Incidental Mutation 'R7451:Wwc2'
ID 577724
Institutional Source Beutler Lab
Gene Symbol Wwc2
Ensembl Gene ENSMUSG00000031563
Gene Name WW, C2 and coiled-coil domain containing 2
Synonyms D8Ertd594e
MMRRC Submission 045525-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R7451 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 48279117-48443579 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 48317610 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 656 (R656W)
Ref Sequence ENSEMBL: ENSMUSP00000056121 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057561]
AlphaFold Q6NXJ0
Predicted Effect not run
Transcript: ENSMUST00000057561
AA Change: R656W
SMART Domains Protein: ENSMUSP00000056121
Gene: ENSMUSG00000031563
AA Change: R656W

DomainStartEndE-ValueType
WW 11 43 3.92e-11 SMART
WW 58 90 4.65e-4 SMART
low complexity region 143 156 N/A INTRINSIC
coiled coil region 162 194 N/A INTRINSIC
coiled coil region 223 254 N/A INTRINSIC
coiled coil region 302 333 N/A INTRINSIC
low complexity region 341 358 N/A INTRINSIC
coiled coil region 359 423 N/A INTRINSIC
low complexity region 540 567 N/A INTRINSIC
C2 713 818 5.29e0 SMART
coiled coil region 857 884 N/A INTRINSIC
coiled coil region 1067 1144 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (84/84)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb6 A G 1: 75,148,797 (GRCm39) I794T probably damaging Het
Abcc5 T A 16: 20,193,820 (GRCm39) H767L probably damaging Het
Adgrb2 A T 4: 129,908,350 (GRCm39) M1031L probably damaging Het
Akna T A 4: 63,296,904 (GRCm39) M891L probably benign Het
Aloxe3 C A 11: 69,033,746 (GRCm39) T620K possibly damaging Het
Amph A G 13: 19,261,538 (GRCm39) Y63C probably damaging Het
Asprv1 A G 6: 86,605,930 (GRCm39) I259V probably benign Het
Atp7b C T 8: 22,504,700 (GRCm39) W652* probably null Het
Atp8a2 C T 14: 60,028,630 (GRCm39) D946N probably null Het
BC024063 T A 10: 81,944,576 (GRCm39) N65K probably benign Het
Bean1 A T 8: 104,940,628 (GRCm39) M154L probably benign Het
Bltp1 G T 3: 37,076,956 (GRCm39) probably null Het
Cacna1c C T 6: 118,570,981 (GRCm39) V2181M unknown Het
Cacna1g A G 11: 94,319,901 (GRCm39) I1425T probably damaging Het
Caskin2 A G 11: 115,702,981 (GRCm39) probably benign Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Cfap97d1 A T 11: 101,882,283 (GRCm39) N147I possibly damaging Het
Cfd T A 10: 79,727,362 (GRCm39) V43E probably damaging Het
Chd9 GCCCC GCCC 8: 91,760,418 (GRCm39) probably null Het
Chd9 T A 8: 91,760,446 (GRCm39) S2064T probably benign Het
Cpsf2 T G 12: 101,967,051 (GRCm39) V646G possibly damaging Het
Ctif T C 18: 75,652,874 (GRCm39) D461G possibly damaging Het
Cyp3a41a T A 5: 145,636,550 (GRCm39) E414D probably benign Het
Dagla A G 19: 10,230,719 (GRCm39) V544A probably damaging Het
Dhx57 A T 17: 80,554,542 (GRCm39) V1228E probably damaging Het
Eif2b3 T A 4: 116,909,993 (GRCm39) L176* probably null Het
Fbxw26 T A 9: 109,561,691 (GRCm39) I168L probably benign Het
Flt3 T A 5: 147,286,477 (GRCm39) Y703F probably damaging Het
Frmpd1 C T 4: 45,279,558 (GRCm39) P761L probably benign Het
Gabrd A G 4: 155,472,916 (GRCm39) V89A possibly damaging Het
Galnt14 A T 17: 73,881,804 (GRCm39) H98Q probably benign Het
Gli3 T C 13: 15,900,876 (GRCm39) V1421A possibly damaging Het
Gprin2 A G 14: 33,917,762 (GRCm39) S3P probably damaging Het
Ifi211 T G 1: 173,727,058 (GRCm39) D362A probably damaging Het
Lars1 G T 18: 42,335,615 (GRCm39) T1167K probably benign Het
Lce1b T C 3: 92,563,207 (GRCm39) S109G unknown Het
Lrp2 T G 2: 69,343,677 (GRCm39) E894A probably damaging Het
Mamdc4 A G 2: 25,454,473 (GRCm39) V1081A possibly damaging Het
Mcub T C 3: 129,710,752 (GRCm39) S227G possibly damaging Het
Mki67 A G 7: 135,301,080 (GRCm39) I1318T probably benign Het
Mybl2 C T 2: 162,914,626 (GRCm39) T248I possibly damaging Het
Myo9b A T 8: 71,804,832 (GRCm39) H1441L probably benign Het
Nav2 T A 7: 49,202,577 (GRCm39) probably null Het
Neb C T 2: 52,091,466 (GRCm39) V5339I probably benign Het
Nktr T A 9: 121,558,722 (GRCm39) S88T probably damaging Het
Nup155 C T 15: 8,175,091 (GRCm39) Q963* probably null Het
Oas1c A C 5: 120,940,207 (GRCm39) L320V possibly damaging Het
Or10ak14 C T 4: 118,610,884 (GRCm39) A286T probably benign Het
Or10d1b G A 9: 39,613,423 (GRCm39) T214I probably damaging Het
Or1o11 C A 17: 37,757,196 (GRCm39) S261R probably damaging Het
Or2t46 A G 11: 58,472,516 (GRCm39) Y282C probably damaging Het
Or4a81 A G 2: 89,619,453 (GRCm39) M81T probably benign Het
Or52b4i T C 7: 102,191,461 (GRCm39) I106T probably benign Het
Pcdhga7 A G 18: 37,849,057 (GRCm39) S355G possibly damaging Het
Pde11a C T 2: 75,853,117 (GRCm39) V834I possibly damaging Het
Pdzrn4 A T 15: 92,667,948 (GRCm39) D700V possibly damaging Het
Pif1 C A 9: 65,495,630 (GRCm39) P180Q probably benign Het
Pkig G T 2: 163,563,083 (GRCm39) E5* probably null Het
Pla2r1 T A 2: 60,365,346 (GRCm39) M75L probably damaging Het
Pllp T C 8: 95,402,871 (GRCm39) S157G probably damaging Het
Ppfia1 A T 7: 144,061,947 (GRCm39) H566Q probably benign Het
Ptpn13 A G 5: 103,674,961 (GRCm39) D646G probably benign Het
Rab11fip5 T A 6: 85,318,538 (GRCm39) T784S probably benign Het
Rad51ap2 T G 12: 11,507,982 (GRCm39) S635A probably benign Het
Ranbp17 A T 11: 33,234,114 (GRCm39) probably null Het
Rce1 C T 19: 4,675,081 (GRCm39) G111D probably damaging Het
Rcor3 C A 1: 191,822,173 (GRCm39) G8V probably damaging Het
Rhox4d G A X: 36,700,645 (GRCm39) G191E unknown Het
Rimbp2 C T 5: 128,865,435 (GRCm39) V631I probably benign Het
Scai T C 2: 39,015,148 (GRCm39) T94A probably damaging Het
Sfmbt1 G A 14: 30,538,768 (GRCm39) A796T probably benign Het
Slc6a11 C A 6: 114,222,644 (GRCm39) Y546* probably null Het
Slc7a2 T C 8: 41,365,686 (GRCm39) S506P probably damaging Het
Synj2 T A 17: 6,080,066 (GRCm39) N1098K possibly damaging Het
Tmem177 G A 1: 119,837,971 (GRCm39) A236V probably damaging Het
Togaram1 T A 12: 65,043,749 (GRCm39) D1249E probably damaging Het
Trav17 A T 14: 54,044,096 (GRCm39) M1L probably damaging Het
Trim25 C A 11: 88,906,563 (GRCm39) A433D possibly damaging Het
Trim69 T C 2: 121,998,508 (GRCm39) F160S probably benign Het
Trio A T 15: 27,747,999 (GRCm39) V1407E probably benign Het
Trpm7 A T 2: 126,668,657 (GRCm39) M753K probably damaging Het
Ttc12 G T 9: 49,383,179 (GRCm39) A75E probably benign Het
Uchl4 A T 9: 64,143,013 (GRCm39) I165L probably benign Het
Uvrag A T 7: 98,790,120 (GRCm39) L13Q unknown Het
Other mutations in Wwc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Wwc2 APN 8 48,299,193 (GRCm39) missense unknown
IGL01397:Wwc2 APN 8 48,321,311 (GRCm39) missense unknown
IGL01522:Wwc2 APN 8 48,321,668 (GRCm39) missense unknown
IGL01530:Wwc2 APN 8 48,316,974 (GRCm39) missense unknown
IGL01867:Wwc2 APN 8 48,336,615 (GRCm39) missense probably benign 0.02
IGL01991:Wwc2 APN 8 48,322,901 (GRCm39) nonsense probably null
IGL02092:Wwc2 APN 8 48,317,570 (GRCm39) missense unknown
IGL02320:Wwc2 APN 8 48,316,882 (GRCm39) splice site probably null
IGL02503:Wwc2 APN 8 48,302,418 (GRCm39) missense unknown
H8562:Wwc2 UTSW 8 48,373,701 (GRCm39) missense possibly damaging 0.77
R0244:Wwc2 UTSW 8 48,353,756 (GRCm39) missense probably benign 0.16
R0331:Wwc2 UTSW 8 48,333,239 (GRCm39) missense probably benign 0.15
R0349:Wwc2 UTSW 8 48,321,701 (GRCm39) missense unknown
R0542:Wwc2 UTSW 8 48,321,414 (GRCm39) missense unknown
R0645:Wwc2 UTSW 8 48,353,674 (GRCm39) splice site probably benign
R1081:Wwc2 UTSW 8 48,281,799 (GRCm39) unclassified probably benign
R1167:Wwc2 UTSW 8 48,311,814 (GRCm39) nonsense probably null
R1646:Wwc2 UTSW 8 48,295,937 (GRCm39) missense unknown
R1860:Wwc2 UTSW 8 48,443,137 (GRCm39) missense possibly damaging 0.90
R2070:Wwc2 UTSW 8 48,321,356 (GRCm39) missense unknown
R2183:Wwc2 UTSW 8 48,295,961 (GRCm39) missense unknown
R3969:Wwc2 UTSW 8 48,309,358 (GRCm39) missense unknown
R4096:Wwc2 UTSW 8 48,295,937 (GRCm39) missense unknown
R4387:Wwc2 UTSW 8 48,284,681 (GRCm39) missense unknown
R4447:Wwc2 UTSW 8 48,321,702 (GRCm39) missense unknown
R4448:Wwc2 UTSW 8 48,321,702 (GRCm39) missense unknown
R4450:Wwc2 UTSW 8 48,321,702 (GRCm39) missense unknown
R4646:Wwc2 UTSW 8 48,373,636 (GRCm39) missense probably damaging 1.00
R4869:Wwc2 UTSW 8 48,373,713 (GRCm39) missense probably damaging 0.99
R5159:Wwc2 UTSW 8 48,353,796 (GRCm39) missense probably benign 0.03
R5317:Wwc2 UTSW 8 48,300,590 (GRCm39) missense unknown
R5391:Wwc2 UTSW 8 48,316,906 (GRCm39) missense unknown
R5728:Wwc2 UTSW 8 48,317,096 (GRCm39) missense unknown
R5871:Wwc2 UTSW 8 48,321,458 (GRCm39) missense unknown
R5943:Wwc2 UTSW 8 48,443,137 (GRCm39) missense possibly damaging 0.90
R6137:Wwc2 UTSW 8 48,309,298 (GRCm39) missense unknown
R6169:Wwc2 UTSW 8 48,311,878 (GRCm39) missense unknown
R6363:Wwc2 UTSW 8 48,340,197 (GRCm39) splice site probably null
R6421:Wwc2 UTSW 8 48,353,781 (GRCm39) missense probably damaging 1.00
R6467:Wwc2 UTSW 8 48,304,943 (GRCm39) missense unknown
R6712:Wwc2 UTSW 8 48,353,838 (GRCm39) missense probably benign 0.42
R6765:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6766:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6767:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6768:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6782:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6993:Wwc2 UTSW 8 48,300,500 (GRCm39) missense unknown
R7016:Wwc2 UTSW 8 48,300,583 (GRCm39) missense unknown
R7079:Wwc2 UTSW 8 48,300,580 (GRCm39) missense unknown
R7219:Wwc2 UTSW 8 48,311,919 (GRCm39) missense unknown
R7258:Wwc2 UTSW 8 48,296,034 (GRCm39) missense unknown
R7334:Wwc2 UTSW 8 48,322,829 (GRCm39) missense unknown
R7375:Wwc2 UTSW 8 48,316,955 (GRCm39) missense unknown
R7505:Wwc2 UTSW 8 48,333,185 (GRCm39) missense probably damaging 0.96
R7825:Wwc2 UTSW 8 48,443,197 (GRCm39) missense probably damaging 1.00
R7854:Wwc2 UTSW 8 48,321,512 (GRCm39) missense unknown
R7904:Wwc2 UTSW 8 48,309,270 (GRCm39) missense unknown
R8811:Wwc2 UTSW 8 48,336,579 (GRCm39) missense possibly damaging 0.48
R8985:Wwc2 UTSW 8 48,331,919 (GRCm39) missense probably benign 0.09
R9004:Wwc2 UTSW 8 48,373,732 (GRCm39) missense probably damaging 0.99
R9133:Wwc2 UTSW 8 48,305,007 (GRCm39) missense unknown
R9339:Wwc2 UTSW 8 48,353,859 (GRCm39) missense probably damaging 1.00
R9598:Wwc2 UTSW 8 48,328,360 (GRCm39) missense probably damaging 0.98
R9633:Wwc2 UTSW 8 48,304,959 (GRCm39) frame shift probably null
R9634:Wwc2 UTSW 8 48,304,959 (GRCm39) frame shift probably null
R9691:Wwc2 UTSW 8 48,281,799 (GRCm39) unclassified probably benign
R9799:Wwc2 UTSW 8 48,321,595 (GRCm39) missense unknown
Z1176:Wwc2 UTSW 8 48,321,584 (GRCm39) missense unknown
Predicted Primers
Posted On 2019-10-07