Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00472:Zfp760'

5774

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp760

Ensembl Gene

ENSMUSG00000067928

Gene Name

zinc finger protein 760

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.135) question?

Stock #

IGL00472

Quality Score

Status

Chromosome

Chromosomal Location

21926723-21944617 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 21942457 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 544 (Y544C)

Ref Sequence

ENSEMBL: ENSMUSP00000073038 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073312]

AlphaFold

E9QAF5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000073312
AA Change: Y544C

PolyPhen 2 Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000073038
Gene: ENSMUSG00000067928
AA Change: Y544C

Domain	Start	End	E-Value	Type
KRAB	8	69	3.62e-21	SMART
ZnF_C2H2	183	202	1.78e2	SMART
ZnF_C2H2	208	230	1.69e-3	SMART
ZnF_C2H2	236	258	4.54e-4	SMART
ZnF_C2H2	264	286	2.79e-4	SMART
ZnF_C2H2	292	314	1.1e-2	SMART
ZnF_C2H2	320	342	2.71e-2	SMART
ZnF_C2H2	348	370	7.9e-4	SMART
ZnF_C2H2	376	398	1.72e-4	SMART
ZnF_C2H2	404	426	1.14e0	SMART
ZnF_C2H2	432	454	4.05e-1	SMART
ZnF_C2H2	460	482	5.14e-3	SMART
ZnF_C2H2	488	510	1.18e-2	SMART
ZnF_C2H2	516	538	1.95e-3	SMART
ZnF_C2H2	544	566	1.82e-3	SMART
ZnF_C2H2	572	594	4.17e-3	SMART
ZnF_C2H2	600	622	1.04e-3	SMART
ZnF_C2H2	628	650	1.28e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 16 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg2a	A	G	3: 37,490,793 (GRCm39)	H446R	probably benign	Het
Alpk3	C	T	7: 80,745,401 (GRCm39)		probably benign	Het
Atp8b1	T	A	18: 64,697,501 (GRCm39)	I448F	probably benign	Het
C2cd2l	A	G	9: 44,228,400 (GRCm39)	L156P	probably damaging	Het
Cbll1	G	A	12: 31,537,832 (GRCm39)	P308S	probably damaging	Het
Ccl3	C	T	11: 83,539,467 (GRCm39)	S39N	possibly damaging	Het
Cnih4	G	T	1: 180,989,659 (GRCm39)	G30C	probably damaging	Het
Endod1	A	T	9: 14,268,049 (GRCm39)	F479I	possibly damaging	Het
Gm572	T	G	4: 148,751,849 (GRCm39)	V238G	possibly damaging	Het
Grhl1	G	T	12: 24,662,169 (GRCm39)	R536L	probably damaging	Het
Itgae	A	G	11: 73,004,520 (GRCm39)	K269R	probably benign	Het
Nin	C	A	12: 70,076,862 (GRCm39)	M1064I	probably damaging	Het
Pnkd	A	G	1: 74,325,081 (GRCm39)	K50E	probably damaging	Het
Rpl39l	A	G	16: 9,992,258 (GRCm39)	M29V	probably benign	Het
Strip2	C	T	6: 29,931,213 (GRCm39)	A388V	probably benign	Het
Tex21	A	T	12: 76,253,571 (GRCm39)	N447K	probably damaging	Het

Other mutations in Zfp760

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00862:Zfp760	APN	17	21,941,265 (GRCm39)	missense	probably benign	0.00
IGL02198:Zfp760	APN	17	21,941,193 (GRCm39)	missense	probably benign	0.00
R0478:Zfp760	UTSW	17	21,940,995 (GRCm39)	nonsense	probably null
R0835:Zfp760	UTSW	17	21,942,559 (GRCm39)	missense	possibly damaging	0.63
R1191:Zfp760	UTSW	17	21,942,286 (GRCm39)	missense	probably damaging	1.00
R1760:Zfp760	UTSW	17	21,941,311 (GRCm39)	missense	probably damaging	1.00
R2698:Zfp760	UTSW	17	21,939,935 (GRCm39)	missense	probably damaging	0.99
R3722:Zfp760	UTSW	17	21,941,143 (GRCm39)	missense	probably damaging	1.00
R4561:Zfp760	UTSW	17	21,942,648 (GRCm39)	missense	probably benign	0.00
R4700:Zfp760	UTSW	17	21,941,388 (GRCm39)	missense	probably benign	0.01
R4859:Zfp760	UTSW	17	21,942,516 (GRCm39)	nonsense	probably null
R4859:Zfp760	UTSW	17	21,942,511 (GRCm39)	missense	probably damaging	0.97
R4897:Zfp760	UTSW	17	21,942,229 (GRCm39)	missense	probably benign	0.02
R6675:Zfp760	UTSW	17	21,941,991 (GRCm39)	missense	possibly damaging	0.92
R7286:Zfp760	UTSW	17	21,941,760 (GRCm39)	missense	probably benign	0.04
R7336:Zfp760	UTSW	17	21,942,814 (GRCm39)	missense	unknown
R7356:Zfp760	UTSW	17	21,941,601 (GRCm39)	missense	probably benign
R7369:Zfp760	UTSW	17	21,942,214 (GRCm39)	missense	probably benign	0.00
R7504:Zfp760	UTSW	17	21,941,655 (GRCm39)	missense	probably damaging	0.97
R7553:Zfp760	UTSW	17	21,941,872 (GRCm39)	missense	possibly damaging	0.82
R7577:Zfp760	UTSW	17	21,941,242 (GRCm39)	nonsense	probably null
R7579:Zfp760	UTSW	17	21,941,907 (GRCm39)	missense	possibly damaging	0.93
R7608:Zfp760	UTSW	17	21,941,797 (GRCm39)	missense	probably benign	0.00
R7973:Zfp760	UTSW	17	21,941,084 (GRCm39)	missense	probably benign	0.00
R8078:Zfp760	UTSW	17	21,942,436 (GRCm39)	missense	probably benign	0.27
R8332:Zfp760	UTSW	17	21,942,301 (GRCm39)	missense	probably damaging	0.99
R8750:Zfp760	UTSW	17	21,941,356 (GRCm39)	missense	possibly damaging	0.56
R9094:Zfp760	UTSW	17	21,941,932 (GRCm39)	missense	possibly damaging	0.86
R9264:Zfp760	UTSW	17	21,942,663 (GRCm39)	missense	possibly damaging	0.80
R9372:Zfp760	UTSW	17	21,941,035 (GRCm39)	missense	probably benign	0.00
R9520:Zfp760	UTSW	17	21,941,036 (GRCm39)	missense	probably benign	0.00
R9564:Zfp760	UTSW	17	21,942,272 (GRCm39)	missense	possibly damaging	0.94
R9743:Zfp760	UTSW	17	21,942,338 (GRCm39)	missense	probably benign
X0057:Zfp760	UTSW	17	21,942,663 (GRCm39)	missense	possibly damaging	0.80

Posted On

2012-04-20