Incidental Mutation 'R7474:Or6d13'
ID 579333
Institutional Source Beutler Lab
Gene Symbol Or6d13
Ensembl Gene ENSMUSG00000081649
Gene Name olfactory receptor family 6 subfamily D member 13
Synonyms GA_x54KRFPKN04-58174409-58175392, Olfr213, MOR119-3
MMRRC Submission 045548-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R7474 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 116517416-116518399 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 116517999 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 195 (C195F)
Ref Sequence ENSEMBL: ENSMUSP00000151916 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121958] [ENSMUST00000220008]
AlphaFold Q7TS32
Predicted Effect probably damaging
Transcript: ENSMUST00000121958
AA Change: C195F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000112931
Gene: ENSMUSG00000081649
AA Change: C195F

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 4e-45 PFAM
Pfam:7tm_1 47 296 5.4e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000220008
AA Change: C195F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,278,088 (GRCm39) C3089* probably null Het
Abcc1 A G 16: 14,290,850 (GRCm39) T1487A possibly damaging Het
Agfg1 T A 1: 82,860,132 (GRCm39) L333* probably null Het
Agfg2 C A 5: 137,652,130 (GRCm39) V410F possibly damaging Het
Amotl2 T C 9: 102,607,310 (GRCm39) V706A probably benign Het
Apob A T 12: 8,059,185 (GRCm39) T2556S probably benign Het
Asb18 T A 1: 89,920,755 (GRCm39) H174L possibly damaging Het
Atp10a G A 7: 58,308,275 (GRCm39) E25K unknown Het
Aup1 T C 6: 83,031,948 (GRCm39) L65P probably benign Het
Blvra T C 2: 126,928,769 (GRCm39) F86L probably damaging Het
Cabp4 T C 19: 4,189,398 (GRCm39) D53G probably benign Het
Cd300c2 T A 11: 114,889,122 (GRCm39) E153V probably benign Het
Crxos A G 7: 15,636,856 (GRCm39) E143G possibly damaging Het
Csmd2 A G 4: 128,439,920 (GRCm39) N3125D Het
Cyp2c67 T A 19: 39,605,876 (GRCm39) Q340L probably null Het
Dscam T A 16: 96,621,089 (GRCm39) N540Y possibly damaging Het
E2f8 G A 7: 48,525,508 (GRCm39) R155W probably damaging Het
Ext1 A T 15: 53,207,885 (GRCm39) V292D probably damaging Het
Extl3 T C 14: 65,314,090 (GRCm39) E364G possibly damaging Het
Fmn2 CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC 1: 174,436,769 (GRCm39) probably benign Het
Fsd1 A T 17: 56,295,149 (GRCm39) D46V possibly damaging Het
Gcnt2 T A 13: 41,111,733 (GRCm39) L374H probably damaging Het
Gm10309 G A 17: 86,812,095 (GRCm39) probably benign Het
Gm14410 A T 2: 176,894,618 (GRCm39) probably null Het
Gm5114 A T 7: 39,057,404 (GRCm39) S738R probably benign Het
Gtf3c2 C A 5: 31,325,100 (GRCm39) G502W probably damaging Het
Insc G A 7: 114,368,058 (GRCm39) probably null Het
Kcnt2 T C 1: 140,498,216 (GRCm39) Y898H possibly damaging Het
Kctd19 C A 8: 106,118,664 (GRCm39) R299L probably benign Het
Klf10 T C 15: 38,297,446 (GRCm39) N198S probably benign Het
L3mbtl1 A T 2: 162,808,524 (GRCm39) D574V probably damaging Het
Lamc1 G A 1: 153,208,011 (GRCm39) A92V possibly damaging Het
Lrrc63 T A 14: 75,363,643 (GRCm39) T163S possibly damaging Het
Mak T A 13: 41,204,956 (GRCm39) K127N probably damaging Het
Mdga2 G A 12: 66,533,535 (GRCm39) Q945* probably null Het
Mthfr T A 4: 148,137,059 (GRCm39) I519N possibly damaging Het
Mtmr2 C A 9: 13,710,521 (GRCm39) H357N probably damaging Het
Myh13 A C 11: 67,258,537 (GRCm39) Q184P Het
Myh13 A T 11: 67,217,990 (GRCm39) E21V possibly damaging Het
Nans T A 4: 46,502,484 (GRCm39) L307Q probably damaging Het
Ncan C A 8: 70,554,691 (GRCm39) R1042L possibly damaging Het
Nrg3 T C 14: 38,733,956 (GRCm39) E310G probably damaging Het
Obsl1 A C 1: 75,474,828 (GRCm39) N857K probably benign Het
Olfml2a T C 2: 38,850,273 (GRCm39) V663A probably damaging Het
Or14j10 T C 17: 37,935,277 (GRCm39) D83G probably benign Het
Or51v15-ps1 C A 7: 103,278,354 (GRCm39) W271L unknown Het
Or52e19b A G 7: 103,032,969 (GRCm39) I80T probably damaging Het
Or8i2 T C 2: 86,852,898 (GRCm39) probably benign Het
Pla2g4a T C 1: 149,740,951 (GRCm39) M363V possibly damaging Het
Pramel26 T C 4: 143,538,269 (GRCm39) D234G probably benign Het
Prickle1 A T 15: 93,406,552 (GRCm39) V157D possibly damaging Het
Pstk A G 7: 130,975,362 (GRCm39) N105S probably benign Het
Ptpn21 A G 12: 98,703,622 (GRCm39) probably null Het
Rnf2 T A 1: 151,347,467 (GRCm39) E277D probably benign Het
Rnpepl1 T C 1: 92,846,694 (GRCm39) F532S probably benign Het
Rtn1 C T 12: 72,355,164 (GRCm39) A261T possibly damaging Het
Ryr2 A G 13: 11,609,762 (GRCm39) S4355P probably benign Het
Sacs T G 14: 61,448,627 (GRCm39) L3558V probably benign Het
Senp6 T C 9: 80,049,610 (GRCm39) V1047A probably damaging Het
Slco2b1 A T 7: 99,314,039 (GRCm39) C515S probably damaging Het
Smgc T A 15: 91,744,892 (GRCm39) V732E possibly damaging Het
Sorcs1 T C 19: 50,141,550 (GRCm39) M1105V possibly damaging Het
Spats1 A G 17: 45,768,087 (GRCm39) Y160H possibly damaging Het
Tnfsf14 T A 17: 57,497,848 (GRCm39) D128V Het
Tns3 T C 11: 8,480,894 (GRCm39) Q234R probably damaging Het
Uxs1 A G 1: 43,796,184 (GRCm39) V306A possibly damaging Het
Vac14 T A 8: 111,363,066 (GRCm39) V304D probably damaging Het
Vangl1 A G 3: 102,091,565 (GRCm39) F174L probably benign Het
Vav1 A G 17: 57,606,102 (GRCm39) E242G probably benign Het
Vsir A G 10: 60,204,701 (GRCm39) N305D probably benign Het
Vwce T A 19: 10,624,305 (GRCm39) C399S possibly damaging Het
Wrn A T 8: 33,819,209 (GRCm39) L248M probably damaging Het
Zfp141 T A 7: 42,125,678 (GRCm39) K265* probably null Het
Zfp735 A T 11: 73,602,002 (GRCm39) K315N possibly damaging Het
Other mutations in Or6d13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Or6d13 APN 6 116,517,968 (GRCm39) missense probably damaging 1.00
IGL02671:Or6d13 APN 6 116,518,104 (GRCm39) missense possibly damaging 0.50
IGL03107:Or6d13 APN 6 116,517,900 (GRCm39) missense possibly damaging 0.82
R0041:Or6d13 UTSW 6 116,518,295 (GRCm39) missense possibly damaging 0.55
R0426:Or6d13 UTSW 6 116,517,446 (GRCm39) missense probably damaging 1.00
R0627:Or6d13 UTSW 6 116,517,949 (GRCm39) missense possibly damaging 0.56
R0829:Or6d13 UTSW 6 116,518,226 (GRCm39) missense probably benign 0.01
R2111:Or6d13 UTSW 6 116,517,611 (GRCm39) missense possibly damaging 0.95
R2112:Or6d13 UTSW 6 116,517,611 (GRCm39) missense possibly damaging 0.95
R2120:Or6d13 UTSW 6 116,517,416 (GRCm39) start codon destroyed probably null 0.04
R3161:Or6d13 UTSW 6 116,517,807 (GRCm39) missense probably damaging 1.00
R3700:Or6d13 UTSW 6 116,517,489 (GRCm39) missense probably benign 0.10
R4710:Or6d13 UTSW 6 116,517,611 (GRCm39) missense possibly damaging 0.95
R5244:Or6d13 UTSW 6 116,518,187 (GRCm39) missense probably damaging 1.00
R5859:Or6d13 UTSW 6 116,517,861 (GRCm39) missense probably damaging 1.00
R6273:Or6d13 UTSW 6 116,518,277 (GRCm39) missense possibly damaging 0.74
R6505:Or6d13 UTSW 6 116,517,561 (GRCm39) missense probably benign 0.01
R7350:Or6d13 UTSW 6 116,517,495 (GRCm39) missense probably benign 0.28
R7380:Or6d13 UTSW 6 116,517,894 (GRCm39) missense probably benign 0.03
R8054:Or6d13 UTSW 6 116,517,960 (GRCm39) missense probably damaging 1.00
R8476:Or6d13 UTSW 6 116,517,507 (GRCm39) missense probably benign
R8862:Or6d13 UTSW 6 116,518,186 (GRCm39) missense probably benign 0.03
R9082:Or6d13 UTSW 6 116,517,969 (GRCm39) missense probably damaging 1.00
R9100:Or6d13 UTSW 6 116,517,990 (GRCm39) missense possibly damaging 0.93
R9124:Or6d13 UTSW 6 116,517,416 (GRCm39) start codon destroyed probably null 0.04
R9151:Or6d13 UTSW 6 116,517,990 (GRCm39) missense possibly damaging 0.93
R9321:Or6d13 UTSW 6 116,518,370 (GRCm39) missense probably benign
R9404:Or6d13 UTSW 6 116,517,708 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTGGCCATCTGCAAACCTC -3'
(R):5'- TACACAGCTGCCATACATTAGAGAG -3'

Sequencing Primer
(F):5'- GGCCATCTGCAAACCTCTACATTATC -3'
(R):5'- CTGCCATACATTAGAGAGAGGAC -3'
Posted On 2019-10-07