Incidental Mutation 'IGL00392:Mettl26'
ID 5766
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl26
Ensembl Gene ENSMUSG00000025731
Gene Name methyltransferase like 26
Synonyms 0610011F06Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # IGL00392
Quality Score
Status
Chromosome 17
Chromosomal Location 26094474-26096137 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 26095098 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000126198 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026827] [ENSMUST00000095487] [ENSMUST00000110456] [ENSMUST00000163356] [ENSMUST00000169085] [ENSMUST00000169308] [ENSMUST00000176696]
AlphaFold Q9DCS2
Predicted Effect probably null
Transcript: ENSMUST00000026827
SMART Domains Protein: ENSMUSP00000026827
Gene: ENSMUSG00000025731

DomainStartEndE-ValueType
Pfam:DUF938 1 203 7.4e-95 PFAM
Pfam:Methyltransf_25 31 133 1.1e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000095487
SMART Domains Protein: ENSMUSP00000093141
Gene: ENSMUSG00000071192

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
WAP 32 82 4.04e-3 SMART
KAZAL 119 161 1.96e-2 SMART
IGc2 202 274 2.54e-14 SMART
KU 301 356 4.2e-3 SMART
KU 361 414 1.82e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110456
SMART Domains Protein: ENSMUSP00000106086
Gene: ENSMUSG00000025731

DomainStartEndE-ValueType
Pfam:DUF938 1 78 8.6e-30 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000163356
SMART Domains Protein: ENSMUSP00000130209
Gene: ENSMUSG00000025731

DomainStartEndE-ValueType
Pfam:DUF938 1 172 1.6e-74 PFAM
Pfam:Methyltransf_25 31 133 9e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169085
SMART Domains Protein: ENSMUSP00000125990
Gene: ENSMUSG00000025731

DomainStartEndE-ValueType
Pfam:DUF938 1 65 6.5e-29 PFAM
Pfam:DUF938 64 106 3.5e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000169308
SMART Domains Protein: ENSMUSP00000126198
Gene: ENSMUSG00000025731

DomainStartEndE-ValueType
Pfam:DUF938 1 194 5.6e-86 PFAM
Pfam:Methyltransf_25 31 133 4.4e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Predicted Effect probably benign
Transcript: ENSMUST00000176696
SMART Domains Protein: ENSMUSP00000135083
Gene: ENSMUSG00000071192

DomainStartEndE-ValueType
WAP 2 48 8.8e-2 SMART
KAZAL 85 127 1.96e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk3 T C 7: 80,727,757 (GRCm39) Y296H possibly damaging Het
Armh3 T G 19: 45,928,927 (GRCm39) H389P probably benign Het
Brca2 A G 5: 150,464,705 (GRCm39) T1490A probably benign Het
Btaf1 A T 19: 36,987,102 (GRCm39) D1732V probably damaging Het
Capzb T C 4: 139,016,258 (GRCm39) I273T probably benign Het
Carmil1 G A 13: 24,278,474 (GRCm39) T165I probably damaging Het
Cc2d2a A G 5: 43,881,722 (GRCm39) probably benign Het
Cdh22 A G 2: 164,954,521 (GRCm39) Y667H possibly damaging Het
Celsr1 T A 15: 85,815,546 (GRCm39) Q1823L probably benign Het
Cfap210 T C 2: 69,602,328 (GRCm39) H361R probably benign Het
Cntrl T C 2: 35,027,826 (GRCm39) probably benign Het
Dhx15 A T 5: 52,314,924 (GRCm39) probably benign Het
Dip2c A T 13: 9,543,144 (GRCm39) D30V probably damaging Het
Dyrk2 T C 10: 118,695,749 (GRCm39) D503G probably damaging Het
Enpp1 T A 10: 24,521,325 (GRCm39) I801F possibly damaging Het
Fnbp4 A C 2: 90,581,966 (GRCm39) probably benign Het
Klk1b5 T A 7: 43,865,928 (GRCm39) W2R probably benign Het
Lama2 T C 10: 27,064,261 (GRCm39) K1240R probably benign Het
Matn2 A G 15: 34,403,002 (GRCm39) N409S probably benign Het
Mep1b A T 18: 21,217,243 (GRCm39) K121* probably null Het
Myh7 T C 14: 55,224,845 (GRCm39) E574G probably damaging Het
Nfkbie G A 17: 45,871,139 (GRCm39) probably null Het
Nlrc4 T C 17: 74,753,529 (GRCm39) R285G probably benign Het
Pax8 T C 2: 24,333,144 (GRCm39) Y66C probably damaging Het
Plxna2 A G 1: 194,482,876 (GRCm39) D1523G probably damaging Het
Pou2f1 A G 1: 165,724,159 (GRCm39) probably benign Het
Prom1 A G 5: 44,164,363 (GRCm39) probably null Het
Ptk6 T C 2: 180,837,611 (GRCm39) D436G probably benign Het
Robo4 T A 9: 37,319,525 (GRCm39) F592I probably damaging Het
Sec24c C A 14: 20,743,271 (GRCm39) S964R probably benign Het
Sgcb G T 5: 73,793,021 (GRCm39) N260K possibly damaging Het
Smarcd2 T C 11: 106,156,730 (GRCm39) D221G probably damaging Het
Unc13b C T 4: 43,240,285 (GRCm39) R3569W probably damaging Het
Zfpl1 C A 19: 6,131,137 (GRCm39) R285L possibly damaging Het
Other mutations in Mettl26
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4985:Mettl26 UTSW 17 26,095,750 (GRCm39) makesense probably null
R5813:Mettl26 UTSW 17 26,094,995 (GRCm39) missense probably damaging 1.00
R6974:Mettl26 UTSW 17 26,095,658 (GRCm39) missense probably damaging 1.00
R9776:Mettl26 UTSW 17 26,094,511 (GRCm39) missense probably benign 0.00
Posted On 2012-04-20