Incidental Mutation 'R7390:Adamts15'
| ID |
573364 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts15
|
| Ensembl Gene |
ENSMUSG00000033453 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 15 |
| Synonyms |
|
| MMRRC Submission |
045472-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7390 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
30810451-30833748 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to T
at 30822404 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000067022
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000065112]
[ENSMUST00000216215]
|
| AlphaFold |
P59384 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000065112
|
| SMART Domains |
Protein: ENSMUSP00000067022
Gene: ENSMUSG00000033453
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
24 |
157 |
8.7e-27 |
PFAM |
|
Pfam:Reprolysin_4
|
216 |
422 |
8.2e-7 |
PFAM |
|
Pfam:Reprolysin_5
|
217 |
404 |
7.2e-13 |
PFAM |
|
Pfam:Reprolysin
|
218 |
427 |
3.7e-20 |
PFAM |
|
Pfam:Reprolysin_3
|
240 |
372 |
6.1e-10 |
PFAM |
|
Blast:ACR
|
429 |
507 |
1e-25 |
BLAST |
|
TSP1
|
519 |
571 |
7.85e-12 |
SMART |
|
Pfam:ADAM_spacer1
|
683 |
801 |
7.1e-36 |
PFAM |
|
TSP1
|
842 |
895 |
3e-8 |
SMART |
|
TSP1
|
896 |
949 |
4.21e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000216215
|
| Meta Mutation Damage Score |
0.9489 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
97% (66/68) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active versicanase enzyme. This gene is located adjacent to a related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq, Jul 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930486L24Rik |
A |
T |
13: 60,992,152 (GRCm39) |
D291E |
probably benign |
Het |
| Abca9 |
C |
T |
11: 110,036,487 (GRCm39) |
V541I |
probably benign |
Het |
| Adgrg7 |
A |
G |
16: 56,553,207 (GRCm39) |
I630T |
probably damaging |
Het |
| Ahnak |
A |
G |
19: 8,980,569 (GRCm39) |
I618V |
probably benign |
Het |
| Amotl2 |
T |
A |
9: 102,608,889 (GRCm39) |
V801E |
probably damaging |
Het |
| Ankrd17 |
T |
C |
5: 90,430,779 (GRCm39) |
T1002A |
probably benign |
Het |
| Bmp7 |
C |
T |
2: 172,711,998 (GRCm39) |
D409N |
probably damaging |
Het |
| Bpifb2 |
A |
G |
2: 153,731,726 (GRCm39) |
N293S |
possibly damaging |
Het |
| Ccdc162 |
A |
G |
10: 41,510,044 (GRCm39) |
C854R |
probably benign |
Het |
| Ccdc171 |
A |
G |
4: 83,736,304 (GRCm39) |
E1225G |
probably damaging |
Het |
| Cep350 |
T |
C |
1: 155,741,833 (GRCm39) |
E2146G |
possibly damaging |
Het |
| Ces1a |
A |
C |
8: 93,771,469 (GRCm39) |
|
probably null |
Het |
| Cfap45 |
T |
G |
1: 172,368,925 (GRCm39) |
D444E |
probably benign |
Het |
| Cfap61 |
T |
C |
2: 145,843,802 (GRCm39) |
V296A |
probably benign |
Het |
| Cgnl1 |
C |
T |
9: 71,552,931 (GRCm39) |
R1011H |
probably benign |
Het |
| Cops4 |
C |
T |
5: 100,691,741 (GRCm39) |
R347C |
probably damaging |
Het |
| D16Ertd472e |
G |
T |
16: 78,344,576 (GRCm39) |
D177E |
probably benign |
Het |
| Dcdc2a |
T |
C |
13: 25,291,600 (GRCm39) |
V195A |
possibly damaging |
Het |
| Dipk2a |
A |
G |
9: 94,419,436 (GRCm39) |
S165P |
probably damaging |
Het |
| Dpagt1 |
G |
A |
9: 44,243,319 (GRCm39) |
V285I |
probably benign |
Het |
| Dspp |
G |
T |
5: 104,323,552 (GRCm39) |
A232S |
probably damaging |
Het |
| Efcab3 |
T |
C |
11: 104,615,411 (GRCm39) |
I726T |
possibly damaging |
Het |
| Ephx2 |
G |
A |
14: 66,347,904 (GRCm39) |
|
|
Het |
| Fat1 |
T |
C |
8: 45,405,511 (GRCm39) |
V754A |
possibly damaging |
Het |
| Fstl3 |
G |
A |
10: 79,615,865 (GRCm39) |
C117Y |
probably damaging |
Het |
| Gldc |
A |
T |
19: 30,077,314 (GRCm39) |
S953T |
possibly damaging |
Het |
| Gm1123 |
T |
C |
9: 98,893,033 (GRCm39) |
N315S |
probably benign |
Het |
| Golga2 |
A |
G |
2: 32,178,202 (GRCm39) |
E37G |
|
Het |
| Gpr139 |
T |
A |
7: 118,743,835 (GRCm39) |
Q250L |
probably benign |
Het |
| Grik3 |
C |
T |
4: 125,543,532 (GRCm39) |
R283C |
probably damaging |
Het |
| Haao |
A |
C |
17: 84,154,081 (GRCm39) |
V22G |
probably damaging |
Het |
| Hspg2 |
T |
A |
4: 137,266,490 (GRCm39) |
F1884I |
probably damaging |
Het |
| Hyal3 |
G |
A |
9: 107,462,166 (GRCm39) |
G67S |
probably damaging |
Het |
| Kbtbd3 |
T |
A |
9: 4,330,424 (GRCm39) |
I266K |
probably benign |
Het |
| Klhl26 |
A |
C |
8: 70,905,499 (GRCm39) |
L137R |
probably damaging |
Het |
| Krt15 |
A |
T |
11: 100,026,386 (GRCm39) |
V100E |
possibly damaging |
Het |
| Lars1 |
A |
G |
18: 42,343,083 (GRCm39) |
|
probably null |
Het |
| Lats1 |
C |
T |
10: 7,577,859 (GRCm39) |
Q328* |
probably null |
Het |
| Lingo3 |
G |
A |
10: 80,670,463 (GRCm39) |
T489I |
probably damaging |
Het |
| Lmtk2 |
T |
C |
5: 144,066,261 (GRCm39) |
V65A |
possibly damaging |
Het |
| Lysmd1 |
T |
C |
3: 95,045,795 (GRCm39) |
S211P |
probably damaging |
Het |
| Med15 |
C |
T |
16: 17,540,626 (GRCm39) |
S21N |
unknown |
Het |
| Nav1 |
T |
C |
1: 135,512,656 (GRCm39) |
T135A |
probably benign |
Het |
| Nt5c1a |
G |
C |
4: 123,102,272 (GRCm39) |
R66T |
probably benign |
Het |
| Pclo |
T |
C |
5: 14,732,024 (GRCm39) |
Y3509H |
unknown |
Het |
| Pkp4 |
G |
A |
2: 59,140,484 (GRCm39) |
G397R |
possibly damaging |
Het |
| Ppp1r21 |
G |
A |
17: 88,856,958 (GRCm39) |
A138T |
probably benign |
Het |
| Pum3 |
A |
T |
19: 27,401,642 (GRCm39) |
V136D |
probably benign |
Het |
| Rab11fip3 |
A |
T |
17: 26,287,126 (GRCm39) |
D342E |
possibly damaging |
Het |
| Rcvrn |
T |
A |
11: 67,590,883 (GRCm39) |
W156R |
probably damaging |
Het |
| Rspry1 |
C |
T |
8: 95,349,813 (GRCm39) |
T67I |
probably benign |
Het |
| Serpina1d |
T |
C |
12: 103,734,037 (GRCm39) |
D89G |
possibly damaging |
Het |
| Sgsm3 |
T |
A |
15: 80,893,021 (GRCm39) |
V366E |
possibly damaging |
Het |
| Shank3 |
T |
G |
15: 89,433,515 (GRCm39) |
L1420R |
probably benign |
Het |
| Sirpb1b |
A |
T |
3: 15,608,100 (GRCm39) |
L215* |
probably null |
Het |
| Slc16a13 |
C |
T |
11: 70,109,797 (GRCm39) |
V235I |
probably benign |
Het |
| Slc16a14 |
T |
C |
1: 84,907,187 (GRCm39) |
D29G |
probably benign |
Het |
| Speer1a |
T |
C |
5: 11,394,879 (GRCm39) |
V122A |
probably benign |
Het |
| Spns2 |
T |
A |
11: 72,347,704 (GRCm39) |
T329S |
possibly damaging |
Het |
| Sufu |
G |
A |
19: 46,439,108 (GRCm39) |
|
probably null |
Het |
| Tll2 |
A |
G |
19: 41,108,608 (GRCm39) |
|
probably null |
Het |
| Trim10 |
G |
A |
17: 37,180,773 (GRCm39) |
M1I |
probably null |
Het |
| Trim42 |
A |
C |
9: 97,241,182 (GRCm39) |
N683K |
probably damaging |
Het |
| Trmt5 |
A |
G |
12: 73,328,394 (GRCm39) |
S270P |
probably damaging |
Het |
| Vmn1r59 |
C |
A |
7: 5,456,986 (GRCm39) |
R258L |
possibly damaging |
Het |
| Vmn2r32 |
A |
G |
7: 7,482,851 (GRCm39) |
L41S |
probably benign |
Het |
| Vmn2r93 |
A |
T |
17: 18,525,329 (GRCm39) |
E329V |
probably damaging |
Het |
| Ywhae |
G |
T |
11: 75,655,487 (GRCm39) |
E253* |
probably null |
Het |
|
| Other mutations in Adamts15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00930:Adamts15
|
APN |
9 |
30,813,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01325:Adamts15
|
APN |
9 |
30,832,984 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01506:Adamts15
|
APN |
9 |
30,833,430 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01897:Adamts15
|
APN |
9 |
30,813,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02137:Adamts15
|
APN |
9 |
30,821,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Adamts15
|
APN |
9 |
30,815,818 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02997:Adamts15
|
APN |
9 |
30,817,353 (GRCm39) |
splice site |
probably benign |
|
|
IGL03094:Adamts15
|
APN |
9 |
30,815,768 (GRCm39) |
splice site |
probably benign |
|
|
IGL03146:Adamts15
|
APN |
9 |
30,832,863 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03241:Adamts15
|
APN |
9 |
30,815,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Awareness
|
UTSW |
9 |
30,822,404 (GRCm39) |
critical splice donor site |
probably null |
|
|
heightened
|
UTSW |
9 |
30,816,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Pugsley
|
UTSW |
9 |
30,817,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
sparticus
|
UTSW |
9 |
30,821,898 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0118:Adamts15
|
UTSW |
9 |
30,823,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0635:Adamts15
|
UTSW |
9 |
30,816,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0827:Adamts15
|
UTSW |
9 |
30,832,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0946:Adamts15
|
UTSW |
9 |
30,813,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1608:Adamts15
|
UTSW |
9 |
30,813,775 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1806:Adamts15
|
UTSW |
9 |
30,816,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1954:Adamts15
|
UTSW |
9 |
30,822,004 (GRCm39) |
missense |
probably benign |
|
|
R1967:Adamts15
|
UTSW |
9 |
30,832,605 (GRCm39) |
nonsense |
probably null |
|
|
R2009:Adamts15
|
UTSW |
9 |
30,833,433 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2129:Adamts15
|
UTSW |
9 |
30,815,799 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2329:Adamts15
|
UTSW |
9 |
30,813,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2991:Adamts15
|
UTSW |
9 |
30,832,690 (GRCm39) |
missense |
probably benign |
|
|
R3970:Adamts15
|
UTSW |
9 |
30,821,898 (GRCm39) |
missense |
probably benign |
0.40 |
|
R4212:Adamts15
|
UTSW |
9 |
30,817,470 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4326:Adamts15
|
UTSW |
9 |
30,815,814 (GRCm39) |
missense |
probably benign |
|
|
R4329:Adamts15
|
UTSW |
9 |
30,815,814 (GRCm39) |
missense |
probably benign |
|
|
R4594:Adamts15
|
UTSW |
9 |
30,832,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5110:Adamts15
|
UTSW |
9 |
30,832,740 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5120:Adamts15
|
UTSW |
9 |
30,832,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5697:Adamts15
|
UTSW |
9 |
30,823,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5901:Adamts15
|
UTSW |
9 |
30,813,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6011:Adamts15
|
UTSW |
9 |
30,814,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6020:Adamts15
|
UTSW |
9 |
30,813,358 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6651:Adamts15
|
UTSW |
9 |
30,833,448 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6665:Adamts15
|
UTSW |
9 |
30,815,775 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7021:Adamts15
|
UTSW |
9 |
30,832,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7231:Adamts15
|
UTSW |
9 |
30,817,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7290:Adamts15
|
UTSW |
9 |
30,813,906 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7798:Adamts15
|
UTSW |
9 |
30,815,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7833:Adamts15
|
UTSW |
9 |
30,833,401 (GRCm39) |
missense |
probably benign |
|
|
R7908:Adamts15
|
UTSW |
9 |
30,813,522 (GRCm39) |
missense |
probably benign |
|
|
R8175:Adamts15
|
UTSW |
9 |
30,815,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Adamts15
|
UTSW |
9 |
30,833,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8347:Adamts15
|
UTSW |
9 |
30,813,846 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8348:Adamts15
|
UTSW |
9 |
30,813,846 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8374:Adamts15
|
UTSW |
9 |
30,814,002 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8473:Adamts15
|
UTSW |
9 |
30,816,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8680:Adamts15
|
UTSW |
9 |
30,823,055 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9113:Adamts15
|
UTSW |
9 |
30,822,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9336:Adamts15
|
UTSW |
9 |
30,816,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9381:Adamts15
|
UTSW |
9 |
30,813,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0063:Adamts15
|
UTSW |
9 |
30,833,526 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0067:Adamts15
|
UTSW |
9 |
30,832,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adamts15
|
UTSW |
9 |
30,821,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Adamts15
|
UTSW |
9 |
30,813,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAGGACATTTGCTGGGACAAG -3'
(R):5'- ATTTTGCTCCATCCCACAGG -3'
Sequencing Primer
(F):5'- CATTTGCTGGGACAAGATGGAAAAG -3'
(R):5'- TCCATCCCACAGGCCATG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation