Mutagenetix > Incidental Mutation

Incidental Mutation 'R7405:Or10w1'

574550

Institutional Source

Beutler Lab

Gene Symbol

Or10w1

Ensembl Gene

ENSMUSG00000061387

Gene Name

olfactory receptor family 10 subfamily W member 1

Synonyms

Olfr1490, GA_x6K02T2RE5P-3987000-3987950, MOR266-6P

MMRRC Submission

045376-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.128) question?

Stock #

R7405 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

13631810-13632760 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 13632246 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 151 (V151A)

Ref Sequence

ENSEMBL: ENSMUSP00000151186 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080162] [ENSMUST00000213900]

AlphaFold

A0A1L1SVH0

Predicted Effect

probably benign
Transcript: ENSMUST00000080162
AA Change: V146A

PolyPhen 2 Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000079057
Gene: ENSMUSG00000061387
AA Change: V146A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	5.3e-48	PFAM
Pfam:7tm_1	41	290	2e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213900
AA Change: V151A

PolyPhen 2 Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	G	T	17: 9,220,649 (GRCm39)	V383L	probably damaging	Het
4930507D05Rik	C	A	10: 62,285,563 (GRCm39)	H96N	unknown	Het
5730480H06Rik	T	C	5: 48,545,458 (GRCm39)	I235T	possibly damaging	Het
Abcb11	A	G	2: 69,117,963 (GRCm39)	Y472H	probably damaging	Het
Adam39	A	T	8: 41,277,659 (GRCm39)	I17L	probably benign	Het
Aire	T	C	10: 77,870,447 (GRCm39)	H458R	probably benign	Het
Ap3d1	T	C	10: 80,577,734 (GRCm39)	D31G	probably benign	Het
Atad2b	T	A	12: 4,993,232 (GRCm39)	H250Q	probably benign	Het
Bnip5	G	A	17: 29,124,298 (GRCm39)	R335W	probably damaging	Het
Borcs5	C	A	6: 134,662,945 (GRCm39)	T74N	probably benign	Het
Btbd16	C	T	7: 130,407,586 (GRCm39)	T292I	probably benign	Het
Catsperd	G	A	17: 56,939,335 (GRCm39)	V55M	possibly damaging	Het
Cfap107	T	C	4: 144,146,323 (GRCm39)	N110S	probably damaging	Het
Ctr9	T	C	7: 110,642,921 (GRCm39)	F462S	possibly damaging	Het
Cyp4f39	A	G	17: 32,700,789 (GRCm39)	S153G	probably benign	Het
Ddo	T	C	10: 40,523,993 (GRCm39)	C328R	possibly damaging	Het
Ddr1	A	G	17: 36,000,992 (GRCm39)	V251A	probably damaging	Het
Dis3l	A	G	9: 64,221,986 (GRCm39)	F475L	probably damaging	Het
Dkk4	G	A	8: 23,115,859 (GRCm39)	V99M	probably benign	Het
Dync1h1	C	T	12: 110,600,654 (GRCm39)	A1938V	probably damaging	Het
Ecel1	A	T	1: 87,081,238 (GRCm39)		probably null	Het
Fbxo7	T	A	10: 85,880,445 (GRCm39)	Y377N	probably damaging	Het
Fbxw24	T	C	9: 109,436,136 (GRCm39)	I299V	possibly damaging	Het
Fkbp10	C	T	11: 100,306,707 (GRCm39)	A33V	probably damaging	Het
Gabra1	T	C	11: 42,045,850 (GRCm39)	T87A	probably damaging	Het
Gm21886	ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG	ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG	18: 80,133,040 (GRCm39)		probably benign	Het
Golga3	A	T	5: 110,356,312 (GRCm39)	I1000F	probably damaging	Het
Grid2ip	T	C	5: 143,366,199 (GRCm39)	I563T	probably benign	Het
Gsx1	T	C	5: 147,125,943 (GRCm39)	S82P	possibly damaging	Het
Heg1	A	G	16: 33,583,819 (GRCm39)	K34E	possibly damaging	Het
Kank1	T	A	19: 25,387,683 (GRCm39)	L452*	probably null	Het
Lce1k	A	T	3: 92,714,181 (GRCm39)	M1K	probably null	Het
Lcmt2	A	G	2: 120,969,868 (GRCm39)	I185T	probably benign	Het
Lrp1	T	C	10: 127,417,620 (GRCm39)	D1046G	possibly damaging	Het
Lrrc37	A	T	11: 103,505,987 (GRCm39)	Y1994N	probably benign	Het
Mast3	A	T	8: 71,238,815 (GRCm39)	D496E	probably damaging	Het
Mst1r	C	T	9: 107,792,321 (GRCm39)	S925F	possibly damaging	Het
Mterf2	C	T	10: 84,956,360 (GRCm39)	G88D	probably damaging	Het
Mthfd1	T	C	12: 76,358,648 (GRCm39)	V783A	probably damaging	Het
Mybpc2	A	T	7: 44,156,618 (GRCm39)	W778R	probably damaging	Het
Nbea	A	G	3: 55,712,687 (GRCm39)	L2130P	possibly damaging	Het
Ndst4	A	G	3: 125,476,865 (GRCm39)	N30S	probably benign	Het
Nphs1	T	C	7: 30,162,253 (GRCm39)	V299A	possibly damaging	Het
Nup107	T	C	10: 117,606,320 (GRCm39)	D474G	probably benign	Het
Or10ag56	A	C	2: 87,139,339 (GRCm39)	I89L	probably benign	Het
Or2w25	T	A	11: 59,504,899 (GRCm39)	F370I	possibly damaging	Het
Or7a42	T	C	10: 78,791,531 (GRCm39)	V164A	probably benign	Het
Pgap2	T	C	7: 101,880,595 (GRCm39)	V41A	probably benign	Het
Plekhh1	C	T	12: 79,101,821 (GRCm39)	T297I	probably benign	Het
Plxna4	A	T	6: 32,173,254 (GRCm39)	Y1226N	probably benign	Het
Polr3b	A	G	10: 84,520,043 (GRCm39)	D653G	probably benign	Het
Ppp2r2c	T	C	5: 37,104,486 (GRCm39)	F289L	possibly damaging	Het
Prickle2	A	G	6: 92,435,524 (GRCm39)	S82P	probably damaging	Het
Ptger2	T	A	14: 45,226,531 (GRCm39)	V37D	probably damaging	Het
Rasa2	G	A	9: 96,448,080 (GRCm39)	P526S	probably benign	Het
Rbm47	A	T	5: 66,183,838 (GRCm39)	I255N	probably damaging	Het
Sez6	A	T	11: 77,853,717 (GRCm39)	T296S	probably benign	Het
Slc2a9	T	A	5: 38,549,167 (GRCm39)	I316F	probably damaging	Het
Slc41a1	T	A	1: 131,766,884 (GRCm39)	V134D	probably damaging	Het
Slc5a7	A	T	17: 54,604,161 (GRCm39)	S2T	probably benign	Het
Slc9a4	C	T	1: 40,640,086 (GRCm39)	R293C	probably damaging	Het
Son	CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC	CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC	16: 91,453,579 (GRCm39)		probably benign	Het
Suco	A	G	1: 161,655,783 (GRCm39)	F1039L	possibly damaging	Het
Sycp1	A	G	3: 102,832,543 (GRCm39)	Y208H	possibly damaging	Het
Tpr	T	C	1: 150,317,878 (GRCm39)	S2129P	probably benign	Het
Trim34b	T	A	7: 103,985,690 (GRCm39)	S442T	probably damaging	Het
Ttn	A	T	2: 76,573,690 (GRCm39)	Y25734*	probably null	Het
Uchl5	C	T	1: 143,675,752 (GRCm39)	Q276*	probably null	Het
Wrn	C	G	8: 33,738,994 (GRCm39)	W1278S	probably benign	Het
Yeats2	T	A	16: 20,041,663 (GRCm39)	D1184E	probably damaging	Het
Zfat	G	A	15: 68,056,334 (GRCm39)	R241W	probably damaging	Het
Zfp646	T	A	7: 127,477,968 (GRCm39)	Y48*	probably null	Het
Zfp998	T	C	13: 66,579,118 (GRCm39)	Q455R	unknown	Het

Other mutations in Or10w1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01324:Or10w1	APN	19	13,632,297 (GRCm39)	missense	probably damaging	0.96
IGL01335:Or10w1	APN	19	13,632,540 (GRCm39)	missense	probably damaging	1.00
IGL01561:Or10w1	APN	19	13,632,269 (GRCm39)	missense	probably benign
IGL01644:Or10w1	APN	19	13,632,768 (GRCm39)	utr 3 prime	probably benign
IGL02257:Or10w1	APN	19	13,632,629 (GRCm39)	missense	probably benign
IGL02282:Or10w1	APN	19	13,632,622 (GRCm39)	missense	probably damaging	1.00
IGL02355:Or10w1	APN	19	13,632,597 (GRCm39)	missense	probably benign	0.02
IGL02362:Or10w1	APN	19	13,632,597 (GRCm39)	missense	probably benign	0.02
IGL02639:Or10w1	APN	19	13,631,960 (GRCm39)	missense	possibly damaging	0.73
R0078:Or10w1	UTSW	19	13,632,179 (GRCm39)	missense	probably benign	0.00
R0278:Or10w1	UTSW	19	13,632,129 (GRCm39)	missense	probably damaging	1.00
R0278:Or10w1	UTSW	19	13,632,128 (GRCm39)	missense	probably damaging	1.00
R0506:Or10w1	UTSW	19	13,632,261 (GRCm39)	missense	possibly damaging	0.62
R0927:Or10w1	UTSW	19	13,631,816 (GRCm39)	missense	probably damaging	0.99
R1087:Or10w1	UTSW	19	13,632,376 (GRCm39)	nonsense	probably null
R1762:Or10w1	UTSW	19	13,631,868 (GRCm39)	missense	probably benign
R2901:Or10w1	UTSW	19	13,632,309 (GRCm39)	missense	probably damaging	1.00
R2907:Or10w1	UTSW	19	13,632,611 (GRCm39)	missense	possibly damaging	0.84
R3625:Or10w1	UTSW	19	13,632,346 (GRCm39)	nonsense	probably null
R3838:Or10w1	UTSW	19	13,632,321 (GRCm39)	missense	probably benign	0.00
R4745:Or10w1	UTSW	19	13,632,750 (GRCm39)	missense	probably benign
R4804:Or10w1	UTSW	19	13,631,882 (GRCm39)	missense	probably benign
R5026:Or10w1	UTSW	19	13,632,296 (GRCm39)	missense	probably benign	0.03
R5314:Or10w1	UTSW	19	13,632,630 (GRCm39)	missense	probably benign	0.08
R6052:Or10w1	UTSW	19	13,631,871 (GRCm39)	missense	possibly damaging	0.95
R6235:Or10w1	UTSW	19	13,632,145 (GRCm39)	nonsense	probably null
R7557:Or10w1	UTSW	19	13,632,390 (GRCm39)	missense	possibly damaging	0.71
R8038:Or10w1	UTSW	19	13,632,719 (GRCm39)	missense	possibly damaging	0.91
R8338:Or10w1	UTSW	19	13,632,216 (GRCm39)	missense	possibly damaging	0.92
R8366:Or10w1	UTSW	19	13,631,903 (GRCm39)	missense	probably damaging	1.00
R8496:Or10w1	UTSW	19	13,632,388 (GRCm39)	missense	probably damaging	0.96
R8783:Or10w1	UTSW	19	13,632,323 (GRCm39)	missense	probably damaging	1.00
R8838:Or10w1	UTSW	19	13,632,371 (GRCm39)	missense	probably damaging	0.98
R8859:Or10w1	UTSW	19	13,632,246 (GRCm39)	missense	probably damaging	0.99
R9064:Or10w1	UTSW	19	13,632,719 (GRCm39)	missense	possibly damaging	0.91
R9161:Or10w1	UTSW	19	13,632,038 (GRCm39)	missense	probably damaging	1.00
R9466:Or10w1	UTSW	19	13,631,796 (GRCm39)	start codon destroyed	probably null
R9596:Or10w1	UTSW	19	13,632,002 (GRCm39)	missense	probably damaging	1.00
R9623:Or10w1	UTSW	19	13,632,414 (GRCm39)	missense	probably damaging	1.00
Z1176:Or10w1	UTSW	19	13,631,827 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GACCATTTCTCTGCTGAGCTG -3'
(R):5'- AGTTTGAGCACAGCAGCCAC -3'

Sequencing Primer
(F):5'- TGAGCTGTGCCACTCAGATG -3'
(R):5'- CCACTATCAAGGCATAGGTGGTG -3'

Posted On

2019-09-13