Incidental Mutation 'R7406:Mroh5'
ID 574766
Institutional Source Beutler Lab
Gene Symbol Mroh5
Ensembl Gene ENSMUSG00000072487
Gene Name maestro heat-like repeat family member 5
Synonyms Gm628, LOC268816
MMRRC Submission 045487-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R7406 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 73658785-73711520 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73659583 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 416 (D416G)
Ref Sequence ENSEMBL: ENSMUSP00000071366 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071419] [ENSMUST00000110021] [ENSMUST00000151999]
AlphaFold A0A571BEG0
Predicted Effect probably benign
Transcript: ENSMUST00000071419
AA Change: D416G

PolyPhen 2 Score 0.375 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000071366
Gene: ENSMUSG00000072487
AA Change: D416G

DomainStartEndE-ValueType
low complexity region 173 184 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110021
AA Change: D419G

PolyPhen 2 Score 0.375 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000151999
SMART Domains Protein: ENSMUSP00000118236
Gene: ENSMUSG00000072487

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
SCOP:d1gw5a_ 294 635 1e-2 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (60/61)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810459M11Rik T C 1: 85,974,231 (GRCm39) S183P possibly damaging Het
2900092C05Rik A G 7: 12,249,391 (GRCm39) T75A possibly damaging Het
Abhd8 A G 8: 71,914,406 (GRCm39) V74A probably benign Het
Agrn A C 4: 156,256,758 (GRCm39) S1282R possibly damaging Het
Atf5 T C 7: 44,462,380 (GRCm39) N248S possibly damaging Het
Atp2a3 A G 11: 72,869,576 (GRCm39) Y497C probably damaging Het
Bpifa2 T G 2: 153,851,739 (GRCm39) S58R probably benign Het
Cacna1h C T 17: 25,604,600 (GRCm39) E1238K possibly damaging Het
Ccdc71 T A 9: 108,340,523 (GRCm39) L112* probably null Het
Cd300e A T 11: 114,946,128 (GRCm39) I111N probably damaging Het
Cdkl3 A T 11: 51,924,369 (GRCm39) E552D probably benign Het
Chst5 A G 8: 112,617,245 (GRCm39) V125A probably benign Het
Clock A T 5: 76,414,692 (GRCm39) M1K probably null Het
Cops7b T A 1: 86,528,852 (GRCm39) L193Q probably benign Het
Csmd1 T C 8: 16,338,707 (GRCm39) T467A probably damaging Het
Ctr9 A G 7: 110,652,615 (GRCm39) E971G unknown Het
Dcp2 A G 18: 44,543,254 (GRCm39) T271A probably benign Het
Dsp A G 13: 38,381,172 (GRCm39) N2639S possibly damaging Het
Fhip1a T C 3: 85,637,784 (GRCm39) I172V probably benign Het
Gm11168 C G 9: 3,006,912 (GRCm39) C212W probably benign Het
Gpr179 G T 11: 97,242,420 (GRCm39) D141E probably damaging Het
H2bc4 A G 13: 23,868,342 (GRCm39) Y43C probably damaging Het
Hdhd2 C T 18: 77,031,811 (GRCm39) T89M probably benign Het
Krt6b T G 15: 101,587,513 (GRCm39) T194P probably benign Het
Lrp1b T C 2: 41,266,030 (GRCm39) probably null Het
Maneal A T 4: 124,754,161 (GRCm39) I214N possibly damaging Het
Map1lc3b T A 8: 122,317,355 (GRCm39) C11S unknown Het
Mapt G A 11: 104,213,350 (GRCm39) G296E possibly damaging Het
Mgam A G 6: 40,640,459 (GRCm39) N509S probably benign Het
Mrgprx1 T A 7: 47,671,733 (GRCm39) I5F possibly damaging Het
Ncan T G 8: 70,562,749 (GRCm39) D503A probably benign Het
Nedd1 A T 10: 92,547,185 (GRCm39) probably null Het
Ogdh A G 11: 6,298,351 (GRCm39) T641A probably benign Het
Or2b6 T C 13: 21,823,316 (GRCm39) I126V probably benign Het
Or4k2 T A 14: 50,424,015 (GRCm39) I221F probably damaging Het
Or6c219 A T 10: 129,781,435 (GRCm39) D50E probably benign Het
Or8b1b T A 9: 38,375,439 (GRCm39) M34K possibly damaging Het
Pcdhga8 A C 18: 37,859,238 (GRCm39) Q98P possibly damaging Het
Pik3c2a A G 7: 115,953,242 (GRCm39) Y1218H probably damaging Het
Ppp3cc A T 14: 70,483,387 (GRCm39) S229T possibly damaging Het
Prss43 T G 9: 110,657,764 (GRCm39) I221S probably damaging Het
Rasal1 A T 5: 120,801,002 (GRCm39) T221S probably benign Het
Serpinb9f G T 13: 33,518,543 (GRCm39) E348* probably null Het
Sfxn5 A G 6: 85,244,889 (GRCm39) Y169H probably damaging Het
Skint9 T C 4: 112,246,428 (GRCm39) N228S probably benign Het
Slx4ip A T 2: 136,842,162 (GRCm39) D29V probably damaging Het
Snx29 G T 16: 11,573,180 (GRCm39) G474V probably damaging Het
Spata6 T A 4: 111,638,017 (GRCm39) D282E possibly damaging Het
Srek1 A T 13: 103,905,890 (GRCm39) V77E probably damaging Het
Timd6 A G 11: 46,468,285 (GRCm39) T120A possibly damaging Het
Tmt1a3 T C 15: 100,233,289 (GRCm39) V160A probably benign Het
Tnfrsf22 T C 7: 143,194,564 (GRCm39) D121G probably damaging Het
Ucma G A 2: 4,990,170 (GRCm39) W122* probably null Het
Vmn2r124 T C 17: 18,282,306 (GRCm39) M113T unknown Het
Vmn2r54 A T 7: 12,350,150 (GRCm39) probably null Het
Vmn2r8 A G 5: 108,948,442 (GRCm39) L482S probably benign Het
Vwa3a T A 7: 120,378,138 (GRCm39) I476N probably damaging Het
Vwa8 A C 14: 79,219,674 (GRCm39) probably null Het
Wdr26 A T 1: 181,015,240 (GRCm39) S390R probably damaging Het
Zbtb40 A T 4: 136,728,205 (GRCm39) S471T probably benign Het
Other mutations in Mroh5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Mroh5 APN 15 73,664,638 (GRCm39) splice site probably benign
IGL00466:Mroh5 APN 15 73,664,638 (GRCm39) splice site probably benign
IGL02937:Mroh5 APN 15 73,661,827 (GRCm39) missense probably damaging 1.00
R0102:Mroh5 UTSW 15 73,691,199 (GRCm39) missense probably benign 0.07
R0321:Mroh5 UTSW 15 73,661,892 (GRCm39) missense probably damaging 1.00
R0433:Mroh5 UTSW 15 73,662,657 (GRCm39) missense probably damaging 1.00
R0433:Mroh5 UTSW 15 73,661,877 (GRCm39) missense probably benign 0.01
R0707:Mroh5 UTSW 15 73,662,588 (GRCm39) missense possibly damaging 0.48
R1666:Mroh5 UTSW 15 73,659,754 (GRCm39) missense probably benign 0.43
R1668:Mroh5 UTSW 15 73,659,754 (GRCm39) missense probably benign 0.43
R2139:Mroh5 UTSW 15 73,661,940 (GRCm39) missense probably damaging 1.00
R2269:Mroh5 UTSW 15 73,664,997 (GRCm39) missense probably benign 0.02
R4078:Mroh5 UTSW 15 73,657,889 (GRCm39) missense possibly damaging 0.79
R4420:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R4460:Mroh5 UTSW 15 73,663,645 (GRCm39) missense probably damaging 0.97
R4585:Mroh5 UTSW 15 73,661,120 (GRCm39) missense probably benign 0.38
R5285:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R5287:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R5437:Mroh5 UTSW 15 73,659,818 (GRCm39) missense probably benign 0.02
R5760:Mroh5 UTSW 15 73,693,356 (GRCm39) missense probably damaging 0.98
R5972:Mroh5 UTSW 15 73,662,568 (GRCm39) critical splice donor site probably null
R6192:Mroh5 UTSW 15 73,662,630 (GRCm39) missense probably damaging 1.00
R6457:Mroh5 UTSW 15 73,662,691 (GRCm39) missense probably damaging 1.00
R6477:Mroh5 UTSW 15 73,662,604 (GRCm39) missense probably damaging 1.00
R6776:Mroh5 UTSW 15 73,661,817 (GRCm39) critical splice donor site probably null
R6979:Mroh5 UTSW 15 73,664,978 (GRCm39) missense probably benign 0.16
R7238:Mroh5 UTSW 15 73,663,278 (GRCm39) critical splice acceptor site probably null
R7853:Mroh5 UTSW 15 73,663,189 (GRCm39) missense probably benign 0.00
R7973:Mroh5 UTSW 15 73,664,614 (GRCm39) nonsense probably null
R8215:Mroh5 UTSW 15 73,691,139 (GRCm39) missense probably damaging 0.96
R8251:Mroh5 UTSW 15 73,655,002 (GRCm39) missense probably benign 0.01
R8771:Mroh5 UTSW 15 73,693,203 (GRCm39) missense possibly damaging 0.92
R9032:Mroh5 UTSW 15 73,655,302 (GRCm39) missense probably benign 0.00
R9070:Mroh5 UTSW 15 73,656,688 (GRCm39) missense probably damaging 1.00
R9238:Mroh5 UTSW 15 73,663,586 (GRCm39) missense probably benign 0.05
R9321:Mroh5 UTSW 15 73,661,113 (GRCm39) missense probably benign 0.00
X0024:Mroh5 UTSW 15 73,659,570 (GRCm39) missense probably benign 0.01
Z1088:Mroh5 UTSW 15 73,659,880 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- GAACACATTCCTTTGAGAGAGC -3'
(R):5'- ACATCAACATCCAGGTGCGG -3'

Sequencing Primer
(F):5'- CCTCTTCTGTGAATTCCTTGGGTTG -3'
(R):5'- CGGCCTGCACTTAAGCC -3'
Posted On 2019-10-07