2: 162,776,489 (GRCm39)	S278P	unknown	Het
Stag3	G	A	5: 138,280,222 (GRCm39)	R29H	probably benign	Het
Stambp	C	T	6: 83,540,888 (GRCm39)	V98I	not run	Het
Styxl2	G	T	1: 165,939,632 (GRCm39)	S58*	probably null	Het
Suco	T	C	1: 161,689,780 (GRCm39)	D89G	possibly damaging	Het
Suox	C	T	10: 128,506,910 (GRCm39)	V373I	probably benign	Het
Sv2b	T	A	7: 74,797,476 (GRCm39)		probably null	Het
Tatdn2	T	C	6: 113,681,662 (GRCm39)	L565P	probably damaging	Het
Tbpl2	T	A	2: 23,984,712 (GRCm39)	E145V	probably benign	Het
Tlr1	T	C	5: 65,082,571 (GRCm39)	I669V	not run	Het
Tmc1	A	T	19: 20,845,753 (GRCm39)	F157I	probably damaging	Het
Tmem26	T	G	10: 68,559,922 (GRCm39)		probably null	Het
Tmem33	A	T	5: 67,443,476 (GRCm39)	I218F	probably benign	Het
Tmem94	T	A	11: 115,685,000 (GRCm39)	D862E	probably damaging	Het
Tnr	T	C	1: 159,712,432 (GRCm39)		probably null	Het
Tnrc6c	T	C	11: 117,632,606 (GRCm39)	S1103P	probably benign	Het
Tomm70a	T	A	16: 56,966,407 (GRCm39)	Y453*	probably null	Het
Trabd	C	A	15: 88,969,493 (GRCm39)	R229S	possibly damaging	Het
Trappc10	T	C	10: 78,029,252 (GRCm39)	D1095G	probably damaging	Het
Trim27	A	G	13: 21,376,631 (GRCm39)	T460A	possibly damaging	Het
Tsen54	T	G	11: 115,712,531 (GRCm39)	D433E	probably benign	Het
Ubap2	A	G	4: 41,235,515 (GRCm39)		probably null	Het
Vat1l	A	T	8: 115,016,132 (GRCm39)	N341Y	possibly damaging	Het
Vmn2r82	C	G	10: 79,232,276 (GRCm39)	Y758*	probably null	Het
Vps16	T	G	2: 130,280,099 (GRCm39)	V108G	probably damaging	Het
Vps53	T	A	11: 75,967,900 (GRCm39)	I585F	possibly damaging	Het
Wrnip1	G	A	13: 33,000,264 (GRCm39)	V424M	probably benign	Het
Yif1a	G	A	19: 5,139,818 (GRCm39)	V88M	possibly damaging	Het
Zfat	T	C	15: 68,052,969 (GRCm39)	Y275C	probably damaging	Het
Zfhx3	A	G	8: 109,519,880 (GRCm39)	E334G	probably damaging	Het
Zfp277	T	C	12: 40,365,852 (GRCm39)	D539G	possibly damaging	Het
Zfp292	A	T	4: 34,808,384 (GRCm39)	N1558K	probably benign	Het
Zfp3	A	G	11: 70,662,899 (GRCm39)	K286R	probably benign	Het
Zfp366	T	C	13: 99,366,023 (GRCm39)	C395R	probably damaging	Het

Other mutations in Slc4a7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00974:Slc4a7	APN	14	14,760,292 (GRCm38)	missense	probably benign	0.18
IGL01468:Slc4a7	APN	14	14,737,480 (GRCm38)	missense	probably damaging	1.00
IGL01863:Slc4a7	APN	14	14,762,430 (GRCm38)	missense	probably damaging	0.97
IGL03122:Slc4a7	APN	14	14,782,040 (GRCm38)	splice site	probably benign
R0020:Slc4a7	UTSW	14	14,796,108 (GRCm38)	missense	probably benign
R0403:Slc4a7	UTSW	14	14,766,808 (GRCm38)	missense	probably benign	0.02
R0410:Slc4a7	UTSW	14	14,738,299 (GRCm38)	missense	probably damaging	1.00
R0624:Slc4a7	UTSW	14	14,794,059 (GRCm38)	critical splice donor site	probably null
R0631:Slc4a7	UTSW	14	14,757,382 (GRCm38)	missense	probably damaging	1.00
R1128:Slc4a7	UTSW	14	14,733,832 (GRCm38)	missense	probably damaging	1.00
R1556:Slc4a7	UTSW	14	14,778,872 (GRCm38)	missense	probably benign	0.01
R1672:Slc4a7	UTSW	14	14,760,247 (GRCm38)	missense	possibly damaging	0.91
R1711:Slc4a7	UTSW	14	14,765,709 (GRCm38)	missense	probably benign	0.45
R1870:Slc4a7	UTSW	14	14,737,509 (GRCm38)	critical splice donor site	probably null
R1939:Slc4a7	UTSW	14	14,748,581 (GRCm38)	missense	probably damaging	1.00
R2012:Slc4a7	UTSW	14	14,733,727 (GRCm38)	nonsense	probably null
R2042:Slc4a7	UTSW	14	14,737,386 (GRCm38)	missense	probably damaging	1.00
R2064:Slc4a7	UTSW	14	14,733,773 (GRCm38)	missense	probably damaging	1.00
R2404:Slc4a7	UTSW	14	14,733,733 (GRCm38)	missense	probably damaging	1.00
R2880:Slc4a7	UTSW	14	14,773,277 (GRCm38)	missense	probably damaging	1.00
R3729:Slc4a7	UTSW	14	14,729,276 (GRCm38)	missense	probably damaging	1.00
R4368:Slc4a7	UTSW	14	14,733,775 (GRCm38)	missense	probably damaging	1.00
R4395:Slc4a7	UTSW	14	14,765,665 (GRCm38)	missense	probably damaging	1.00
R4432:Slc4a7	UTSW	14	14,757,323 (GRCm38)	missense	probably damaging	1.00
R4592:Slc4a7	UTSW	14	14,778,850 (GRCm38)	missense	probably damaging	1.00
R4705:Slc4a7	UTSW	14	14,733,856 (GRCm38)	missense	probably damaging	1.00
R4743:Slc4a7	UTSW	14	14,796,073 (GRCm38)	splice site	probably null
R4765:Slc4a7	UTSW	14	14,762,414 (GRCm38)	missense	probably damaging	1.00
R4831:Slc4a7	UTSW	14	14,772,699 (GRCm38)	critical splice donor site	probably null
R4845:Slc4a7	UTSW	14	14,733,803 (GRCm38)	missense	probably damaging	1.00
R4880:Slc4a7	UTSW	14	14,757,342 (GRCm38)	missense	probably damaging	1.00
R4948:Slc4a7	UTSW	14	14,771,283 (GRCm38)	missense	possibly damaging	0.68
R5348:Slc4a7	UTSW	14	14,786,310 (GRCm38)	missense	probably benign	0.02
R5385:Slc4a7	UTSW	14	14,773,345 (GRCm38)	missense	possibly damaging	0.94
R5418:Slc4a7	UTSW	14	14,760,280 (GRCm38)	missense	probably benign	0.25
R5480:Slc4a7	UTSW	14	14,782,138 (GRCm38)	missense	probably damaging	1.00
R5842:Slc4a7	UTSW	14	14,778,866 (GRCm38)	missense	probably damaging	1.00
R5919:Slc4a7	UTSW	14	14,791,092 (GRCm38)	missense	probably benign
R6063:Slc4a7	UTSW	14	14,793,964 (GRCm38)	missense	possibly damaging	0.60
R6065:Slc4a7	UTSW	14	14,739,836 (GRCm38)	missense	probably benign	0.29
R6549:Slc4a7	UTSW	14	14,748,564 (GRCm38)	missense	probably damaging	1.00
R6845:Slc4a7	UTSW	14	14,775,000 (GRCm38)	missense	probably damaging	1.00
R6870:Slc4a7	UTSW	14	14,733,846 (GRCm38)	missense	probably damaging	1.00
R6881:Slc4a7	UTSW	14	14,737,452 (GRCm38)	missense	probably benign	0.43
R6962:Slc4a7	UTSW	14	14,746,021 (GRCm38)	missense	probably damaging	0.99
R7099:Slc4a7	UTSW	14	14,733,750 (GRCm38)	missense	probably damaging	1.00
R7180:Slc4a7	UTSW	14	14,765,580 (GRCm38)	missense	probably damaging	1.00
R7346:Slc4a7	UTSW	14	14,775,000 (GRCm38)	missense	probably damaging	1.00
R7646:Slc4a7	UTSW	14	14,773,348 (GRCm38)	missense	probably benign	0.01
R7647:Slc4a7	UTSW	14	14,773,348 (GRCm38)	missense	probably benign	0.01
R7648:Slc4a7	UTSW	14	14,773,348 (GRCm38)	missense	probably benign	0.01
R7650:Slc4a7	UTSW	14	14,773,348 (GRCm38)	missense	probably benign	0.01
R7857:Slc4a7	UTSW	14	14,772,624 (GRCm38)	missense	probably benign	0.00
R7892:Slc4a7	UTSW	14	14,773,348 (GRCm38)	missense	probably benign	0.01
R8124:Slc4a7	UTSW	14	14,729,211 (GRCm38)	missense	possibly damaging	0.92
R8225:Slc4a7	UTSW	14	14,738,224 (GRCm38)	nonsense	probably null
R8354:Slc4a7	UTSW	14	14,786,313 (GRCm38)	missense	probably damaging	1.00
R8998:Slc4a7	UTSW	14	14,775,346 (GRCm38)	missense	probably damaging	1.00
R9016:Slc4a7	UTSW	14	14,773,241 (GRCm38)	missense	probably damaging	0.99
R9043:Slc4a7	UTSW	14	14,775,048 (GRCm38)	missense	probably damaging	1.00
R9139:Slc4a7	UTSW	14	14,796,115 (GRCm38)	missense	probably damaging	0.98
R9342:Slc4a7	UTSW	14	14,772,541 (GRCm38)	nonsense	probably null
R9383:Slc4a7	UTSW	14	14,766,803 (GRCm38)	nonsense	probably null
R9568:Slc4a7	UTSW	14	14,796,073 (GRCm38)	splice site	probably null
R9798:Slc4a7	UTSW	14	14,782,056 (GRCm38)	missense	probably damaging	1.00
X0067:Slc4a7	UTSW	14	14,771,276 (GRCm38)	missense	possibly damaging	0.93

Predicted Primers

PCR Primer
(F):5'- TCCACTGTAAAATCTCTCTACTCAG -3'
(R):5'- GTGGTACATCCTGTCTGATGC -3'

Sequencing Primer
(F):5'- GATCGTAATGACCTCCTATCTG -3'
(R):5'- GTCTGATGCACCACCACTG -3'

Posted On

2019-09-13