Mutagenetix > Incidental Mutation

Incidental Mutation 'R7414:Hdac7'

575334

Institutional Source

Beutler Lab

Gene Symbol

Hdac7

Ensembl Gene

ENSMUSG00000022475

Gene Name

histone deacetylase 7

Synonyms

Hdac7a, 5830434K02Rik

MMRRC Submission

045494-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7414 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

97690545-97742383 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 97706392 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 272 (H272L)

Ref Sequence

ENSEMBL: ENSMUSP00000112110 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079838] [ENSMUST00000088402] [ENSMUST00000116408] [ENSMUST00000116409] [ENSMUST00000118294] [ENSMUST00000119670] [ENSMUST00000120683] [ENSMUST00000121514] [ENSMUST00000156045]

AlphaFold

Q8C2B3

Predicted Effect

probably benign
Transcript: ENSMUST00000079838
AA Change: H270L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000078766
Gene: ENSMUSG00000022475
AA Change: H270L

Domain	Start	End	E-Value	Type
low complexity region	79	93	N/A	INTRINSIC
low complexity region	97	113	N/A	INTRINSIC
low complexity region	196	211	N/A	INTRINSIC
low complexity region	357	375	N/A	INTRINSIC
low complexity region	426	438	N/A	INTRINSIC
low complexity region	442	454	N/A	INTRINSIC
low complexity region	485	498	N/A	INTRINSIC
Pfam:Hist_deacetyl	523	853	2.5e-91	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000088402
AA Change: H257L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000085744
Gene: ENSMUSG00000022475
AA Change: H257L

Domain	Start	End	E-Value	Type
low complexity region	79	93	N/A	INTRINSIC
low complexity region	97	113	N/A	INTRINSIC
low complexity region	151	169	N/A	INTRINSIC
low complexity region	220	235	N/A	INTRINSIC
low complexity region	344	362	N/A	INTRINSIC
low complexity region	420	432	N/A	INTRINSIC
low complexity region	436	448	N/A	INTRINSIC
low complexity region	479	492	N/A	INTRINSIC
Pfam:Hist_deacetyl	517	847	2.5e-91	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000116408
AA Change: H235L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000112109
Gene: ENSMUSG00000022475
AA Change: H235L

Domain	Start	End	E-Value	Type
low complexity region	57	71	N/A	INTRINSIC
low complexity region	75	91	N/A	INTRINSIC
low complexity region	129	147	N/A	INTRINSIC
low complexity region	198	213	N/A	INTRINSIC
low complexity region	322	340	N/A	INTRINSIC
low complexity region	398	410	N/A	INTRINSIC
low complexity region	414	426	N/A	INTRINSIC
low complexity region	457	470	N/A	INTRINSIC
Pfam:Hist_deacetyl	495	825	2.3e-91	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000116409
AA Change: H272L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000112110
Gene: ENSMUSG00000022475
AA Change: H272L

Domain	Start	End	E-Value	Type
low complexity region	57	71	N/A	INTRINSIC
low complexity region	75	91	N/A	INTRINSIC
low complexity region	129	147	N/A	INTRINSIC
low complexity region	198	213	N/A	INTRINSIC
low complexity region	359	377	N/A	INTRINSIC
low complexity region	435	447	N/A	INTRINSIC
low complexity region	451	463	N/A	INTRINSIC
low complexity region	494	507	N/A	INTRINSIC
Pfam:Hist_deacetyl	532	862	9.1e-83	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000118294
AA Change: H272L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000113380
Gene: ENSMUSG00000022475
AA Change: H272L

Domain	Start	End	E-Value	Type
low complexity region	57	71	N/A	INTRINSIC
low complexity region	75	91	N/A	INTRINSIC
low complexity region	129	147	N/A	INTRINSIC
low complexity region	198	213	N/A	INTRINSIC
low complexity region	359	377	N/A	INTRINSIC
low complexity region	428	440	N/A	INTRINSIC
low complexity region	444	456	N/A	INTRINSIC
low complexity region	487	500	N/A	INTRINSIC
Pfam:Hist_deacetyl	525	855	2.6e-91	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000119670
AA Change: H211L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000112459
Gene: ENSMUSG00000022475
AA Change: H211L

Domain	Start	End	E-Value	Type
low complexity region	57	71	N/A	INTRINSIC
low complexity region	75	91	N/A	INTRINSIC
low complexity region	174	189	N/A	INTRINSIC
low complexity region	298	316	N/A	INTRINSIC
low complexity region	374	386	N/A	INTRINSIC
low complexity region	390	402	N/A	INTRINSIC
low complexity region	433	446	N/A	INTRINSIC
Pfam:Hist_deacetyl	471	801	2.3e-91	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000120683
AA Change: H235L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000112446
Gene: ENSMUSG00000022475
AA Change: H235L

Domain	Start	End	E-Value	Type
low complexity region	57	71	N/A	INTRINSIC
low complexity region	75	91	N/A	INTRINSIC
low complexity region	129	147	N/A	INTRINSIC
low complexity region	198	213	N/A	INTRINSIC
low complexity region	322	340	N/A	INTRINSIC
low complexity region	398	410	N/A	INTRINSIC
low complexity region	414	426	N/A	INTRINSIC
low complexity region	457	470	N/A	INTRINSIC
Pfam:Hist_deacetyl	495	623	7.9e-9	PFAM
Pfam:Hist_deacetyl	623	777	3.5e-50	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000121514
AA Change: H235L

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000112641
Gene: ENSMUSG00000022475
AA Change: H235L

Domain	Start	End	E-Value	Type
low complexity region	57	71	N/A	INTRINSIC
low complexity region	75	91	N/A	INTRINSIC
low complexity region	129	147	N/A	INTRINSIC
low complexity region	198	213	N/A	INTRINSIC
low complexity region	322	340	N/A	INTRINSIC
low complexity region	392	405	N/A	INTRINSIC
Pfam:Hist_deacetyl	430	760	9e-92	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000134258

SMART Domains

Protein: ENSMUSP00000118599
Gene: ENSMUSG00000022475

Domain	Start	End	E-Value	Type
low complexity region	52	64	N/A	INTRINSIC
low complexity region	68	80	N/A	INTRINSIC
low complexity region	111	124	N/A	INTRINSIC
PDB:3ZNS\|C	127	241	5e-70	PDB
SCOP:d1c3pa_	139	219	2e-17	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000135651

SMART Domains

Protein: ENSMUSP00000119970
Gene: ENSMUSG00000022475

Domain	Start	End	E-Value	Type
low complexity region	10	22	N/A	INTRINSIC
low complexity region	53	66	N/A	INTRINSIC
Pfam:Hist_deacetyl	166	213	8.8e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000156045
AA Change: H257L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000120576
Gene: ENSMUSG00000022475
AA Change: H257L

Domain	Start	End	E-Value	Type
low complexity region	79	93	N/A	INTRINSIC
low complexity region	97	113	N/A	INTRINSIC
low complexity region	151	169	N/A	INTRINSIC
low complexity region	220	235	N/A	INTRINSIC
low complexity region	344	362	N/A	INTRINSIC
low complexity region	420	432	N/A	INTRINSIC
low complexity region	436	448	N/A	INTRINSIC
low complexity region	479	492	N/A	INTRINSIC
PDB:3ZNS\|C	495	602	2e-60	PDB
SCOP:d1c3pa_	507	587	6e-16	SMART
low complexity region	603	621	N/A	INTRINSIC

Meta Mutation Damage Score

0.0597

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

97% (98/101)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 101 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3110082I17Rik	G	A	5: 139,349,779 (GRCm39)	T90M	probably damaging	Het
Abca4	T	A	3: 121,896,387 (GRCm39)	S540T	probably benign	Het
Adcy4	G	A	14: 56,019,090 (GRCm39)	L156F	probably benign	Het
Adcyap1	T	A	17: 93,510,256 (GRCm39)	L95M	probably damaging	Het
Ahctf1	T	C	1: 179,611,670 (GRCm39)	T567A	probably benign	Het
Ankrd26	T	C	6: 118,485,741 (GRCm39)	I1378V	possibly damaging	Het
Ankrd44	T	A	1: 54,706,539 (GRCm39)	H639L	probably damaging	Het
Arfrp1	C	T	2: 181,001,307 (GRCm39)	R189Q	possibly damaging	Het
Astn2	T	C	4: 65,459,193 (GRCm39)	D1126G	possibly damaging	Het
Bap1	G	C	14: 30,975,572 (GRCm39)	G139R	probably benign	Het
Bms1	C	T	6: 118,360,706 (GRCm39)	R1254Q	possibly damaging	Het
Ceacam15	A	G	7: 16,407,235 (GRCm39)	V94A	probably benign	Het
Cfap57	C	T	4: 118,472,128 (GRCm39)	V84I	probably benign	Het
Cip2a	T	C	16: 48,821,998 (GRCm39)	F209L	probably benign	Het
Clec2m	T	C	6: 129,302,596 (GRCm39)	T144A	probably benign	Het
Clock	T	C	5: 76,410,611 (GRCm39)	T87A	probably benign	Het
Cntrl	A	T	2: 35,055,479 (GRCm39)	I1706L	probably benign	Het
Cr2	C	A	1: 194,832,344 (GRCm39)	V981L	probably benign	Het
Cxcr6	G	A	9: 123,639,287 (GRCm39)	W103*	probably null	Het
Dld	A	T	12: 31,385,525 (GRCm39)	F272Y	probably damaging	Het
Dmrt2	T	A	19: 25,650,950 (GRCm39)	D45E	probably benign	Het
Eif2a	T	A	3: 58,433,502 (GRCm39)	L8*	probably null	Het
Epg5	G	T	18: 78,026,747 (GRCm39)	R1246L	possibly damaging	Het
Ets1	T	A	9: 32,664,153 (GRCm39)	C350*	probably null	Het
Fam135b	C	T	15: 71,350,105 (GRCm39)	R345Q	probably damaging	Het
Fbn2	C	T	18: 58,229,122 (GRCm39)	R696H	probably damaging	Het
Gbf1	C	A	19: 46,271,797 (GRCm39)	Y159*	probably null	Het
Gcsam	T	C	16: 45,437,301 (GRCm39)		probably null	Het
Gmpr2	G	T	14: 55,910,259 (GRCm39)		probably null	Het
H2-T3	C	A	17: 36,498,275 (GRCm39)	V257L	not run	Het
Hadha	A	G	5: 30,331,610 (GRCm39)	F449L	possibly damaging	Het
Haus3	T	A	5: 34,323,477 (GRCm39)	I378L	probably benign	Het
Icam5	T	C	9: 20,948,889 (GRCm39)	V747A	probably damaging	Het
Ifrd2	G	A	9: 107,467,370 (GRCm39)	V81M	possibly damaging	Het
Insyn2a	G	T	7: 134,519,738 (GRCm39)	A264D	probably benign	Het
Ipcef1	G	T	10: 6,840,673 (GRCm39)	C345*	probably null	Het
Ipmk	T	A	10: 71,217,124 (GRCm39)	F223I	probably damaging	Het
Itpr2	A	T	6: 146,274,706 (GRCm39)	N825K	probably benign	Het
Itprid2	A	G	2: 79,475,072 (GRCm39)	K344E	possibly damaging	Het
Kazn	G	A	4: 141,836,649 (GRCm39)	T530I		Het
Kmt2d	C	T	15: 98,737,737 (GRCm39)	V5120M	unknown	Het
Krt6b	T	G	15: 101,587,449 (GRCm39)	D215A	probably benign	Het
Lgals12	T	C	19: 7,581,335 (GRCm39)	K124R	probably damaging	Het
Lpar6	T	A	14: 73,476,240 (GRCm39)	V67D	probably damaging	Het
Lrch3	T	C	16: 32,818,883 (GRCm39)	Y661H	probably damaging	Het
Lrrc32	A	T	7: 98,149,201 (GRCm39)	Q660H	probably benign	Het
Lurap1l	T	A	4: 80,871,991 (GRCm39)	H161Q	probably benign	Het
Map3k19	A	G	1: 127,766,189 (GRCm39)	I245T	probably damaging	Het
Mcf2l	T	A	8: 13,069,022 (GRCm39)	*1119K	probably null	Het
Mertk	C	A	2: 128,571,313 (GRCm39)	A89E	possibly damaging	Het
Mical3	A	T	6: 121,011,074 (GRCm39)	Y375N	probably damaging	Het
Myo15a	T	A	11: 60,374,309 (GRCm39)	D121E		Het
N4bp2l1	T	A	5: 150,499,758 (GRCm39)	N116I	probably damaging	Het
Nbeal1	T	C	1: 60,233,756 (GRCm39)		probably null	Het
Nlrp12	A	T	7: 3,289,977 (GRCm39)	D178E	probably benign	Het
Nt5c2	C	A	19: 46,878,328 (GRCm39)	G444C	probably damaging	Het
Or10g7	T	A	9: 39,905,349 (GRCm39)	M81K	possibly damaging	Het
Or2f1b	T	A	6: 42,739,762 (GRCm39)	Y259N	probably damaging	Het
Or8b48	T	C	9: 38,492,764 (GRCm39)	F64L	probably benign	Het
Pdcl2	A	C	5: 76,460,359 (GRCm39)	S220A	possibly damaging	Het
Pip5kl1	T	C	2: 32,468,247 (GRCm39)	S138P	possibly damaging	Het
Pkd1l1	A	T	11: 8,866,267 (GRCm39)	N979K		Het
Prkcb	A	T	7: 122,167,450 (GRCm39)	T387S	possibly damaging	Het
Pxdc1	A	G	13: 34,821,135 (GRCm39)		probably benign	Het
Sbf2	C	T	7: 109,913,271 (GRCm39)	E1668K	possibly damaging	Het
Sec16a	T	G	2: 26,313,643 (GRCm39)	T455P		Het
Sec24b	C	A	3: 129,803,514 (GRCm39)	V412F	probably benign	Het
Serpina3b	A	G	12: 104,099,145 (GRCm39)	N220S	probably benign	Het
Sgip1	C	T	4: 102,824,821 (GRCm39)	Q581*	probably null	Het
Shf	A	T	2: 122,190,063 (GRCm39)	I175N	possibly damaging	Het
Slc16a10	G	A	10: 40,017,992 (GRCm39)	T14M	probably benign	Het
Slc22a4	A	T	11: 53,888,254 (GRCm39)	M258K	probably benign	Het
Slfn8	A	T	11: 82,907,618 (GRCm39)	Y308*	probably null	Het
Slfnl1	T	C	4: 120,392,451 (GRCm39)	Y249H	probably damaging	Het
Smchd1	T	C	17: 71,782,074 (GRCm39)	Y29C	probably damaging	Het
Snai1	C	A	2: 167,380,588 (GRCm39)		probably null	Het
Sntg1	T	C	1: 8,518,289 (GRCm39)	Y368C	probably damaging	Het
Snx33	C	T	9: 56,833,151 (GRCm39)	R306H	probably damaging	Het
Spop	G	A	11: 95,365,334 (GRCm39)	V126M	probably damaging	Het
Taar3	A	T	10: 23,825,715 (GRCm39)	Y87F	probably damaging	Het
Tarm1	C	A	7: 3,545,318 (GRCm39)	M177I	probably benign	Het
Tcerg1l	A	G	7: 137,819,786 (GRCm39)	F485L	probably damaging	Het
Thsd7b	A	T	1: 129,556,717 (GRCm39)	I435F	probably damaging	Het
Tiam2	A	G	17: 3,464,388 (GRCm39)	D39G	possibly damaging	Het
Tigd4	T	C	3: 84,501,128 (GRCm39)	V15A	probably benign	Het
Tll2	T	C	19: 41,092,268 (GRCm39)	D523G	probably damaging	Het
Tmem117	A	G	15: 94,612,776 (GRCm39)	D104G	probably damaging	Het
Tmem132b	T	C	5: 125,864,555 (GRCm39)	L887P	probably damaging	Het
Tnfrsf26	A	T	7: 143,168,642 (GRCm39)	V132D	probably damaging	Het
Tomt	T	A	7: 101,549,715 (GRCm39)	D191V	probably damaging	Het
Ttc39b	T	C	4: 83,160,459 (GRCm39)	M373V	probably damaging	Het
Ttn	G	A	2: 76,568,493 (GRCm39)	P27467S	possibly damaging	Het
Ttn	A	C	2: 76,573,130 (GRCm39)	V25921G	probably damaging	Het
Ubxn2a	A	C	12: 4,941,381 (GRCm39)	V75G	probably damaging	Het
Uchl5	A	T	1: 143,682,433 (GRCm39)	K319N	unknown	Het
Ugt2b1	T	C	5: 87,073,693 (GRCm39)	D222G	probably damaging	Het
Vmn1r213	A	G	13: 23,195,446 (GRCm39)	I10V	unknown	Het
Vps13b	T	C	15: 35,910,973 (GRCm39)	I3579T	probably damaging	Het
Xpo5	T	A	17: 46,532,295 (GRCm39)	H443Q	probably benign	Het
Zfp316	A	G	5: 143,250,407 (GRCm39)	M2T	unknown	Het
Zscan4-ps2	A	G	7: 11,251,359 (GRCm39)	T160A	possibly damaging	Het

Other mutations in Hdac7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00435:Hdac7	APN	15	97,707,376 (GRCm39)	missense	probably damaging	0.98
IGL01011:Hdac7	APN	15	97,691,816 (GRCm39)	missense	possibly damaging	0.83
IGL01361:Hdac7	APN	15	97,709,323 (GRCm39)	missense	possibly damaging	0.85
IGL01474:Hdac7	APN	15	97,695,820 (GRCm39)	critical splice donor site	probably null
IGL02314:Hdac7	APN	15	97,706,885 (GRCm39)	missense	probably damaging	1.00
IGL02379:Hdac7	APN	15	97,706,266 (GRCm39)	missense	probably damaging	0.99
IGL02665:Hdac7	APN	15	97,694,838 (GRCm39)	unclassified	probably benign
IGL03010:Hdac7	APN	15	97,691,810 (GRCm39)	critical splice donor site	probably null
IGL03023:Hdac7	APN	15	97,695,838 (GRCm39)	missense	probably damaging	1.00
IGL03081:Hdac7	APN	15	97,696,187 (GRCm39)	missense	probably damaging	1.00
Cairn	UTSW	15	97,706,376 (GRCm39)	frame shift	probably null
Signpost	UTSW	15	97,700,628 (GRCm39)	missense	probably damaging	1.00
R0285:Hdac7	UTSW	15	97,696,103 (GRCm39)	critical splice donor site	probably null
R0518:Hdac7	UTSW	15	97,704,380 (GRCm39)	nonsense	probably null
R0521:Hdac7	UTSW	15	97,704,380 (GRCm39)	nonsense	probably null
R0522:Hdac7	UTSW	15	97,704,560 (GRCm39)	splice site	probably null
R1543:Hdac7	UTSW	15	97,707,410 (GRCm39)	splice site	probably benign
R1623:Hdac7	UTSW	15	97,706,285 (GRCm39)	nonsense	probably null
R1665:Hdac7	UTSW	15	97,704,406 (GRCm39)	missense	probably damaging	1.00
R1844:Hdac7	UTSW	15	97,705,857 (GRCm39)	missense	probably damaging	0.98
R1895:Hdac7	UTSW	15	97,694,767 (GRCm39)	missense	probably damaging	1.00
R1975:Hdac7	UTSW	15	97,704,386 (GRCm39)	nonsense	probably null
R1976:Hdac7	UTSW	15	97,704,386 (GRCm39)	nonsense	probably null
R2038:Hdac7	UTSW	15	97,696,151 (GRCm39)	missense	probably damaging	1.00
R2155:Hdac7	UTSW	15	97,691,944 (GRCm39)	missense	probably benign	0.00
R2156:Hdac7	UTSW	15	97,691,944 (GRCm39)	missense	probably benign	0.00
R2263:Hdac7	UTSW	15	97,708,732 (GRCm39)	critical splice donor site	probably null
R3546:Hdac7	UTSW	15	97,705,890 (GRCm39)	missense	probably damaging	1.00
R4438:Hdac7	UTSW	15	97,705,596 (GRCm39)	missense	probably damaging	1.00
R4642:Hdac7	UTSW	15	97,704,397 (GRCm39)	missense	probably damaging	1.00
R4704:Hdac7	UTSW	15	97,694,097 (GRCm39)	missense	probably damaging	1.00
R4705:Hdac7	UTSW	15	97,709,468 (GRCm39)	missense	probably damaging	0.99
R5303:Hdac7	UTSW	15	97,695,899 (GRCm39)	missense	probably damaging	0.97
R5577:Hdac7	UTSW	15	97,709,336 (GRCm39)	missense	probably benign	0.09
R5966:Hdac7	UTSW	15	97,700,372 (GRCm39)	missense	probably damaging	1.00
R5974:Hdac7	UTSW	15	97,699,953 (GRCm39)	splice site	probably null
R6270:Hdac7	UTSW	15	97,706,376 (GRCm39)	frame shift	probably null
R6384:Hdac7	UTSW	15	97,709,387 (GRCm39)	nonsense	probably null
R6835:Hdac7	UTSW	15	97,700,628 (GRCm39)	missense	probably damaging	1.00
R6869:Hdac7	UTSW	15	97,694,057 (GRCm39)	missense	probably damaging	1.00
R7261:Hdac7	UTSW	15	97,704,415 (GRCm39)	missense	probably benign
R7338:Hdac7	UTSW	15	97,707,903 (GRCm39)	missense	probably benign	0.30
R7753:Hdac7	UTSW	15	97,704,369 (GRCm39)	missense	probably benign	0.00
R7753:Hdac7	UTSW	15	97,698,642 (GRCm39)	missense	possibly damaging	0.93
R8523:Hdac7	UTSW	15	97,706,251 (GRCm39)	missense	probably damaging	1.00
R8911:Hdac7	UTSW	15	97,694,789 (GRCm39)	missense	possibly damaging	0.71
R9141:Hdac7	UTSW	15	97,697,649 (GRCm39)	missense	probably benign	0.12
R9354:Hdac7	UTSW	15	97,694,769 (GRCm39)	missense	probably damaging	1.00
R9443:Hdac7	UTSW	15	97,700,352 (GRCm39)	missense	probably benign	0.05
R9759:Hdac7	UTSW	15	97,699,989 (GRCm39)	missense	probably benign	0.00
R9792:Hdac7	UTSW	15	97,698,671 (GRCm39)	missense	possibly damaging	0.92
R9793:Hdac7	UTSW	15	97,698,671 (GRCm39)	missense	possibly damaging	0.92
X0028:Hdac7	UTSW	15	97,706,889 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCTGCCTATTCTGGGAGAAG -3'
(R):5'- CTTTGCCGACAGTGTCCTTG -3'

Sequencing Primer
(F):5'- CTATTCTGGGAGAAGCGGCAAG -3'
(R):5'- TGCCCGCAATCACACTGG -3'

Posted On

2019-10-07