Incidental Mutation 'R7426:Fn1'
| ID |
576030 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fn1
|
| Ensembl Gene |
ENSMUSG00000026193 |
| Gene Name |
fibronectin 1 |
| Synonyms |
Fn-1, Fn |
| MMRRC Submission |
045504-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7426 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
71624679-71692359 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 71688384 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 173
(N173K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000054499
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055226]
[ENSMUST00000186129]
[ENSMUST00000186736]
[ENSMUST00000186940]
[ENSMUST00000187938]
[ENSMUST00000188674]
[ENSMUST00000188894]
[ENSMUST00000189821]
[ENSMUST00000190780]
|
| AlphaFold |
P11276 |
| PDB Structure |
SOLUTION NMR STRUCTURE OF LINKED CELL ATTACHMENT MODULES OF MOUSE FIBRONECTIN CONTAINING THE RGD AND SYNERGY REGIONS, 20 STRUCTURES [SOLUTION NMR]
SOLUTION NMR STRUCTURE OF LINKED CELL ATTACHMENT MODULES OF MOUSE FIBRONECTIN CONTAINING THE RGD AND SYNERGY REGIONS, 10 STRUCTURES [SOLUTION NMR]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055226
AA Change: N173K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000054499
Gene: ENSMUSG00000026193
AA Change: N173K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
19 |
N/A |
INTRINSIC |
|
FN1
|
53 |
93 |
6.38e-18 |
SMART |
|
FN1
|
98 |
141 |
6.04e-19 |
SMART |
|
FN1
|
142 |
185 |
6.94e-19 |
SMART |
|
FN1
|
187 |
231 |
3.47e-19 |
SMART |
|
FN1
|
232 |
276 |
6.04e-19 |
SMART |
|
FN1
|
308 |
347 |
5.91e-13 |
SMART |
|
FN2
|
353 |
401 |
6.66e-30 |
SMART |
|
FN2
|
413 |
461 |
5.05e-30 |
SMART |
|
FN1
|
470 |
513 |
2.59e-18 |
SMART |
|
FN1
|
518 |
560 |
1.68e-17 |
SMART |
|
FN1
|
561 |
604 |
5.69e-15 |
SMART |
|
FN3
|
609 |
688 |
3.79e-2 |
SMART |
|
FN3
|
719 |
798 |
1.27e-3 |
SMART |
|
FN3
|
810 |
888 |
7.92e-14 |
SMART |
|
FN3
|
906 |
985 |
4.28e-10 |
SMART |
|
FN3
|
996 |
1074 |
2.53e-12 |
SMART |
|
FN3
|
1086 |
1160 |
1.31e-5 |
SMART |
|
FN3
|
1173 |
1255 |
1.13e-9 |
SMART |
|
FN3
|
1264 |
1346 |
4.22e-9 |
SMART |
|
FN3
|
1357 |
1437 |
9.6e-13 |
SMART |
|
FN3
|
1448 |
1527 |
1.82e-13 |
SMART |
|
FN3
|
1538 |
1617 |
6.69e-12 |
SMART |
|
FN3
|
1632 |
1711 |
2.72e-12 |
SMART |
|
FN3
|
1722 |
1801 |
8.9e-8 |
SMART |
|
FN3
|
1812 |
1891 |
1.66e-7 |
SMART |
|
FN3
|
1904 |
1983 |
4.92e-10 |
SMART |
|
FN3
|
1993 |
2074 |
3.64e-13 |
SMART |
|
low complexity region
|
2148 |
2165 |
N/A |
INTRINSIC |
|
FN3
|
2193 |
2272 |
2.9e0 |
SMART |
|
FN1
|
2296 |
2340 |
3.72e-19 |
SMART |
|
FN1
|
2341 |
2383 |
2.49e-20 |
SMART |
|
FN1
|
2385 |
2425 |
2.69e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186129
AA Change: N173K
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000141123
Gene: ENSMUSG00000026193
AA Change: N173K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
19 |
N/A |
INTRINSIC |
|
FN1
|
53 |
93 |
6.38e-18 |
SMART |
|
FN1
|
98 |
141 |
6.04e-19 |
SMART |
|
FN1
|
142 |
185 |
6.94e-19 |
SMART |
|
FN1
|
187 |
231 |
3.47e-19 |
SMART |
|
FN1
|
232 |
276 |
6.04e-19 |
SMART |
|
FN1
|
308 |
347 |
5.91e-13 |
SMART |
|
FN2
|
353 |
401 |
6.66e-30 |
SMART |
|
FN2
|
413 |
461 |
5.05e-30 |
SMART |
|
FN1
|
470 |
513 |
2.59e-18 |
SMART |
|
FN1
|
518 |
560 |
1.68e-17 |
SMART |
|
FN1
|
561 |
604 |
5.69e-15 |
SMART |
|
FN3
|
609 |
688 |
3.79e-2 |
SMART |
|
FN3
|
719 |
798 |
1.27e-3 |
SMART |
|
FN3
|
810 |
888 |
7.92e-14 |
SMART |
|
FN3
|
906 |
985 |
4.28e-10 |
SMART |
|
FN3
|
996 |
1074 |
2.53e-12 |
SMART |
|
FN3
|
1086 |
1160 |
1.31e-5 |
SMART |
|
FN3
|
1173 |
1255 |
1.13e-9 |
SMART |
|
FN3
|
1266 |
1346 |
9.6e-13 |
SMART |
|
FN3
|
1357 |
1436 |
1.82e-13 |
SMART |
|
FN3
|
1447 |
1526 |
6.69e-12 |
SMART |
|
FN3
|
1541 |
1620 |
2.72e-12 |
SMART |
|
FN3
|
1631 |
1710 |
1.66e-7 |
SMART |
|
FN3
|
1723 |
1802 |
4.92e-10 |
SMART |
|
FN3
|
1812 |
1893 |
3.64e-13 |
SMART |
|
low complexity region
|
1967 |
1984 |
N/A |
INTRINSIC |
|
FN3
|
2012 |
2091 |
2.9e0 |
SMART |
|
FN1
|
2115 |
2159 |
3.72e-19 |
SMART |
|
FN1
|
2160 |
2202 |
2.49e-20 |
SMART |
|
FN1
|
2204 |
2244 |
2.69e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186736
AA Change: N84K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000140372
Gene: ENSMUSG00000026193
AA Change: N84K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
FN1
|
53 |
96 |
3.3e-21 |
SMART |
|
FN1
|
98 |
142 |
1.7e-21 |
SMART |
|
Pfam:fn1
|
143 |
160 |
1.2e-4 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186940
AA Change: N173K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140315
Gene: ENSMUSG00000026193
AA Change: N173K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
FN1
|
53 |
93 |
6.38e-18 |
SMART |
|
FN1
|
98 |
141 |
6.04e-19 |
SMART |
|
FN1
|
142 |
185 |
6.94e-19 |
SMART |
|
FN1
|
187 |
231 |
3.47e-19 |
SMART |
|
FN1
|
232 |
276 |
6.04e-19 |
SMART |
|
FN1
|
308 |
347 |
1.77e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000187938
AA Change: N173K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140975
Gene: ENSMUSG00000026193
AA Change: N173K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
19 |
N/A |
INTRINSIC |
|
FN1
|
53 |
93 |
6.38e-18 |
SMART |
|
FN1
|
98 |
141 |
6.04e-19 |
SMART |
|
FN1
|
142 |
185 |
6.94e-19 |
SMART |
|
FN1
|
187 |
231 |
3.47e-19 |
SMART |
|
FN1
|
232 |
276 |
6.04e-19 |
SMART |
|
FN1
|
308 |
347 |
5.91e-13 |
SMART |
|
FN2
|
353 |
401 |
6.66e-30 |
SMART |
|
FN2
|
413 |
461 |
5.05e-30 |
SMART |
|
FN1
|
470 |
513 |
2.59e-18 |
SMART |
|
FN1
|
518 |
560 |
1.68e-17 |
SMART |
|
FN1
|
561 |
604 |
5.69e-15 |
SMART |
|
FN3
|
609 |
688 |
3.79e-2 |
SMART |
|
FN3
|
719 |
798 |
1.27e-3 |
SMART |
|
FN3
|
810 |
888 |
7.92e-14 |
SMART |
|
FN3
|
906 |
985 |
4.28e-10 |
SMART |
|
FN3
|
996 |
1074 |
2.53e-12 |
SMART |
|
FN3
|
1086 |
1160 |
1.31e-5 |
SMART |
|
FN3
|
1173 |
1255 |
1.13e-9 |
SMART |
|
FN3
|
1266 |
1346 |
9.6e-13 |
SMART |
|
FN3
|
1357 |
1436 |
1.82e-13 |
SMART |
|
FN3
|
1447 |
1526 |
6.69e-12 |
SMART |
|
FN3
|
1541 |
1620 |
2.72e-12 |
SMART |
|
FN3
|
1631 |
1710 |
8.9e-8 |
SMART |
|
FN3
|
1721 |
1800 |
1.66e-7 |
SMART |
|
FN3
|
1813 |
1892 |
4.92e-10 |
SMART |
|
FN3
|
1902 |
1983 |
3.64e-13 |
SMART |
|
low complexity region
|
2032 |
2049 |
N/A |
INTRINSIC |
|
FN3
|
2077 |
2156 |
2.9e0 |
SMART |
|
FN1
|
2180 |
2224 |
3.72e-19 |
SMART |
|
FN1
|
2225 |
2267 |
2.49e-20 |
SMART |
|
FN1
|
2269 |
2309 |
2.69e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000188674
AA Change: N173K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140907
Gene: ENSMUSG00000026193
AA Change: N173K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
19 |
N/A |
INTRINSIC |
|
FN1
|
53 |
93 |
6.38e-18 |
SMART |
|
FN1
|
98 |
141 |
6.04e-19 |
SMART |
|
FN1
|
142 |
185 |
6.94e-19 |
SMART |
|
FN1
|
187 |
231 |
3.47e-19 |
SMART |
|
FN1
|
232 |
276 |
6.04e-19 |
SMART |
|
FN1
|
308 |
347 |
5.91e-13 |
SMART |
|
FN2
|
353 |
401 |
6.66e-30 |
SMART |
|
FN2
|
413 |
461 |
5.05e-30 |
SMART |
|
FN1
|
470 |
513 |
2.59e-18 |
SMART |
|
FN1
|
518 |
560 |
1.68e-17 |
SMART |
|
FN1
|
561 |
604 |
5.69e-15 |
SMART |
|
FN3
|
609 |
688 |
3.79e-2 |
SMART |
|
FN3
|
719 |
798 |
1.27e-3 |
SMART |
|
FN3
|
810 |
888 |
7.92e-14 |
SMART |
|
FN3
|
906 |
985 |
4.28e-10 |
SMART |
|
FN3
|
996 |
1074 |
2.53e-12 |
SMART |
|
FN3
|
1086 |
1160 |
1.31e-5 |
SMART |
|
FN3
|
1173 |
1255 |
1.13e-9 |
SMART |
|
FN3
|
1266 |
1346 |
9.6e-13 |
SMART |
|
FN3
|
1357 |
1436 |
1.82e-13 |
SMART |
|
FN3
|
1447 |
1526 |
6.69e-12 |
SMART |
|
FN3
|
1541 |
1620 |
2.72e-12 |
SMART |
|
FN3
|
1631 |
1710 |
8.9e-8 |
SMART |
|
FN3
|
1721 |
1800 |
1.66e-7 |
SMART |
|
FN3
|
1813 |
1892 |
4.92e-10 |
SMART |
|
FN3
|
1902 |
1981 |
6.79e-13 |
SMART |
|
FN3
|
1983 |
2061 |
1.01e1 |
SMART |
|
FN1
|
2085 |
2129 |
3.72e-19 |
SMART |
|
FN1
|
2130 |
2172 |
2.49e-20 |
SMART |
|
FN1
|
2174 |
2214 |
2.69e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000188894
AA Change: N173K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000140471
Gene: ENSMUSG00000026193
AA Change: N173K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
19 |
N/A |
INTRINSIC |
|
FN1
|
53 |
93 |
6.38e-18 |
SMART |
|
FN1
|
98 |
141 |
6.04e-19 |
SMART |
|
FN1
|
142 |
185 |
6.94e-19 |
SMART |
|
FN1
|
187 |
231 |
3.47e-19 |
SMART |
|
FN1
|
232 |
276 |
6.04e-19 |
SMART |
|
FN1
|
308 |
347 |
5.91e-13 |
SMART |
|
FN2
|
353 |
401 |
6.66e-30 |
SMART |
|
FN2
|
413 |
461 |
5.05e-30 |
SMART |
|
FN1
|
470 |
513 |
2.59e-18 |
SMART |
|
FN1
|
518 |
560 |
1.68e-17 |
SMART |
|
FN1
|
561 |
604 |
5.69e-15 |
SMART |
|
FN3
|
609 |
688 |
3.79e-2 |
SMART |
|
FN3
|
719 |
798 |
1.27e-3 |
SMART |
|
FN3
|
810 |
888 |
7.92e-14 |
SMART |
|
FN3
|
906 |
985 |
4.28e-10 |
SMART |
|
FN3
|
996 |
1074 |
2.53e-12 |
SMART |
|
FN3
|
1086 |
1160 |
1.31e-5 |
SMART |
|
FN3
|
1173 |
1255 |
1.13e-9 |
SMART |
|
FN3
|
1266 |
1346 |
9.6e-13 |
SMART |
|
FN3
|
1357 |
1436 |
1.82e-13 |
SMART |
|
FN3
|
1447 |
1526 |
6.69e-12 |
SMART |
|
FN3
|
1541 |
1620 |
2.72e-12 |
SMART |
|
FN3
|
1631 |
1710 |
8.9e-8 |
SMART |
|
FN3
|
1721 |
1800 |
1.66e-7 |
SMART |
|
FN3
|
1813 |
1892 |
4.92e-10 |
SMART |
|
FN3
|
1902 |
1983 |
3.64e-13 |
SMART |
|
low complexity region
|
2057 |
2074 |
N/A |
INTRINSIC |
|
FN3
|
2102 |
2181 |
2.9e0 |
SMART |
|
FN1
|
2205 |
2249 |
3.72e-19 |
SMART |
|
FN1
|
2250 |
2292 |
2.49e-20 |
SMART |
|
FN1
|
2294 |
2334 |
2.69e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000189821
AA Change: N173K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000139702
Gene: ENSMUSG00000026193
AA Change: N173K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
19 |
N/A |
INTRINSIC |
|
FN1
|
53 |
93 |
6.38e-18 |
SMART |
|
FN1
|
98 |
141 |
6.04e-19 |
SMART |
|
FN1
|
142 |
185 |
6.94e-19 |
SMART |
|
FN1
|
187 |
231 |
3.47e-19 |
SMART |
|
FN1
|
232 |
276 |
6.04e-19 |
SMART |
|
FN1
|
308 |
347 |
5.91e-13 |
SMART |
|
FN2
|
353 |
401 |
6.66e-30 |
SMART |
|
FN2
|
413 |
461 |
5.05e-30 |
SMART |
|
FN1
|
470 |
513 |
2.59e-18 |
SMART |
|
FN1
|
518 |
560 |
1.68e-17 |
SMART |
|
FN1
|
561 |
604 |
5.69e-15 |
SMART |
|
FN3
|
609 |
688 |
3.79e-2 |
SMART |
|
FN3
|
719 |
798 |
1.27e-3 |
SMART |
|
FN3
|
810 |
888 |
7.92e-14 |
SMART |
|
FN3
|
906 |
985 |
4.28e-10 |
SMART |
|
FN3
|
996 |
1074 |
2.53e-12 |
SMART |
|
FN3
|
1086 |
1160 |
1.31e-5 |
SMART |
|
FN3
|
1173 |
1255 |
1.13e-9 |
SMART |
|
FN3
|
1266 |
1346 |
9.6e-13 |
SMART |
|
FN3
|
1357 |
1436 |
1.82e-13 |
SMART |
|
FN3
|
1447 |
1526 |
6.69e-12 |
SMART |
|
FN3
|
1541 |
1620 |
2.72e-12 |
SMART |
|
FN3
|
1631 |
1710 |
1.66e-7 |
SMART |
|
FN3
|
1723 |
1802 |
4.92e-10 |
SMART |
|
FN3
|
1812 |
1891 |
6.79e-13 |
SMART |
|
FN3
|
1893 |
1971 |
1.01e1 |
SMART |
|
FN1
|
1995 |
2039 |
3.72e-19 |
SMART |
|
FN1
|
2040 |
2082 |
2.49e-20 |
SMART |
|
FN1
|
2084 |
2124 |
2.69e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000190780
AA Change: N173K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140816
Gene: ENSMUSG00000026193
AA Change: N173K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
19 |
N/A |
INTRINSIC |
|
FN1
|
53 |
93 |
6.38e-18 |
SMART |
|
FN1
|
98 |
141 |
6.04e-19 |
SMART |
|
FN1
|
142 |
185 |
6.94e-19 |
SMART |
|
FN1
|
187 |
231 |
3.47e-19 |
SMART |
|
FN1
|
232 |
276 |
6.04e-19 |
SMART |
|
FN1
|
308 |
347 |
5.91e-13 |
SMART |
|
FN2
|
353 |
401 |
6.66e-30 |
SMART |
|
FN2
|
413 |
461 |
5.05e-30 |
SMART |
|
FN1
|
470 |
513 |
2.59e-18 |
SMART |
|
FN1
|
518 |
560 |
1.68e-17 |
SMART |
|
FN1
|
561 |
604 |
5.69e-15 |
SMART |
|
FN3
|
609 |
688 |
3.79e-2 |
SMART |
|
FN3
|
719 |
798 |
1.27e-3 |
SMART |
|
FN3
|
810 |
888 |
7.92e-14 |
SMART |
|
FN3
|
906 |
985 |
4.28e-10 |
SMART |
|
FN3
|
996 |
1074 |
2.53e-12 |
SMART |
|
FN3
|
1086 |
1160 |
1.31e-5 |
SMART |
|
FN3
|
1173 |
1255 |
1.13e-9 |
SMART |
|
FN3
|
1266 |
1346 |
9.6e-13 |
SMART |
|
FN3
|
1357 |
1436 |
1.82e-13 |
SMART |
|
FN3
|
1447 |
1526 |
6.69e-12 |
SMART |
|
FN3
|
1541 |
1620 |
2.72e-12 |
SMART |
|
FN3
|
1631 |
1710 |
1.66e-7 |
SMART |
|
FN3
|
1723 |
1802 |
4.92e-10 |
SMART |
|
FN3
|
1812 |
1893 |
3.64e-13 |
SMART |
|
low complexity region
|
1942 |
1959 |
N/A |
INTRINSIC |
|
FN3
|
1987 |
2066 |
2.9e0 |
SMART |
|
FN1
|
2090 |
2134 |
3.72e-19 |
SMART |
|
FN1
|
2135 |
2177 |
2.49e-20 |
SMART |
|
FN1
|
2179 |
2219 |
2.69e-16 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
97% (114/118) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mutants are defective in mesodermal function. Null mutants are embryonic lethal with major patterning and organizational defects. Conditional mutants live and show increased neuronal apoptosis and susceptibility to induced cerebral ischemia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca15 |
C |
A |
7: 119,945,221 (GRCm39) |
N432K |
possibly damaging |
Het |
| Abitram |
A |
G |
4: 56,804,230 (GRCm39) |
I82V |
probably null |
Het |
| Adamtsl5 |
G |
A |
10: 80,180,693 (GRCm39) |
T123I |
probably benign |
Het |
| Aff4 |
T |
C |
11: 53,263,702 (GRCm39) |
S241P |
probably damaging |
Het |
| Agl |
A |
G |
3: 116,552,404 (GRCm39) |
L510P |
|
Het |
| Aox1 |
A |
T |
1: 58,329,142 (GRCm39) |
K196* |
probably null |
Het |
| Arhgef37 |
A |
G |
18: 61,637,456 (GRCm39) |
L402P |
probably damaging |
Het |
| Arid4b |
T |
C |
13: 14,355,891 (GRCm39) |
|
probably null |
Het |
| Atp5pb |
A |
G |
3: 105,851,118 (GRCm39) |
V193A |
probably benign |
Het |
| Atp8b3 |
A |
G |
10: 80,365,463 (GRCm39) |
|
probably null |
Het |
| Baz2a |
G |
T |
10: 127,951,947 (GRCm39) |
R555L |
probably damaging |
Het |
| Casp4 |
G |
T |
9: 5,321,345 (GRCm39) |
S32I |
possibly damaging |
Het |
| Cd300lb |
A |
G |
11: 114,819,128 (GRCm39) |
V167A |
probably damaging |
Het |
| Cdc42bpg |
C |
T |
19: 6,368,428 (GRCm39) |
T1042I |
probably damaging |
Het |
| Ceacam20 |
T |
C |
7: 19,704,159 (GRCm39) |
F70S |
probably damaging |
Het |
| Cep162 |
C |
T |
9: 87,074,819 (GRCm39) |
V1388I |
probably damaging |
Het |
| Cfap65 |
A |
G |
1: 74,959,585 (GRCm39) |
V855A |
possibly damaging |
Het |
| Chil3 |
G |
T |
3: 106,063,022 (GRCm39) |
D189E |
probably benign |
Het |
| Cln3 |
A |
G |
7: 126,180,912 (GRCm39) |
I43T |
probably benign |
Het |
| Cntnap5a |
A |
G |
1: 116,370,110 (GRCm39) |
Q909R |
probably benign |
Het |
| Ctsd |
C |
A |
7: 141,937,278 (GRCm39) |
A77S |
probably damaging |
Het |
| Dnah12 |
T |
A |
14: 26,445,781 (GRCm39) |
S781T |
probably benign |
Het |
| Dnah17 |
T |
A |
11: 117,981,543 (GRCm39) |
Q1716L |
probably null |
Het |
| Dock3 |
C |
A |
9: 106,772,782 (GRCm39) |
M490I |
probably benign |
Het |
| Erg |
T |
C |
16: 95,260,015 (GRCm39) |
|
probably null |
Het |
| Farp2 |
A |
T |
1: 93,548,950 (GRCm39) |
M1019L |
possibly damaging |
Het |
| Fcgbp |
A |
G |
7: 27,785,949 (GRCm39) |
K462R |
probably benign |
Het |
| Fsip2 |
A |
T |
2: 82,810,441 (GRCm39) |
L2253F |
probably damaging |
Het |
| Gabrd |
C |
T |
4: 155,469,970 (GRCm39) |
R413H |
possibly damaging |
Het |
| Galnt5 |
A |
T |
2: 57,907,151 (GRCm39) |
D538V |
probably damaging |
Het |
| Gje1 |
T |
A |
10: 14,592,223 (GRCm39) |
L186F |
probably damaging |
Het |
| Gm16686 |
A |
T |
4: 88,673,563 (GRCm39) |
C89S |
unknown |
Het |
| Gna15 |
G |
T |
10: 81,338,831 (GRCm39) |
A336E |
probably benign |
Het |
| Golga4 |
C |
T |
9: 118,388,563 (GRCm39) |
S1895L |
probably benign |
Het |
| Gon4l |
A |
T |
3: 88,814,829 (GRCm39) |
M1933L |
probably benign |
Het |
| Gpr183 |
T |
C |
14: 122,192,156 (GRCm39) |
S122G |
possibly damaging |
Het |
| Gtf2h4 |
G |
A |
17: 35,980,250 (GRCm39) |
T348I |
probably damaging |
Het |
| Hace1 |
T |
C |
10: 45,481,636 (GRCm39) |
Y120H |
probably damaging |
Het |
| Hivep2 |
C |
T |
10: 14,007,061 (GRCm39) |
H1220Y |
possibly damaging |
Het |
| Hmx2 |
T |
C |
7: 131,156,232 (GRCm39) |
F66S |
probably benign |
Het |
| Hoxd12 |
A |
T |
2: 74,505,569 (GRCm39) |
S47C |
possibly damaging |
Het |
| Hp |
C |
A |
8: 110,301,832 (GRCm39) |
|
probably null |
Het |
| Idh3a |
T |
A |
9: 54,508,492 (GRCm39) |
D355E |
probably benign |
Het |
| Itga2b |
A |
T |
11: 102,347,120 (GRCm39) |
M921K |
probably benign |
Het |
| Jcad |
A |
G |
18: 4,675,529 (GRCm39) |
D1097G |
probably benign |
Het |
| Kdm5b |
A |
T |
1: 134,523,571 (GRCm39) |
T249S |
probably benign |
Het |
| Klhl11 |
G |
T |
11: 100,355,178 (GRCm39) |
H214Q |
probably benign |
Het |
| L3hypdh |
A |
T |
12: 72,131,705 (GRCm39) |
Y76N |
probably damaging |
Het |
| Lama4 |
G |
T |
10: 38,921,751 (GRCm39) |
R424L |
possibly damaging |
Het |
| Lepr |
A |
G |
4: 101,602,853 (GRCm39) |
I214V |
probably benign |
Het |
| Lipc |
G |
T |
9: 70,709,450 (GRCm39) |
N432K |
probably benign |
Het |
| Lipm |
C |
T |
19: 34,093,598 (GRCm39) |
A216V |
possibly damaging |
Het |
| Lrrc23 |
A |
G |
6: 124,756,088 (GRCm39) |
S2P |
unknown |
Het |
| Lyst |
T |
A |
13: 13,812,109 (GRCm39) |
D840E |
probably benign |
Het |
| Mmp23 |
T |
A |
4: 155,736,041 (GRCm39) |
T204S |
probably damaging |
Het |
| Mms19 |
T |
C |
19: 41,936,717 (GRCm39) |
T785A |
probably benign |
Het |
| Mov10 |
A |
T |
3: 104,707,368 (GRCm39) |
|
probably null |
Het |
| Mtf2 |
A |
G |
5: 108,248,836 (GRCm39) |
T383A |
probably benign |
Het |
| Myo5c |
G |
A |
9: 75,158,809 (GRCm39) |
|
probably null |
Het |
| Nfxl1 |
A |
T |
5: 72,681,517 (GRCm39) |
C671* |
probably null |
Het |
| Npepps |
A |
G |
11: 97,103,982 (GRCm39) |
V813A |
probably benign |
Het |
| Nrn1 |
C |
A |
13: 36,910,825 (GRCm39) |
W69L |
probably damaging |
Het |
| Oprd1 |
A |
C |
4: 131,841,378 (GRCm39) |
D193E |
probably benign |
Het |
| Or2ag1b |
T |
A |
7: 106,288,417 (GRCm39) |
I174F |
possibly damaging |
Het |
| Or52p1 |
C |
T |
7: 104,267,059 (GRCm39) |
H58Y |
probably damaging |
Het |
| Or55b3 |
A |
T |
7: 102,126,883 (GRCm39) |
Y65N |
probably damaging |
Het |
| Or56b2j |
T |
A |
7: 104,352,796 (GRCm39) |
D7E |
probably benign |
Het |
| Or6c202 |
A |
G |
10: 128,996,620 (GRCm39) |
Y78H |
possibly damaging |
Het |
| Or6c209 |
T |
C |
10: 129,483,027 (GRCm39) |
I10T |
probably damaging |
Het |
| Or6k6 |
A |
C |
1: 173,944,753 (GRCm39) |
F276L |
probably benign |
Het |
| Pcdhac1 |
G |
T |
18: 37,225,550 (GRCm39) |
V788L |
probably benign |
Het |
| Pcdhb11 |
G |
A |
18: 37,556,313 (GRCm39) |
V548M |
probably damaging |
Het |
| Pde4c |
A |
T |
8: 71,201,621 (GRCm39) |
E517V |
possibly damaging |
Het |
| Pdzd7 |
T |
C |
19: 45,022,086 (GRCm39) |
R521G |
possibly damaging |
Het |
| Pik3c2a |
T |
A |
7: 115,972,089 (GRCm39) |
K780N |
probably damaging |
Het |
| Plb1 |
T |
G |
5: 32,478,591 (GRCm39) |
|
probably null |
Het |
| Plcb4 |
T |
A |
2: 135,842,139 (GRCm39) |
L1041Q |
probably benign |
Het |
| Pnpla6 |
G |
A |
8: 3,566,540 (GRCm39) |
|
probably null |
Het |
| Ppat |
A |
T |
5: 77,063,826 (GRCm39) |
N441K |
probably damaging |
Het |
| Ppp1r1b |
G |
A |
11: 98,246,305 (GRCm39) |
A132T |
probably damaging |
Het |
| Prl2c2 |
A |
C |
13: 13,172,065 (GRCm39) |
|
probably null |
Het |
| Prr14 |
T |
C |
7: 127,074,458 (GRCm39) |
I330T |
probably benign |
Het |
| Pycr1 |
T |
C |
11: 120,533,749 (GRCm39) |
D36G |
probably benign |
Het |
| Rabep2 |
T |
A |
7: 126,037,891 (GRCm39) |
I221N |
probably damaging |
Het |
| Rad23b |
A |
G |
4: 55,370,469 (GRCm39) |
D165G |
probably benign |
Het |
| Reln |
G |
A |
5: 22,176,951 (GRCm39) |
T1905I |
probably damaging |
Het |
| Ripor2 |
T |
C |
13: 24,878,188 (GRCm39) |
V321A |
probably benign |
Het |
| Rnf43 |
A |
G |
11: 87,622,678 (GRCm39) |
D466G |
probably benign |
Het |
| Rpl6 |
A |
T |
5: 121,343,655 (GRCm39) |
R63W |
possibly damaging |
Het |
| S100a14 |
A |
G |
3: 90,435,511 (GRCm39) |
T102A |
probably benign |
Het |
| Samd11 |
C |
A |
4: 156,333,857 (GRCm39) |
V195L |
probably benign |
Het |
| Scaper |
G |
A |
9: 55,669,561 (GRCm39) |
Q372* |
probably null |
Het |
| Sec14l5 |
G |
T |
16: 4,998,739 (GRCm39) |
C593F |
probably damaging |
Het |
| Sema6d |
T |
C |
2: 124,496,078 (GRCm39) |
Y41H |
probably damaging |
Het |
| Serac1 |
G |
A |
17: 6,119,589 (GRCm39) |
R114W |
probably damaging |
Het |
| Slc12a4 |
T |
C |
8: 106,677,468 (GRCm39) |
E388G |
probably benign |
Het |
| Smarcd3 |
T |
C |
5: 24,800,810 (GRCm39) |
T164A |
probably benign |
Het |
| Smtn |
C |
A |
11: 3,480,249 (GRCm39) |
R324L |
probably benign |
Het |
| Spata31d1c |
C |
T |
13: 65,183,175 (GRCm39) |
P239L |
probably benign |
Het |
| Srcap |
T |
C |
7: 127,137,689 (GRCm39) |
V1013A |
possibly damaging |
Het |
| Sv2b |
T |
C |
7: 74,773,812 (GRCm39) |
N553S |
probably damaging |
Het |
| Tex35 |
T |
A |
1: 156,932,656 (GRCm39) |
N52I |
probably damaging |
Het |
| Ticrr |
T |
C |
7: 79,343,734 (GRCm39) |
S1200P |
probably benign |
Het |
| Tmem19 |
A |
G |
10: 115,183,604 (GRCm39) |
L125P |
probably damaging |
Het |
| Trio |
A |
G |
15: 27,856,193 (GRCm39) |
V666A |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,747,627 (GRCm39) |
D4474G |
probably benign |
Het |
| Usp43 |
A |
T |
11: 67,783,842 (GRCm39) |
S368T |
possibly damaging |
Het |
| Vmn2r72 |
T |
A |
7: 85,400,348 (GRCm39) |
M234L |
probably benign |
Het |
| Wdr93 |
T |
A |
7: 79,427,055 (GRCm39) |
|
probably null |
Het |
| Wrap73 |
T |
A |
4: 154,240,584 (GRCm39) |
W359R |
probably damaging |
Het |
| Ywhah |
A |
G |
5: 33,183,985 (GRCm39) |
I63V |
probably benign |
Het |
| Zbtb7b |
G |
T |
3: 89,288,366 (GRCm39) |
P151T |
probably damaging |
Het |
| Zfp318 |
A |
G |
17: 46,710,995 (GRCm39) |
N906S |
probably damaging |
Het |
| Zfp423 |
C |
A |
8: 88,507,341 (GRCm39) |
C1001F |
probably damaging |
Het |
| Zmym1 |
A |
G |
4: 126,943,191 (GRCm39) |
I399T |
possibly damaging |
Het |
| Zmynd15 |
G |
A |
11: 70,353,014 (GRCm39) |
G296D |
probably benign |
Het |
| Znfx1 |
T |
A |
2: 166,890,475 (GRCm39) |
I670F |
probably damaging |
Het |
|
| Other mutations in Fn1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00236:Fn1
|
APN |
1 |
71,692,032 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL00402:Fn1
|
APN |
1 |
71,680,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00946:Fn1
|
APN |
1 |
71,684,699 (GRCm39) |
splice site |
probably benign |
|
|
IGL01311:Fn1
|
APN |
1 |
71,667,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01338:Fn1
|
APN |
1 |
71,665,369 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01353:Fn1
|
APN |
1 |
71,626,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01674:Fn1
|
APN |
1 |
71,645,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01701:Fn1
|
APN |
1 |
71,669,012 (GRCm39) |
splice site |
probably benign |
|
|
IGL01734:Fn1
|
APN |
1 |
71,658,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01788:Fn1
|
APN |
1 |
71,652,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02186:Fn1
|
APN |
1 |
71,677,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02398:Fn1
|
APN |
1 |
71,657,829 (GRCm39) |
splice site |
probably null |
|
|
IGL02425:Fn1
|
APN |
1 |
71,680,302 (GRCm39) |
splice site |
probably benign |
|
|
IGL02516:Fn1
|
APN |
1 |
71,676,482 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02593:Fn1
|
APN |
1 |
71,641,591 (GRCm39) |
missense |
probably benign |
|
|
IGL02651:Fn1
|
APN |
1 |
71,636,835 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02681:Fn1
|
APN |
1 |
71,658,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02890:Fn1
|
APN |
1 |
71,637,531 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02929:Fn1
|
APN |
1 |
71,634,821 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03036:Fn1
|
APN |
1 |
71,668,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03088:Fn1
|
APN |
1 |
71,653,197 (GRCm39) |
splice site |
probably null |
|
|
IGL03142:Fn1
|
APN |
1 |
71,676,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Fn1
|
APN |
1 |
71,680,421 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03184:Fn1
|
APN |
1 |
71,648,656 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03212:Fn1
|
APN |
1 |
71,680,484 (GRCm39) |
nonsense |
probably null |
|
|
IGL03246:Fn1
|
APN |
1 |
71,663,455 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03367:Fn1
|
APN |
1 |
71,636,712 (GRCm39) |
missense |
probably benign |
0.27 |
|
depth
|
UTSW |
1 |
71,647,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
flooded
|
UTSW |
1 |
71,636,675 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0684_Fn1_062
|
UTSW |
1 |
71,634,968 (GRCm39) |
splice site |
probably null |
|
|
series
|
UTSW |
1 |
71,634,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4514001:Fn1
|
UTSW |
1 |
71,667,615 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0008:Fn1
|
UTSW |
1 |
71,634,879 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0112:Fn1
|
UTSW |
1 |
71,648,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0138:Fn1
|
UTSW |
1 |
71,663,269 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0383:Fn1
|
UTSW |
1 |
71,636,844 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0386:Fn1
|
UTSW |
1 |
71,634,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0648:Fn1
|
UTSW |
1 |
71,636,744 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0684:Fn1
|
UTSW |
1 |
71,634,968 (GRCm39) |
splice site |
probably null |
|
|
R1054:Fn1
|
UTSW |
1 |
71,625,373 (GRCm39) |
makesense |
probably null |
|
|
R1183:Fn1
|
UTSW |
1 |
71,625,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1405:Fn1
|
UTSW |
1 |
71,681,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1405:Fn1
|
UTSW |
1 |
71,681,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1414:Fn1
|
UTSW |
1 |
71,640,462 (GRCm39) |
splice site |
probably benign |
|
|
R1677:Fn1
|
UTSW |
1 |
71,636,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1773:Fn1
|
UTSW |
1 |
71,676,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1830:Fn1
|
UTSW |
1 |
71,663,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1987:Fn1
|
UTSW |
1 |
71,690,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1989:Fn1
|
UTSW |
1 |
71,690,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Fn1
|
UTSW |
1 |
71,639,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2113:Fn1
|
UTSW |
1 |
71,665,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2145:Fn1
|
UTSW |
1 |
71,645,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2246:Fn1
|
UTSW |
1 |
71,667,694 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2273:Fn1
|
UTSW |
1 |
71,653,102 (GRCm39) |
missense |
probably null |
1.00 |
|
R2274:Fn1
|
UTSW |
1 |
71,653,102 (GRCm39) |
missense |
probably null |
1.00 |
|
R2275:Fn1
|
UTSW |
1 |
71,653,102 (GRCm39) |
missense |
probably null |
1.00 |
|
R2303:Fn1
|
UTSW |
1 |
71,653,195 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2379:Fn1
|
UTSW |
1 |
71,688,443 (GRCm39) |
nonsense |
probably null |
|
|
R2382:Fn1
|
UTSW |
1 |
71,687,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2567:Fn1
|
UTSW |
1 |
71,636,895 (GRCm39) |
nonsense |
probably null |
|
|
R2864:Fn1
|
UTSW |
1 |
71,641,578 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3154:Fn1
|
UTSW |
1 |
71,632,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3837:Fn1
|
UTSW |
1 |
71,692,314 (GRCm39) |
splice site |
probably null |
|
|
R3844:Fn1
|
UTSW |
1 |
71,648,733 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R3886:Fn1
|
UTSW |
1 |
71,679,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3887:Fn1
|
UTSW |
1 |
71,679,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3888:Fn1
|
UTSW |
1 |
71,679,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3889:Fn1
|
UTSW |
1 |
71,679,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3905:Fn1
|
UTSW |
1 |
71,647,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3906:Fn1
|
UTSW |
1 |
71,647,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3907:Fn1
|
UTSW |
1 |
71,647,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3909:Fn1
|
UTSW |
1 |
71,647,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4611:Fn1
|
UTSW |
1 |
71,663,337 (GRCm39) |
nonsense |
probably null |
|
|
R4724:Fn1
|
UTSW |
1 |
71,687,307 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4732:Fn1
|
UTSW |
1 |
71,641,671 (GRCm39) |
splice site |
probably null |
|
|
R4733:Fn1
|
UTSW |
1 |
71,641,671 (GRCm39) |
splice site |
probably null |
|
|
R4756:Fn1
|
UTSW |
1 |
71,629,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4809:Fn1
|
UTSW |
1 |
71,691,959 (GRCm39) |
intron |
probably benign |
|
|
R4839:Fn1
|
UTSW |
1 |
71,681,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4915:Fn1
|
UTSW |
1 |
71,634,968 (GRCm39) |
splice site |
probably null |
|
|
R4917:Fn1
|
UTSW |
1 |
71,634,968 (GRCm39) |
splice site |
probably null |
|
|
R4918:Fn1
|
UTSW |
1 |
71,634,968 (GRCm39) |
splice site |
probably null |
|
|
R5002:Fn1
|
UTSW |
1 |
71,668,887 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5015:Fn1
|
UTSW |
1 |
71,665,336 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5022:Fn1
|
UTSW |
1 |
71,663,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5109:Fn1
|
UTSW |
1 |
71,688,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5267:Fn1
|
UTSW |
1 |
71,668,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5323:Fn1
|
UTSW |
1 |
71,636,591 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5333:Fn1
|
UTSW |
1 |
71,663,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5631:Fn1
|
UTSW |
1 |
71,629,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5644:Fn1
|
UTSW |
1 |
71,666,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5754:Fn1
|
UTSW |
1 |
71,639,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5807:Fn1
|
UTSW |
1 |
71,687,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Fn1
|
UTSW |
1 |
71,638,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6133:Fn1
|
UTSW |
1 |
71,636,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6186:Fn1
|
UTSW |
1 |
71,676,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6270:Fn1
|
UTSW |
1 |
71,676,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6332:Fn1
|
UTSW |
1 |
71,667,230 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6431:Fn1
|
UTSW |
1 |
71,687,003 (GRCm39) |
splice site |
probably null |
|
|
R6571:Fn1
|
UTSW |
1 |
71,665,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6596:Fn1
|
UTSW |
1 |
71,648,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6862:Fn1
|
UTSW |
1 |
71,653,066 (GRCm39) |
missense |
probably benign |
0.43 |
|
R6898:Fn1
|
UTSW |
1 |
71,639,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6984:Fn1
|
UTSW |
1 |
71,665,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Fn1
|
UTSW |
1 |
71,666,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7121:Fn1
|
UTSW |
1 |
71,639,697 (GRCm39) |
intron |
probably benign |
|
|
R7127:Fn1
|
UTSW |
1 |
71,636,703 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7194:Fn1
|
UTSW |
1 |
71,641,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7274:Fn1
|
UTSW |
1 |
71,667,272 (GRCm39) |
missense |
probably benign |
|
|
R7285:Fn1
|
UTSW |
1 |
71,676,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Fn1
|
UTSW |
1 |
71,630,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7508:Fn1
|
UTSW |
1 |
71,636,675 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7724:Fn1
|
UTSW |
1 |
71,642,894 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7848:Fn1
|
UTSW |
1 |
71,689,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7992:Fn1
|
UTSW |
1 |
71,638,825 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8036:Fn1
|
UTSW |
1 |
71,629,310 (GRCm39) |
nonsense |
probably null |
|
|
R8077:Fn1
|
UTSW |
1 |
71,651,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8175:Fn1
|
UTSW |
1 |
71,638,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Fn1
|
UTSW |
1 |
71,648,746 (GRCm39) |
missense |
probably benign |
|
|
R8212:Fn1
|
UTSW |
1 |
71,682,064 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8322:Fn1
|
UTSW |
1 |
71,667,618 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8745:Fn1
|
UTSW |
1 |
71,676,528 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8780:Fn1
|
UTSW |
1 |
71,682,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8805:Fn1
|
UTSW |
1 |
71,644,239 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8927:Fn1
|
UTSW |
1 |
71,638,535 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8928:Fn1
|
UTSW |
1 |
71,638,535 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8928:Fn1
|
UTSW |
1 |
71,641,777 (GRCm39) |
intron |
probably benign |
|
|
R8989:Fn1
|
UTSW |
1 |
71,663,446 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8991:Fn1
|
UTSW |
1 |
71,676,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9095:Fn1
|
UTSW |
1 |
71,647,149 (GRCm39) |
missense |
probably null |
0.02 |
|
R9455:Fn1
|
UTSW |
1 |
71,647,112 (GRCm39) |
missense |
probably benign |
|
|
R9589:Fn1
|
UTSW |
1 |
71,668,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Fn1
|
UTSW |
1 |
71,625,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9645:Fn1
|
UTSW |
1 |
71,667,629 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9723:Fn1
|
UTSW |
1 |
71,663,369 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
X0023:Fn1
|
UTSW |
1 |
71,637,532 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1088:Fn1
|
UTSW |
1 |
71,688,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Fn1
|
UTSW |
1 |
71,636,570 (GRCm39) |
missense |
probably benign |
0.10 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTCAGGATCTGATTTCCTTAAGGC -3'
(R):5'- TCCCTCAGGATTAGGGATTGC -3'
Sequencing Primer
(F):5'- CTTAAGGCTGGTGACTCGCAG -3'
(R):5'- GGGATTGCATTTTGGCCAACATAC -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation