Incidental Mutation 'R7384:Apc2'
| ID |
572963 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Apc2
|
| Ensembl Gene |
ENSMUSG00000020135 |
| Gene Name |
APC regulator of WNT signaling pathway 2 |
| Synonyms |
APCL |
| MMRRC Submission |
045466-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.163)
|
| Stock # |
R7384 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
80131811-80154097 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 80148458 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 1171
(V1171I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000100996
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020349]
[ENSMUST00000105359]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020349
AA Change: V1142I
PolyPhen 2
Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000020349
Gene: ENSMUSG00000020135
AA Change: V1142I
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
4 |
57 |
9e-17 |
PDB |
|
Pfam:Suppressor_APC
|
123 |
205 |
1.3e-28 |
PFAM |
|
coiled coil region
|
214 |
236 |
N/A |
INTRINSIC |
|
low complexity region
|
242 |
261 |
N/A |
INTRINSIC |
|
ARM
|
300 |
355 |
2.95e0 |
SMART |
|
ARM
|
417 |
468 |
2.22e-2 |
SMART |
|
ARM
|
470 |
511 |
3.22e0 |
SMART |
|
ARM
|
513 |
555 |
3.56e-1 |
SMART |
|
ARM
|
557 |
602 |
2.1e1 |
SMART |
|
ARM
|
607 |
647 |
1.82e-7 |
SMART |
|
Blast:ARM
|
649 |
689 |
6e-18 |
BLAST |
|
low complexity region
|
772 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
971 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1103 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1134 |
1159 |
4.4e-9 |
PFAM |
|
low complexity region
|
1197 |
1208 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1244 |
1269 |
4.1e-8 |
PFAM |
|
Pfam:SAMP
|
1323 |
1343 |
2.1e-10 |
PFAM |
|
Pfam:APC_crr
|
1369 |
1394 |
5.8e-8 |
PFAM |
|
low complexity region
|
1500 |
1516 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1540 |
1565 |
5.7e-8 |
PFAM |
|
Pfam:SAMP
|
1594 |
1613 |
8.8e-11 |
PFAM |
|
low complexity region
|
1673 |
1699 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1757 |
2093 |
1.1e-142 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105359
AA Change: V1171I
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000100996
Gene: ENSMUSG00000020135
AA Change: V1171I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:APC_N_CC
|
30 |
81 |
2.7e-34 |
PFAM |
|
Pfam:Suppressor_APC
|
148 |
228 |
1.4e-27 |
PFAM |
|
coiled coil region
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
285 |
N/A |
INTRINSIC |
|
ARM
|
324 |
379 |
2.95e0 |
SMART |
|
ARM
|
446 |
497 |
2.22e-2 |
SMART |
|
ARM
|
499 |
540 |
3.22e0 |
SMART |
|
ARM
|
542 |
584 |
3.56e-1 |
SMART |
|
ARM
|
586 |
631 |
2.1e1 |
SMART |
|
ARM
|
636 |
676 |
1.82e-7 |
SMART |
|
Blast:ARM
|
678 |
718 |
6e-18 |
BLAST |
|
Pfam:Arm_APC_u3
|
719 |
977 |
1.1e-26 |
PFAM |
|
low complexity region
|
1000 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1086 |
1098 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1164 |
1187 |
9.3e-8 |
PFAM |
|
low complexity region
|
1226 |
1237 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1274 |
1297 |
7.9e-10 |
PFAM |
|
Pfam:APC_crr
|
1399 |
1423 |
1.3e-9 |
PFAM |
|
low complexity region
|
1529 |
1545 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1603 |
N/A |
INTRINSIC |
|
Pfam:SAMP
|
1624 |
1642 |
1.3e-11 |
PFAM |
|
low complexity region
|
1702 |
1728 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1786 |
2122 |
1.3e-122 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl4fm5 |
T |
A |
4: 144,507,191 (GRCm39) |
I65F |
possibly damaging |
Het |
| Abca13 |
C |
A |
11: 9,283,257 (GRCm39) |
S3226R |
probably damaging |
Het |
| Abhd14b |
A |
G |
9: 106,327,340 (GRCm39) |
I41V |
probably benign |
Het |
| Acot2 |
T |
C |
12: 84,039,441 (GRCm39) |
S317P |
probably benign |
Het |
| Acp7 |
T |
C |
7: 28,314,513 (GRCm39) |
E284G |
possibly damaging |
Het |
| Adamts5 |
A |
G |
16: 85,696,714 (GRCm39) |
F148L |
probably benign |
Het |
| Adcy10 |
C |
T |
1: 165,404,177 (GRCm39) |
P1611S |
unknown |
Het |
| Agr2 |
A |
G |
12: 36,045,923 (GRCm39) |
T57A |
probably damaging |
Het |
| Ankar |
T |
G |
1: 72,697,624 (GRCm39) |
I1060L |
probably benign |
Het |
| Ano10 |
T |
A |
9: 122,005,409 (GRCm39) |
D77V |
unknown |
Het |
| Anxa2r1 |
T |
A |
13: 120,496,797 (GRCm39) |
Q24L |
possibly damaging |
Het |
| Apoa4 |
G |
A |
9: 46,152,772 (GRCm39) |
R19Q |
not run |
Het |
| Arhgap33 |
A |
G |
7: 30,226,696 (GRCm39) |
S504P |
probably damaging |
Het |
| Atg2a |
T |
C |
19: 6,311,707 (GRCm39) |
V1862A |
probably damaging |
Het |
| Atp7b |
T |
C |
8: 22,512,331 (GRCm39) |
S511G |
probably benign |
Het |
| Bcl10 |
A |
G |
3: 145,638,795 (GRCm39) |
K146E |
possibly damaging |
Het |
| Bsg |
A |
T |
10: 79,545,631 (GRCm39) |
D181V |
probably damaging |
Het |
| Btg4 |
T |
C |
9: 51,030,413 (GRCm39) |
V171A |
probably benign |
Het |
| Cdh8 |
A |
C |
8: 99,957,138 (GRCm39) |
N188K |
probably benign |
Het |
| Cflar |
C |
A |
1: 58,791,735 (GRCm39) |
T346K |
|
Het |
| Chrna5 |
T |
C |
9: 54,912,117 (GRCm39) |
S306P |
probably damaging |
Het |
| Cldn20 |
G |
A |
17: 3,582,886 (GRCm39) |
G20R |
probably damaging |
Het |
| Clns1a |
G |
A |
7: 97,345,988 (GRCm39) |
A18T |
probably benign |
Het |
| D130043K22Rik |
A |
G |
13: 25,066,588 (GRCm39) |
Y795C |
probably damaging |
Het |
| Dync1li2 |
A |
C |
8: 105,169,175 (GRCm39) |
S38A |
probably benign |
Het |
| Dysf |
A |
G |
6: 84,091,087 (GRCm39) |
E1043G |
probably benign |
Het |
| Elapor1 |
A |
T |
3: 108,370,784 (GRCm39) |
|
probably null |
Het |
| Eral1 |
A |
G |
11: 77,964,927 (GRCm39) |
I422T |
possibly damaging |
Het |
| Exoc3 |
G |
A |
13: 74,320,275 (GRCm39) |
P729S |
probably benign |
Het |
| Eya1 |
T |
A |
1: 14,299,736 (GRCm39) |
Y339F |
probably damaging |
Het |
| Faah |
G |
T |
4: 115,862,364 (GRCm39) |
N206K |
probably damaging |
Het |
| Fem1a |
A |
G |
17: 56,564,537 (GRCm39) |
E210G |
probably benign |
Het |
| Gcc2 |
T |
A |
10: 58,105,786 (GRCm39) |
S341T |
probably damaging |
Het |
| Gfpt2 |
A |
T |
11: 49,701,817 (GRCm39) |
I123F |
possibly damaging |
Het |
| Gm3047 |
T |
A |
14: 4,558,271 (GRCm38) |
N164K |
probably damaging |
Het |
| Gm3327 |
A |
G |
14: 44,362,334 (GRCm39) |
K78E |
|
Het |
| Herpud1 |
A |
G |
8: 95,116,005 (GRCm39) |
I57V |
probably damaging |
Het |
| Homer1 |
A |
T |
13: 93,529,547 (GRCm39) |
R285S |
possibly damaging |
Het |
| Hps6 |
T |
A |
19: 45,992,456 (GRCm39) |
V131E |
possibly damaging |
Het |
| Il1r1 |
T |
A |
1: 40,321,421 (GRCm39) |
I11N |
possibly damaging |
Het |
| Jakmip1 |
T |
A |
5: 37,330,551 (GRCm39) |
D410E |
possibly damaging |
Het |
| Kif3a |
T |
A |
11: 53,469,681 (GRCm39) |
F97L |
probably damaging |
Het |
| Klf11 |
C |
T |
12: 24,703,742 (GRCm39) |
T76I |
probably damaging |
Het |
| Ldlr |
A |
C |
9: 21,651,090 (GRCm39) |
T503P |
probably benign |
Het |
| Mapk3 |
G |
C |
7: 126,363,463 (GRCm39) |
R279P |
|
Het |
| Mb21d2 |
A |
T |
16: 28,647,664 (GRCm39) |
D103E |
probably benign |
Het |
| Msh4 |
T |
A |
3: 153,594,385 (GRCm39) |
M333L |
probably benign |
Het |
| Mycbp2 |
A |
G |
14: 103,513,829 (GRCm39) |
I836T |
probably damaging |
Het |
| Myh1 |
A |
T |
11: 67,115,201 (GRCm39) |
E1912V |
possibly damaging |
Het |
| Ncapd2 |
A |
G |
6: 125,150,364 (GRCm39) |
V887A |
probably benign |
Het |
| Nlrp4a |
G |
A |
7: 26,148,963 (GRCm39) |
R190Q |
not run |
Het |
| Nop53 |
T |
C |
7: 15,673,420 (GRCm39) |
T344A |
probably damaging |
Het |
| Or2r3 |
A |
T |
6: 42,448,257 (GRCm39) |
L285Q |
possibly damaging |
Het |
| Or5an11 |
T |
C |
19: 12,246,440 (GRCm39) |
V282A |
possibly damaging |
Het |
| Or7h8 |
A |
G |
9: 20,124,041 (GRCm39) |
Y132C |
probably damaging |
Het |
| Pcyox1l |
A |
C |
18: 61,831,461 (GRCm39) |
V266G |
probably damaging |
Het |
| Pde5a |
A |
G |
3: 122,618,649 (GRCm39) |
Y654C |
probably damaging |
Het |
| Polq |
T |
C |
16: 36,849,780 (GRCm39) |
S345P |
probably damaging |
Het |
| Polr1f |
G |
T |
12: 33,483,631 (GRCm39) |
G128W |
probably damaging |
Het |
| Prdm1 |
A |
T |
10: 44,334,503 (GRCm39) |
C8S |
probably benign |
Het |
| Psg17 |
T |
A |
7: 18,552,585 (GRCm39) |
Q230L |
possibly damaging |
Het |
| Rab11fip5 |
A |
T |
6: 85,325,312 (GRCm39) |
S332T |
possibly damaging |
Het |
| Rac2 |
T |
A |
15: 78,446,131 (GRCm39) |
K186* |
probably null |
Het |
| S100pbp |
T |
C |
4: 129,075,702 (GRCm39) |
N208D |
probably benign |
Het |
| Scaf11 |
A |
T |
15: 96,318,268 (GRCm39) |
V432D |
possibly damaging |
Het |
| Skic3 |
A |
C |
13: 76,298,854 (GRCm39) |
S1187R |
possibly damaging |
Het |
| Slc34a1 |
G |
T |
13: 55,550,747 (GRCm39) |
C225F |
probably benign |
Het |
| Slc35e2 |
A |
T |
4: 155,695,089 (GRCm39) |
M152L |
probably benign |
Het |
| Slc49a3 |
A |
T |
5: 108,593,926 (GRCm39) |
I61K |
probably damaging |
Het |
| Slc9a4 |
T |
A |
1: 40,651,411 (GRCm39) |
I563K |
probably benign |
Het |
| Sppl3 |
T |
G |
5: 115,199,700 (GRCm39) |
|
probably null |
Het |
| Stam |
T |
C |
2: 14,139,241 (GRCm39) |
F301L |
probably benign |
Het |
| Supt16 |
G |
A |
14: 52,418,619 (GRCm39) |
R213W |
probably damaging |
Het |
| Tbc1d8 |
A |
T |
1: 39,433,179 (GRCm39) |
D334E |
probably benign |
Het |
| Tmem87a |
C |
T |
2: 120,202,004 (GRCm39) |
|
probably null |
Het |
| Tnk1 |
T |
C |
11: 69,742,447 (GRCm39) |
Y661C |
probably damaging |
Het |
| Tnpo2 |
G |
A |
8: 85,776,748 (GRCm39) |
R485H |
probably damaging |
Het |
| Tnxb |
A |
G |
17: 34,937,492 (GRCm39) |
D2947G |
probably damaging |
Het |
| Traf4 |
A |
G |
11: 78,051,617 (GRCm39) |
|
probably null |
Het |
| Trappc10 |
A |
T |
10: 78,045,218 (GRCm39) |
M490K |
possibly damaging |
Het |
| Trav12-1 |
A |
G |
14: 53,775,993 (GRCm39) |
T49A |
probably benign |
Het |
| Ubap1l |
AGAGGAGGAGGAGGAGGA |
AGAGGAGGAGGAGGA |
9: 65,279,032 (GRCm39) |
|
probably benign |
Het |
| Unc79 |
G |
T |
12: 103,137,837 (GRCm39) |
V2485L |
probably benign |
Het |
| Ush2a |
T |
C |
1: 188,132,360 (GRCm39) |
S861P |
probably damaging |
Het |
| Vcam1 |
A |
G |
3: 115,910,877 (GRCm39) |
V507A |
possibly damaging |
Het |
| Vmn1r218 |
A |
G |
13: 23,320,895 (GRCm39) |
M81V |
probably benign |
Het |
| Zfp652 |
G |
T |
11: 95,643,830 (GRCm39) |
V343L |
probably damaging |
Het |
|
| Other mutations in Apc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01069:Apc2
|
APN |
10 |
80,147,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01154:Apc2
|
APN |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01411:Apc2
|
APN |
10 |
80,150,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01598:Apc2
|
APN |
10 |
80,148,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01621:Apc2
|
APN |
10 |
80,142,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01720:Apc2
|
APN |
10 |
80,150,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Apc2
|
APN |
10 |
80,150,492 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01933:Apc2
|
APN |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02243:Apc2
|
APN |
10 |
80,138,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02292:Apc2
|
APN |
10 |
80,138,258 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02956:Apc2
|
APN |
10 |
80,142,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03081:Apc2
|
APN |
10 |
80,148,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Apc2
|
APN |
10 |
80,149,220 (GRCm39) |
missense |
probably damaging |
0.98 |
|
LCD18:Apc2
|
UTSW |
10 |
80,135,808 (GRCm39) |
intron |
probably benign |
|
|
R0278:Apc2
|
UTSW |
10 |
80,148,647 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0501:Apc2
|
UTSW |
10 |
80,150,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Apc2
|
UTSW |
10 |
80,142,090 (GRCm39) |
nonsense |
probably null |
|
|
R0607:Apc2
|
UTSW |
10 |
80,149,935 (GRCm39) |
missense |
probably benign |
|
|
R0624:Apc2
|
UTSW |
10 |
80,150,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0633:Apc2
|
UTSW |
10 |
80,143,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0638:Apc2
|
UTSW |
10 |
80,140,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0647:Apc2
|
UTSW |
10 |
80,140,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0830:Apc2
|
UTSW |
10 |
80,151,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Apc2
|
UTSW |
10 |
80,147,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1221:Apc2
|
UTSW |
10 |
80,142,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Apc2
|
UTSW |
10 |
80,148,183 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1579:Apc2
|
UTSW |
10 |
80,147,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Apc2
|
UTSW |
10 |
80,137,676 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1700:Apc2
|
UTSW |
10 |
80,148,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Apc2
|
UTSW |
10 |
80,144,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Apc2
|
UTSW |
10 |
80,149,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Apc2
|
UTSW |
10 |
80,150,678 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1915:Apc2
|
UTSW |
10 |
80,151,701 (GRCm39) |
missense |
probably benign |
|
|
R1999:Apc2
|
UTSW |
10 |
80,144,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Apc2
|
UTSW |
10 |
80,143,443 (GRCm39) |
splice site |
probably null |
|
|
R2219:Apc2
|
UTSW |
10 |
80,144,943 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2393:Apc2
|
UTSW |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3862:Apc2
|
UTSW |
10 |
80,143,393 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3900:Apc2
|
UTSW |
10 |
80,131,806 (GRCm39) |
splice site |
probably null |
|
|
R3901:Apc2
|
UTSW |
10 |
80,150,922 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3952:Apc2
|
UTSW |
10 |
80,150,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Apc2
|
UTSW |
10 |
80,149,426 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4090:Apc2
|
UTSW |
10 |
80,141,378 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4695:Apc2
|
UTSW |
10 |
80,146,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Apc2
|
UTSW |
10 |
80,150,192 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4807:Apc2
|
UTSW |
10 |
80,150,196 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4886:Apc2
|
UTSW |
10 |
80,150,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Apc2
|
UTSW |
10 |
80,149,841 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5056:Apc2
|
UTSW |
10 |
80,137,148 (GRCm39) |
missense |
probably benign |
|
|
R5057:Apc2
|
UTSW |
10 |
80,144,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Apc2
|
UTSW |
10 |
80,151,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5241:Apc2
|
UTSW |
10 |
80,148,068 (GRCm39) |
missense |
probably benign |
|
|
R5649:Apc2
|
UTSW |
10 |
80,149,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Apc2
|
UTSW |
10 |
80,147,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6124:Apc2
|
UTSW |
10 |
80,142,185 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6218:Apc2
|
UTSW |
10 |
80,142,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6376:Apc2
|
UTSW |
10 |
80,148,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Apc2
|
UTSW |
10 |
80,149,757 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6572:Apc2
|
UTSW |
10 |
80,147,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Apc2
|
UTSW |
10 |
80,149,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7171:Apc2
|
UTSW |
10 |
80,151,170 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7180:Apc2
|
UTSW |
10 |
80,146,990 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7326:Apc2
|
UTSW |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Apc2
|
UTSW |
10 |
80,149,316 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7378:Apc2
|
UTSW |
10 |
80,147,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Apc2
|
UTSW |
10 |
80,138,017 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7543:Apc2
|
UTSW |
10 |
80,150,720 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7743:Apc2
|
UTSW |
10 |
80,140,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7759:Apc2
|
UTSW |
10 |
80,147,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Apc2
|
UTSW |
10 |
80,151,166 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8327:Apc2
|
UTSW |
10 |
80,137,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8489:Apc2
|
UTSW |
10 |
80,143,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8494:Apc2
|
UTSW |
10 |
80,150,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Apc2
|
UTSW |
10 |
80,149,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8773:Apc2
|
UTSW |
10 |
80,142,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8920:Apc2
|
UTSW |
10 |
80,149,934 (GRCm39) |
missense |
probably benign |
|
|
R9178:Apc2
|
UTSW |
10 |
80,150,235 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9224:Apc2
|
UTSW |
10 |
80,150,111 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9357:Apc2
|
UTSW |
10 |
80,146,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9394:Apc2
|
UTSW |
10 |
80,145,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Apc2
|
UTSW |
10 |
80,147,183 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9689:Apc2
|
UTSW |
10 |
80,150,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Apc2
|
UTSW |
10 |
80,148,098 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Apc2
|
UTSW |
10 |
80,147,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTTGACAGCGATTCATCCC -3'
(R):5'- TTTCCCACTGCAGGCTGAAC -3'
Sequencing Primer
(F):5'- TTGACAGCGATTCATCCCTGGAG -3'
(R):5'- CTGAACTGGCTGGTCTCAG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation