Mutagenetix > Incidental Mutation

Incidental Mutation 'R7467:Apbb1'

578862

Institutional Source

Beutler Lab

Gene Symbol

Apbb1

Ensembl Gene

ENSMUSG00000037032

Gene Name

amyloid beta precursor protein binding family B member 1

Synonyms

Fe65, Rir

MMRRC Submission

045541-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7467 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

105207690-105230860 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 105215339 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 434 (V434A)

Ref Sequence

ENSEMBL: ENSMUSP00000140973 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081165] [ENSMUST00000186814] [ENSMUST00000186868] [ENSMUST00000187051] [ENSMUST00000187057] [ENSMUST00000187683] [ENSMUST00000187721] [ENSMUST00000191011] [ENSMUST00000188001] [ENSMUST00000188368] [ENSMUST00000188440] [ENSMUST00000189072] [ENSMUST00000189265] [ENSMUST00000189378] [ENSMUST00000190369] [ENSMUST00000191601] [ENSMUST00000210079]

AlphaFold

Q9QXJ1

Predicted Effect

probably benign
Transcript: ENSMUST00000081165
AA Change: V434A

PolyPhen 2 Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000079932
Gene: ENSMUSG00000037032
AA Change: V434A

Domain	Start	End	E-Value	Type
low complexity region	146	184	N/A	INTRINSIC
WW	254	285	6.23e-5	SMART
low complexity region	287	299	N/A	INTRINSIC
PTB	365	512	4.16e-38	SMART
PTB	538	667	1.76e-36	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000186814
AA Change: V101A

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)

Predicted Effect

probably benign
Transcript: ENSMUST00000186868

SMART Domains

Protein: ENSMUSP00000140052
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	1.1e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000187051

SMART Domains

Protein: ENSMUSP00000139755
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	1.4e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
SCOP:d1shca_	74	120	9e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187057
AA Change: V211A

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000139899
Gene: ENSMUSG00000037032
AA Change: V211A

Domain	Start	End	E-Value	Type
WW	31	62	3.7e-7	SMART
low complexity region	64	76	N/A	INTRINSIC
PTB	142	287	3.8e-41	SMART
PTB	313	442	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187683

SMART Domains

Protein: ENSMUSP00000139426
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	2.1e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
Pfam:PID	111	158	5.9e-6	PFAM

Predicted Effect

SMART Domains

Protein: ENSMUSP00000140192
Gene: ENSMUSG00000037032
AA Change: V234A

Domain	Start	End	E-Value	Type
low complexity region	2	15	N/A	INTRINSIC
WW	54	85	3.7e-7	SMART
low complexity region	87	99	N/A	INTRINSIC
Pfam:PID	170	242	1.5e-11	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000191011
AA Change: V434A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000140973
Gene: ENSMUSG00000037032
AA Change: V434A

Domain	Start	End	E-Value	Type
low complexity region	146	184	N/A	INTRINSIC
WW	254	285	6.23e-5	SMART
low complexity region	287	299	N/A	INTRINSIC
PTB	365	510	6.86e-39	SMART
PTB	536	665	1.76e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000188001

Predicted Effect

probably benign
Transcript: ENSMUST00000188368
AA Change: V211A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000139788
Gene: ENSMUSG00000037032
AA Change: V211A

Domain	Start	End	E-Value	Type
WW	31	62	3.7e-7	SMART
low complexity region	64	76	N/A	INTRINSIC
PTB	142	289	1.8e-40	SMART
PTB	315	444	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000188440
AA Change: V175A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000140715
Gene: ENSMUSG00000037032
AA Change: V175A

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	3.4e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
PTB	106	223	1.4e-14	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000189072
AA Change: V175A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000139575
Gene: ENSMUSG00000037032
AA Change: V175A

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	8.1e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
PTB	106	253	1.8e-40	SMART
PTB	279	408	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000189265

SMART Domains

Protein: ENSMUSP00000140137
Gene: ENSMUSG00000037032

Domain	Start	End	E-Value	Type
Pfam:PID	1	34	2.3e-6	PFAM
PTB	63	192	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000189378
AA Change: V434A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000140979
Gene: ENSMUSG00000037032
AA Change: V434A

Domain	Start	End	E-Value	Type
low complexity region	146	184	N/A	INTRINSIC
WW	254	285	6.23e-5	SMART
low complexity region	287	299	N/A	INTRINSIC
PTB	365	510	6.86e-39	SMART
PTB	536	665	1.76e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000190369
AA Change: V175A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000140486
Gene: ENSMUSG00000037032
AA Change: V175A

Domain	Start	End	E-Value	Type
Pfam:WW	1	24	8.1e-5	PFAM
low complexity region	28	40	N/A	INTRINSIC
PTB	106	253	1.8e-40	SMART
PTB	279	408	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000191601
AA Change: V434A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000140116
Gene: ENSMUSG00000037032
AA Change: V434A

Domain	Start	End	E-Value	Type
low complexity region	146	184	N/A	INTRINSIC
WW	254	285	3.7e-7	SMART
low complexity region	287	299	N/A	INTRINSIC
PTB	365	512	1.8e-40	SMART
PTB	538	667	9.5e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000210079

Predicted Effect

probably benign
Transcript: ENSMUST00000211614

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

98% (103/105)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
PHENOTYPE: Homozygotes for a null allele are hypersensitive to ionizing radiation while mouse embryonic fibroblasts are hypersensitive to DNA damaging agents. Homozygotes for a second null allele display impaired performance in learning and memory tasks, with a striking deficit in reversal spatial learning. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 106 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre4	G	A	17: 56,098,952 (GRCm39)	V153I	probably benign	Het
Akap13	G	A	7: 75,380,213 (GRCm39)	R462H	probably damaging	Het
Aldh16a1	A	G	7: 44,795,331 (GRCm39)	Y443H	probably benign	Het
Atrip	A	G	9: 108,898,422 (GRCm39)	M199T	probably damaging	Het
Atxn2	T	C	5: 121,940,330 (GRCm39)		probably null	Het
AU040320	A	G	4: 126,708,103 (GRCm39)	T240A	probably benign	Het
Btf3l4	A	T	4: 108,675,589 (GRCm39)		probably null	Het
Ccdc106	A	G	7: 5,063,325 (GRCm39)	T277A	probably damaging	Het
Cdk15	G	T	1: 59,328,938 (GRCm39)	W282L	probably null	Het
Cflar	T	A	1: 58,765,597 (GRCm39)	M1K	probably null	Het
Champ1	C	A	8: 13,928,579 (GRCm39)	P246T	possibly damaging	Het
Crat	A	C	2: 30,299,994 (GRCm39)	F129V	probably damaging	Het
Csmd3	T	C	15: 47,492,640 (GRCm39)	N2256S		Het
Cwh43	C	A	5: 73,569,311 (GRCm39)	Q118K	probably damaging	Het
Daam1	A	T	12: 72,032,580 (GRCm39)	K949*	probably null	Het
Ddn	C	G	15: 98,703,247 (GRCm39)	E682Q	possibly damaging	Het
Des	T	A	1: 75,339,605 (GRCm39)	M321K	possibly damaging	Het
Dnm2	T	C	9: 21,392,672 (GRCm39)	V460A	probably damaging	Het
Dst	G	A	1: 34,230,236 (GRCm39)	E2610K	probably benign	Het
Efr3a	C	T	15: 65,729,360 (GRCm39)	T660I	possibly damaging	Het
Eogt	T	C	6: 97,119,794 (GRCm39)	E138G	probably benign	Het
Epha8	G	A	4: 136,658,399 (GRCm39)	A992V	possibly damaging	Het
Exoc2	A	T	13: 31,109,716 (GRCm39)	D217E	probably damaging	Het
Fam222b	T	C	11: 78,045,173 (GRCm39)	S245P	probably damaging	Het
Fbxo45	T	C	16: 32,057,339 (GRCm39)	Y185C	probably damaging	Het
Fbxo47	T	C	11: 97,755,993 (GRCm39)	T170A	probably benign	Het
Fbxw26	A	T	9: 109,561,765 (GRCm39)	V143E	probably benign	Het
Foxb2	T	C	19: 16,851,004 (GRCm39)	M1V	probably null	Het
Gm11596	C	A	11: 99,683,962 (GRCm39)	V53L	unknown	Het
Gm47791	A	G	1: 82,748,547 (GRCm39)	*140Q	probably null	Het
Gpr179	C	T	11: 97,226,115 (GRCm39)	M2013I	probably benign	Het
Hck	T	A	2: 152,971,850 (GRCm39)	L137*	probably null	Het
Hectd4	T	A	5: 121,462,024 (GRCm39)	C964S	possibly damaging	Het
Hexa	T	C	9: 59,464,683 (GRCm39)		probably null	Het
Ifna12	C	A	4: 88,521,502 (GRCm39)	S15I	possibly damaging	Het
Kif18b	C	A	11: 102,807,234 (GRCm39)	V34L	probably damaging	Het
Kif18b	A	T	11: 102,803,174 (GRCm39)		probably null	Het
Kifap3	A	T	1: 163,643,402 (GRCm39)	H209L	probably benign	Het
Klhl1	A	T	14: 96,360,713 (GRCm39)	D712E	probably damaging	Het
Kmt2c	T	C	5: 25,513,530 (GRCm39)	D3088G	probably damaging	Het
Mageb3	A	G	2: 121,784,953 (GRCm39)	Y250H	probably damaging	Het
Manba	G	T	3: 135,250,562 (GRCm39)	E396D	probably damaging	Het
Mapkbp1	T	A	2: 119,852,669 (GRCm39)	V997E	probably damaging	Het
Mdc1	A	G	17: 36,155,448 (GRCm39)	H41R	probably benign	Het
Mis18a	T	G	16: 90,516,866 (GRCm39)	M179L	probably benign	Het
Mmp25	C	G	17: 23,863,756 (GRCm39)	G25R	possibly damaging	Het
Mmp3	A	G	9: 7,447,621 (GRCm39)	D202G	possibly damaging	Het
Mmp3	C	T	9: 7,450,125 (GRCm39)	P286S	probably benign	Het
Mrgpra2b	G	A	7: 47,114,277 (GRCm39)	H152Y	possibly damaging	Het
Mslnl	A	T	17: 25,955,895 (GRCm39)	M1L	probably benign	Het
Myo1d	G	A	11: 80,477,743 (GRCm39)	T880I	probably damaging	Het
Ncaph	T	A	2: 126,975,795 (GRCm39)		probably benign	Het
Nln	T	C	13: 104,161,530 (GRCm39)	D680G	possibly damaging	Het
Noct	C	T	3: 51,132,622 (GRCm39)	A33V	probably benign	Het
Nolc1	A	G	19: 46,070,773 (GRCm39)	T325A	unknown	Het
Nr2e3	A	G	9: 59,856,434 (GRCm39)		probably null	Het
Nrg2	T	A	18: 36,155,459 (GRCm39)	H450L	probably benign	Het
Or13a21	T	C	7: 139,999,287 (GRCm39)	N133S	probably benign	Het
Or2t43	A	C	11: 58,457,288 (GRCm39)	N294K	possibly damaging	Het
Or5ak24	T	G	2: 85,261,171 (GRCm39)	M1L	possibly damaging	Het
Or5an1	T	A	19: 12,260,839 (GRCm39)	C142*	probably null	Het
Or6b3	T	A	1: 92,439,570 (GRCm39)	Y60F	possibly damaging	Het
Pank2	T	A	2: 131,115,967 (GRCm39)	N128K	possibly damaging	Het
Pcdha3	T	C	18: 37,080,584 (GRCm39)	V442A	probably damaging	Het
Pds5b	T	A	5: 150,659,792 (GRCm39)	S252T	probably damaging	Het
Pfpl	T	C	19: 12,405,878 (GRCm39)	L43S	probably damaging	Het
Pigu	T	A	2: 155,141,009 (GRCm39)	I295F	probably damaging	Het
Piwil4	T	C	9: 14,616,337 (GRCm39)	Y673C	probably damaging	Het
Pls1	A	G	9: 95,651,166 (GRCm39)	Y414H	possibly damaging	Het
Ppp1r13l	A	T	7: 19,105,305 (GRCm39)	Q359L	probably damaging	Het
Ppp2r5c	A	G	12: 110,519,317 (GRCm39)	Y263C	probably damaging	Het
Prrc2c	A	T	1: 162,504,932 (GRCm39)	S2638R	possibly damaging	Het
Prss39	T	A	1: 34,538,473 (GRCm39)		probably null	Het
Psmd1	G	A	1: 86,044,355 (GRCm39)	V648M	probably damaging	Het
Rad50	T	C	11: 53,545,735 (GRCm39)	D1196G	probably damaging	Het
Rfx1	T	C	8: 84,800,542 (GRCm39)	Y48H	possibly damaging	Het
Rgs20	A	G	1: 4,982,553 (GRCm39)	I305T	probably benign	Het
Rpl9	T	C	5: 65,548,310 (GRCm39)	T9A	probably benign	Het
Samd4	A	G	14: 47,325,313 (GRCm39)	N598D	probably benign	Het
Sema7a	T	C	9: 57,868,705 (GRCm39)	Y606H	probably damaging	Het
Sf3b3	A	G	8: 111,538,088 (GRCm39)	S1150P	possibly damaging	Het
Sirt1	T	C	10: 63,157,929 (GRCm39)	N495S	probably benign	Het
Slc17a3	T	C	13: 24,030,950 (GRCm39)		probably null	Het
Slc25a22	T	C	7: 141,013,889 (GRCm39)	T24A	probably benign	Het
Slc30a9	T	C	5: 67,502,987 (GRCm39)	I363T	probably benign	Het
Srbd1	A	G	17: 86,406,702 (GRCm39)	V561A	probably damaging	Het
Srgap1	C	A	10: 121,691,344 (GRCm39)	E297*	probably null	Het
Srgap2	T	C	1: 131,220,405 (GRCm39)	S896G	probably damaging	Het
Sspo	T	C	6: 48,463,237 (GRCm39)	C3730R	probably damaging	Het
Stat2	T	A	10: 128,113,772 (GRCm39)		probably null	Het
Tcof1	T	C	18: 60,964,977 (GRCm39)	K581E	unknown	Het
Tdpoz6	T	A	3: 93,600,265 (GRCm39)	T35S	probably benign	Het
Thbs1	T	C	2: 117,948,681 (GRCm39)	S446P	probably damaging	Het
Thsd7a	T	C	6: 12,331,584 (GRCm39)	Y1330C		Het
Tmem121	C	A	12: 113,152,690 (GRCm39)	P303T	probably benign	Het
Tmem87b	T	A	2: 128,691,071 (GRCm39)		probably null	Het
Tmem98	A	T	11: 80,711,011 (GRCm39)		probably null	Het
Trpm3	T	A	19: 22,955,698 (GRCm39)	I1091N	possibly damaging	Het
Urb2	A	G	8: 124,755,250 (GRCm39)	E319G	probably benign	Het
Vmn1r170	A	T	7: 23,306,320 (GRCm39)	M241L	not run	Het
Vmn1r238	T	C	18: 3,123,393 (GRCm39)	N7S	probably benign	Het
Wdr6	T	C	9: 108,450,201 (GRCm39)	H1109R	probably benign	Het
Zdhhc13	T	C	7: 48,454,156 (GRCm39)	V193A	probably benign	Het
Zfp354c	T	C	11: 50,706,253 (GRCm39)	Y274C	probably damaging	Het
Zfp738	T	A	13: 67,821,080 (GRCm39)	E89V	probably benign	Het
Zswim3	T	A	2: 164,661,795 (GRCm39)	F92I	possibly damaging	Het

Other mutations in Apbb1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02171:Apbb1	APN	7	105,208,333 (GRCm39)	splice site	probably benign
athena	UTSW	7	105,215,902 (GRCm39)	missense	probably benign
R0092:Apbb1	UTSW	7	105,208,361 (GRCm39)	missense	probably damaging	1.00
R0348:Apbb1	UTSW	7	105,214,510 (GRCm39)	missense	probably damaging	0.98
R0633:Apbb1	UTSW	7	105,208,170 (GRCm39)	missense	probably damaging	1.00
R0946:Apbb1	UTSW	7	105,223,062 (GRCm39)	missense	probably benign	0.09
R1076:Apbb1	UTSW	7	105,223,062 (GRCm39)	missense	probably benign	0.09
R1332:Apbb1	UTSW	7	105,214,750 (GRCm39)	missense	possibly damaging	0.74
R1658:Apbb1	UTSW	7	105,223,291 (GRCm39)	missense	probably damaging	1.00
R1739:Apbb1	UTSW	7	105,223,434 (GRCm39)	missense	probably benign
R4230:Apbb1	UTSW	7	105,216,891 (GRCm39)	missense	probably damaging	1.00
R4296:Apbb1	UTSW	7	105,223,033 (GRCm39)	missense	probably benign	0.16
R4385:Apbb1	UTSW	7	105,216,483 (GRCm39)	missense	probably benign	0.00
R4571:Apbb1	UTSW	7	105,222,969 (GRCm39)	missense	probably damaging	1.00
R4647:Apbb1	UTSW	7	105,214,745 (GRCm39)	missense	probably benign	0.01
R4812:Apbb1	UTSW	7	105,223,232 (GRCm39)	missense	probably damaging	0.99
R5044:Apbb1	UTSW	7	105,214,889 (GRCm39)	intron	probably benign
R5109:Apbb1	UTSW	7	105,214,242 (GRCm39)	missense	probably damaging	1.00
R5479:Apbb1	UTSW	7	105,214,232 (GRCm39)	missense	probably damaging	0.97
R5611:Apbb1	UTSW	7	105,208,690 (GRCm39)	missense	probably damaging	1.00
R5677:Apbb1	UTSW	7	105,208,453 (GRCm39)	missense	probably damaging	1.00
R5785:Apbb1	UTSW	7	105,216,922 (GRCm39)	missense	probably damaging	1.00
R5850:Apbb1	UTSW	7	105,216,790 (GRCm39)	missense	probably damaging	1.00
R5896:Apbb1	UTSW	7	105,223,432 (GRCm39)	missense	probably damaging	1.00
R6151:Apbb1	UTSW	7	105,223,459 (GRCm39)	nonsense	probably null
R6186:Apbb1	UTSW	7	105,216,933 (GRCm39)	missense	probably damaging	1.00
R6229:Apbb1	UTSW	7	105,222,938 (GRCm39)	missense	probably damaging	0.98
R6229:Apbb1	UTSW	7	105,222,937 (GRCm39)	missense	probably damaging	0.98
R6288:Apbb1	UTSW	7	105,208,434 (GRCm39)	missense	probably damaging	1.00
R6295:Apbb1	UTSW	7	105,215,902 (GRCm39)	missense	probably benign
R6443:Apbb1	UTSW	7	105,222,970 (GRCm39)	missense	probably damaging	1.00
R6729:Apbb1	UTSW	7	105,214,588 (GRCm39)	missense	probably damaging	1.00
R7130:Apbb1	UTSW	7	105,214,538 (GRCm39)	missense	probably damaging	0.98
R7209:Apbb1	UTSW	7	105,215,292 (GRCm39)	missense	probably damaging	1.00
R7489:Apbb1	UTSW	7	105,216,687 (GRCm39)	missense	probably benign	0.30
R7588:Apbb1	UTSW	7	105,223,173 (GRCm39)	missense	probably benign	0.29
R7754:Apbb1	UTSW	7	105,208,509 (GRCm39)	missense	probably damaging	0.97
R7768:Apbb1	UTSW	7	105,216,295 (GRCm39)	missense	probably benign
R7785:Apbb1	UTSW	7	105,216,630 (GRCm39)	missense	probably benign	0.00
R7804:Apbb1	UTSW	7	105,215,807 (GRCm39)	missense	probably damaging	1.00
R7809:Apbb1	UTSW	7	105,223,014 (GRCm39)	missense	probably benign	0.04
R7995:Apbb1	UTSW	7	105,214,852 (GRCm39)	missense	probably benign	0.09
R9206:Apbb1	UTSW	7	105,208,727 (GRCm39)	missense	probably damaging	0.97
R9208:Apbb1	UTSW	7	105,208,727 (GRCm39)	missense	probably damaging	0.97
R9225:Apbb1	UTSW	7	105,218,063 (GRCm39)	missense
Z1088:Apbb1	UTSW	7	105,208,343 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCAGTCTAGGTGTAGGAGGAG -3'
(R):5'- AAGGTGGATGATCTGACAGCC -3'

Sequencing Primer
(F):5'- GCAGACGGATGTTAATACCTCTC -3'
(R):5'- GGATGATCTGACAGCCAAGTC -3'

Posted On

2019-10-07