Incidental Mutation 'R7421:Ccnc'
ID 575651
Institutional Source Beutler Lab
Gene Symbol Ccnc
Ensembl Gene ENSMUSG00000028252
Gene Name cyclin C
Synonyms
MMRRC Submission 045499-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7421 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 21727701-21759922 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21743291 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 192 (Y192C)
Ref Sequence ENSEMBL: ENSMUSP00000100062 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065928] [ENSMUST00000102997] [ENSMUST00000108240] [ENSMUST00000120679]
AlphaFold Q62447
Predicted Effect probably damaging
Transcript: ENSMUST00000065928
AA Change: Y192C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069076
Gene: ENSMUSG00000028252
AA Change: Y192C

DomainStartEndE-ValueType
CYCLIN 46 144 2.41e-13 SMART
CYCLIN 157 236 4.11e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000102997
AA Change: Y192C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000100062
Gene: ENSMUSG00000028252
AA Change: Y192C

DomainStartEndE-ValueType
CYCLIN 46 144 2.41e-13 SMART
CYCLIN 157 236 4.11e-7 SMART
low complexity region 258 264 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000108240
AA Change: Y192C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103875
Gene: ENSMUSG00000028252
AA Change: Y192C

DomainStartEndE-ValueType
CYCLIN 46 144 2.41e-13 SMART
CYCLIN 157 236 4.11e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000120679
AA Change: Y192C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113682
Gene: ENSMUSG00000028252
AA Change: Y192C

DomainStartEndE-ValueType
CYCLIN 46 144 2.41e-13 SMART
CYCLIN 157 236 4.11e-7 SMART
low complexity region 258 264 N/A INTRINSIC
Meta Mutation Damage Score 0.5709 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice die prenatally and exhibit growth retardation and placental defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aar2 T C 2: 156,397,915 (GRCm39) I309T possibly damaging Het
Abca12 A C 1: 71,286,295 (GRCm39) L2513* probably null Het
Abca13 G C 11: 9,460,463 (GRCm39) V4158L probably benign Het
Acaca A G 11: 84,254,562 (GRCm39) T1880A possibly damaging Het
Arhgap5 C T 12: 52,564,783 (GRCm39) R585C probably benign Het
Arsk A C 13: 76,210,634 (GRCm39) I471S possibly damaging Het
Asb7 T C 7: 66,309,868 (GRCm39) D116G probably damaging Het
Atad2 A G 15: 57,998,322 (GRCm39) S17P probably benign Het
Atf5 T C 7: 44,464,562 (GRCm39) E10G probably damaging Het
B3gntl1 G T 11: 121,515,004 (GRCm39) P255T probably benign Het
Cacna1s A G 1: 136,014,540 (GRCm39) N649S probably damaging Het
Cd28 A G 1: 60,802,459 (GRCm39) N126S probably benign Het
Cep57 A G 9: 13,721,969 (GRCm39) S360P possibly damaging Het
Ces1e C T 8: 93,941,703 (GRCm39) V257I probably benign Het
Chd1 A G 17: 15,969,660 (GRCm39) K913R probably benign Het
Cluap1 A T 16: 3,758,657 (GRCm39) D373V probably damaging Het
Cnmd T C 14: 79,882,947 (GRCm39) I160V probably benign Het
Col6a4 G A 9: 105,897,994 (GRCm39) P1686S probably damaging Het
Coro7 G T 16: 4,486,615 (GRCm39) A186E probably benign Het
Cuta T C 17: 27,158,431 (GRCm39) probably benign Het
Dnah2 G A 11: 69,383,631 (GRCm39) H1098Y probably benign Het
Duox1 T A 2: 122,153,711 (GRCm39) C345S probably damaging Het
Ephb4 T A 5: 137,352,687 (GRCm39) I90K possibly damaging Het
Erich3 T A 3: 154,439,198 (GRCm39) M280K probably damaging Het
Fcer2a T A 8: 3,740,335 (GRCm39) H4L probably benign Het
Grk1 A T 8: 13,455,316 (GRCm39) I67F probably damaging Het
Grm8 A C 6: 27,762,476 (GRCm39) S250A possibly damaging Het
H2-Q6 A G 17: 35,644,204 (GRCm39) E62G possibly damaging Het
Inppl1 C T 7: 101,482,144 (GRCm39) R144H probably damaging Het
Itga3 G T 11: 94,959,681 (GRCm39) P33Q probably benign Het
Itgax G A 7: 127,739,604 (GRCm39) S672N probably damaging Het
Itpk1 A T 12: 102,540,324 (GRCm39) V253E possibly damaging Het
Krt15 A T 11: 100,026,386 (GRCm39) V100E possibly damaging Het
Mrps7 T C 11: 115,495,717 (GRCm39) V85A probably benign Het
Muc2 T C 7: 141,301,863 (GRCm39) L427P Het
Myef2 G T 2: 124,952,537 (GRCm39) Q185K probably benign Het
Or1e1b-ps1 G T 11: 73,846,335 (GRCm39) C273F unknown Het
Or4a76 T A 2: 89,460,915 (GRCm39) D109V probably damaging Het
Pcdh15 G A 10: 74,289,897 (GRCm39) M905I possibly damaging Het
Pgm5 C T 19: 24,686,663 (GRCm39) V515M probably benign Het
Pik3r1 A G 13: 101,825,644 (GRCm39) I381T probably damaging Het
Pla2g4f A G 2: 120,137,737 (GRCm39) M341T probably benign Het
Prmt2 A G 10: 76,056,912 (GRCm39) F204L probably benign Het
Pwwp3a T A 10: 80,068,587 (GRCm39) S244T probably benign Het
Rasa2 A G 9: 96,493,500 (GRCm39) V50A unknown Het
Scn7a A C 2: 66,505,876 (GRCm39) I1671S probably benign Het
Sco2 G A 15: 89,255,923 (GRCm39) R244C possibly damaging Het
Skic3 A T 13: 76,296,944 (GRCm39) K1100N probably benign Het
Slfn1 A G 11: 83,011,967 (GRCm39) M28V possibly damaging Het
Slfn9 A T 11: 82,872,197 (GRCm39) C846* probably null Het
Slfn9 A G 11: 82,878,562 (GRCm39) I189T probably damaging Het
Svil T A 18: 5,056,109 (GRCm39) S327R probably benign Het
Tcaf3 A T 6: 42,573,776 (GRCm39) N145K probably benign Het
Trarg1 G A 11: 76,585,051 (GRCm39) R147Q unknown Het
Trgv6 G T 13: 19,374,814 (GRCm39) G40W possibly damaging Het
Upp2 G T 2: 58,661,586 (GRCm39) V130F possibly damaging Het
Vnn3 G A 10: 23,741,666 (GRCm39) A324T probably benign Het
Wasf2 A G 4: 132,912,412 (GRCm39) E88G unknown Het
Zfp39 A T 11: 58,780,933 (GRCm39) C610S probably damaging Het
Other mutations in Ccnc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00895:Ccnc APN 4 21,742,642 (GRCm39) nonsense probably null
IGL01536:Ccnc APN 4 21,732,505 (GRCm39) missense probably benign 0.01
IGL03083:Ccnc APN 4 21,742,683 (GRCm39) missense possibly damaging 0.83
R1220:Ccnc UTSW 4 21,732,491 (GRCm39) missense probably damaging 1.00
R1237:Ccnc UTSW 4 21,730,457 (GRCm39) missense probably benign
R1558:Ccnc UTSW 4 21,742,671 (GRCm39) missense probably benign 0.31
R2012:Ccnc UTSW 4 21,741,955 (GRCm39) missense possibly damaging 0.65
R4901:Ccnc UTSW 4 21,727,894 (GRCm39) missense probably damaging 0.96
R6427:Ccnc UTSW 4 21,747,578 (GRCm39) critical splice donor site probably null
R6509:Ccnc UTSW 4 21,740,642 (GRCm39) missense probably benign 0.27
R7563:Ccnc UTSW 4 21,732,220 (GRCm39) missense probably damaging 0.99
R7842:Ccnc UTSW 4 21,730,480 (GRCm39) missense probably damaging 0.99
R7917:Ccnc UTSW 4 21,748,158 (GRCm39) missense possibly damaging 0.72
R8023:Ccnc UTSW 4 21,747,578 (GRCm39) critical splice donor site probably null
R9408:Ccnc UTSW 4 21,746,776 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- ATCCAGTAATGCCTGTCCCC -3'
(R):5'- AATAATGCTAATCTGGGATGGTTG -3'

Sequencing Primer
(F):5'- ACACTCATGCATTCCATTGCTTAG -3'
(R):5'- TGGTTGTAGTGTATATCATTGAGAAC -3'
Posted On 2019-10-07