Incidental Mutation 'R7442:Vmn2r96'
| ID |
577050 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r96
|
| Ensembl Gene |
ENSMUSG00000091679 |
| Gene Name |
vomeronasal 2, receptor 96 |
| Synonyms |
EG433070 |
| MMRRC Submission |
045518-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.156)
|
| Stock # |
R7442 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
18793282-18818419 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 18793662 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 2
(F2S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135095
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177244]
[ENSMUST00000231261]
[ENSMUST00000231286]
|
| AlphaFold |
E9PZU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177244
AA Change: F2S
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: F2S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
245 |
4.2e-19 |
PFAM |
|
Pfam:NCD3G
|
317 |
370 |
6.9e-21 |
PFAM |
|
Pfam:7tm_3
|
400 |
639 |
3.4e-75 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231261
AA Change: F2S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231286
AA Change: F2S
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (76/76) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700011L22Rik |
A |
G |
8: 79,946,919 (GRCm39) |
I109T |
probably damaging |
Het |
| A430033K04Rik |
T |
C |
5: 138,645,509 (GRCm39) |
S465P |
possibly damaging |
Het |
| Acap3 |
T |
C |
4: 155,990,078 (GRCm39) |
F753L |
probably damaging |
Het |
| Adam9 |
A |
T |
8: 25,457,223 (GRCm39) |
V635E |
probably damaging |
Het |
| Adgre4 |
T |
A |
17: 56,159,340 (GRCm39) |
V675E |
probably benign |
Het |
| Anapc4 |
T |
C |
5: 53,014,543 (GRCm39) |
Y469H |
probably benign |
Het |
| Ankdd1b |
T |
G |
13: 96,561,268 (GRCm39) |
K325N |
possibly damaging |
Het |
| Aox1 |
T |
C |
1: 58,121,172 (GRCm39) |
V881A |
probably damaging |
Het |
| Arhgap5 |
A |
G |
12: 52,563,739 (GRCm39) |
T237A |
probably benign |
Het |
| Asah1 |
T |
C |
8: 41,796,602 (GRCm39) |
D331G |
possibly damaging |
Het |
| Atp5f1a |
G |
A |
18: 77,866,820 (GRCm39) |
R231H |
probably benign |
Het |
| Bod1l |
G |
A |
5: 41,964,522 (GRCm39) |
P2694L |
probably damaging |
Het |
| Bst1 |
T |
C |
5: 43,979,084 (GRCm39) |
S143P |
probably benign |
Het |
| Cacna1b |
A |
C |
2: 24,497,513 (GRCm39) |
S2132A |
probably benign |
Het |
| Caps2 |
G |
T |
10: 112,044,259 (GRCm39) |
R486L |
probably damaging |
Het |
| Ccdc168 |
A |
G |
1: 44,097,868 (GRCm39) |
S1077P |
possibly damaging |
Het |
| Cd68 |
T |
C |
11: 69,556,754 (GRCm39) |
T18A |
probably benign |
Het |
| Cdk8 |
T |
C |
5: 146,229,579 (GRCm39) |
|
probably null |
Het |
| Col18a1 |
A |
T |
10: 76,932,072 (GRCm39) |
I127N |
unknown |
Het |
| Dsc3 |
T |
C |
18: 20,114,213 (GRCm39) |
D347G |
probably damaging |
Het |
| Dyrk2 |
T |
C |
10: 118,695,786 (GRCm39) |
S491G |
probably damaging |
Het |
| Edem1 |
T |
A |
6: 108,828,266 (GRCm39) |
Y530* |
probably null |
Het |
| Enc1 |
A |
T |
13: 97,383,248 (GRCm39) |
H586L |
probably benign |
Het |
| Ephb6 |
T |
G |
6: 41,594,981 (GRCm39) |
|
probably null |
Het |
| Etv5 |
G |
T |
16: 22,254,809 (GRCm39) |
Q48K |
probably damaging |
Het |
| Exoc3l |
A |
G |
8: 106,019,558 (GRCm39) |
W404R |
probably damaging |
Het |
| Fbn1 |
C |
A |
2: 125,245,132 (GRCm39) |
A252S |
possibly damaging |
Het |
| Foxe3 |
A |
G |
4: 114,782,490 (GRCm39) |
S241P |
unknown |
Het |
| Gm49380 |
T |
A |
9: 44,023,709 (GRCm39) |
M180L |
probably benign |
Het |
| Hoxd1 |
A |
T |
2: 74,593,903 (GRCm39) |
D153V |
probably damaging |
Het |
| Ifi207 |
C |
T |
1: 173,554,997 (GRCm39) |
S895N |
probably benign |
Het |
| Igf1r |
G |
A |
7: 67,823,026 (GRCm39) |
V385M |
probably damaging |
Het |
| Ints9 |
C |
T |
14: 65,232,513 (GRCm39) |
Q191* |
probably null |
Het |
| Ktn1 |
A |
G |
14: 47,952,097 (GRCm39) |
E979G |
probably benign |
Het |
| Lama3 |
G |
A |
18: 12,605,238 (GRCm39) |
|
probably null |
Het |
| Lrtm2 |
C |
T |
6: 119,294,392 (GRCm39) |
M246I |
probably damaging |
Het |
| Mdm1 |
T |
C |
10: 117,982,590 (GRCm39) |
V75A |
probably benign |
Het |
| Mia3 |
T |
C |
1: 183,140,220 (GRCm39) |
E165G |
probably benign |
Het |
| Mrps21 |
T |
C |
3: 95,770,128 (GRCm39) |
E67G |
probably damaging |
Het |
| Mybpc1 |
A |
C |
10: 88,362,155 (GRCm39) |
I995S |
probably damaging |
Het |
| Mylk2 |
T |
G |
2: 152,753,346 (GRCm39) |
|
probably benign |
Het |
| Myo16 |
G |
A |
8: 10,322,537 (GRCm39) |
C11Y |
probably damaging |
Het |
| Nudt18 |
A |
C |
14: 70,816,798 (GRCm39) |
D134A |
probably benign |
Het |
| Obox1 |
G |
T |
7: 15,289,491 (GRCm39) |
K93N |
probably benign |
Het |
| Or12d2 |
T |
A |
17: 37,624,816 (GRCm39) |
H153L |
possibly damaging |
Het |
| Or2r3 |
A |
T |
6: 42,448,434 (GRCm39) |
M226K |
probably benign |
Het |
| Or56a4 |
T |
C |
7: 104,806,289 (GRCm39) |
Y200C |
probably damaging |
Het |
| Or5ar1 |
A |
T |
2: 85,672,096 (GRCm39) |
V13D |
probably benign |
Het |
| Pkd2l1 |
T |
C |
19: 44,145,668 (GRCm39) |
H185R |
probably benign |
Het |
| Ptpn18 |
A |
G |
1: 34,501,831 (GRCm39) |
T48A |
probably benign |
Het |
| Ptprd |
A |
T |
4: 75,978,058 (GRCm39) |
Y583* |
probably null |
Het |
| Ptprk |
G |
A |
10: 28,450,815 (GRCm39) |
G992D |
probably damaging |
Het |
| Setdb2 |
A |
G |
14: 59,656,700 (GRCm39) |
F206L |
probably damaging |
Het |
| Slain1 |
A |
G |
14: 103,923,150 (GRCm39) |
D247G |
probably damaging |
Het |
| Slc10a2 |
A |
T |
8: 5,139,086 (GRCm39) |
V286E |
possibly damaging |
Het |
| Slc44a2 |
C |
T |
9: 21,256,819 (GRCm39) |
T367I |
probably damaging |
Het |
| Slco4a1 |
T |
C |
2: 180,115,919 (GRCm39) |
V685A |
probably benign |
Het |
| Srp54c |
T |
A |
12: 55,302,347 (GRCm39) |
Y333N |
probably damaging |
Het |
| Srrm2 |
T |
C |
17: 24,039,091 (GRCm39) |
S1912P |
unknown |
Het |
| St7l |
A |
G |
3: 104,796,645 (GRCm39) |
T253A |
possibly damaging |
Het |
| Styxl2 |
T |
C |
1: 165,928,584 (GRCm39) |
K343E |
probably benign |
Het |
| Sun3 |
T |
G |
11: 8,981,445 (GRCm39) |
Y53S |
possibly damaging |
Het |
| Tktl2 |
A |
G |
8: 66,965,561 (GRCm39) |
N373S |
possibly damaging |
Het |
| Tmco3 |
T |
A |
8: 13,370,781 (GRCm39) |
S648R |
probably damaging |
Het |
| Tmem178 |
T |
A |
17: 81,252,185 (GRCm39) |
V23D |
probably damaging |
Het |
| Tmem229a |
C |
A |
6: 24,955,689 (GRCm39) |
G22W |
probably damaging |
Het |
| Top3a |
C |
T |
11: 60,644,744 (GRCm39) |
S320N |
possibly damaging |
Het |
| Treml1 |
C |
A |
17: 48,673,719 (GRCm39) |
D243E |
probably damaging |
Het |
| Trim42 |
C |
T |
9: 97,244,998 (GRCm39) |
V601M |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,573,350 (GRCm39) |
S25848P |
probably damaging |
Het |
| Vmn1r86 |
A |
T |
7: 12,835,983 (GRCm39) |
F298I |
possibly damaging |
Het |
| Xpc |
A |
G |
6: 91,481,631 (GRCm39) |
L230P |
probably damaging |
Het |
| Xpo4 |
A |
G |
14: 57,867,680 (GRCm39) |
V189A |
probably benign |
Het |
| Zfhx3 |
A |
G |
8: 109,519,468 (GRCm39) |
T197A |
probably damaging |
Het |
| Zswim1 |
A |
G |
2: 164,667,710 (GRCm39) |
K321E |
probably damaging |
Het |
|
| Other mutations in Vmn2r96 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00562:Vmn2r96
|
APN |
17 |
18,804,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00563:Vmn2r96
|
APN |
17 |
18,804,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00769:Vmn2r96
|
APN |
17 |
18,804,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01314:Vmn2r96
|
APN |
17 |
18,803,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01983:Vmn2r96
|
APN |
17 |
18,817,527 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02314:Vmn2r96
|
APN |
17 |
18,804,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02600:Vmn2r96
|
APN |
17 |
18,817,829 (GRCm39) |
missense |
probably benign |
|
|
IGL02672:Vmn2r96
|
APN |
17 |
18,818,376 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02750:Vmn2r96
|
APN |
17 |
18,802,851 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03068:Vmn2r96
|
APN |
17 |
18,803,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r96
|
APN |
17 |
18,806,634 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0316:Vmn2r96
|
UTSW |
17 |
18,802,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0502:Vmn2r96
|
UTSW |
17 |
18,804,262 (GRCm39) |
missense |
probably benign |
|
|
R0580:Vmn2r96
|
UTSW |
17 |
18,802,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Vmn2r96
|
UTSW |
17 |
18,817,830 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0789:Vmn2r96
|
UTSW |
17 |
18,802,738 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1462:Vmn2r96
|
UTSW |
17 |
18,817,660 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1462:Vmn2r96
|
UTSW |
17 |
18,817,660 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1660:Vmn2r96
|
UTSW |
17 |
18,817,988 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1755:Vmn2r96
|
UTSW |
17 |
18,802,915 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1843:Vmn2r96
|
UTSW |
17 |
18,818,183 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1943:Vmn2r96
|
UTSW |
17 |
18,806,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1993:Vmn2r96
|
UTSW |
17 |
18,804,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2018:Vmn2r96
|
UTSW |
17 |
18,804,263 (GRCm39) |
missense |
probably benign |
|
|
R2405:Vmn2r96
|
UTSW |
17 |
18,818,102 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3977:Vmn2r96
|
UTSW |
17 |
18,817,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3979:Vmn2r96
|
UTSW |
17 |
18,817,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4059:Vmn2r96
|
UTSW |
17 |
18,818,339 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4693:Vmn2r96
|
UTSW |
17 |
18,803,270 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4709:Vmn2r96
|
UTSW |
17 |
18,803,088 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4776:Vmn2r96
|
UTSW |
17 |
18,817,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4882:Vmn2r96
|
UTSW |
17 |
18,817,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4920:Vmn2r96
|
UTSW |
17 |
18,802,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5143:Vmn2r96
|
UTSW |
17 |
18,804,120 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5301:Vmn2r96
|
UTSW |
17 |
18,817,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5507:Vmn2r96
|
UTSW |
17 |
18,818,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn2r96
|
UTSW |
17 |
18,804,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6181:Vmn2r96
|
UTSW |
17 |
18,804,126 (GRCm39) |
missense |
probably benign |
|
|
R6339:Vmn2r96
|
UTSW |
17 |
18,804,124 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6404:Vmn2r96
|
UTSW |
17 |
18,817,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6452:Vmn2r96
|
UTSW |
17 |
18,804,117 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6749:Vmn2r96
|
UTSW |
17 |
18,818,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6813:Vmn2r96
|
UTSW |
17 |
18,802,116 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6851:Vmn2r96
|
UTSW |
17 |
18,802,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6944:Vmn2r96
|
UTSW |
17 |
18,817,891 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6949:Vmn2r96
|
UTSW |
17 |
18,818,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6962:Vmn2r96
|
UTSW |
17 |
18,818,283 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6990:Vmn2r96
|
UTSW |
17 |
18,804,082 (GRCm39) |
missense |
probably benign |
|
|
R7149:Vmn2r96
|
UTSW |
17 |
18,817,989 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7346:Vmn2r96
|
UTSW |
17 |
18,803,029 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7385:Vmn2r96
|
UTSW |
17 |
18,803,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7509:Vmn2r96
|
UTSW |
17 |
18,802,995 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7652:Vmn2r96
|
UTSW |
17 |
18,793,832 (GRCm39) |
missense |
probably benign |
|
|
R7659:Vmn2r96
|
UTSW |
17 |
18,793,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7753:Vmn2r96
|
UTSW |
17 |
18,806,663 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7855:Vmn2r96
|
UTSW |
17 |
18,818,130 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8166:Vmn2r96
|
UTSW |
17 |
18,802,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Vmn2r96
|
UTSW |
17 |
18,804,243 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8323:Vmn2r96
|
UTSW |
17 |
18,803,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8787:Vmn2r96
|
UTSW |
17 |
18,818,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8837:Vmn2r96
|
UTSW |
17 |
18,802,888 (GRCm39) |
missense |
probably benign |
|
|
R8933:Vmn2r96
|
UTSW |
17 |
18,804,241 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9306:Vmn2r96
|
UTSW |
17 |
18,803,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9481:Vmn2r96
|
UTSW |
17 |
18,793,621 (GRCm39) |
start gained |
probably benign |
|
|
R9626:Vmn2r96
|
UTSW |
17 |
18,793,758 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9629:Vmn2r96
|
UTSW |
17 |
18,803,257 (GRCm39) |
missense |
probably benign |
0.15 |
|
Z1088:Vmn2r96
|
UTSW |
17 |
18,817,628 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1177:Vmn2r96
|
UTSW |
17 |
18,818,376 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTCAGTAGCAGAGTTCATGTG -3'
(R):5'- TTGATTACCTTTCCCTCTGAGTGAG -3'
Sequencing Primer
(F):5'- GAGTGACAAACTGAGTCATCA -3'
(R):5'- TCTAAGAGTGAATTGGCCAAAATC -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation