Incidental Mutation 'R7474:Lrrc63'
ID 579368
Institutional Source Beutler Lab
Gene Symbol Lrrc63
Ensembl Gene ENSMUSG00000021997
Gene Name leucine rich repeat containing 63
Synonyms 4921509B22Rik
MMRRC Submission 045548-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R7474 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 75321743-75368321 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 75363643 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 163 (T163S)
Ref Sequence ENSEMBL: ENSMUSP00000022574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022574] [ENSMUST00000134114] [ENSMUST00000143539]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000022574
AA Change: T163S

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000022574
Gene: ENSMUSG00000021997
AA Change: T163S

DomainStartEndE-ValueType
low complexity region 15 37 N/A INTRINSIC
low complexity region 139 152 N/A INTRINSIC
low complexity region 276 310 N/A INTRINSIC
LRR 412 434 2.82e0 SMART
LRR 435 458 1.45e1 SMART
LRR 481 504 1.53e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000134114
SMART Domains Protein: ENSMUSP00000121376
Gene: ENSMUSG00000021998

DomainStartEndE-ValueType
EFh 13 41 6.91e-5 SMART
EFh 53 81 7.7e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000143539
SMART Domains Protein: ENSMUSP00000118721
Gene: ENSMUSG00000021998

DomainStartEndE-ValueType
EFh 13 41 6.91e-5 SMART
EFh 53 76 4.45e1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,278,088 (GRCm39) C3089* probably null Het
Abcc1 A G 16: 14,290,850 (GRCm39) T1487A possibly damaging Het
Agfg1 T A 1: 82,860,132 (GRCm39) L333* probably null Het
Agfg2 C A 5: 137,652,130 (GRCm39) V410F possibly damaging Het
Amotl2 T C 9: 102,607,310 (GRCm39) V706A probably benign Het
Apob A T 12: 8,059,185 (GRCm39) T2556S probably benign Het
Asb18 T A 1: 89,920,755 (GRCm39) H174L possibly damaging Het
Atp10a G A 7: 58,308,275 (GRCm39) E25K unknown Het
Aup1 T C 6: 83,031,948 (GRCm39) L65P probably benign Het
Blvra T C 2: 126,928,769 (GRCm39) F86L probably damaging Het
Cabp4 T C 19: 4,189,398 (GRCm39) D53G probably benign Het
Cd300c2 T A 11: 114,889,122 (GRCm39) E153V probably benign Het
Crxos A G 7: 15,636,856 (GRCm39) E143G possibly damaging Het
Csmd2 A G 4: 128,439,920 (GRCm39) N3125D Het
Cyp2c67 T A 19: 39,605,876 (GRCm39) Q340L probably null Het
Dscam T A 16: 96,621,089 (GRCm39) N540Y possibly damaging Het
E2f8 G A 7: 48,525,508 (GRCm39) R155W probably damaging Het
Ext1 A T 15: 53,207,885 (GRCm39) V292D probably damaging Het
Extl3 T C 14: 65,314,090 (GRCm39) E364G possibly damaging Het
Fmn2 CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC 1: 174,436,769 (GRCm39) probably benign Het
Fsd1 A T 17: 56,295,149 (GRCm39) D46V possibly damaging Het
Gcnt2 T A 13: 41,111,733 (GRCm39) L374H probably damaging Het
Gm10309 G A 17: 86,812,095 (GRCm39) probably benign Het
Gm14410 A T 2: 176,894,618 (GRCm39) probably null Het
Gm5114 A T 7: 39,057,404 (GRCm39) S738R probably benign Het
Gtf3c2 C A 5: 31,325,100 (GRCm39) G502W probably damaging Het
Insc G A 7: 114,368,058 (GRCm39) probably null Het
Kcnt2 T C 1: 140,498,216 (GRCm39) Y898H possibly damaging Het
Kctd19 C A 8: 106,118,664 (GRCm39) R299L probably benign Het
Klf10 T C 15: 38,297,446 (GRCm39) N198S probably benign Het
L3mbtl1 A T 2: 162,808,524 (GRCm39) D574V probably damaging Het
Lamc1 G A 1: 153,208,011 (GRCm39) A92V possibly damaging Het
Mak T A 13: 41,204,956 (GRCm39) K127N probably damaging Het
Mdga2 G A 12: 66,533,535 (GRCm39) Q945* probably null Het
Mthfr T A 4: 148,137,059 (GRCm39) I519N possibly damaging Het
Mtmr2 C A 9: 13,710,521 (GRCm39) H357N probably damaging Het
Myh13 A T 11: 67,217,990 (GRCm39) E21V possibly damaging Het
Myh13 A C 11: 67,258,537 (GRCm39) Q184P Het
Nans T A 4: 46,502,484 (GRCm39) L307Q probably damaging Het
Ncan C A 8: 70,554,691 (GRCm39) R1042L possibly damaging Het
Nrg3 T C 14: 38,733,956 (GRCm39) E310G probably damaging Het
Obsl1 A C 1: 75,474,828 (GRCm39) N857K probably benign Het
Olfml2a T C 2: 38,850,273 (GRCm39) V663A probably damaging Het
Or14j10 T C 17: 37,935,277 (GRCm39) D83G probably benign Het
Or51v15-ps1 C A 7: 103,278,354 (GRCm39) W271L unknown Het
Or52e19b A G 7: 103,032,969 (GRCm39) I80T probably damaging Het
Or6d13 G T 6: 116,517,999 (GRCm39) C195F probably damaging Het
Or8i2 T C 2: 86,852,898 (GRCm39) probably benign Het
Pla2g4a T C 1: 149,740,951 (GRCm39) M363V possibly damaging Het
Pramel26 T C 4: 143,538,269 (GRCm39) D234G probably benign Het
Prickle1 A T 15: 93,406,552 (GRCm39) V157D possibly damaging Het
Pstk A G 7: 130,975,362 (GRCm39) N105S probably benign Het
Ptpn21 A G 12: 98,703,622 (GRCm39) probably null Het
Rnf2 T A 1: 151,347,467 (GRCm39) E277D probably benign Het
Rnpepl1 T C 1: 92,846,694 (GRCm39) F532S probably benign Het
Rtn1 C T 12: 72,355,164 (GRCm39) A261T possibly damaging Het
Ryr2 A G 13: 11,609,762 (GRCm39) S4355P probably benign Het
Sacs T G 14: 61,448,627 (GRCm39) L3558V probably benign Het
Senp6 T C 9: 80,049,610 (GRCm39) V1047A probably damaging Het
Slco2b1 A T 7: 99,314,039 (GRCm39) C515S probably damaging Het
Smgc T A 15: 91,744,892 (GRCm39) V732E possibly damaging Het
Sorcs1 T C 19: 50,141,550 (GRCm39) M1105V possibly damaging Het
Spats1 A G 17: 45,768,087 (GRCm39) Y160H possibly damaging Het
Tnfsf14 T A 17: 57,497,848 (GRCm39) D128V Het
Tns3 T C 11: 8,480,894 (GRCm39) Q234R probably damaging Het
Uxs1 A G 1: 43,796,184 (GRCm39) V306A possibly damaging Het
Vac14 T A 8: 111,363,066 (GRCm39) V304D probably damaging Het
Vangl1 A G 3: 102,091,565 (GRCm39) F174L probably benign Het
Vav1 A G 17: 57,606,102 (GRCm39) E242G probably benign Het
Vsir A G 10: 60,204,701 (GRCm39) N305D probably benign Het
Vwce T A 19: 10,624,305 (GRCm39) C399S possibly damaging Het
Wrn A T 8: 33,819,209 (GRCm39) L248M probably damaging Het
Zfp141 T A 7: 42,125,678 (GRCm39) K265* probably null Het
Zfp735 A T 11: 73,602,002 (GRCm39) K315N possibly damaging Het
Other mutations in Lrrc63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01688:Lrrc63 APN 14 75,322,422 (GRCm39) missense possibly damaging 0.73
IGL02222:Lrrc63 APN 14 75,323,580 (GRCm39) missense probably damaging 0.99
IGL02385:Lrrc63 APN 14 75,323,640 (GRCm39) missense probably benign
FR4548:Lrrc63 UTSW 14 75,362,622 (GRCm39) small deletion probably benign
FR4589:Lrrc63 UTSW 14 75,362,622 (GRCm39) small deletion probably benign
R0398:Lrrc63 UTSW 14 75,363,910 (GRCm39) missense probably benign 0.06
R0637:Lrrc63 UTSW 14 75,335,660 (GRCm39) splice site probably benign
R0669:Lrrc63 UTSW 14 75,363,550 (GRCm39) missense probably benign 0.27
R1465:Lrrc63 UTSW 14 75,344,829 (GRCm39) missense possibly damaging 0.92
R1465:Lrrc63 UTSW 14 75,344,829 (GRCm39) missense possibly damaging 0.92
R1478:Lrrc63 UTSW 14 75,363,424 (GRCm39) missense probably benign
R1591:Lrrc63 UTSW 14 75,363,332 (GRCm39) missense possibly damaging 0.92
R1753:Lrrc63 UTSW 14 75,323,784 (GRCm39) splice site probably null
R3713:Lrrc63 UTSW 14 75,344,776 (GRCm39) missense probably benign 0.12
R4013:Lrrc63 UTSW 14 75,335,731 (GRCm39) missense probably damaging 0.98
R4793:Lrrc63 UTSW 14 75,363,601 (GRCm39) missense possibly damaging 0.93
R4888:Lrrc63 UTSW 14 75,363,406 (GRCm39) missense probably benign
R4937:Lrrc63 UTSW 14 75,322,389 (GRCm39) missense probably damaging 0.99
R5197:Lrrc63 UTSW 14 75,322,322 (GRCm39) missense possibly damaging 0.68
R5747:Lrrc63 UTSW 14 75,363,904 (GRCm39) missense probably benign
R5861:Lrrc63 UTSW 14 75,344,806 (GRCm39) missense possibly damaging 0.83
R5905:Lrrc63 UTSW 14 75,323,614 (GRCm39) missense possibly damaging 0.92
R6028:Lrrc63 UTSW 14 75,323,614 (GRCm39) missense possibly damaging 0.92
R6661:Lrrc63 UTSW 14 75,362,633 (GRCm39) missense unknown
R6982:Lrrc63 UTSW 14 75,322,211 (GRCm39) missense probably benign 0.33
R7062:Lrrc63 UTSW 14 75,323,737 (GRCm39) missense probably benign 0.00
R7439:Lrrc63 UTSW 14 75,363,697 (GRCm39) missense possibly damaging 0.84
R7440:Lrrc63 UTSW 14 75,358,453 (GRCm39) missense possibly damaging 0.91
R7441:Lrrc63 UTSW 14 75,363,697 (GRCm39) missense possibly damaging 0.84
R7604:Lrrc63 UTSW 14 75,322,409 (GRCm39) missense possibly damaging 0.68
R7703:Lrrc63 UTSW 14 75,360,447 (GRCm39) missense possibly damaging 0.91
R7819:Lrrc63 UTSW 14 75,362,661 (GRCm39) small insertion probably benign
R8519:Lrrc63 UTSW 14 75,363,312 (GRCm39) missense possibly damaging 0.96
R8970:Lrrc63 UTSW 14 75,362,631 (GRCm39) missense unknown
R9025:Lrrc63 UTSW 14 75,322,284 (GRCm39) missense probably benign
R9547:Lrrc63 UTSW 14 75,344,828 (GRCm39) missense probably damaging 0.99
R9589:Lrrc63 UTSW 14 75,322,379 (GRCm39) missense possibly damaging 0.68
R9780:Lrrc63 UTSW 14 75,360,500 (GRCm39) missense probably damaging 0.99
Z1088:Lrrc63 UTSW 14 75,363,430 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- AAGGGTGTGTCCGTTCAGAC -3'
(R):5'- TTTTCACTGGAAGGTCCCAAAG -3'

Sequencing Primer
(F):5'- GTGTGTCCGTTCAGACCACTG -3'
(R):5'- AAAGAGCACCGCTGGTTC -3'
Posted On 2019-10-07