Incidental Mutation 'R7474:Zfp735'
| ID |
579356 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp735
|
| Ensembl Gene |
ENSMUSG00000060630 |
| Gene Name |
zinc finger protein 735 |
| Synonyms |
1700012C15Rik |
| MMRRC Submission |
045548-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R7474 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
73579604-73604624 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 73602002 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 315
(K315N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000079269
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080407]
|
| AlphaFold |
B1ARH2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000080407
AA Change: K315N
PolyPhen 2
Score 0.719 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: K315N
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
2.2e-34 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
1.81e1 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
4.87e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
A |
11: 9,278,088 (GRCm39) |
C3089* |
probably null |
Het |
| Abcc1 |
A |
G |
16: 14,290,850 (GRCm39) |
T1487A |
possibly damaging |
Het |
| Agfg1 |
T |
A |
1: 82,860,132 (GRCm39) |
L333* |
probably null |
Het |
| Agfg2 |
C |
A |
5: 137,652,130 (GRCm39) |
V410F |
possibly damaging |
Het |
| Amotl2 |
T |
C |
9: 102,607,310 (GRCm39) |
V706A |
probably benign |
Het |
| Apob |
A |
T |
12: 8,059,185 (GRCm39) |
T2556S |
probably benign |
Het |
| Asb18 |
T |
A |
1: 89,920,755 (GRCm39) |
H174L |
possibly damaging |
Het |
| Atp10a |
G |
A |
7: 58,308,275 (GRCm39) |
E25K |
unknown |
Het |
| Aup1 |
T |
C |
6: 83,031,948 (GRCm39) |
L65P |
probably benign |
Het |
| Blvra |
T |
C |
2: 126,928,769 (GRCm39) |
F86L |
probably damaging |
Het |
| Cabp4 |
T |
C |
19: 4,189,398 (GRCm39) |
D53G |
probably benign |
Het |
| Cd300c2 |
T |
A |
11: 114,889,122 (GRCm39) |
E153V |
probably benign |
Het |
| Crxos |
A |
G |
7: 15,636,856 (GRCm39) |
E143G |
possibly damaging |
Het |
| Csmd2 |
A |
G |
4: 128,439,920 (GRCm39) |
N3125D |
|
Het |
| Cyp2c67 |
T |
A |
19: 39,605,876 (GRCm39) |
Q340L |
probably null |
Het |
| Dscam |
T |
A |
16: 96,621,089 (GRCm39) |
N540Y |
possibly damaging |
Het |
| E2f8 |
G |
A |
7: 48,525,508 (GRCm39) |
R155W |
probably damaging |
Het |
| Ext1 |
A |
T |
15: 53,207,885 (GRCm39) |
V292D |
probably damaging |
Het |
| Extl3 |
T |
C |
14: 65,314,090 (GRCm39) |
E364G |
possibly damaging |
Het |
| Fmn2 |
CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC |
CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC |
1: 174,436,769 (GRCm39) |
|
probably benign |
Het |
| Fsd1 |
A |
T |
17: 56,295,149 (GRCm39) |
D46V |
possibly damaging |
Het |
| Gcnt2 |
T |
A |
13: 41,111,733 (GRCm39) |
L374H |
probably damaging |
Het |
| Gm10309 |
G |
A |
17: 86,812,095 (GRCm39) |
|
probably benign |
Het |
| Gm14410 |
A |
T |
2: 176,894,618 (GRCm39) |
|
probably null |
Het |
| Gm5114 |
A |
T |
7: 39,057,404 (GRCm39) |
S738R |
probably benign |
Het |
| Gtf3c2 |
C |
A |
5: 31,325,100 (GRCm39) |
G502W |
probably damaging |
Het |
| Insc |
G |
A |
7: 114,368,058 (GRCm39) |
|
probably null |
Het |
| Kcnt2 |
T |
C |
1: 140,498,216 (GRCm39) |
Y898H |
possibly damaging |
Het |
| Kctd19 |
C |
A |
8: 106,118,664 (GRCm39) |
R299L |
probably benign |
Het |
| Klf10 |
T |
C |
15: 38,297,446 (GRCm39) |
N198S |
probably benign |
Het |
| L3mbtl1 |
A |
T |
2: 162,808,524 (GRCm39) |
D574V |
probably damaging |
Het |
| Lamc1 |
G |
A |
1: 153,208,011 (GRCm39) |
A92V |
possibly damaging |
Het |
| Lrrc63 |
T |
A |
14: 75,363,643 (GRCm39) |
T163S |
possibly damaging |
Het |
| Mak |
T |
A |
13: 41,204,956 (GRCm39) |
K127N |
probably damaging |
Het |
| Mdga2 |
G |
A |
12: 66,533,535 (GRCm39) |
Q945* |
probably null |
Het |
| Mthfr |
T |
A |
4: 148,137,059 (GRCm39) |
I519N |
possibly damaging |
Het |
| Mtmr2 |
C |
A |
9: 13,710,521 (GRCm39) |
H357N |
probably damaging |
Het |
| Myh13 |
A |
C |
11: 67,258,537 (GRCm39) |
Q184P |
|
Het |
| Myh13 |
A |
T |
11: 67,217,990 (GRCm39) |
E21V |
possibly damaging |
Het |
| Nans |
T |
A |
4: 46,502,484 (GRCm39) |
L307Q |
probably damaging |
Het |
| Ncan |
C |
A |
8: 70,554,691 (GRCm39) |
R1042L |
possibly damaging |
Het |
| Nrg3 |
T |
C |
14: 38,733,956 (GRCm39) |
E310G |
probably damaging |
Het |
| Obsl1 |
A |
C |
1: 75,474,828 (GRCm39) |
N857K |
probably benign |
Het |
| Olfml2a |
T |
C |
2: 38,850,273 (GRCm39) |
V663A |
probably damaging |
Het |
| Or14j10 |
T |
C |
17: 37,935,277 (GRCm39) |
D83G |
probably benign |
Het |
| Or51v15-ps1 |
C |
A |
7: 103,278,354 (GRCm39) |
W271L |
unknown |
Het |
| Or52e19b |
A |
G |
7: 103,032,969 (GRCm39) |
I80T |
probably damaging |
Het |
| Or6d13 |
G |
T |
6: 116,517,999 (GRCm39) |
C195F |
probably damaging |
Het |
| Or8i2 |
T |
C |
2: 86,852,898 (GRCm39) |
|
probably benign |
Het |
| Pla2g4a |
T |
C |
1: 149,740,951 (GRCm39) |
M363V |
possibly damaging |
Het |
| Pramel26 |
T |
C |
4: 143,538,269 (GRCm39) |
D234G |
probably benign |
Het |
| Prickle1 |
A |
T |
15: 93,406,552 (GRCm39) |
V157D |
possibly damaging |
Het |
| Pstk |
A |
G |
7: 130,975,362 (GRCm39) |
N105S |
probably benign |
Het |
| Ptpn21 |
A |
G |
12: 98,703,622 (GRCm39) |
|
probably null |
Het |
| Rnf2 |
T |
A |
1: 151,347,467 (GRCm39) |
E277D |
probably benign |
Het |
| Rnpepl1 |
T |
C |
1: 92,846,694 (GRCm39) |
F532S |
probably benign |
Het |
| Rtn1 |
C |
T |
12: 72,355,164 (GRCm39) |
A261T |
possibly damaging |
Het |
| Ryr2 |
A |
G |
13: 11,609,762 (GRCm39) |
S4355P |
probably benign |
Het |
| Sacs |
T |
G |
14: 61,448,627 (GRCm39) |
L3558V |
probably benign |
Het |
| Senp6 |
T |
C |
9: 80,049,610 (GRCm39) |
V1047A |
probably damaging |
Het |
| Slco2b1 |
A |
T |
7: 99,314,039 (GRCm39) |
C515S |
probably damaging |
Het |
| Smgc |
T |
A |
15: 91,744,892 (GRCm39) |
V732E |
possibly damaging |
Het |
| Sorcs1 |
T |
C |
19: 50,141,550 (GRCm39) |
M1105V |
possibly damaging |
Het |
| Spats1 |
A |
G |
17: 45,768,087 (GRCm39) |
Y160H |
possibly damaging |
Het |
| Tnfsf14 |
T |
A |
17: 57,497,848 (GRCm39) |
D128V |
|
Het |
| Tns3 |
T |
C |
11: 8,480,894 (GRCm39) |
Q234R |
probably damaging |
Het |
| Uxs1 |
A |
G |
1: 43,796,184 (GRCm39) |
V306A |
possibly damaging |
Het |
| Vac14 |
T |
A |
8: 111,363,066 (GRCm39) |
V304D |
probably damaging |
Het |
| Vangl1 |
A |
G |
3: 102,091,565 (GRCm39) |
F174L |
probably benign |
Het |
| Vav1 |
A |
G |
17: 57,606,102 (GRCm39) |
E242G |
probably benign |
Het |
| Vsir |
A |
G |
10: 60,204,701 (GRCm39) |
N305D |
probably benign |
Het |
| Vwce |
T |
A |
19: 10,624,305 (GRCm39) |
C399S |
possibly damaging |
Het |
| Wrn |
A |
T |
8: 33,819,209 (GRCm39) |
L248M |
probably damaging |
Het |
| Zfp141 |
T |
A |
7: 42,125,678 (GRCm39) |
K265* |
probably null |
Het |
|
| Other mutations in Zfp735 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Zfp735
|
APN |
11 |
73,602,192 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL00798:Zfp735
|
APN |
11 |
73,602,386 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01642:Zfp735
|
APN |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01684:Zfp735
|
APN |
11 |
73,581,191 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02096:Zfp735
|
APN |
11 |
73,602,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02238:Zfp735
|
APN |
11 |
73,601,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02505:Zfp735
|
APN |
11 |
73,580,626 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02740:Zfp735
|
APN |
11 |
73,601,412 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02957:Zfp735
|
APN |
11 |
73,601,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
bananaquit
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
bescher
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Galvanic
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
grassquit
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0114:Zfp735
|
UTSW |
11 |
73,601,488 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0217:Zfp735
|
UTSW |
11 |
73,602,112 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0943:Zfp735
|
UTSW |
11 |
73,602,909 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1421:Zfp735
|
UTSW |
11 |
73,601,523 (GRCm39) |
missense |
probably benign |
|
|
R1460:Zfp735
|
UTSW |
11 |
73,603,159 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1493:Zfp735
|
UTSW |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1517:Zfp735
|
UTSW |
11 |
73,601,470 (GRCm39) |
missense |
probably benign |
|
|
R1676:Zfp735
|
UTSW |
11 |
73,602,301 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1709:Zfp735
|
UTSW |
11 |
73,602,589 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1871:Zfp735
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
R1931:Zfp735
|
UTSW |
11 |
73,602,677 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2219:Zfp735
|
UTSW |
11 |
73,601,851 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2227:Zfp735
|
UTSW |
11 |
73,602,223 (GRCm39) |
nonsense |
probably null |
|
|
R2227:Zfp735
|
UTSW |
11 |
73,602,222 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3552:Zfp735
|
UTSW |
11 |
73,602,067 (GRCm39) |
nonsense |
probably null |
|
|
R3856:Zfp735
|
UTSW |
11 |
73,602,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3925:Zfp735
|
UTSW |
11 |
73,601,950 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4572:Zfp735
|
UTSW |
11 |
73,580,611 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4585:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4586:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4619:Zfp735
|
UTSW |
11 |
73,602,031 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,682 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5435:Zfp735
|
UTSW |
11 |
73,602,939 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5489:Zfp735
|
UTSW |
11 |
73,601,419 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Zfp735
|
UTSW |
11 |
73,601,640 (GRCm39) |
missense |
probably benign |
|
|
R5654:Zfp735
|
UTSW |
11 |
73,602,964 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5990:Zfp735
|
UTSW |
11 |
73,581,174 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6332:Zfp735
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
R6427:Zfp735
|
UTSW |
11 |
73,581,140 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6460:Zfp735
|
UTSW |
11 |
73,602,478 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6820:Zfp735
|
UTSW |
11 |
73,579,783 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R6831:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6833:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6834:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Zfp735
|
UTSW |
11 |
73,601,880 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6941:Zfp735
|
UTSW |
11 |
73,581,159 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7335:Zfp735
|
UTSW |
11 |
73,602,379 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7366:Zfp735
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7487:Zfp735
|
UTSW |
11 |
73,581,154 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7583:Zfp735
|
UTSW |
11 |
73,601,933 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7866:Zfp735
|
UTSW |
11 |
73,601,629 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8005:Zfp735
|
UTSW |
11 |
73,603,140 (GRCm39) |
nonsense |
probably null |
|
|
R8500:Zfp735
|
UTSW |
11 |
73,601,811 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8551:Zfp735
|
UTSW |
11 |
73,603,122 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8754:Zfp735
|
UTSW |
11 |
73,603,000 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8769:Zfp735
|
UTSW |
11 |
73,581,127 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8794:Zfp735
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8835:Zfp735
|
UTSW |
11 |
73,601,692 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8869:Zfp735
|
UTSW |
11 |
73,602,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8969:Zfp735
|
UTSW |
11 |
73,602,699 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9072:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9073:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9193:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9355:Zfp735
|
UTSW |
11 |
73,602,362 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9414:Zfp735
|
UTSW |
11 |
73,602,023 (GRCm39) |
nonsense |
probably null |
|
|
R9456:Zfp735
|
UTSW |
11 |
73,602,403 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9573:Zfp735
|
UTSW |
11 |
73,602,936 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9647:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9710:Zfp735
|
UTSW |
11 |
73,601,806 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1176:Zfp735
|
UTSW |
11 |
73,601,641 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGAAGCAGTTGTGGGAACTC -3'
(R):5'- ACTTATCATATCCCGGGGCCAG -3'
Sequencing Primer
(F):5'- CCCCTTTCTGAAGTATTACC -3'
(R):5'- GGCATTCCTGTATATATCACATGTG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation