Incidental Mutation 'R7455:Tut7'
ID 578090
Institutional Source Beutler Lab
Gene Symbol Tut7
Ensembl Gene ENSMUSG00000035248
Gene Name terminal uridylyl transferase 7
Synonyms Zcchc6, Tent3b, 6030448M23Rik
MMRRC Submission 045529-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.761) question?
Stock # R7455 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 59919690-59971060 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59969871 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 8 (Y8C)
Ref Sequence ENSEMBL: ENSMUSP00000071623 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071703] [ENSMUST00000225179] [ENSMUST00000225576] [ENSMUST00000225987]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000071703
AA Change: Y8C

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000071623
Gene: ENSMUSG00000035248
AA Change: Y8C

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
low complexity region 176 190 N/A INTRINSIC
ZnF_C2H2 244 268 2.61e1 SMART
SCOP:d1f5aa2 284 497 4e-25 SMART
low complexity region 522 534 N/A INTRINSIC
Pfam:PAP_assoc 550 603 6.7e-14 PFAM
low complexity region 811 825 N/A INTRINSIC
low complexity region 846 857 N/A INTRINSIC
low complexity region 882 898 N/A INTRINSIC
ZnF_C2HC 960 976 3.3e-3 SMART
Pfam:NTP_transf_2 1022 1134 4e-8 PFAM
Pfam:PAP_assoc 1229 1282 1.7e-17 PFAM
ZnF_C2HC 1342 1358 2.09e-3 SMART
Pfam:TUTF7_u4 1359 1446 1.6e-42 PFAM
ZnF_C2HC 1448 1464 1.06e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000225179
AA Change: Y8C

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000225576
AA Change: Y8C

PolyPhen 2 Score 0.374 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000225987
AA Change: Y8C

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Meta Mutation Damage Score 0.0616 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl1 C T 7: 76,074,503 (GRCm39) H646Y unknown Het
Ak5 C T 3: 152,187,209 (GRCm39) R426H probably damaging Het
Akap9 T C 5: 4,022,792 (GRCm39) V1207A probably benign Het
Asph A T 4: 9,531,732 (GRCm39) probably null Het
Avpr1a T G 10: 122,285,169 (GRCm39) C154G probably damaging Het
Boll T C 1: 55,339,262 (GRCm39) Q283R probably benign Het
Cad C T 5: 31,231,506 (GRCm39) P1743S probably damaging Het
Ccdc137 T G 11: 120,350,985 (GRCm39) M129R probably damaging Het
Cdh23 A G 10: 60,142,003 (GRCm39) I3028T possibly damaging Het
Cep68 T A 11: 20,180,571 (GRCm39) I687F probably damaging Het
Ces2a T A 8: 105,464,154 (GRCm39) I262N probably damaging Het
Cfap44 A G 16: 44,225,147 (GRCm39) probably benign Het
Cfap69 T G 5: 5,675,873 (GRCm39) H247P possibly damaging Het
Cideb T C 14: 55,992,292 (GRCm39) T134A probably damaging Het
Cilp2 A T 8: 70,333,721 (GRCm39) D1092E probably damaging Het
Cptp G A 4: 155,950,957 (GRCm39) R170C probably damaging Het
Cysrt1 A G 2: 25,129,422 (GRCm39) L30S probably benign Het
Dcc A G 18: 71,553,394 (GRCm39) V754A probably benign Het
Entrep2 A G 7: 64,409,161 (GRCm39) V411A probably benign Het
Fer1l5 A T 1: 36,428,064 (GRCm39) T453S probably benign Het
Fnbp4 ACCACCTCCACCTCCACCTCC ACCACCTCCACCTCCACCTCCACCTCC 2: 90,608,159 (GRCm39) probably benign Het
Frem2 C T 3: 53,479,701 (GRCm39) probably null Het
Gm13941 A G 2: 110,925,085 (GRCm39) F173L unknown Het
Greb1l G A 18: 10,554,915 (GRCm39) A1654T probably damaging Het
Inpp4b T A 8: 82,798,332 (GRCm39) I840N probably damaging Het
Kdm4b T A 17: 56,703,657 (GRCm39) I746N probably damaging Het
Lins1 C A 7: 66,361,692 (GRCm39) H448N probably benign Het
Ly9 A T 1: 171,421,507 (GRCm39) Y581* probably null Het
Mark1 T A 1: 184,651,947 (GRCm39) E186V probably damaging Het
Mcph1 T A 8: 18,681,775 (GRCm39) V304E probably benign Het
Mical3 T C 6: 120,935,705 (GRCm39) D1607G probably damaging Het
Mup18 A G 4: 61,592,171 (GRCm39) V31A probably benign Het
Nectin3 A T 16: 46,317,105 (GRCm39) C11* probably null Het
Nedd1 A T 10: 92,536,787 (GRCm39) L172M probably benign Het
Nim1k G A 13: 120,173,995 (GRCm39) R300W probably damaging Het
Oprm1 T C 10: 6,780,204 (GRCm39) F289L probably damaging Het
Or4c115 G T 2: 88,927,434 (GRCm39) P279Q probably damaging Het
Or7g12 A G 9: 18,900,150 (GRCm39) I289V possibly damaging Het
Or8c8 T C 9: 38,165,550 (GRCm39) V276A probably damaging Het
Parg T C 14: 31,931,432 (GRCm39) Y351H probably benign Het
Phf3 A C 1: 30,876,239 (GRCm39) V118G probably damaging Het
Pik3c2g T C 6: 139,913,643 (GRCm39) Y1014H unknown Het
Pmp22 A G 11: 63,025,339 (GRCm39) probably null Het
Ppfibp1 T A 6: 146,917,848 (GRCm39) F501L probably damaging Het
Rgl2 G A 17: 34,151,657 (GRCm39) A234T probably benign Het
Rhpn2 G A 7: 35,070,669 (GRCm39) probably null Het
Ryr3 T C 2: 112,559,211 (GRCm39) K3058E probably damaging Het
Sbsn A T 7: 30,452,602 (GRCm39) Q539L possibly damaging Het
Scgn G A 13: 24,150,848 (GRCm39) R168C probably benign Het
Serpinb10 A G 1: 107,463,832 (GRCm39) Y38C probably damaging Het
Sfmbt2 G A 2: 10,582,766 (GRCm39) V709I probably benign Het
Slc1a2 A T 2: 102,566,299 (GRCm39) M10L probably benign Het
Sox6 T G 7: 115,088,904 (GRCm39) I653L probably benign Het
Tespa1 A G 10: 130,196,559 (GRCm39) I166V probably benign Het
Tex15 T C 8: 34,067,025 (GRCm39) Y2152H possibly damaging Het
Tlr9 A G 9: 106,101,729 (GRCm39) N340S probably benign Het
Tmem198 G A 1: 75,456,430 (GRCm39) R28Q unknown Het
Vmn2r7 T C 3: 64,624,014 (GRCm39) D102G probably benign Het
Wdr93 A G 7: 79,425,267 (GRCm39) M529V probably benign Het
Zfp110 A G 7: 12,581,984 (GRCm39) H310R probably benign Het
Zfp36l2 A G 17: 84,494,575 (GRCm39) S21P probably damaging Het
Zfp534 G A 4: 147,759,212 (GRCm39) H486Y probably damaging Het
Zfp638 G A 6: 83,907,127 (GRCm39) V431I probably damaging Het
Other mutations in Tut7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tut7 APN 13 59,964,512 (GRCm39) missense probably damaging 1.00
IGL01361:Tut7 APN 13 59,933,614 (GRCm39) missense probably damaging 1.00
IGL02002:Tut7 APN 13 59,929,910 (GRCm39) missense possibly damaging 0.76
IGL02015:Tut7 APN 13 59,937,072 (GRCm39) missense probably damaging 1.00
IGL02029:Tut7 APN 13 59,932,702 (GRCm39) unclassified probably benign
IGL02216:Tut7 APN 13 59,948,237 (GRCm39) missense probably benign 0.01
IGL02705:Tut7 APN 13 59,937,017 (GRCm39) missense probably damaging 1.00
IGL02742:Tut7 APN 13 59,964,156 (GRCm39) missense probably damaging 0.99
IGL02810:Tut7 APN 13 59,929,830 (GRCm39) critical splice donor site probably null
IGL02942:Tut7 APN 13 59,959,335 (GRCm39) missense probably damaging 0.98
IGL03104:Tut7 APN 13 59,962,717 (GRCm39) missense probably benign 0.04
R0025:Tut7 UTSW 13 59,953,142 (GRCm39) missense probably benign 0.08
R0025:Tut7 UTSW 13 59,953,142 (GRCm39) missense probably benign 0.08
R0153:Tut7 UTSW 13 59,930,150 (GRCm39) nonsense probably null
R0269:Tut7 UTSW 13 59,964,669 (GRCm39) splice site probably null
R0358:Tut7 UTSW 13 59,929,918 (GRCm39) missense probably damaging 0.99
R0555:Tut7 UTSW 13 59,948,131 (GRCm39) missense probably benign 0.00
R0599:Tut7 UTSW 13 59,957,301 (GRCm39) missense probably damaging 1.00
R0609:Tut7 UTSW 13 59,947,596 (GRCm39) nonsense probably null
R0617:Tut7 UTSW 13 59,964,669 (GRCm39) splice site probably null
R0680:Tut7 UTSW 13 59,948,413 (GRCm39) missense possibly damaging 0.79
R0699:Tut7 UTSW 13 59,929,828 (GRCm39) splice site probably benign
R1214:Tut7 UTSW 13 59,953,140 (GRCm39) missense possibly damaging 0.76
R1271:Tut7 UTSW 13 59,969,669 (GRCm39) missense probably damaging 0.99
R1556:Tut7 UTSW 13 59,948,054 (GRCm39) missense probably benign 0.02
R1662:Tut7 UTSW 13 59,947,717 (GRCm39) missense possibly damaging 0.93
R1777:Tut7 UTSW 13 59,939,635 (GRCm39) missense probably damaging 1.00
R1834:Tut7 UTSW 13 59,962,749 (GRCm39) nonsense probably null
R1928:Tut7 UTSW 13 59,964,548 (GRCm39) missense probably damaging 1.00
R2012:Tut7 UTSW 13 59,959,352 (GRCm39) missense probably damaging 0.99
R2045:Tut7 UTSW 13 59,948,470 (GRCm39) missense probably damaging 1.00
R2336:Tut7 UTSW 13 59,946,868 (GRCm39) missense probably damaging 1.00
R3764:Tut7 UTSW 13 59,948,194 (GRCm39) missense probably damaging 0.98
R3899:Tut7 UTSW 13 59,937,069 (GRCm39) nonsense probably null
R3918:Tut7 UTSW 13 59,929,838 (GRCm39) missense probably damaging 1.00
R4423:Tut7 UTSW 13 59,969,863 (GRCm39) missense probably damaging 0.96
R4664:Tut7 UTSW 13 59,948,413 (GRCm39) missense possibly damaging 0.79
R4673:Tut7 UTSW 13 59,944,659 (GRCm39) missense probably damaging 1.00
R4770:Tut7 UTSW 13 59,920,698 (GRCm39) unclassified probably benign
R4884:Tut7 UTSW 13 59,937,266 (GRCm39) missense probably damaging 1.00
R5186:Tut7 UTSW 13 59,964,470 (GRCm39) critical splice donor site probably null
R5337:Tut7 UTSW 13 59,939,666 (GRCm39) missense probably damaging 1.00
R5385:Tut7 UTSW 13 59,937,660 (GRCm39) critical splice donor site probably null
R5452:Tut7 UTSW 13 59,948,471 (GRCm39) missense probably damaging 1.00
R5534:Tut7 UTSW 13 59,936,367 (GRCm39) missense probably damaging 1.00
R5566:Tut7 UTSW 13 59,936,443 (GRCm39) nonsense probably null
R5928:Tut7 UTSW 13 59,969,880 (GRCm39) missense probably benign 0.16
R5994:Tut7 UTSW 13 59,937,023 (GRCm39) missense probably damaging 1.00
R6415:Tut7 UTSW 13 59,964,110 (GRCm39) splice site probably null
R6495:Tut7 UTSW 13 59,947,753 (GRCm39) missense possibly damaging 0.95
R6577:Tut7 UTSW 13 59,955,975 (GRCm39) missense probably damaging 1.00
R7205:Tut7 UTSW 13 59,936,364 (GRCm39) missense probably damaging 1.00
R7286:Tut7 UTSW 13 59,969,463 (GRCm39) missense probably benign 0.18
R7355:Tut7 UTSW 13 59,969,616 (GRCm39) missense probably benign 0.00
R7369:Tut7 UTSW 13 59,929,867 (GRCm39) missense possibly damaging 0.71
R7557:Tut7 UTSW 13 59,936,280 (GRCm39) missense possibly damaging 0.89
R7635:Tut7 UTSW 13 59,947,904 (GRCm39) missense probably benign 0.03
R7727:Tut7 UTSW 13 59,947,496 (GRCm39) missense probably benign 0.00
R7798:Tut7 UTSW 13 59,963,389 (GRCm39) missense possibly damaging 0.81
R7912:Tut7 UTSW 13 59,946,819 (GRCm39) missense probably damaging 1.00
R7915:Tut7 UTSW 13 59,932,628 (GRCm39) missense probably benign 0.12
R8035:Tut7 UTSW 13 59,937,004 (GRCm39) missense probably benign 0.00
R8531:Tut7 UTSW 13 59,937,074 (GRCm39) missense probably damaging 1.00
R8777:Tut7 UTSW 13 59,933,597 (GRCm39) missense probably benign 0.15
R8777-TAIL:Tut7 UTSW 13 59,933,597 (GRCm39) missense probably benign 0.15
R8850:Tut7 UTSW 13 59,937,011 (GRCm39) missense possibly damaging 0.83
R8929:Tut7 UTSW 13 59,947,942 (GRCm39) missense probably benign
R9254:Tut7 UTSW 13 59,936,288 (GRCm39) missense possibly damaging 0.48
R9313:Tut7 UTSW 13 59,947,798 (GRCm39) missense probably benign 0.01
R9373:Tut7 UTSW 13 59,944,681 (GRCm39) missense probably damaging 1.00
R9379:Tut7 UTSW 13 59,936,288 (GRCm39) missense possibly damaging 0.48
R9404:Tut7 UTSW 13 59,947,701 (GRCm39) missense probably benign 0.00
R9461:Tut7 UTSW 13 59,963,512 (GRCm39) missense probably damaging 1.00
R9462:Tut7 UTSW 13 59,929,957 (GRCm39) missense possibly damaging 0.89
R9661:Tut7 UTSW 13 59,937,332 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGGAAACCCCATACAGTCCTTTC -3'
(R):5'- GAACACTGTAACTTCTGGAATGC -3'

Sequencing Primer
(F):5'- CATACAGTCCTTTCCTGGGGG -3'
(R):5'- AGATAAAGGCTTCAGGGC -3'
Posted On 2019-10-07