Incidental Mutation 'R0630:Trip12'
| ID |
57797 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
038819-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0630 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 84771636 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 213
(R213G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139682
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000185909]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000186894]
[ENSMUST00000187818]
[ENSMUST00000189496]
[ENSMUST00000190067]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027421
AA Change: R171G
PolyPhen 2
Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: R171G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000185909
AA Change: R213G
PolyPhen 2
Score 0.524 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219
AA Change: R213G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186465
AA Change: R171G
PolyPhen 2
Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: R171G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186648
AA Change: R171G
PolyPhen 2
Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: R171G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000186894
AA Change: R171G
PolyPhen 2
Score 0.635 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000140267
Gene: ENSMUSG00000026219
AA Change: R171G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
3e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
7e-6 |
PDB |
|
Blast:ARM
|
476 |
516 |
6e-6 |
BLAST |
|
WWE
|
764 |
839 |
6.9e-25 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187818
|
| SMART Domains |
Protein: ENSMUSP00000140917
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000189496
AA Change: R213G
PolyPhen 2
Score 0.702 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000139682
Gene: ENSMUSG00000026219
AA Change: R213G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190464
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190067
|
| SMART Domains |
Protein: ENSMUSP00000140817
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1100 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 99.0%
- 10x: 97.9%
- 20x: 96.2%
|
| Validation Efficiency |
97% (108/111) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700056E22Rik |
C |
T |
1: 183,766,104 (GRCm39) |
|
probably benign |
Het |
| 4930562C15Rik |
T |
A |
16: 4,668,803 (GRCm39) |
N731K |
possibly damaging |
Het |
| Adgra1 |
A |
T |
7: 139,432,500 (GRCm39) |
K113* |
probably null |
Het |
| Adgrl2 |
T |
C |
3: 148,544,880 (GRCm39) |
I659M |
probably damaging |
Het |
| Adm |
G |
T |
7: 110,227,755 (GRCm39) |
R41L |
probably damaging |
Het |
| Aimp2 |
T |
C |
5: 143,843,419 (GRCm39) |
E97G |
probably benign |
Het |
| Aox1 |
T |
C |
1: 58,376,480 (GRCm39) |
|
probably benign |
Het |
| Arhgap20 |
G |
A |
9: 51,760,684 (GRCm39) |
R809H |
probably damaging |
Het |
| Arsa |
T |
C |
15: 89,358,207 (GRCm39) |
|
probably benign |
Het |
| Atg2a |
G |
T |
19: 6,294,547 (GRCm39) |
A88S |
probably damaging |
Het |
| Atm |
G |
A |
9: 53,442,922 (GRCm39) |
|
probably benign |
Het |
| Atp1a2 |
A |
T |
1: 172,118,842 (GRCm39) |
I100N |
possibly damaging |
Het |
| Camta2 |
G |
C |
11: 70,569,131 (GRCm39) |
L605V |
probably damaging |
Het |
| Cand2 |
G |
A |
6: 115,780,766 (GRCm39) |
E1217K |
probably damaging |
Het |
| Ccdc60 |
A |
G |
5: 116,274,440 (GRCm39) |
V388A |
possibly damaging |
Het |
| Cdk14 |
C |
T |
5: 5,185,422 (GRCm39) |
|
probably benign |
Het |
| Cdyl2 |
C |
T |
8: 117,350,774 (GRCm39) |
G119E |
probably benign |
Het |
| Celsr3 |
A |
G |
9: 108,704,891 (GRCm39) |
N458S |
probably damaging |
Het |
| Chd3 |
A |
C |
11: 69,238,021 (GRCm39) |
H1808Q |
probably damaging |
Het |
| Cntnap2 |
T |
C |
6: 46,965,694 (GRCm39) |
V835A |
probably damaging |
Het |
| Col4a1 |
C |
A |
8: 11,249,889 (GRCm39) |
|
probably benign |
Het |
| Cpsf1 |
A |
G |
15: 76,486,171 (GRCm39) |
V357A |
probably damaging |
Het |
| Cryzl1 |
A |
G |
16: 91,504,107 (GRCm39) |
|
probably benign |
Het |
| Cts8 |
T |
C |
13: 61,401,256 (GRCm39) |
K90R |
possibly damaging |
Het |
| Cux1 |
A |
G |
5: 136,315,689 (GRCm39) |
V1117A |
probably damaging |
Het |
| Dbx1 |
T |
C |
7: 49,282,444 (GRCm39) |
T254A |
probably damaging |
Het |
| Dgki |
C |
A |
6: 36,977,133 (GRCm39) |
C659F |
probably damaging |
Het |
| Dnajc1 |
T |
G |
2: 18,236,612 (GRCm39) |
D332A |
probably damaging |
Het |
| Dock8 |
C |
A |
19: 25,038,524 (GRCm39) |
T70K |
probably benign |
Het |
| Dsc1 |
T |
A |
18: 20,218,919 (GRCm39) |
T828S |
probably damaging |
Het |
| Dst |
T |
G |
1: 34,232,531 (GRCm39) |
V3510G |
probably benign |
Het |
| Dst |
T |
C |
1: 34,238,554 (GRCm39) |
V1738A |
probably damaging |
Het |
| Ehmt2 |
A |
G |
17: 35,118,818 (GRCm39) |
T167A |
probably benign |
Het |
| Eri2 |
A |
T |
7: 119,385,640 (GRCm39) |
V287E |
probably benign |
Het |
| Fat4 |
T |
A |
3: 39,054,321 (GRCm39) |
L4121H |
probably damaging |
Het |
| Fbn1 |
T |
A |
2: 125,236,690 (GRCm39) |
D330V |
possibly damaging |
Het |
| Fign |
A |
G |
2: 63,810,485 (GRCm39) |
Y262H |
possibly damaging |
Het |
| Fnd3c2 |
C |
T |
X: 105,282,763 (GRCm39) |
M593I |
probably benign |
Het |
| Fndc7 |
T |
A |
3: 108,783,931 (GRCm39) |
E226V |
probably damaging |
Het |
| Gad2 |
A |
T |
2: 22,580,348 (GRCm39) |
Q583L |
probably benign |
Het |
| Gcn1 |
G |
A |
5: 115,719,148 (GRCm39) |
A334T |
probably benign |
Het |
| Ggt1 |
A |
G |
10: 75,421,336 (GRCm39) |
|
probably null |
Het |
| Gli2 |
C |
T |
1: 118,769,648 (GRCm39) |
G635R |
possibly damaging |
Het |
| Gm10253 |
T |
C |
3: 88,646,420 (GRCm39) |
E93G |
unknown |
Het |
| Gm10428 |
A |
G |
11: 62,644,256 (GRCm39) |
|
probably benign |
Het |
| Gm7104 |
T |
C |
12: 88,252,479 (GRCm39) |
|
noncoding transcript |
Het |
| Gm8258 |
T |
G |
5: 104,924,385 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr107 |
A |
G |
2: 31,104,309 (GRCm39) |
N538S |
possibly damaging |
Het |
| Hars1 |
T |
C |
18: 36,904,442 (GRCm39) |
E190G |
probably damaging |
Het |
| Hoxc10 |
C |
T |
15: 102,875,917 (GRCm39) |
P209S |
probably benign |
Het |
| Ighg3 |
T |
C |
12: 113,323,714 (GRCm39) |
|
probably benign |
Het |
| Igsf10 |
C |
A |
3: 59,233,483 (GRCm39) |
W1750L |
probably damaging |
Het |
| Igsf5 |
C |
A |
16: 96,174,023 (GRCm39) |
|
probably benign |
Het |
| Itga10 |
T |
C |
3: 96,563,615 (GRCm39) |
|
probably benign |
Het |
| Ldhd |
T |
C |
8: 112,353,934 (GRCm39) |
K422R |
probably benign |
Het |
| Masp1 |
T |
C |
16: 23,271,169 (GRCm39) |
K693R |
probably benign |
Het |
| Mb21d2 |
G |
A |
16: 28,748,324 (GRCm39) |
A31V |
probably benign |
Het |
| Mbd1 |
T |
A |
18: 74,409,798 (GRCm39) |
|
probably benign |
Het |
| Mdm4 |
G |
A |
1: 132,919,491 (GRCm39) |
T459I |
possibly damaging |
Het |
| Megf10 |
A |
T |
18: 57,421,067 (GRCm39) |
I902F |
probably benign |
Het |
| Mta3 |
A |
G |
17: 84,022,056 (GRCm39) |
N37S |
probably damaging |
Het |
| Mterf3 |
T |
A |
13: 67,060,372 (GRCm39) |
Y372F |
probably damaging |
Het |
| Nbeal2 |
A |
G |
9: 110,465,102 (GRCm39) |
|
probably benign |
Het |
| Nbr1 |
T |
C |
11: 101,457,913 (GRCm39) |
|
probably benign |
Het |
| Ndst3 |
A |
G |
3: 123,355,720 (GRCm39) |
M103T |
probably damaging |
Het |
| Notch3 |
C |
A |
17: 32,366,446 (GRCm39) |
|
probably benign |
Het |
| Npr2 |
A |
T |
4: 43,641,219 (GRCm39) |
E415V |
probably benign |
Het |
| Or2n1c |
A |
G |
17: 38,519,304 (GRCm39) |
H56R |
probably damaging |
Het |
| Or4k40 |
T |
C |
2: 111,251,191 (GRCm39) |
Y35C |
probably damaging |
Het |
| Or52h9 |
G |
C |
7: 104,202,998 (GRCm39) |
V291L |
probably benign |
Het |
| Or5be3 |
A |
T |
2: 86,863,653 (GRCm39) |
M304K |
probably benign |
Het |
| Or8b50 |
T |
A |
9: 38,518,192 (GRCm39) |
F144I |
probably benign |
Het |
| Pappa2 |
T |
A |
1: 158,660,343 (GRCm39) |
D1246V |
probably benign |
Het |
| Pcdhgc5 |
A |
T |
18: 37,954,931 (GRCm39) |
D735V |
probably benign |
Het |
| Pik3ca |
A |
G |
3: 32,504,176 (GRCm39) |
Y622C |
possibly damaging |
Het |
| Plppr2 |
A |
G |
9: 21,859,197 (GRCm39) |
D438G |
probably benign |
Het |
| Ppfibp2 |
A |
T |
7: 107,337,806 (GRCm39) |
|
probably null |
Het |
| Prdm15 |
A |
T |
16: 97,638,907 (GRCm39) |
L77Q |
probably null |
Het |
| Prdm8 |
T |
C |
5: 98,332,380 (GRCm39) |
S94P |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,628,665 (GRCm39) |
Q3470L |
probably damaging |
Het |
| Prl3c1 |
T |
C |
13: 27,384,674 (GRCm39) |
|
probably benign |
Het |
| Ptchd4 |
A |
T |
17: 42,688,076 (GRCm39) |
H206L |
probably benign |
Het |
| Rack1 |
G |
A |
11: 48,694,804 (GRCm39) |
|
probably benign |
Het |
| Rere |
T |
C |
4: 150,703,545 (GRCm39) |
L1509P |
probably damaging |
Het |
| Rgma |
T |
A |
7: 73,067,366 (GRCm39) |
L301Q |
probably damaging |
Het |
| Rgs6 |
T |
A |
12: 83,094,324 (GRCm39) |
|
probably benign |
Het |
| Rictor |
C |
A |
15: 6,823,973 (GRCm39) |
R1613S |
probably damaging |
Het |
| Ripk1 |
T |
G |
13: 34,211,764 (GRCm39) |
F358C |
probably damaging |
Het |
| Robo2 |
T |
C |
16: 73,713,093 (GRCm39) |
D1217G |
probably benign |
Het |
| Shc2 |
A |
T |
10: 79,461,975 (GRCm39) |
W357R |
probably null |
Het |
| Slc25a45 |
T |
C |
19: 5,930,556 (GRCm39) |
L81P |
probably damaging |
Het |
| Slc9c1 |
A |
T |
16: 45,363,483 (GRCm39) |
|
probably benign |
Het |
| Spats2 |
T |
C |
15: 99,083,909 (GRCm39) |
|
probably null |
Het |
| Stac3 |
A |
T |
10: 127,343,632 (GRCm39) |
E258V |
probably damaging |
Het |
| Thada |
A |
G |
17: 84,536,603 (GRCm39) |
S1648P |
probably damaging |
Het |
| Tmem168 |
T |
C |
6: 13,583,064 (GRCm39) |
T222A |
probably benign |
Het |
| Tmtc4 |
T |
C |
14: 123,163,502 (GRCm39) |
|
probably benign |
Het |
| Trappc14 |
A |
G |
5: 138,260,551 (GRCm39) |
S292P |
probably damaging |
Het |
| Trim38 |
T |
G |
13: 23,975,115 (GRCm39) |
Y351* |
probably null |
Het |
| Vav3 |
C |
T |
3: 109,331,328 (GRCm39) |
R76W |
probably damaging |
Het |
| Vmn1r63 |
G |
T |
7: 5,806,263 (GRCm39) |
P123H |
probably damaging |
Het |
| Wdr5 |
A |
G |
2: 27,410,619 (GRCm39) |
N130S |
probably benign |
Het |
| Wnk4 |
C |
A |
11: 101,156,212 (GRCm39) |
R27S |
probably damaging |
Het |
| Ykt6 |
G |
A |
11: 5,909,323 (GRCm39) |
S44N |
probably benign |
Het |
| Ythdc1 |
T |
A |
5: 86,957,207 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGGCTAACTTTGGGGCTGAAGCG -3'
(R):5'- TGAAATCTGCACAATTGCCGTCAAC -3'
Sequencing Primer
(F):5'- GAAGAGCCACCAGTTTTACTCTG -3'
(R):5'- TTGCCGTCAACAAGCAAGG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation