Incidental Mutation 'R7409:Adgrb2'
| ID |
574909 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb2
|
| Ensembl Gene |
ENSMUSG00000028782 |
| Gene Name |
adhesion G protein-coupled receptor B2 |
| Synonyms |
Bai2 |
| MMRRC Submission |
045490-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7409 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
129878663-129916426 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 129912862 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 1329
(A1329V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112869
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030571]
[ENSMUST00000097868]
[ENSMUST00000106015]
[ENSMUST00000106017]
[ENSMUST00000106018]
[ENSMUST00000120204]
[ENSMUST00000121049]
|
| AlphaFold |
Q8CGM1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030571
AA Change: A1384V
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000030571
Gene: ENSMUSG00000028782
AA Change: A1384V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:GAIN
|
600 |
842 |
1.6e-41 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
1.7e-67 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097868
AA Change: A1351V
PolyPhen 2
Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000095480
Gene: ENSMUSG00000028782
AA Change: A1351V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
1.2e-54 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1159 |
2.6e-69 |
PFAM |
|
low complexity region
|
1324 |
1338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106015
AA Change: A1384V
PolyPhen 2
Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000101636
Gene: ENSMUSG00000028782
AA Change: A1384V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.4e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
4.1e-68 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106017
AA Change: A1372V
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000101638
Gene: ENSMUSG00000028782
AA Change: A1372V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.3e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1180 |
4.6e-68 |
PFAM |
|
low complexity region
|
1345 |
1359 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106018
AA Change: A1296V
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000101639
Gene: ENSMUSG00000028782
AA Change: A1296V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
1.1e-54 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
2.4e-69 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120204
AA Change: A1296V
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000112524
Gene: ENSMUSG00000028782
AA Change: A1296V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
8.2e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
9.6e-70 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121049
AA Change: A1329V
PolyPhen 2
Score 0.153 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000112869
Gene: ENSMUSG00000028782
AA Change: A1329V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
6.1e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1137 |
3.8e-68 |
PFAM |
|
low complexity region
|
1302 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163625
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136416
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136787
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
98% (82/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene show a lessening of depression like behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aida |
A |
G |
1: 183,099,809 (GRCm39) |
T215A |
probably benign |
Het |
| Alpk2 |
A |
G |
18: 65,440,023 (GRCm39) |
S457P |
probably benign |
Het |
| Ap4b1 |
G |
A |
3: 103,719,474 (GRCm39) |
V63I |
probably damaging |
Het |
| Apaf1 |
A |
G |
10: 90,903,108 (GRCm39) |
V182A |
probably damaging |
Het |
| B4galnt4 |
G |
A |
7: 140,646,916 (GRCm39) |
|
probably null |
Het |
| Bltp2 |
G |
T |
11: 78,159,583 (GRCm39) |
R544L |
probably damaging |
Het |
| Cacna1a |
T |
G |
8: 85,260,031 (GRCm39) |
D331E |
probably damaging |
Het |
| Carmil2 |
A |
G |
8: 106,419,423 (GRCm39) |
|
probably null |
Het |
| Cdkn1b |
A |
T |
6: 134,898,280 (GRCm39) |
Q133L |
probably benign |
Het |
| Cep192 |
G |
C |
18: 67,967,874 (GRCm39) |
S786T |
possibly damaging |
Het |
| Cfap418 |
T |
A |
4: 10,881,834 (GRCm39) |
C94S |
probably benign |
Het |
| Cfap97 |
G |
A |
8: 46,645,733 (GRCm39) |
R537H |
probably benign |
Het |
| Clpx |
C |
G |
9: 65,231,529 (GRCm39) |
A552G |
possibly damaging |
Het |
| Cryl1 |
G |
A |
14: 57,523,842 (GRCm39) |
T240I |
probably damaging |
Het |
| Ddx60 |
C |
A |
8: 62,411,612 (GRCm39) |
T488K |
probably benign |
Het |
| Dennd4b |
A |
G |
3: 90,181,259 (GRCm39) |
H805R |
probably benign |
Het |
| Dnmbp |
T |
C |
19: 43,878,996 (GRCm39) |
D25G |
unknown |
Het |
| Dysf |
A |
C |
6: 84,126,664 (GRCm39) |
D1293A |
probably benign |
Het |
| Efl1 |
T |
C |
7: 82,347,121 (GRCm39) |
L549P |
probably damaging |
Het |
| Eif5 |
T |
C |
12: 111,506,697 (GRCm39) |
|
probably benign |
Het |
| Eva1c |
A |
G |
16: 90,666,544 (GRCm39) |
K156E |
probably damaging |
Het |
| Fbxw10 |
T |
G |
11: 62,767,606 (GRCm39) |
V814G |
possibly damaging |
Het |
| Gfap |
C |
T |
11: 102,785,358 (GRCm39) |
R206Q |
probably benign |
Het |
| Gjb6 |
A |
T |
14: 57,361,610 (GRCm39) |
L217* |
probably null |
Het |
| Gpatch11 |
T |
A |
17: 79,146,595 (GRCm39) |
L80Q |
probably damaging |
Het |
| Gramd1b |
T |
C |
9: 40,238,727 (GRCm39) |
Q225R |
probably damaging |
Het |
| Gsdmc2 |
A |
G |
15: 63,705,195 (GRCm39) |
S173P |
possibly damaging |
Het |
| Hars1 |
C |
G |
18: 36,903,166 (GRCm39) |
R388P |
probably damaging |
Het |
| Ighm |
C |
T |
12: 113,385,852 (GRCm39) |
R129H |
|
Het |
| Igsf9 |
A |
G |
1: 172,322,841 (GRCm39) |
I602V |
probably benign |
Het |
| Inpp4b |
T |
G |
8: 82,679,314 (GRCm39) |
|
probably null |
Het |
| Itch |
C |
A |
2: 155,041,302 (GRCm39) |
T450K |
probably damaging |
Het |
| Kcnq1 |
T |
C |
7: 142,663,152 (GRCm39) |
F20L |
unknown |
Het |
| Kmt2d |
G |
T |
15: 98,753,235 (GRCm39) |
A153E |
probably damaging |
Het |
| Macf1 |
T |
A |
4: 123,398,263 (GRCm39) |
N750I |
probably damaging |
Het |
| Marveld2 |
T |
A |
13: 100,747,984 (GRCm39) |
H365L |
probably damaging |
Het |
| Med13l |
T |
A |
5: 118,892,386 (GRCm39) |
D1936E |
probably benign |
Het |
| Mettl8 |
A |
T |
2: 70,803,687 (GRCm39) |
V200E |
probably damaging |
Het |
| Mrgbp |
T |
G |
2: 180,227,135 (GRCm39) |
S157A |
possibly damaging |
Het |
| Mrps35 |
A |
G |
6: 146,957,481 (GRCm39) |
T169A |
possibly damaging |
Het |
| Mycbp2 |
A |
T |
14: 103,526,180 (GRCm39) |
Y551N |
probably damaging |
Het |
| Myo18b |
T |
C |
5: 113,021,971 (GRCm39) |
R474G |
probably benign |
Het |
| Nfx1 |
T |
A |
4: 41,021,830 (GRCm39) |
S979R |
possibly damaging |
Het |
| Nlrp1a |
T |
C |
11: 71,013,634 (GRCm39) |
T539A |
probably benign |
Het |
| Oca2 |
T |
A |
7: 56,064,145 (GRCm39) |
D713E |
probably benign |
Het |
| Omt2b |
A |
C |
9: 78,235,894 (GRCm39) |
Y73S |
probably benign |
Het |
| Or10aa1 |
T |
A |
1: 173,870,099 (GRCm39) |
H194Q |
probably benign |
Het |
| Or13a27 |
C |
T |
7: 139,925,318 (GRCm39) |
V195I |
probably benign |
Het |
| Or6c38 |
A |
G |
10: 128,929,081 (GRCm39) |
I254T |
probably damaging |
Het |
| Or6c69 |
A |
T |
10: 129,748,120 (GRCm39) |
V9D |
possibly damaging |
Het |
| Pde11a |
G |
T |
2: 75,836,328 (GRCm39) |
Q20K |
|
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm39) |
|
probably benign |
Het |
| Phrf1 |
C |
A |
7: 140,839,205 (GRCm39) |
T800K |
unknown |
Het |
| Polr1f |
T |
G |
12: 33,486,988 (GRCm39) |
C150W |
possibly damaging |
Het |
| Pramel4 |
T |
C |
4: 143,795,061 (GRCm39) |
S486P |
probably benign |
Het |
| Proc |
T |
C |
18: 32,260,513 (GRCm39) |
D204G |
probably benign |
Het |
| Rasgrp3 |
T |
A |
17: 75,823,411 (GRCm39) |
I494N |
possibly damaging |
Het |
| Samm50 |
A |
G |
15: 84,081,231 (GRCm39) |
D53G |
probably benign |
Het |
| Satb1 |
T |
C |
17: 52,116,217 (GRCm39) |
D22G |
possibly damaging |
Het |
| Scarf2 |
T |
C |
16: 17,624,918 (GRCm39) |
S658P |
probably damaging |
Het |
| Sfta2 |
T |
A |
17: 35,925,410 (GRCm39) |
I29K |
unknown |
Het |
| Slc15a4 |
A |
T |
5: 127,681,742 (GRCm39) |
S292T |
probably benign |
Het |
| Slc37a1 |
C |
T |
17: 31,559,237 (GRCm39) |
T439I |
probably damaging |
Het |
| Slc4a9 |
C |
A |
18: 36,663,858 (GRCm39) |
P294Q |
probably damaging |
Het |
| Slc52a3 |
T |
C |
2: 151,846,086 (GRCm39) |
S16P |
probably damaging |
Het |
| Slc6a15 |
A |
G |
10: 103,244,163 (GRCm39) |
I468V |
probably benign |
Het |
| Spag17 |
T |
C |
3: 99,934,547 (GRCm39) |
S610P |
possibly damaging |
Het |
| Spag17 |
A |
T |
3: 99,941,475 (GRCm39) |
D738V |
probably benign |
Het |
| Ssbp4 |
T |
C |
8: 71,050,617 (GRCm39) |
R269G |
unknown |
Het |
| Tbl1xr1 |
A |
G |
3: 22,257,354 (GRCm39) |
T406A |
possibly damaging |
Het |
| Tep1 |
A |
T |
14: 51,104,312 (GRCm39) |
V194D |
possibly damaging |
Het |
| Thbs4 |
A |
T |
13: 92,909,767 (GRCm39) |
C343* |
probably null |
Het |
| Tmed10 |
A |
T |
12: 85,391,065 (GRCm39) |
S158T |
possibly damaging |
Het |
| Trbv3 |
T |
A |
6: 41,025,524 (GRCm39) |
V38E |
probably damaging |
Het |
| Ttc6 |
T |
C |
12: 57,743,772 (GRCm39) |
M1258T |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,589,320 (GRCm39) |
D21281G |
probably damaging |
Het |
| Usp54 |
T |
C |
14: 20,602,313 (GRCm39) |
R1346G |
probably damaging |
Het |
| Vmn2r8 |
C |
A |
5: 108,956,449 (GRCm39) |
E58* |
probably null |
Het |
| Vps13d |
C |
T |
4: 144,867,824 (GRCm39) |
E2009K |
|
Het |
| Vps33b |
T |
C |
7: 79,935,017 (GRCm39) |
I320T |
probably damaging |
Het |
| Vwa8 |
A |
C |
14: 79,219,674 (GRCm39) |
|
probably null |
Het |
| Ythdf1 |
T |
C |
2: 180,553,786 (GRCm39) |
Y143C |
probably damaging |
Het |
| Zfp213 |
C |
T |
17: 23,778,603 (GRCm39) |
|
probably null |
Het |
| Zfp219 |
A |
T |
14: 52,244,570 (GRCm39) |
Y536* |
probably null |
Het |
|
| Other mutations in Adgrb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Adgrb2
|
APN |
4 |
129,912,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00425:Adgrb2
|
APN |
4 |
129,912,865 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00490:Adgrb2
|
APN |
4 |
129,905,665 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00928:Adgrb2
|
APN |
4 |
129,886,096 (GRCm39) |
missense |
probably benign |
|
|
IGL01353:Adgrb2
|
APN |
4 |
129,906,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Adgrb2
|
APN |
4 |
129,886,085 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01590:Adgrb2
|
APN |
4 |
129,907,606 (GRCm39) |
splice site |
probably benign |
|
|
IGL01813:Adgrb2
|
APN |
4 |
129,906,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01831:Adgrb2
|
APN |
4 |
129,903,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Adgrb2
|
APN |
4 |
129,885,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01960:Adgrb2
|
APN |
4 |
129,906,177 (GRCm39) |
splice site |
probably benign |
|
|
IGL01993:Adgrb2
|
APN |
4 |
129,912,635 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02646:Adgrb2
|
APN |
4 |
129,913,075 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02655:Adgrb2
|
APN |
4 |
129,885,972 (GRCm39) |
nonsense |
probably null |
|
|
IGL02695:Adgrb2
|
APN |
4 |
129,912,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02998:Adgrb2
|
APN |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03372:Adgrb2
|
APN |
4 |
129,911,362 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0098:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0206:Adgrb2
|
UTSW |
4 |
129,886,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Adgrb2
|
UTSW |
4 |
129,910,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0382:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0492:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0544:Adgrb2
|
UTSW |
4 |
129,911,335 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0965:Adgrb2
|
UTSW |
4 |
129,886,209 (GRCm39) |
small deletion |
probably benign |
|
|
R1458:Adgrb2
|
UTSW |
4 |
129,908,384 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1601:Adgrb2
|
UTSW |
4 |
129,886,630 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1711:Adgrb2
|
UTSW |
4 |
129,886,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Adgrb2
|
UTSW |
4 |
129,905,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Adgrb2
|
UTSW |
4 |
129,903,098 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1827:Adgrb2
|
UTSW |
4 |
129,906,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Adgrb2
|
UTSW |
4 |
129,904,024 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1881:Adgrb2
|
UTSW |
4 |
129,904,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Adgrb2
|
UTSW |
4 |
129,900,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Adgrb2
|
UTSW |
4 |
129,902,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Adgrb2
|
UTSW |
4 |
129,902,146 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4490:Adgrb2
|
UTSW |
4 |
129,906,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4499:Adgrb2
|
UTSW |
4 |
129,886,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4758:Adgrb2
|
UTSW |
4 |
129,903,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Adgrb2
|
UTSW |
4 |
129,907,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Adgrb2
|
UTSW |
4 |
129,906,332 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4922:Adgrb2
|
UTSW |
4 |
129,901,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5331:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5550:Adgrb2
|
UTSW |
4 |
129,908,727 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5995:Adgrb2
|
UTSW |
4 |
129,910,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6047:Adgrb2
|
UTSW |
4 |
129,912,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6534:Adgrb2
|
UTSW |
4 |
129,916,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6565:Adgrb2
|
UTSW |
4 |
129,913,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Adgrb2
|
UTSW |
4 |
129,903,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R6966:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R7197:Adgrb2
|
UTSW |
4 |
129,903,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7451:Adgrb2
|
UTSW |
4 |
129,908,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Adgrb2
|
UTSW |
4 |
129,908,430 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7461:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7511:Adgrb2
|
UTSW |
4 |
129,915,904 (GRCm39) |
missense |
probably benign |
|
|
R7613:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7729:Adgrb2
|
UTSW |
4 |
129,885,917 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,762 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8033:Adgrb2
|
UTSW |
4 |
129,912,805 (GRCm39) |
missense |
probably benign |
|
|
R8039:Adgrb2
|
UTSW |
4 |
129,916,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8097:Adgrb2
|
UTSW |
4 |
129,901,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8256:Adgrb2
|
UTSW |
4 |
129,901,921 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8425:Adgrb2
|
UTSW |
4 |
129,898,850 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8804:Adgrb2
|
UTSW |
4 |
129,899,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9011:Adgrb2
|
UTSW |
4 |
129,916,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9018:Adgrb2
|
UTSW |
4 |
129,907,659 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9102:Adgrb2
|
UTSW |
4 |
129,912,802 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9113:Adgrb2
|
UTSW |
4 |
129,910,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Adgrb2
|
UTSW |
4 |
129,906,302 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9211:Adgrb2
|
UTSW |
4 |
129,886,199 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9267:Adgrb2
|
UTSW |
4 |
129,885,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9328:Adgrb2
|
UTSW |
4 |
129,915,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9470:Adgrb2
|
UTSW |
4 |
129,903,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9608:Adgrb2
|
UTSW |
4 |
129,907,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF020:Adgrb2
|
UTSW |
4 |
129,903,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb2
|
UTSW |
4 |
129,911,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,912,912 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,905,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCAGTTGGACCTTACATGG -3'
(R):5'- ACACAGTAGGTAGATTCCCCTCC -3'
Sequencing Primer
(F):5'- CAGTTGGACCTTACATGGATACG -3'
(R):5'- TCAAGGGAGCCCAGCTTCATG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation