Incidental Mutation 'R7379:Or9s14'
ID 572557
Institutional Source Beutler Lab
Gene Symbol Or9s14
Ensembl Gene ENSMUSG00000063583
Gene Name olfactory receptor family 9 subfamily S member 14
Synonyms Olfr1410, MOR208-2, GA_x6K02T2R7CC-81146179-81145211
MMRRC Submission 045461-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R7379 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 92535561-92536529 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 92536189 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 210 (C210F)
Ref Sequence ENSEMBL: ENSMUSP00000078720 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079790] [ENSMUST00000216553] [ENSMUST00000217316]
AlphaFold E9PYK6
Predicted Effect possibly damaging
Transcript: ENSMUST00000079790
AA Change: C210F

PolyPhen 2 Score 0.761 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000078720
Gene: ENSMUSG00000063583
AA Change: C210F

DomainStartEndE-ValueType
Pfam:7tm_4 38 314 2.6e-50 PFAM
Pfam:7tm_1 48 302 9.2e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216553
AA Change: C210F

PolyPhen 2 Score 0.761 (Sensitivity: 0.85; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217316
AA Change: C210F

PolyPhen 2 Score 0.761 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd12 G A 17: 66,292,242 (GRCm39) R1064* probably null Het
Ccdc149 A G 5: 52,562,408 (GRCm39) I206T probably damaging Het
Ctu1 AGGACCGGGCAGGAGCCACCTGTGTATCGCAGAGGGACCTGAGCCTTGGGAATGGAGGGGACCGGGCAGGAGCCACCTGTGTATCGCAG AGGACCGGGCAGGAGCCACCTGTGTATCGCAG 7: 43,326,490 (GRCm39) probably benign Het
Cyp2j6 T C 4: 96,414,183 (GRCm39) T361A probably damaging Het
Cyp4a14 A T 4: 115,350,907 (GRCm39) probably null Het
Cyp7b1 A G 3: 18,151,538 (GRCm39) V225A probably benign Het
Esf1 A G 2: 139,996,854 (GRCm39) I503T probably benign Het
Flrt2 G A 12: 95,747,329 (GRCm39) V556I possibly damaging Het
Gaa T C 11: 119,174,525 (GRCm39) S791P probably benign Het
H2-T22 A G 17: 36,353,232 (GRCm39) probably null Het
Hexb A G 13: 97,317,672 (GRCm39) S342P probably damaging Het
Ift122 C T 6: 115,903,263 (GRCm39) R1176C probably benign Het
Ift57 A G 16: 49,581,357 (GRCm39) E341G probably damaging Het
Itpkc A T 7: 26,927,194 (GRCm39) I240K probably benign Het
Kit A T 5: 75,808,412 (GRCm39) S719C probably damaging Het
Klf1 T A 8: 85,629,846 (GRCm39) Y224N possibly damaging Het
Krt77 T C 15: 101,769,709 (GRCm39) E387G probably damaging Het
L3mbtl1 T A 2: 162,802,899 (GRCm39) D347E probably damaging Het
Map1s A G 8: 71,366,219 (GRCm39) T375A possibly damaging Het
Mturn A G 6: 54,666,069 (GRCm39) T81A possibly damaging Het
Mug2 A G 6: 122,024,446 (GRCm39) E506G possibly damaging Het
Notch1 A G 2: 26,369,479 (GRCm39) F512S probably damaging Het
Or10g1 T C 14: 52,647,718 (GRCm39) T204A probably benign Het
Or12e13 T A 2: 87,664,123 (GRCm39) C247S probably damaging Het
Or4c12b T A 2: 89,647,033 (GRCm39) V115E probably benign Het
Pcdhga10 A G 18: 37,880,619 (GRCm39) N127D probably damaging Het
Plb1 A G 5: 32,502,983 (GRCm39) I1148V probably damaging Het
Plcb1 A G 2: 135,212,430 (GRCm39) D1007G probably benign Het
Prdm16 T A 4: 154,613,316 (GRCm39) E37V probably damaging Het
Prss45 C A 9: 110,668,261 (GRCm39) N151K possibly damaging Het
Rngtt A T 4: 33,498,981 (GRCm39) K513* probably null Het
Serpinb10 T C 1: 107,460,117 (GRCm39) probably benign Het
Shc1 T C 3: 89,334,129 (GRCm39) V402A probably benign Het
Slc25a38 T A 9: 119,949,902 (GRCm39) L227Q probably benign Het
Slc6a13 A T 6: 121,313,798 (GRCm39) K514* probably null Het
Sorcs3 T C 19: 48,760,705 (GRCm39) V911A possibly damaging Het
Sptb A T 12: 76,657,651 (GRCm39) I1290N probably damaging Het
Sptbn1 T C 11: 30,089,292 (GRCm39) K657E possibly damaging Het
Stpg4 T A 17: 87,735,068 (GRCm39) probably null Het
Stx2 A G 5: 129,064,863 (GRCm39) V278A possibly damaging Het
Thoc1 A T 18: 9,992,902 (GRCm39) N558I probably benign Het
Trpm2 T C 10: 77,750,568 (GRCm39) T1343A probably benign Het
Usf3 T A 16: 44,040,939 (GRCm39) D1806E probably benign Het
Vmn2r106 C T 17: 20,488,037 (GRCm39) M787I possibly damaging Het
Wdfy4 A G 14: 32,873,566 (GRCm39) S248P Het
Zeb2 G T 2: 44,891,829 (GRCm39) probably null Het
Other mutations in Or9s14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02310:Or9s14 APN 1 92,535,787 (GRCm39) missense possibly damaging 0.80
R0189:Or9s14 UTSW 1 92,535,615 (GRCm39) missense probably damaging 0.99
R0520:Or9s14 UTSW 1 92,536,471 (GRCm39) missense probably damaging 1.00
R0605:Or9s14 UTSW 1 92,535,618 (GRCm39) missense probably benign 0.02
R1568:Or9s14 UTSW 1 92,535,676 (GRCm39) missense probably damaging 1.00
R1753:Or9s14 UTSW 1 92,536,122 (GRCm39) missense probably benign 0.07
R1778:Or9s14 UTSW 1 92,535,831 (GRCm39) missense possibly damaging 0.88
R2960:Or9s14 UTSW 1 92,536,050 (GRCm39) missense probably benign 0.00
R4206:Or9s14 UTSW 1 92,536,317 (GRCm39) missense possibly damaging 0.95
R7868:Or9s14 UTSW 1 92,536,237 (GRCm39) missense possibly damaging 0.63
R8447:Or9s14 UTSW 1 92,535,494 (GRCm39) start gained probably benign
R8925:Or9s14 UTSW 1 92,536,438 (GRCm39) missense probably damaging 1.00
R8927:Or9s14 UTSW 1 92,536,438 (GRCm39) missense probably damaging 1.00
R9512:Or9s14 UTSW 1 92,535,990 (GRCm39) missense probably benign 0.00
Z1176:Or9s14 UTSW 1 92,535,473 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- ATGTGCCCTATGACCTGTGC -3'
(R):5'- TTGCTCCATGGATGCCACAC -3'

Sequencing Primer
(F):5'- ATGACCTGTGCCCGTCTTG -3'
(R):5'- TCCTGGCTGGCCATATATAACAAAG -3'
Posted On 2019-09-13