Incidental Mutation 'R7443:Nynrin'
| ID |
577120 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nynrin
|
| Ensembl Gene |
ENSMUSG00000075592 |
| Gene Name |
NYN domain and retroviral integrase containing |
| Synonyms |
|
| MMRRC Submission |
045519-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7443 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
56091572-56112193 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 56108873 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 1327
(V1327I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000098098
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100529]
[ENSMUST00000168479]
|
| AlphaFold |
Q5DTZ0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100529
AA Change: V1327I
PolyPhen 2
Score 0.182 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: V1327I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
|
Pfam:RNase_Zc3h12a
|
739 |
890 |
1.6e-54 |
PFAM |
|
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
|
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
|
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
|
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168479
AA Change: V1327I
PolyPhen 2
Score 0.182 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: V1327I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
|
Pfam:RNase_Zc3h12a
|
739 |
890 |
5.5e-54 |
PFAM |
|
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
|
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
|
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
|
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abl2 |
T |
C |
1: 156,452,951 (GRCm39) |
I162T |
probably damaging |
Het |
| Acaca |
G |
A |
11: 84,206,619 (GRCm39) |
S1493N |
probably benign |
Het |
| Arf2 |
T |
A |
11: 103,859,976 (GRCm39) |
M18K |
probably benign |
Het |
| Bag5 |
A |
G |
12: 111,677,161 (GRCm39) |
S221P |
probably damaging |
Het |
| Bcr |
T |
C |
10: 74,978,968 (GRCm39) |
|
probably null |
Het |
| Btg2 |
T |
A |
1: 134,005,433 (GRCm39) |
K51* |
probably null |
Het |
| Chrne |
A |
G |
11: 70,509,092 (GRCm39) |
V130A |
probably benign |
Het |
| Cracd |
T |
C |
5: 77,004,485 (GRCm39) |
V282A |
unknown |
Het |
| Cubn |
T |
A |
2: 13,460,320 (GRCm39) |
D714V |
probably damaging |
Het |
| Cyp4a29 |
A |
T |
4: 115,105,756 (GRCm39) |
I153F |
probably damaging |
Het |
| Dph7 |
C |
A |
2: 24,852,505 (GRCm39) |
H5Q |
probably benign |
Het |
| Epha6 |
T |
C |
16: 59,595,988 (GRCm39) |
N901S |
possibly damaging |
Het |
| Exosc9 |
C |
A |
3: 36,607,990 (GRCm39) |
P66Q |
probably damaging |
Het |
| Foxn3 |
T |
C |
12: 99,355,038 (GRCm39) |
D42G |
possibly damaging |
Het |
| Gbp11 |
A |
G |
5: 105,478,816 (GRCm39) |
|
probably null |
Het |
| Gm3264 |
A |
T |
14: 16,058,304 (GRCm39) |
Y37F |
probably damaging |
Het |
| H2-M10.2 |
T |
A |
17: 36,596,945 (GRCm39) |
I44F |
probably benign |
Het |
| Hemgn |
A |
T |
4: 46,396,145 (GRCm39) |
F364I |
probably damaging |
Het |
| Hnf4a |
A |
G |
2: 163,400,932 (GRCm39) |
I184V |
probably benign |
Het |
| Ighe |
G |
T |
12: 113,235,785 (GRCm39) |
C180* |
probably null |
Het |
| Iigp1c |
A |
T |
18: 60,379,122 (GRCm39) |
N219I |
probably benign |
Het |
| Klk1b22 |
T |
A |
7: 43,765,534 (GRCm39) |
I162K |
probably benign |
Het |
| Lmo3 |
C |
T |
6: 138,354,220 (GRCm39) |
A104T |
probably damaging |
Het |
| Lsm14a |
A |
G |
7: 34,053,263 (GRCm39) |
V263A |
probably benign |
Het |
| Ltbp1 |
T |
C |
17: 75,671,432 (GRCm39) |
Y1538H |
probably damaging |
Het |
| Ly6g6g |
T |
C |
15: 74,647,249 (GRCm39) |
E32G |
|
Het |
| Map9 |
A |
G |
3: 82,278,663 (GRCm39) |
E221G |
possibly damaging |
Het |
| Mccc2 |
G |
A |
13: 100,130,144 (GRCm39) |
A71V |
possibly damaging |
Het |
| Mdc1 |
T |
A |
17: 36,161,712 (GRCm39) |
V875E |
probably damaging |
Het |
| Mier2 |
A |
T |
10: 79,376,289 (GRCm39) |
I212N |
unknown |
Het |
| Mitd1 |
T |
C |
1: 37,920,117 (GRCm39) |
T164A |
probably benign |
Het |
| Myh1 |
T |
C |
11: 67,111,331 (GRCm39) |
I1590T |
probably benign |
Het |
| Mylk2 |
T |
G |
2: 152,753,346 (GRCm39) |
|
probably benign |
Het |
| Ncapg |
T |
A |
5: 45,829,652 (GRCm39) |
V118E |
probably benign |
Het |
| Oas1c |
C |
A |
5: 120,943,484 (GRCm39) |
K218N |
probably damaging |
Het |
| Or11g24 |
A |
G |
14: 50,662,507 (GRCm39) |
D177G |
probably damaging |
Het |
| Or13a18 |
A |
G |
7: 140,190,961 (GRCm39) |
N286S |
probably damaging |
Het |
| Or1e23 |
A |
T |
11: 73,407,674 (GRCm39) |
V117D |
possibly damaging |
Het |
| Or4a80 |
T |
A |
2: 89,582,285 (GRCm39) |
M296L |
probably benign |
Het |
| Or5g26 |
T |
A |
2: 85,493,912 (GRCm39) |
I289F |
probably damaging |
Het |
| Or5h17 |
T |
A |
16: 58,820,353 (GRCm39) |
F102I |
probably damaging |
Het |
| Otoa |
A |
T |
7: 120,731,633 (GRCm39) |
M618L |
probably benign |
Het |
| P3r3urf |
G |
A |
4: 116,030,664 (GRCm39) |
G23R |
probably benign |
Het |
| Plcg2 |
A |
T |
8: 118,231,028 (GRCm39) |
T37S |
probably benign |
Het |
| Plekhg4 |
T |
C |
8: 106,107,499 (GRCm39) |
L1010P |
probably damaging |
Het |
| Plxnb1 |
T |
C |
9: 108,943,675 (GRCm39) |
F1921L |
probably damaging |
Het |
| Prss47 |
T |
A |
13: 65,197,303 (GRCm39) |
K144N |
probably damaging |
Het |
| Rapgef2 |
T |
C |
3: 78,988,531 (GRCm39) |
K953E |
probably damaging |
Het |
| Rasip1 |
T |
A |
7: 45,288,148 (GRCm39) |
I909N |
probably damaging |
Het |
| Rps5 |
A |
G |
7: 12,656,922 (GRCm39) |
T8A |
probably benign |
Het |
| Rsbn1l |
T |
C |
5: 21,132,621 (GRCm39) |
K213E |
possibly damaging |
Het |
| Serpinb5 |
T |
C |
1: 106,809,700 (GRCm39) |
F369L |
probably benign |
Het |
| Slc4a5 |
T |
C |
6: 83,241,297 (GRCm39) |
V306A |
probably benign |
Het |
| Sox13 |
T |
C |
1: 133,312,369 (GRCm39) |
Y465C |
probably damaging |
Het |
| Sox13 |
C |
A |
1: 133,312,311 (GRCm39) |
K484N |
probably damaging |
Het |
| Stx3 |
A |
G |
19: 11,769,208 (GRCm39) |
I39T |
possibly damaging |
Het |
| Tbc1d5 |
T |
C |
17: 51,273,763 (GRCm39) |
Y116C |
probably damaging |
Het |
| Tcp11l1 |
T |
A |
2: 104,514,480 (GRCm39) |
Q429L |
probably benign |
Het |
| Tns3 |
G |
A |
11: 8,401,442 (GRCm39) |
T952I |
probably benign |
Het |
| Trib3 |
T |
C |
2: 152,181,692 (GRCm39) |
H176R |
possibly damaging |
Het |
| Trim12a |
A |
G |
7: 103,950,049 (GRCm39) |
Y297H |
probably damaging |
Het |
| Unc13a |
A |
G |
8: 72,083,603 (GRCm39) |
V1577A |
probably damaging |
Het |
| Vezf1 |
C |
A |
11: 87,965,489 (GRCm39) |
P244T |
probably damaging |
Het |
| Vmn1r121 |
T |
A |
7: 20,831,945 (GRCm39) |
D165V |
probably damaging |
Het |
| Vmn2r117 |
T |
A |
17: 23,679,107 (GRCm39) |
I706F |
probably benign |
Het |
| Vmn2r117 |
C |
T |
17: 23,679,319 (GRCm39) |
C635Y |
probably damaging |
Het |
| Vmn2r13 |
T |
A |
5: 109,339,909 (GRCm39) |
H22L |
probably benign |
Het |
| Vmn2r87 |
A |
T |
10: 130,308,588 (GRCm39) |
M550K |
probably damaging |
Het |
| Wdr6 |
A |
G |
9: 108,451,489 (GRCm39) |
L798P |
probably damaging |
Het |
| Wtap |
C |
T |
17: 13,199,821 (GRCm39) |
G54D |
probably benign |
Het |
| Zfp827 |
A |
G |
8: 79,917,047 (GRCm39) |
S541G |
|
Het |
| Zkscan3 |
A |
T |
13: 21,572,608 (GRCm39) |
Y341* |
probably null |
Het |
|
| Other mutations in Nynrin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01020:Nynrin
|
APN |
14 |
56,105,905 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL01131:Nynrin
|
APN |
14 |
56,110,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01357:Nynrin
|
APN |
14 |
56,107,874 (GRCm39) |
missense |
probably benign |
|
|
IGL01537:Nynrin
|
APN |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01583:Nynrin
|
APN |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01726:Nynrin
|
APN |
14 |
56,101,611 (GRCm39) |
missense |
probably benign |
|
|
IGL02161:Nynrin
|
APN |
14 |
56,101,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nynrin
|
APN |
14 |
56,100,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02247:Nynrin
|
APN |
14 |
56,109,167 (GRCm39) |
nonsense |
probably null |
|
|
IGL02302:Nynrin
|
APN |
14 |
56,105,962 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL02524:Nynrin
|
APN |
14 |
56,108,931 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL02600:Nynrin
|
APN |
14 |
56,101,449 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02639:Nynrin
|
APN |
14 |
56,108,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02654:Nynrin
|
APN |
14 |
56,100,716 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02659:Nynrin
|
APN |
14 |
56,103,554 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02736:Nynrin
|
APN |
14 |
56,108,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02949:Nynrin
|
APN |
14 |
56,109,837 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4458001:Nynrin
|
UTSW |
14 |
56,101,425 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0017:Nynrin
|
UTSW |
14 |
56,109,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0078:Nynrin
|
UTSW |
14 |
56,100,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0413:Nynrin
|
UTSW |
14 |
56,109,648 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0609:Nynrin
|
UTSW |
14 |
56,110,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Nynrin
|
UTSW |
14 |
56,105,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Nynrin
|
UTSW |
14 |
56,091,646 (GRCm39) |
intron |
probably benign |
|
|
R1222:Nynrin
|
UTSW |
14 |
56,100,998 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1385:Nynrin
|
UTSW |
14 |
56,102,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1820:Nynrin
|
UTSW |
14 |
56,107,835 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1829:Nynrin
|
UTSW |
14 |
56,110,404 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1874:Nynrin
|
UTSW |
14 |
56,100,950 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1927:Nynrin
|
UTSW |
14 |
56,101,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2233:Nynrin
|
UTSW |
14 |
56,109,524 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R3018:Nynrin
|
UTSW |
14 |
56,100,867 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3154:Nynrin
|
UTSW |
14 |
56,101,044 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3853:Nynrin
|
UTSW |
14 |
56,101,562 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4648:Nynrin
|
UTSW |
14 |
56,110,351 (GRCm39) |
nonsense |
probably null |
|
|
R4722:Nynrin
|
UTSW |
14 |
56,091,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4735:Nynrin
|
UTSW |
14 |
56,107,625 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4736:Nynrin
|
UTSW |
14 |
56,101,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4780:Nynrin
|
UTSW |
14 |
56,100,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4804:Nynrin
|
UTSW |
14 |
56,102,326 (GRCm39) |
missense |
probably benign |
|
|
R4816:Nynrin
|
UTSW |
14 |
56,109,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Nynrin
|
UTSW |
14 |
56,101,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Nynrin
|
UTSW |
14 |
56,105,948 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5432:Nynrin
|
UTSW |
14 |
56,101,923 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5800:Nynrin
|
UTSW |
14 |
56,108,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5825:Nynrin
|
UTSW |
14 |
56,101,683 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6149:Nynrin
|
UTSW |
14 |
56,091,780 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6244:Nynrin
|
UTSW |
14 |
56,105,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6350:Nynrin
|
UTSW |
14 |
56,105,533 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6379:Nynrin
|
UTSW |
14 |
56,107,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6437:Nynrin
|
UTSW |
14 |
56,109,227 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6501:Nynrin
|
UTSW |
14 |
56,100,989 (GRCm39) |
missense |
probably benign |
|
|
R6702:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6703:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6907:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6908:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6928:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6934:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6935:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7197:Nynrin
|
UTSW |
14 |
56,109,380 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7204:Nynrin
|
UTSW |
14 |
56,110,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7272:Nynrin
|
UTSW |
14 |
56,107,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7335:Nynrin
|
UTSW |
14 |
56,101,371 (GRCm39) |
missense |
probably benign |
|
|
R7361:Nynrin
|
UTSW |
14 |
56,107,857 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7368:Nynrin
|
UTSW |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7584:Nynrin
|
UTSW |
14 |
56,109,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7677:Nynrin
|
UTSW |
14 |
56,107,693 (GRCm39) |
missense |
probably benign |
|
|
R7723:Nynrin
|
UTSW |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7776:Nynrin
|
UTSW |
14 |
56,103,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Nynrin
|
UTSW |
14 |
56,107,980 (GRCm39) |
missense |
probably benign |
|
|
R7842:Nynrin
|
UTSW |
14 |
56,102,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7852:Nynrin
|
UTSW |
14 |
56,108,886 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8040:Nynrin
|
UTSW |
14 |
56,108,982 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8159:Nynrin
|
UTSW |
14 |
56,102,517 (GRCm39) |
missense |
probably benign |
|
|
R8159:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8258:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8259:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8343:Nynrin
|
UTSW |
14 |
56,101,248 (GRCm39) |
missense |
probably benign |
|
|
R8504:Nynrin
|
UTSW |
14 |
56,107,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8671:Nynrin
|
UTSW |
14 |
56,107,899 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8691:Nynrin
|
UTSW |
14 |
56,110,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8777:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
|
R8777-TAIL:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
|
R9041:Nynrin
|
UTSW |
14 |
56,108,753 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9346:Nynrin
|
UTSW |
14 |
56,100,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9366:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9690:Nynrin
|
UTSW |
14 |
56,108,204 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF007:Nynrin
|
UTSW |
14 |
56,103,658 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTACCGTGACGATGAGTTGTG -3'
(R):5'- CTTTGGCAAATCCCACCACTG -3'
Sequencing Primer
(F):5'- GTGCTGGCTTTGGTCTCTACATC -3'
(R):5'- AGAGTGTCCACTGTCACAGC -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation