Incidental Mutation 'R7431:Dpp4'
ID 576440
Institutional Source Beutler Lab
Gene Symbol Dpp4
Ensembl Gene ENSMUSG00000035000
Gene Name dipeptidylpeptidase 4
Synonyms Cd26, THAM, Dpp-4
MMRRC Submission 045509-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7431 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 62160417-62242575 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 62182582 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 566 (N566K)
Ref Sequence ENSEMBL: ENSMUSP00000044050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047812]
AlphaFold P28843
Predicted Effect probably benign
Transcript: ENSMUST00000047812
AA Change: N566K

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000044050
Gene: ENSMUSG00000035000
AA Change: N566K

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:DPPIV_N 102 473 5.7e-110 PFAM
Pfam:Abhydrolase_5 545 752 1e-11 PFAM
Pfam:DLH 546 754 4e-7 PFAM
Pfam:Peptidase_S9 551 760 3.4e-61 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 97% (77/79)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 CA C 11: 110,018,252 (GRCm39) probably null Het
Abcf3 G T 16: 20,377,539 (GRCm39) R510L probably benign Het
Abcg4 T A 9: 44,185,997 (GRCm39) I625F possibly damaging Het
Adam22 A T 5: 8,142,818 (GRCm39) S806T probably damaging Het
Adcy4 T C 14: 56,010,129 (GRCm39) I718V probably benign Het
Adgb A T 10: 10,267,699 (GRCm39) probably null Het
Aldoart1 T A 4: 72,769,678 (GRCm39) K377* probably null Het
Apc2 T A 10: 80,138,017 (GRCm39) V100E possibly damaging Het
Asxl3 T G 18: 22,650,010 (GRCm39) D666E probably damaging Het
Atg4c A T 4: 99,109,632 (GRCm39) I200F possibly damaging Het
Atp1a4 A G 1: 172,078,474 (GRCm39) F255L probably benign Het
Bod1l A C 5: 41,970,463 (GRCm39) probably null Het
Cacna2d4 A T 6: 119,221,237 (GRCm39) T250S probably damaging Het
Ccdc202 A G 14: 96,119,273 (GRCm39) H10R probably benign Het
Ccng1 G A 11: 40,644,745 (GRCm39) R51W possibly damaging Het
Chd6 T C 2: 160,868,248 (GRCm39) E366G possibly damaging Het
Clca4b A T 3: 144,616,894 (GRCm39) S919T probably benign Het
Col5a3 T C 9: 20,682,131 (GRCm39) *1740W probably null Het
Col6a5 A T 9: 105,805,468 (GRCm39) I1146K unknown Het
Cpxm1 T C 2: 130,235,966 (GRCm39) T399A probably benign Het
Cpz T C 5: 35,668,486 (GRCm39) T375A probably benign Het
Cyp2b13 T A 7: 25,760,976 (GRCm39) V11D probably damaging Het
Cyp39a1 A G 17: 43,993,906 (GRCm39) T189A probably benign Het
Desi2 C T 1: 178,084,007 (GRCm39) Q52* probably null Het
Dhx15 A G 5: 52,319,953 (GRCm39) V418A probably damaging Het
Dnah3 T A 7: 119,650,967 (GRCm39) M978L probably damaging Het
Dpagt1 T A 9: 44,237,384 (GRCm39) C17* probably null Het
Dph5 A T 3: 115,686,381 (GRCm39) K52N possibly damaging Het
Elavl4 T C 4: 110,083,830 (GRCm39) Y94C probably damaging Het
Fat2 G A 11: 55,199,927 (GRCm39) T1049I probably damaging Het
Fat4 T A 3: 39,063,306 (GRCm39) Y4421N possibly damaging Het
Fcrl2 C A 3: 87,166,233 (GRCm39) A181S probably damaging Het
Garre1 T C 7: 33,984,219 (GRCm39) I135V possibly damaging Het
Glg1 G T 8: 111,887,386 (GRCm39) N456K unknown Het
Gm10228 A G 16: 88,838,101 (GRCm39) S68P unknown Het
Golga4 G A 9: 118,388,799 (GRCm39) E1974K probably damaging Het
Heatr9 G T 11: 83,410,094 (GRCm39) P49Q probably damaging Het
Hmgxb3 A T 18: 61,280,517 (GRCm39) V662D probably damaging Het
Hs3st4 T C 7: 123,582,513 (GRCm39) L37P probably damaging Het
Ifi205 A T 1: 173,855,943 (GRCm39) M29K probably benign Het
Igkv1-35 C T 6: 69,987,988 (GRCm39) V103M probably damaging Het
Klf13 T A 7: 63,541,504 (GRCm39) K208* probably null Het
Klhl36 A G 8: 120,597,121 (GRCm39) N274S probably benign Het
Mosmo T A 7: 120,329,873 (GRCm39) L165I probably benign Het
Mtcl1 G A 17: 66,649,901 (GRCm39) Q1855* probably null Het
Muc16 A G 9: 18,519,289 (GRCm39) V208A Het
Nin T G 12: 70,124,997 (GRCm39) R108S Het
Odad1 T G 7: 45,578,670 (GRCm39) L81R probably damaging Het
Or13c7d T C 4: 43,770,882 (GRCm39) N43S probably damaging Het
Polr1a G A 6: 71,903,643 (GRCm39) V319I probably benign Het
Pramel7 A G 2: 87,320,282 (GRCm39) V337A possibly damaging Het
Prkar2b A T 12: 32,013,150 (GRCm39) probably null Het
R3hdm2 T A 10: 127,294,016 (GRCm39) M170K probably benign Het
Rbm26 A G 14: 105,354,528 (GRCm39) I919T possibly damaging Het
Rimkla A G 4: 119,335,008 (GRCm39) M125T probably benign Het
Sag T A 1: 87,749,059 (GRCm39) F153I possibly damaging Het
Sbf2 G T 7: 109,950,957 (GRCm39) D1163E probably damaging Het
Scgb2b24 T C 7: 33,438,674 (GRCm39) I13V probably benign Het
Scin G A 12: 40,183,921 (GRCm39) H63Y probably damaging Het
Sele A G 1: 163,879,189 (GRCm39) T275A probably damaging Het
Slc22a15 T A 3: 101,805,256 (GRCm39) T144S probably benign Het
Slc8a1 T A 17: 81,749,092 (GRCm39) K650I probably benign Het
Slc9c1 G T 16: 45,413,847 (GRCm39) V992F probably damaging Het
Spag16 A T 1: 69,963,031 (GRCm39) T393S unknown Het
Taf15 G A 11: 83,395,779 (GRCm39) D495N unknown Het
Tas2r144 T A 6: 42,192,908 (GRCm39) I216N probably damaging Het
Tbccd1 G T 16: 22,644,563 (GRCm39) P271Q probably benign Het
Tcf4 C A 18: 69,480,249 (GRCm39) probably null Het
Thap4 A T 1: 93,678,223 (GRCm39) S188T probably benign Het
Trank1 T C 9: 111,191,470 (GRCm39) V493A probably benign Het
Trip11 A G 12: 101,850,278 (GRCm39) V1262A possibly damaging Het
Tspan2 T A 3: 102,657,107 (GRCm39) W35R probably damaging Het
Usp39 G T 6: 72,313,251 (GRCm39) T313N possibly damaging Het
Vmn2r83 T A 10: 79,327,306 (GRCm39) L638Q probably damaging Het
Vps29 T C 5: 122,492,541 (GRCm39) V2A probably benign Het
Wrap53 A G 11: 69,469,313 (GRCm39) F148L possibly damaging Het
Znfx1 T C 2: 166,897,712 (GRCm39) Y404C probably damaging Het
Zrsr2-ps1 A G 11: 22,923,580 (GRCm39) E118G probably benign Het
Other mutations in Dpp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Dpp4 APN 2 62,209,646 (GRCm39) missense probably damaging 1.00
IGL02205:Dpp4 APN 2 62,182,601 (GRCm39) missense probably damaging 1.00
IGL02276:Dpp4 APN 2 62,187,295 (GRCm39) splice site probably benign
IGL02335:Dpp4 APN 2 62,164,988 (GRCm39) missense probably benign 0.03
IGL02615:Dpp4 APN 2 62,189,672 (GRCm39) missense probably damaging 1.00
IGL02639:Dpp4 APN 2 62,182,584 (GRCm39) missense probably benign
IGL02972:Dpp4 APN 2 62,182,569 (GRCm39) missense probably damaging 1.00
IGL03366:Dpp4 APN 2 62,187,301 (GRCm39) splice site probably null
caribou UTSW 2 62,178,245 (GRCm39) missense possibly damaging 0.69
PIT4449001:Dpp4 UTSW 2 62,186,988 (GRCm39) missense probably benign 0.00
R0502:Dpp4 UTSW 2 62,195,332 (GRCm39) missense probably damaging 0.99
R0581:Dpp4 UTSW 2 62,187,020 (GRCm39) missense probably benign
R1004:Dpp4 UTSW 2 62,162,984 (GRCm39) missense probably benign 0.08
R1075:Dpp4 UTSW 2 62,182,630 (GRCm39) missense probably benign 0.39
R1476:Dpp4 UTSW 2 62,178,245 (GRCm39) missense possibly damaging 0.69
R1702:Dpp4 UTSW 2 62,216,773 (GRCm39) critical splice donor site probably null
R1707:Dpp4 UTSW 2 62,189,679 (GRCm39) splice site probably benign
R1733:Dpp4 UTSW 2 62,203,213 (GRCm39) critical splice acceptor site probably null
R1899:Dpp4 UTSW 2 62,175,394 (GRCm39) splice site probably benign
R2264:Dpp4 UTSW 2 62,208,583 (GRCm39) missense possibly damaging 0.71
R2496:Dpp4 UTSW 2 62,217,477 (GRCm39) missense possibly damaging 0.90
R3765:Dpp4 UTSW 2 62,216,780 (GRCm39) missense probably benign 0.17
R4278:Dpp4 UTSW 2 62,209,667 (GRCm39) missense probably damaging 1.00
R4413:Dpp4 UTSW 2 62,217,484 (GRCm39) missense possibly damaging 0.89
R4432:Dpp4 UTSW 2 62,175,456 (GRCm39) missense probably damaging 1.00
R4647:Dpp4 UTSW 2 62,164,949 (GRCm39) missense probably damaging 1.00
R4710:Dpp4 UTSW 2 62,190,659 (GRCm39) missense probably benign 0.04
R4914:Dpp4 UTSW 2 62,178,236 (GRCm39) missense probably benign 0.20
R5173:Dpp4 UTSW 2 62,217,474 (GRCm39) missense probably damaging 1.00
R5283:Dpp4 UTSW 2 62,190,680 (GRCm39) missense probably damaging 1.00
R5698:Dpp4 UTSW 2 62,164,655 (GRCm39) missense probably damaging 1.00
R6621:Dpp4 UTSW 2 62,182,484 (GRCm39) missense probably damaging 1.00
R6681:Dpp4 UTSW 2 62,178,893 (GRCm39) missense probably benign 0.01
R6739:Dpp4 UTSW 2 62,217,439 (GRCm39) missense probably benign
R6962:Dpp4 UTSW 2 62,203,174 (GRCm39) missense probably benign 0.11
R7249:Dpp4 UTSW 2 62,215,547 (GRCm39) missense probably benign 0.14
R7268:Dpp4 UTSW 2 62,178,186 (GRCm39) missense probably damaging 1.00
R7343:Dpp4 UTSW 2 62,189,245 (GRCm39) nonsense probably null
R7357:Dpp4 UTSW 2 62,217,421 (GRCm39) missense probably benign
R7366:Dpp4 UTSW 2 62,184,943 (GRCm39) missense probably damaging 1.00
R7413:Dpp4 UTSW 2 62,187,333 (GRCm39) missense probably damaging 1.00
R7642:Dpp4 UTSW 2 62,190,627 (GRCm39) critical splice donor site probably null
R8004:Dpp4 UTSW 2 62,189,172 (GRCm39) missense probably benign 0.00
R8197:Dpp4 UTSW 2 62,203,171 (GRCm39) missense probably benign 0.31
R8341:Dpp4 UTSW 2 62,178,234 (GRCm39) missense probably benign 0.10
R8706:Dpp4 UTSW 2 62,208,647 (GRCm39) missense probably benign 0.00
R8977:Dpp4 UTSW 2 62,204,747 (GRCm39) missense probably benign 0.29
R8997:Dpp4 UTSW 2 62,164,958 (GRCm39) missense probably damaging 0.99
R9100:Dpp4 UTSW 2 62,204,733 (GRCm39) missense possibly damaging 0.51
R9616:Dpp4 UTSW 2 62,217,429 (GRCm39) missense probably damaging 1.00
R9777:Dpp4 UTSW 2 62,195,340 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GGGTAAAGGATTATAAATTCACCCTCC -3'
(R):5'- GAACCTATTCTTGATAATCCAGTGCC -3'

Sequencing Primer
(F):5'- GGATTATAAATTCACCCTCCAAAACC -3'
(R):5'- CCAGTGCCTACTATAATTTTCAGTC -3'
Posted On 2019-10-07