Incidental Mutation 'R7453:Fn1'
ID 577840
Institutional Source Beutler Lab
Gene Symbol Fn1
Ensembl Gene ENSMUSG00000026193
Gene Name fibronectin 1
Synonyms Fn-1, Fn
MMRRC Submission 045527-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7453 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 71624679-71692359 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 71630039 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 2343 (D2343V)
Ref Sequence ENSEMBL: ENSMUSP00000054499 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055226] [ENSMUST00000186129] [ENSMUST00000187627] [ENSMUST00000187938] [ENSMUST00000188674] [ENSMUST00000188894] [ENSMUST00000189821] [ENSMUST00000190780]
AlphaFold P11276
PDB Structure SOLUTION NMR STRUCTURE OF LINKED CELL ATTACHMENT MODULES OF MOUSE FIBRONECTIN CONTAINING THE RGD AND SYNERGY REGIONS, 20 STRUCTURES [SOLUTION NMR]
SOLUTION NMR STRUCTURE OF LINKED CELL ATTACHMENT MODULES OF MOUSE FIBRONECTIN CONTAINING THE RGD AND SYNERGY REGIONS, 10 STRUCTURES [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000055226
AA Change: D2343V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054499
Gene: ENSMUSG00000026193
AA Change: D2343V

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1264 1346 4.22e-9 SMART
FN3 1357 1437 9.6e-13 SMART
FN3 1448 1527 1.82e-13 SMART
FN3 1538 1617 6.69e-12 SMART
FN3 1632 1711 2.72e-12 SMART
FN3 1722 1801 8.9e-8 SMART
FN3 1812 1891 1.66e-7 SMART
FN3 1904 1983 4.92e-10 SMART
FN3 1993 2074 3.64e-13 SMART
low complexity region 2148 2165 N/A INTRINSIC
FN3 2193 2272 2.9e0 SMART
FN1 2296 2340 3.72e-19 SMART
FN1 2341 2383 2.49e-20 SMART
FN1 2385 2425 2.69e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000186129
AA Change: D2162V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141123
Gene: ENSMUSG00000026193
AA Change: D2162V

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 1.66e-7 SMART
FN3 1723 1802 4.92e-10 SMART
FN3 1812 1893 3.64e-13 SMART
low complexity region 1967 1984 N/A INTRINSIC
FN3 2012 2091 2.9e0 SMART
FN1 2115 2159 3.72e-19 SMART
FN1 2160 2202 2.49e-20 SMART
FN1 2204 2244 2.69e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187627
SMART Domains Protein: ENSMUSP00000140955
Gene: ENSMUSG00000026193

DomainStartEndE-ValueType
Pfam:fn3 1 49 1.1e-6 PFAM
FN3 58 139 1.7e-15 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000187938
AA Change: D2227V

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000140975
Gene: ENSMUSG00000026193
AA Change: D2227V

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 8.9e-8 SMART
FN3 1721 1800 1.66e-7 SMART
FN3 1813 1892 4.92e-10 SMART
FN3 1902 1983 3.64e-13 SMART
low complexity region 2032 2049 N/A INTRINSIC
FN3 2077 2156 2.9e0 SMART
FN1 2180 2224 3.72e-19 SMART
FN1 2225 2267 2.49e-20 SMART
FN1 2269 2309 2.69e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000188674
AA Change: D2132V

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000140907
Gene: ENSMUSG00000026193
AA Change: D2132V

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 8.9e-8 SMART
FN3 1721 1800 1.66e-7 SMART
FN3 1813 1892 4.92e-10 SMART
FN3 1902 1981 6.79e-13 SMART
FN3 1983 2061 1.01e1 SMART
FN1 2085 2129 3.72e-19 SMART
FN1 2130 2172 2.49e-20 SMART
FN1 2174 2214 2.69e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000188894
AA Change: D2252V

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000140471
Gene: ENSMUSG00000026193
AA Change: D2252V

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 8.9e-8 SMART
FN3 1721 1800 1.66e-7 SMART
FN3 1813 1892 4.92e-10 SMART
FN3 1902 1983 3.64e-13 SMART
low complexity region 2057 2074 N/A INTRINSIC
FN3 2102 2181 2.9e0 SMART
FN1 2205 2249 3.72e-19 SMART
FN1 2250 2292 2.49e-20 SMART
FN1 2294 2334 2.69e-16 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000189821
AA Change: D2042V

PolyPhen 2 Score 0.692 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000139702
Gene: ENSMUSG00000026193
AA Change: D2042V

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 1.66e-7 SMART
FN3 1723 1802 4.92e-10 SMART
FN3 1812 1891 6.79e-13 SMART
FN3 1893 1971 1.01e1 SMART
FN1 1995 2039 3.72e-19 SMART
FN1 2040 2082 2.49e-20 SMART
FN1 2084 2124 2.69e-16 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000190780
AA Change: D2137V

PolyPhen 2 Score 0.920 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000140816
Gene: ENSMUSG00000026193
AA Change: D2137V

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 1.66e-7 SMART
FN3 1723 1802 4.92e-10 SMART
FN3 1812 1893 3.64e-13 SMART
low complexity region 1942 1959 N/A INTRINSIC
FN3 1987 2066 2.9e0 SMART
FN1 2090 2134 3.72e-19 SMART
FN1 2135 2177 2.49e-20 SMART
FN1 2179 2219 2.69e-16 SMART
Meta Mutation Damage Score 0.9532 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (122/122)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mutants are defective in mesodermal function. Null mutants are embryonic lethal with major patterning and organizational defects. Conditional mutants live and show increased neuronal apoptosis and susceptibility to induced cerebral ischemia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 120 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430550D23Rik A G 2: 155,845,309 (GRCm39) S32P possibly damaging Het
Acaca T C 11: 84,136,136 (GRCm39) V497A probably benign Het
Acox1 T C 11: 116,071,787 (GRCm39) T214A probably benign Het
Adgrb2 G A 4: 129,908,430 (GRCm39) probably null Het
Adh1 G A 3: 137,995,702 (GRCm39) probably null Het
Angptl1 G T 1: 156,672,421 (GRCm39) M82I probably benign Het
Arg1 A G 10: 24,791,674 (GRCm39) L269P probably damaging Het
Arid2 T G 15: 96,268,605 (GRCm39) V906G probably benign Het
Arid5b A T 10: 68,078,994 (GRCm39) H114Q probably benign Het
Atad5 T C 11: 80,009,969 (GRCm39) probably null Het
AU040320 G A 4: 126,729,493 (GRCm39) probably null Het
B230104I21Rik A T 4: 154,432,185 (GRCm39) T44S unknown Het
BC024063 G A 10: 81,945,991 (GRCm39) R537H possibly damaging Het
Bfsp2 A T 9: 103,330,306 (GRCm39) L177Q probably damaging Het
Birc5 C A 11: 117,743,507 (GRCm39) H80Q probably damaging Het
Bpifb9a T C 2: 154,106,615 (GRCm39) L382P probably damaging Het
Ces2c A T 8: 105,576,302 (GRCm39) N105I probably benign Het
Cfap91 A G 16: 38,141,841 (GRCm39) S364P possibly damaging Het
Cflar G A 1: 58,792,956 (GRCm39) V441M Het
Ckap4 A G 10: 84,364,463 (GRCm39) V200A probably damaging Het
Clec16a C A 16: 10,462,686 (GRCm39) T668N probably damaging Het
Cntrl A C 2: 35,045,421 (GRCm39) E1376D possibly damaging Het
Col18a1 A T 10: 76,921,044 (GRCm39) probably null Het
Coq2 T C 5: 100,811,452 (GRCm39) Y179C probably benign Het
Cpne6 A G 14: 55,749,473 (GRCm39) E11G probably benign Het
Cr2 A C 1: 194,847,565 (GRCm39) probably null Het
Csf2rb2 C T 15: 78,169,491 (GRCm39) D555N probably benign Het
Cyp2j12 A T 4: 95,990,363 (GRCm39) V401D possibly damaging Het
Dbp C T 7: 45,355,127 (GRCm39) A27V probably benign Het
Dll1 C A 17: 15,595,151 (GRCm39) R42L probably benign Het
Dst C A 1: 34,230,439 (GRCm39) H2677Q possibly damaging Het
Efl1 G T 7: 82,330,675 (GRCm39) V283F possibly damaging Het
Enah C T 1: 181,789,470 (GRCm39) C7Y unknown Het
Fam193a A T 5: 34,621,460 (GRCm39) E1139V possibly damaging Het
Fbn1 G A 2: 125,162,879 (GRCm39) P2136S possibly damaging Het
Fggy T C 4: 95,485,927 (GRCm39) V91A probably damaging Het
Galk2 T C 2: 125,729,781 (GRCm39) V54A possibly damaging Het
Glb1l T A 1: 75,179,350 (GRCm39) Y193F probably damaging Het
Gm45861 G T 8: 28,031,686 (GRCm39) R867L unknown Het
Grin2b T C 6: 135,717,947 (GRCm39) D715G possibly damaging Het
Hltf A T 3: 20,136,916 (GRCm39) R384S possibly damaging Het
Hs3st1 A G 5: 39,772,310 (GRCm39) M111T probably damaging Het
Idua A G 5: 108,829,362 (GRCm39) T388A probably benign Het
Kat14 T C 2: 144,222,654 (GRCm39) S136P possibly damaging Het
Kif24 A C 4: 41,394,673 (GRCm39) C867W possibly damaging Het
Klhdc10 T A 6: 30,447,989 (GRCm39) probably null Het
Klra10 A G 6: 130,257,327 (GRCm39) V59A probably damaging Het
Limk1 T A 5: 134,698,091 (GRCm39) I223F probably damaging Het
Lrp10 G A 14: 54,705,913 (GRCm39) G368S probably damaging Het
Lrrc7 T C 3: 157,891,046 (GRCm39) R374G probably benign Het
Lypd1 T A 1: 125,801,303 (GRCm39) M66L probably benign Het
Mast4 C T 13: 102,941,149 (GRCm39) probably null Het
Mbp C T 18: 82,572,768 (GRCm39) H155Y probably damaging Het
Micu3 G A 8: 40,788,939 (GRCm39) C150Y probably benign Het
Mras C T 9: 99,271,793 (GRCm39) V174I probably benign Het
Mroh1 T A 15: 76,317,745 (GRCm39) I827N probably damaging Het
Ms4a12 C A 19: 11,203,026 (GRCm39) G101* probably null Het
Mylk2 A T 2: 152,754,353 (GRCm39) K149M probably damaging Het
Myom3 T A 4: 135,528,346 (GRCm39) L1064I probably damaging Het
Naa30 A G 14: 49,425,144 (GRCm39) *365W probably null Het
Ncoa1 C T 12: 4,309,307 (GRCm39) G1330R probably damaging Het
Nhlh1 T A 1: 171,881,846 (GRCm39) T7S probably benign Het
Nipsnap3a A G 4: 52,995,882 (GRCm39) Q110R probably benign Het
Nostrin T C 2: 69,014,240 (GRCm39) Y399H possibly damaging Het
Nsfl1c C A 2: 151,351,431 (GRCm39) T263K possibly damaging Het
Nup153 T C 13: 46,834,657 (GRCm39) T1456A probably damaging Het
Or14j10 G T 17: 37,935,276 (GRCm39) D83E probably benign Het
Or1o2 T C 17: 37,542,871 (GRCm39) Y130C probably damaging Het
Or51e1 T A 7: 102,358,724 (GRCm39) I86N probably damaging Het
Or52z1 T A 7: 103,436,879 (GRCm39) I202F possibly damaging Het
Or5g26 T A 2: 85,494,524 (GRCm39) M85L probably benign Het
Or8d1b A T 9: 38,887,500 (GRCm39) H176L probably damaging Het
Pan3 G A 5: 147,463,491 (GRCm39) probably null Het
Pcdhgb2 C T 18: 37,824,068 (GRCm39) T353I probably damaging Het
Pcif1 A T 2: 164,730,284 (GRCm39) H339L probably damaging Het
Pcif1 A G 2: 164,731,550 (GRCm39) H501R possibly damaging Het
Pcnt T C 10: 76,225,284 (GRCm39) H1740R probably benign Het
Polr1b T A 2: 128,967,583 (GRCm39) I992N probably damaging Het
Ppfia2 C T 10: 106,763,691 (GRCm39) T1228M possibly damaging Het
Ppp2r5e A G 12: 75,509,116 (GRCm39) F388L probably damaging Het
Ptpre G T 7: 135,139,803 (GRCm39) R4L unknown Het
Pzp G T 6: 128,463,879 (GRCm39) P1410T probably damaging Het
Qrich1 A C 9: 108,433,675 (GRCm39) K656T possibly damaging Het
Rabep1 C T 11: 70,808,486 (GRCm39) P481S probably damaging Het
Rgs9 T A 11: 109,118,094 (GRCm39) R579W probably damaging Het
Rhot1 T C 11: 80,139,366 (GRCm39) probably null Het
Rnf123 T A 9: 107,947,607 (GRCm39) probably null Het
Rreb1 T G 13: 38,125,545 (GRCm39) C1284G probably damaging Het
Rsph4a A G 10: 33,785,289 (GRCm39) E400G probably benign Het
Rufy4 T A 1: 74,168,493 (GRCm39) probably null Het
S100pbp A G 4: 129,075,878 (GRCm39) L149P probably damaging Het
Sall3 T C 18: 81,015,255 (GRCm39) D891G probably benign Het
Scn10a C T 9: 119,467,618 (GRCm39) V841I probably benign Het
Scn5a T A 9: 119,351,656 (GRCm39) Y775F possibly damaging Het
Sec62 A T 3: 30,863,945 (GRCm39) probably null Het
Slc24a1 A T 9: 64,856,583 (GRCm39) M108K unknown Het
Spata22 T A 11: 73,226,816 (GRCm39) probably null Het
Spmap2l A G 5: 77,208,633 (GRCm39) H387R probably damaging Het
Stk4 A G 2: 163,928,522 (GRCm39) N118S probably benign Het
Stt3a A T 9: 36,659,266 (GRCm39) S358T possibly damaging Het
Tbc1d31 T A 15: 57,814,391 (GRCm39) F531I probably damaging Het
Tfrc A G 16: 32,437,867 (GRCm39) T307A probably damaging Het
Tnpo2 T C 8: 85,781,651 (GRCm39) I811T probably damaging Het
Ttc23l T C 15: 10,533,853 (GRCm39) Y230C probably damaging Het
Ttll13 A G 7: 79,910,182 (GRCm39) D775G probably benign Het
Ttn T C 2: 76,775,273 (GRCm39) K1969R unknown Het
Ube2s G A 7: 4,813,435 (GRCm39) R110* probably null Het
Ubxn11 G A 4: 133,853,540 (GRCm39) R364Q probably benign Het
Unc13d T C 11: 115,958,697 (GRCm39) Q773R probably benign Het
Ush2a T C 1: 188,285,308 (GRCm39) V1948A probably damaging Het
Vmn1r205 A T 13: 22,776,931 (GRCm39) I57N probably damaging Het
Vmn2r69 GAAAA GAAAAA 7: 85,060,768 (GRCm39) probably null Het
Vmn2r71 A T 7: 85,273,297 (GRCm39) T704S probably benign Het
Vmn2r93 T A 17: 18,533,580 (GRCm39) S495T probably benign Het
Wiz T A 17: 32,598,049 (GRCm39) I102F probably benign Het
Zan A C 5: 137,464,264 (GRCm39) L514V probably damaging Het
Zfp106 T A 2: 120,341,008 (GRCm39) N1857I probably damaging Het
Zfp106 A T 2: 120,376,400 (GRCm39) probably null Het
Zfp738 T C 13: 67,818,474 (GRCm39) T506A probably benign Het
Zfp934 T C 13: 62,666,517 (GRCm39) N53S probably benign Het
Other mutations in Fn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Fn1 APN 1 71,692,032 (GRCm39) missense probably benign 0.28
IGL00402:Fn1 APN 1 71,680,322 (GRCm39) missense probably damaging 1.00
IGL00946:Fn1 APN 1 71,684,699 (GRCm39) splice site probably benign
IGL01311:Fn1 APN 1 71,667,299 (GRCm39) missense probably damaging 1.00
IGL01338:Fn1 APN 1 71,665,369 (GRCm39) missense probably damaging 0.98
IGL01353:Fn1 APN 1 71,626,098 (GRCm39) missense probably damaging 1.00
IGL01674:Fn1 APN 1 71,645,900 (GRCm39) missense probably damaging 1.00
IGL01701:Fn1 APN 1 71,669,012 (GRCm39) splice site probably benign
IGL01734:Fn1 APN 1 71,658,644 (GRCm39) missense probably damaging 1.00
IGL01788:Fn1 APN 1 71,652,996 (GRCm39) missense probably damaging 1.00
IGL02186:Fn1 APN 1 71,677,693 (GRCm39) missense probably damaging 1.00
IGL02398:Fn1 APN 1 71,657,829 (GRCm39) splice site probably null
IGL02425:Fn1 APN 1 71,680,302 (GRCm39) splice site probably benign
IGL02516:Fn1 APN 1 71,676,482 (GRCm39) missense possibly damaging 0.78
IGL02593:Fn1 APN 1 71,641,591 (GRCm39) missense probably benign
IGL02651:Fn1 APN 1 71,636,835 (GRCm39) missense possibly damaging 0.65
IGL02681:Fn1 APN 1 71,658,641 (GRCm39) missense probably damaging 1.00
IGL02890:Fn1 APN 1 71,637,531 (GRCm39) critical splice donor site probably null
IGL02929:Fn1 APN 1 71,634,821 (GRCm39) critical splice donor site probably null
IGL03036:Fn1 APN 1 71,668,932 (GRCm39) missense probably damaging 1.00
IGL03088:Fn1 APN 1 71,653,197 (GRCm39) splice site probably null
IGL03142:Fn1 APN 1 71,676,455 (GRCm39) missense probably damaging 1.00
IGL03172:Fn1 APN 1 71,680,421 (GRCm39) missense probably damaging 0.99
IGL03184:Fn1 APN 1 71,648,656 (GRCm39) missense probably benign 0.02
IGL03212:Fn1 APN 1 71,680,484 (GRCm39) nonsense probably null
IGL03246:Fn1 APN 1 71,663,455 (GRCm39) missense possibly damaging 0.89
IGL03367:Fn1 APN 1 71,636,712 (GRCm39) missense probably benign 0.27
depth UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
flooded UTSW 1 71,636,675 (GRCm39) missense probably benign 0.01
R0684_Fn1_062 UTSW 1 71,634,968 (GRCm39) splice site probably null
series UTSW 1 71,634,945 (GRCm39) missense probably damaging 1.00
PIT4514001:Fn1 UTSW 1 71,667,615 (GRCm39) missense probably benign 0.01
R0008:Fn1 UTSW 1 71,634,879 (GRCm39) missense probably damaging 0.98
R0112:Fn1 UTSW 1 71,648,812 (GRCm39) missense probably damaging 1.00
R0138:Fn1 UTSW 1 71,663,269 (GRCm39) missense possibly damaging 0.82
R0383:Fn1 UTSW 1 71,636,844 (GRCm39) missense probably damaging 0.99
R0386:Fn1 UTSW 1 71,634,945 (GRCm39) missense probably damaging 1.00
R0648:Fn1 UTSW 1 71,636,744 (GRCm39) missense possibly damaging 0.79
R0684:Fn1 UTSW 1 71,634,968 (GRCm39) splice site probably null
R1054:Fn1 UTSW 1 71,625,373 (GRCm39) makesense probably null
R1183:Fn1 UTSW 1 71,625,404 (GRCm39) missense probably damaging 0.98
R1405:Fn1 UTSW 1 71,681,237 (GRCm39) missense probably damaging 1.00
R1405:Fn1 UTSW 1 71,681,237 (GRCm39) missense probably damaging 1.00
R1414:Fn1 UTSW 1 71,640,462 (GRCm39) splice site probably benign
R1677:Fn1 UTSW 1 71,636,814 (GRCm39) missense probably benign 0.00
R1773:Fn1 UTSW 1 71,676,542 (GRCm39) missense probably damaging 1.00
R1830:Fn1 UTSW 1 71,663,418 (GRCm39) missense probably damaging 1.00
R1987:Fn1 UTSW 1 71,690,784 (GRCm39) missense probably damaging 1.00
R1989:Fn1 UTSW 1 71,690,784 (GRCm39) missense probably damaging 1.00
R2068:Fn1 UTSW 1 71,639,598 (GRCm39) missense probably damaging 1.00
R2113:Fn1 UTSW 1 71,665,323 (GRCm39) missense probably damaging 1.00
R2145:Fn1 UTSW 1 71,645,163 (GRCm39) missense probably damaging 1.00
R2246:Fn1 UTSW 1 71,667,694 (GRCm39) missense probably benign 0.10
R2273:Fn1 UTSW 1 71,653,102 (GRCm39) missense probably null 1.00
R2274:Fn1 UTSW 1 71,653,102 (GRCm39) missense probably null 1.00
R2275:Fn1 UTSW 1 71,653,102 (GRCm39) missense probably null 1.00
R2303:Fn1 UTSW 1 71,653,195 (GRCm39) critical splice acceptor site probably null
R2379:Fn1 UTSW 1 71,688,443 (GRCm39) nonsense probably null
R2382:Fn1 UTSW 1 71,687,278 (GRCm39) missense probably damaging 1.00
R2567:Fn1 UTSW 1 71,636,895 (GRCm39) nonsense probably null
R2864:Fn1 UTSW 1 71,641,578 (GRCm39) missense probably damaging 0.99
R3154:Fn1 UTSW 1 71,632,242 (GRCm39) missense probably damaging 1.00
R3837:Fn1 UTSW 1 71,692,314 (GRCm39) splice site probably null
R3844:Fn1 UTSW 1 71,648,733 (GRCm39) missense possibly damaging 0.61
R3886:Fn1 UTSW 1 71,679,465 (GRCm39) missense probably damaging 1.00
R3887:Fn1 UTSW 1 71,679,465 (GRCm39) missense probably damaging 1.00
R3888:Fn1 UTSW 1 71,679,465 (GRCm39) missense probably damaging 1.00
R3889:Fn1 UTSW 1 71,679,465 (GRCm39) missense probably damaging 1.00
R3905:Fn1 UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
R3906:Fn1 UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
R3907:Fn1 UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
R3909:Fn1 UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
R4611:Fn1 UTSW 1 71,663,337 (GRCm39) nonsense probably null
R4724:Fn1 UTSW 1 71,687,307 (GRCm39) critical splice acceptor site probably null
R4732:Fn1 UTSW 1 71,641,671 (GRCm39) splice site probably null
R4733:Fn1 UTSW 1 71,641,671 (GRCm39) splice site probably null
R4756:Fn1 UTSW 1 71,629,967 (GRCm39) missense probably damaging 1.00
R4809:Fn1 UTSW 1 71,691,959 (GRCm39) intron probably benign
R4839:Fn1 UTSW 1 71,681,242 (GRCm39) missense probably damaging 1.00
R4915:Fn1 UTSW 1 71,634,968 (GRCm39) splice site probably null
R4917:Fn1 UTSW 1 71,634,968 (GRCm39) splice site probably null
R4918:Fn1 UTSW 1 71,634,968 (GRCm39) splice site probably null
R5002:Fn1 UTSW 1 71,668,887 (GRCm39) missense possibly damaging 0.48
R5015:Fn1 UTSW 1 71,665,336 (GRCm39) missense probably damaging 0.98
R5022:Fn1 UTSW 1 71,663,338 (GRCm39) missense probably damaging 1.00
R5109:Fn1 UTSW 1 71,688,394 (GRCm39) missense probably damaging 1.00
R5267:Fn1 UTSW 1 71,668,863 (GRCm39) missense probably damaging 1.00
R5323:Fn1 UTSW 1 71,636,591 (GRCm39) missense probably benign 0.09
R5333:Fn1 UTSW 1 71,663,339 (GRCm39) missense probably damaging 1.00
R5631:Fn1 UTSW 1 71,629,355 (GRCm39) missense probably damaging 1.00
R5644:Fn1 UTSW 1 71,666,409 (GRCm39) missense probably damaging 1.00
R5754:Fn1 UTSW 1 71,639,481 (GRCm39) missense probably damaging 1.00
R5807:Fn1 UTSW 1 71,687,218 (GRCm39) missense probably damaging 1.00
R6053:Fn1 UTSW 1 71,638,449 (GRCm39) missense probably damaging 1.00
R6133:Fn1 UTSW 1 71,636,886 (GRCm39) missense probably damaging 1.00
R6186:Fn1 UTSW 1 71,676,449 (GRCm39) missense probably damaging 1.00
R6270:Fn1 UTSW 1 71,676,434 (GRCm39) missense probably damaging 1.00
R6332:Fn1 UTSW 1 71,667,230 (GRCm39) missense probably benign 0.01
R6431:Fn1 UTSW 1 71,687,003 (GRCm39) splice site probably null
R6571:Fn1 UTSW 1 71,665,349 (GRCm39) missense probably damaging 1.00
R6596:Fn1 UTSW 1 71,648,641 (GRCm39) missense probably damaging 1.00
R6862:Fn1 UTSW 1 71,653,066 (GRCm39) missense probably benign 0.43
R6898:Fn1 UTSW 1 71,639,572 (GRCm39) missense probably damaging 1.00
R6984:Fn1 UTSW 1 71,665,238 (GRCm39) missense probably damaging 1.00
R7107:Fn1 UTSW 1 71,666,408 (GRCm39) missense probably damaging 1.00
R7121:Fn1 UTSW 1 71,639,697 (GRCm39) intron probably benign
R7127:Fn1 UTSW 1 71,636,703 (GRCm39) missense probably benign 0.16
R7194:Fn1 UTSW 1 71,641,482 (GRCm39) missense probably damaging 1.00
R7274:Fn1 UTSW 1 71,667,272 (GRCm39) missense probably benign
R7285:Fn1 UTSW 1 71,676,498 (GRCm39) missense probably damaging 1.00
R7426:Fn1 UTSW 1 71,688,384 (GRCm39) missense probably damaging 1.00
R7508:Fn1 UTSW 1 71,636,675 (GRCm39) missense probably benign 0.01
R7724:Fn1 UTSW 1 71,642,894 (GRCm39) missense probably benign 0.02
R7848:Fn1 UTSW 1 71,689,760 (GRCm39) missense probably damaging 1.00
R7992:Fn1 UTSW 1 71,638,825 (GRCm39) missense probably benign 0.34
R8036:Fn1 UTSW 1 71,629,310 (GRCm39) nonsense probably null
R8077:Fn1 UTSW 1 71,651,761 (GRCm39) missense probably damaging 1.00
R8175:Fn1 UTSW 1 71,638,824 (GRCm39) missense probably damaging 1.00
R8177:Fn1 UTSW 1 71,648,746 (GRCm39) missense probably benign
R8212:Fn1 UTSW 1 71,682,064 (GRCm39) missense probably benign 0.01
R8322:Fn1 UTSW 1 71,667,618 (GRCm39) missense probably benign 0.04
R8745:Fn1 UTSW 1 71,676,528 (GRCm39) missense probably benign 0.00
R8780:Fn1 UTSW 1 71,682,308 (GRCm39) missense probably benign 0.00
R8805:Fn1 UTSW 1 71,644,239 (GRCm39) missense probably benign 0.27
R8927:Fn1 UTSW 1 71,638,535 (GRCm39) missense probably benign 0.16
R8928:Fn1 UTSW 1 71,638,535 (GRCm39) missense probably benign 0.16
R8928:Fn1 UTSW 1 71,641,777 (GRCm39) intron probably benign
R8989:Fn1 UTSW 1 71,663,446 (GRCm39) missense possibly damaging 0.95
R8991:Fn1 UTSW 1 71,676,491 (GRCm39) missense probably benign 0.05
R9095:Fn1 UTSW 1 71,647,149 (GRCm39) missense probably null 0.02
R9455:Fn1 UTSW 1 71,647,112 (GRCm39) missense probably benign
R9589:Fn1 UTSW 1 71,668,941 (GRCm39) missense probably damaging 1.00
R9631:Fn1 UTSW 1 71,625,387 (GRCm39) missense probably benign 0.01
R9645:Fn1 UTSW 1 71,667,629 (GRCm39) missense probably benign 0.35
R9723:Fn1 UTSW 1 71,663,369 (GRCm39) missense possibly damaging 0.95
X0023:Fn1 UTSW 1 71,637,532 (GRCm39) critical splice donor site probably null
Z1088:Fn1 UTSW 1 71,688,451 (GRCm39) missense probably damaging 1.00
Z1176:Fn1 UTSW 1 71,636,570 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- CGGCTCAGTTAGGAACATGG -3'
(R):5'- ACTGGTTGGTCCTCTGAAATGATC -3'

Sequencing Primer
(F):5'- CTCAGTTAGGAACATGGGAGTAC -3'
(R):5'- AAGTCTTAACACTGGCCTGG -3'
Posted On 2019-10-07