Incidental Mutation 'R7406:Or6c219'
ID 574750
Institutional Source Beutler Lab
Gene Symbol Or6c219
Ensembl Gene ENSMUSG00000058071
Gene Name olfactory receptor family 6 subfamily C member 219
Synonyms Olfr818, GA_x6K02T2PULF-11624146-11623190, MOR110-2
MMRRC Submission 045487-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R7406 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129780973-129781929 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129781435 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 50 (D50E)
Ref Sequence ENSEMBL: ENSMUSP00000145108 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074308] [ENSMUST00000205227] [ENSMUST00000215527]
AlphaFold Q8VG46
Predicted Effect probably benign
Transcript: ENSMUST00000074308
AA Change: D165E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000073918
Gene: ENSMUSG00000058071
AA Change: D165E

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.4e-47 PFAM
Pfam:7tm_1 39 287 3.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205227
AA Change: D50E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000145108
Gene: ENSMUSG00000058071
AA Change: D50E

DomainStartEndE-ValueType
Pfam:7tm_1 1 122 5e-13 PFAM
Pfam:7tm_4 1 123 8.7e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215527
AA Change: D165E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810459M11Rik T C 1: 85,974,231 (GRCm39) S183P possibly damaging Het
2900092C05Rik A G 7: 12,249,391 (GRCm39) T75A possibly damaging Het
Abhd8 A G 8: 71,914,406 (GRCm39) V74A probably benign Het
Agrn A C 4: 156,256,758 (GRCm39) S1282R possibly damaging Het
Atf5 T C 7: 44,462,380 (GRCm39) N248S possibly damaging Het
Atp2a3 A G 11: 72,869,576 (GRCm39) Y497C probably damaging Het
Bpifa2 T G 2: 153,851,739 (GRCm39) S58R probably benign Het
Cacna1h C T 17: 25,604,600 (GRCm39) E1238K possibly damaging Het
Ccdc71 T A 9: 108,340,523 (GRCm39) L112* probably null Het
Cd300e A T 11: 114,946,128 (GRCm39) I111N probably damaging Het
Cdkl3 A T 11: 51,924,369 (GRCm39) E552D probably benign Het
Chst5 A G 8: 112,617,245 (GRCm39) V125A probably benign Het
Clock A T 5: 76,414,692 (GRCm39) M1K probably null Het
Cops7b T A 1: 86,528,852 (GRCm39) L193Q probably benign Het
Csmd1 T C 8: 16,338,707 (GRCm39) T467A probably damaging Het
Ctr9 A G 7: 110,652,615 (GRCm39) E971G unknown Het
Dcp2 A G 18: 44,543,254 (GRCm39) T271A probably benign Het
Dsp A G 13: 38,381,172 (GRCm39) N2639S possibly damaging Het
Fhip1a T C 3: 85,637,784 (GRCm39) I172V probably benign Het
Gm11168 C G 9: 3,006,912 (GRCm39) C212W probably benign Het
Gpr179 G T 11: 97,242,420 (GRCm39) D141E probably damaging Het
H2bc4 A G 13: 23,868,342 (GRCm39) Y43C probably damaging Het
Hdhd2 C T 18: 77,031,811 (GRCm39) T89M probably benign Het
Krt6b T G 15: 101,587,513 (GRCm39) T194P probably benign Het
Lrp1b T C 2: 41,266,030 (GRCm39) probably null Het
Maneal A T 4: 124,754,161 (GRCm39) I214N possibly damaging Het
Map1lc3b T A 8: 122,317,355 (GRCm39) C11S unknown Het
Mapt G A 11: 104,213,350 (GRCm39) G296E possibly damaging Het
Mgam A G 6: 40,640,459 (GRCm39) N509S probably benign Het
Mrgprx1 T A 7: 47,671,733 (GRCm39) I5F possibly damaging Het
Mroh5 T C 15: 73,659,583 (GRCm39) D416G probably benign Het
Ncan T G 8: 70,562,749 (GRCm39) D503A probably benign Het
Nedd1 A T 10: 92,547,185 (GRCm39) probably null Het
Ogdh A G 11: 6,298,351 (GRCm39) T641A probably benign Het
Or2b6 T C 13: 21,823,316 (GRCm39) I126V probably benign Het
Or4k2 T A 14: 50,424,015 (GRCm39) I221F probably damaging Het
Or8b1b T A 9: 38,375,439 (GRCm39) M34K possibly damaging Het
Pcdhga8 A C 18: 37,859,238 (GRCm39) Q98P possibly damaging Het
Pik3c2a A G 7: 115,953,242 (GRCm39) Y1218H probably damaging Het
Ppp3cc A T 14: 70,483,387 (GRCm39) S229T possibly damaging Het
Prss43 T G 9: 110,657,764 (GRCm39) I221S probably damaging Het
Rasal1 A T 5: 120,801,002 (GRCm39) T221S probably benign Het
Serpinb9f G T 13: 33,518,543 (GRCm39) E348* probably null Het
Sfxn5 A G 6: 85,244,889 (GRCm39) Y169H probably damaging Het
Skint9 T C 4: 112,246,428 (GRCm39) N228S probably benign Het
Slx4ip A T 2: 136,842,162 (GRCm39) D29V probably damaging Het
Snx29 G T 16: 11,573,180 (GRCm39) G474V probably damaging Het
Spata6 T A 4: 111,638,017 (GRCm39) D282E possibly damaging Het
Srek1 A T 13: 103,905,890 (GRCm39) V77E probably damaging Het
Timd6 A G 11: 46,468,285 (GRCm39) T120A possibly damaging Het
Tmt1a3 T C 15: 100,233,289 (GRCm39) V160A probably benign Het
Tnfrsf22 T C 7: 143,194,564 (GRCm39) D121G probably damaging Het
Ucma G A 2: 4,990,170 (GRCm39) W122* probably null Het
Vmn2r124 T C 17: 18,282,306 (GRCm39) M113T unknown Het
Vmn2r54 A T 7: 12,350,150 (GRCm39) probably null Het
Vmn2r8 A G 5: 108,948,442 (GRCm39) L482S probably benign Het
Vwa3a T A 7: 120,378,138 (GRCm39) I476N probably damaging Het
Vwa8 A C 14: 79,219,674 (GRCm39) probably null Het
Wdr26 A T 1: 181,015,240 (GRCm39) S390R probably damaging Het
Zbtb40 A T 4: 136,728,205 (GRCm39) S471T probably benign Het
Other mutations in Or6c219
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Or6c219 APN 10 129,781,780 (GRCm39) missense possibly damaging 0.95
IGL00951:Or6c219 APN 10 129,781,581 (GRCm39) missense probably damaging 0.99
IGL01700:Or6c219 APN 10 129,781,810 (GRCm39) missense probably damaging 1.00
IGL02313:Or6c219 APN 10 129,781,772 (GRCm39) missense probably damaging 1.00
IGL02373:Or6c219 APN 10 129,781,334 (GRCm39) missense probably benign 0.11
IGL02983:Or6c219 APN 10 129,781,058 (GRCm39) missense probably damaging 1.00
R0730:Or6c219 UTSW 10 129,780,980 (GRCm39) missense probably benign 0.04
R1574:Or6c219 UTSW 10 129,781,379 (GRCm39) missense probably damaging 1.00
R1574:Or6c219 UTSW 10 129,781,379 (GRCm39) missense probably damaging 1.00
R1789:Or6c219 UTSW 10 129,781,451 (GRCm39) nonsense probably null
R1824:Or6c219 UTSW 10 129,781,206 (GRCm39) missense possibly damaging 0.67
R2107:Or6c219 UTSW 10 129,781,581 (GRCm39) missense probably damaging 0.99
R2398:Or6c219 UTSW 10 129,781,076 (GRCm39) missense probably benign 0.04
R5799:Or6c219 UTSW 10 129,781,780 (GRCm39) missense possibly damaging 0.95
R6048:Or6c219 UTSW 10 129,781,695 (GRCm39) missense possibly damaging 0.67
R7027:Or6c219 UTSW 10 129,781,041 (GRCm39) missense possibly damaging 0.60
R7222:Or6c219 UTSW 10 129,781,758 (GRCm39) missense probably damaging 1.00
R8483:Or6c219 UTSW 10 129,780,998 (GRCm39) missense probably benign 0.02
R9306:Or6c219 UTSW 10 129,781,289 (GRCm39) missense probably damaging 1.00
R9752:Or6c219 UTSW 10 129,780,990 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- CAACCATGTGTGAGGAGCAG -3'
(R):5'- AGAGTTCTACCTCCTGGCTG -3'

Sequencing Primer
(F):5'- CCTTTGTTGAGCTGAAGGGAAC -3'
(R):5'- GCCATGTCCTATGATCGCTATGTAG -3'
Posted On 2019-10-07