Incidental Mutation 'R7424:Trip11'
| ID |
575944 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
045502-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7424 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 101851457 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Histidine
at position 869
(L869H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021605
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000176728]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000021605
AA Change: L869H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: L869H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176728
|
| SMART Domains |
Protein: ENSMUSP00000134992
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
Pfam:Orthopox_A5L
|
48 |
282 |
6.5e-9 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177183
AA Change: L584H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: L584H
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
99% (76/77) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6430548M08Rik |
C |
T |
8: 120,872,284 (GRCm39) |
R71C |
probably damaging |
Het |
| Aanat |
A |
T |
11: 116,486,455 (GRCm39) |
|
probably benign |
Het |
| Ahrr |
G |
T |
13: 74,405,664 (GRCm39) |
S91* |
probably null |
Het |
| Ampd1 |
A |
T |
3: 102,995,758 (GRCm39) |
N223Y |
probably benign |
Het |
| Ankar |
T |
G |
1: 72,719,217 (GRCm39) |
N544T |
probably damaging |
Het |
| Ankk1 |
A |
G |
9: 49,330,050 (GRCm39) |
S302P |
possibly damaging |
Het |
| Bcr |
T |
C |
10: 74,992,932 (GRCm39) |
V809A |
probably benign |
Het |
| Bpifb2 |
A |
G |
2: 153,732,460 (GRCm39) |
N353S |
possibly damaging |
Het |
| Cyth1 |
A |
T |
11: 118,074,835 (GRCm39) |
|
probably null |
Het |
| Ddx5 |
A |
T |
11: 106,673,006 (GRCm39) |
N506K |
probably benign |
Het |
| Dnaja1 |
A |
T |
4: 40,730,244 (GRCm39) |
I239F |
probably benign |
Het |
| Ethe1 |
C |
T |
7: 24,305,676 (GRCm39) |
T141I |
probably damaging |
Het |
| Fhip2b |
T |
C |
14: 70,831,447 (GRCm39) |
H29R |
probably damaging |
Het |
| Gdap2 |
A |
T |
3: 100,109,382 (GRCm39) |
I36F |
unknown |
Het |
| Gm13030 |
A |
T |
4: 138,598,577 (GRCm39) |
D115E |
unknown |
Het |
| Gm17019 |
A |
T |
5: 15,079,386 (GRCm39) |
L227Q |
probably damaging |
Het |
| Gm9195 |
T |
A |
14: 72,673,217 (GRCm39) |
E2517D |
possibly damaging |
Het |
| Gramd2a |
T |
A |
9: 59,615,354 (GRCm39) |
V39D |
possibly damaging |
Het |
| Hmcn1 |
C |
T |
1: 150,506,017 (GRCm39) |
W3836* |
probably null |
Het |
| Hspa14 |
C |
T |
2: 3,490,078 (GRCm39) |
D494N |
possibly damaging |
Het |
| Ifit2 |
A |
G |
19: 34,550,598 (GRCm39) |
N46S |
probably benign |
Het |
| Ifna6 |
A |
T |
4: 88,746,044 (GRCm39) |
E131V |
possibly damaging |
Het |
| Ift140 |
T |
C |
17: 25,256,010 (GRCm39) |
V504A |
possibly damaging |
Het |
| Irgc |
T |
C |
7: 24,131,653 (GRCm39) |
N388S |
probably damaging |
Het |
| Itgal |
T |
A |
7: 126,916,537 (GRCm39) |
V743E |
probably benign |
Het |
| Itih5 |
T |
C |
2: 10,250,448 (GRCm39) |
S716P |
probably damaging |
Het |
| Kcnab1 |
A |
T |
3: 65,173,924 (GRCm39) |
K78N |
possibly damaging |
Het |
| Kif1a |
A |
T |
1: 92,982,039 (GRCm39) |
V787E |
possibly damaging |
Het |
| Krt15 |
A |
T |
11: 100,026,386 (GRCm39) |
V100E |
possibly damaging |
Het |
| Krt39 |
A |
T |
11: 99,408,917 (GRCm39) |
V293E |
probably damaging |
Het |
| Lrrn4 |
A |
G |
2: 132,711,663 (GRCm39) |
F720S |
possibly damaging |
Het |
| Map2 |
G |
A |
1: 66,453,983 (GRCm39) |
A958T |
possibly damaging |
Het |
| Map3k9 |
A |
G |
12: 81,770,871 (GRCm39) |
S906P |
probably benign |
Het |
| Mdc1 |
T |
C |
17: 36,164,201 (GRCm39) |
S1250P |
probably benign |
Het |
| Meltf |
G |
A |
16: 31,703,764 (GRCm39) |
V164I |
probably damaging |
Het |
| Mtap |
T |
G |
4: 89,097,699 (GRCm39) |
|
probably null |
Het |
| Mtus1 |
C |
A |
8: 41,475,443 (GRCm39) |
V184F |
probably damaging |
Het |
| Myh1 |
A |
T |
11: 67,104,489 (GRCm39) |
D1015V |
probably damaging |
Het |
| Ndrg1 |
T |
C |
15: 66,816,787 (GRCm39) |
|
probably null |
Het |
| Nkd1 |
G |
T |
8: 89,311,803 (GRCm39) |
V130L |
probably benign |
Het |
| Nsfl1c |
A |
G |
2: 151,342,673 (GRCm39) |
D81G |
probably benign |
Het |
| Nt5c1b |
T |
A |
12: 10,431,391 (GRCm39) |
|
probably null |
Het |
| Nucb1 |
T |
C |
7: 45,148,202 (GRCm39) |
K204E |
possibly damaging |
Het |
| Nwd1 |
T |
G |
8: 73,401,801 (GRCm39) |
M774R |
possibly damaging |
Het |
| Or2m13 |
A |
T |
16: 19,225,944 (GRCm39) |
V274E |
probably damaging |
Het |
| Or52u1 |
G |
C |
7: 104,237,907 (GRCm39) |
E299Q |
probably damaging |
Het |
| Or5an1c |
A |
T |
19: 12,218,318 (GRCm39) |
S236T |
possibly damaging |
Het |
| Pan3 |
T |
A |
5: 147,473,082 (GRCm39) |
|
probably null |
Het |
| Pcdh15 |
A |
T |
10: 74,342,317 (GRCm39) |
T1135S |
probably benign |
Het |
| Pfas |
A |
G |
11: 68,890,918 (GRCm39) |
I331T |
probably damaging |
Het |
| Plxna2 |
T |
A |
1: 194,488,647 (GRCm39) |
I1641N |
probably damaging |
Het |
| Pramel27 |
C |
T |
4: 143,579,779 (GRCm39) |
P455S |
probably benign |
Het |
| Ptar1 |
A |
T |
19: 23,695,465 (GRCm39) |
R311W |
probably damaging |
Het |
| Ranbp2 |
T |
G |
10: 58,315,016 (GRCm39) |
M1912R |
probably damaging |
Het |
| Rbm12 |
A |
G |
2: 155,939,223 (GRCm39) |
F350L |
possibly damaging |
Het |
| Sdhaf1 |
T |
C |
7: 30,021,468 (GRCm39) |
D96G |
probably benign |
Het |
| Serpinb6b |
T |
A |
13: 33,152,650 (GRCm39) |
M53K |
probably damaging |
Het |
| Sh2d6 |
A |
T |
6: 72,494,147 (GRCm39) |
L147Q |
probably benign |
Het |
| Slc19a2 |
T |
A |
1: 164,088,445 (GRCm39) |
C298S |
probably benign |
Het |
| Son |
AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG |
AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG |
16: 91,457,222 (GRCm39) |
|
probably benign |
Het |
| St8sia2 |
T |
A |
7: 73,610,650 (GRCm39) |
Q211L |
possibly damaging |
Het |
| Sult2a2 |
T |
C |
7: 13,468,822 (GRCm39) |
I96T |
possibly damaging |
Het |
| Tab2 |
G |
T |
10: 7,783,247 (GRCm39) |
H678Q |
probably damaging |
Het |
| Tnfaip6 |
A |
G |
2: 51,928,228 (GRCm39) |
E14G |
probably benign |
Het |
| Tslp |
T |
C |
18: 32,952,133 (GRCm39) |
Y133H |
not run |
Het |
| Ttn |
T |
C |
2: 76,571,334 (GRCm39) |
I26520V |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,762,487 (GRCm39) |
V3374A |
unknown |
Het |
| Tubgcp2 |
T |
A |
7: 139,587,837 (GRCm39) |
I263F |
possibly damaging |
Het |
| Uaca |
A |
G |
9: 60,777,392 (GRCm39) |
E593G |
probably damaging |
Het |
| Unc13b |
C |
T |
4: 43,172,235 (GRCm39) |
T1021I |
unknown |
Het |
| Ush1c |
T |
A |
7: 45,874,979 (GRCm39) |
I131F |
probably benign |
Het |
| Usp24 |
C |
A |
4: 106,236,304 (GRCm39) |
D997E |
probably benign |
Het |
| Usp54 |
T |
C |
14: 20,627,108 (GRCm39) |
T517A |
probably benign |
Het |
| Vmn1r151 |
A |
T |
7: 22,198,505 (GRCm39) |
M200K |
possibly damaging |
Het |
| Vmn2r43 |
T |
C |
7: 8,258,328 (GRCm39) |
D295G |
probably damaging |
Het |
| Vmn2r70 |
G |
A |
7: 85,213,076 (GRCm39) |
P444S |
probably damaging |
Het |
| Vmn2r85 |
G |
T |
10: 130,254,849 (GRCm39) |
P612T |
probably damaging |
Het |
| Vps13d |
A |
T |
4: 144,875,317 (GRCm39) |
V1736D |
|
Het |
| Zbtb11 |
A |
T |
16: 55,810,850 (GRCm39) |
H336L |
probably benign |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTGTAGAGACTGGAGTAGCTGC -3'
(R):5'- TGGATACTGATCATAAACGAACCAAGG -3'
Sequencing Primer
(F):5'- GCTGCAGCTTGCTCTGG -3'
(R):5'- GACTTTGTCATCTAGTTTAGAAGAGC -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation