Incidental Mutation 'R0631:Itgae'
ID |
57983 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Itgae
|
Ensembl Gene |
ENSMUSG00000005947 |
Gene Name |
integrin alpha E, epithelial-associated |
Synonyms |
alpha-E1, CD103 |
MMRRC Submission |
038820-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R0631 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
72981409-73038272 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 73005733 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Aspartic acid
at position 299
(V299D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000099596
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006101]
[ENSMUST00000102537]
|
AlphaFold |
Q60677 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000006101
AA Change: V299D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000006101 Gene: ENSMUSG00000005947 AA Change: V299D
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Blast:Int_alpha
|
36 |
118 |
1e-24 |
BLAST |
VWA
|
193 |
380 |
1.13e-39 |
SMART |
Int_alpha
|
448 |
496 |
1.49e-3 |
SMART |
Int_alpha
|
502 |
559 |
6.83e-12 |
SMART |
Int_alpha
|
565 |
626 |
1.79e-15 |
SMART |
Int_alpha
|
633 |
685 |
6.29e0 |
SMART |
transmembrane domain
|
1115 |
1137 |
N/A |
INTRINSIC |
Pfam:Integrin_alpha
|
1138 |
1152 |
1.1e-6 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000102537
AA Change: V299D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000099596 Gene: ENSMUSG00000005947 AA Change: V299D
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Blast:Int_alpha
|
36 |
118 |
5e-25 |
BLAST |
VWA
|
193 |
380 |
1.13e-39 |
SMART |
Int_alpha
|
448 |
496 |
1.49e-3 |
SMART |
Int_alpha
|
502 |
559 |
6.83e-12 |
SMART |
Int_alpha
|
565 |
626 |
1.79e-15 |
SMART |
Int_alpha
|
633 |
685 |
6.29e0 |
SMART |
|
Meta Mutation Damage Score |
0.7396 |
Coding Region Coverage |
- 1x: 99.4%
- 3x: 99.1%
- 10x: 98.1%
- 20x: 96.8%
|
Validation Efficiency |
97% (129/133) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008] PHENOTYPE: Homozygotes for a targeted null mutation exhibit reductions in the numbers of intestinal and vaginal intraepithelial lymphocytes and of T lymphocytes of the lamina propria. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 131 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadat |
T |
C |
8: 60,982,479 (GRCm39) |
|
probably benign |
Het |
Afap1l2 |
T |
C |
19: 56,904,517 (GRCm39) |
E594G |
probably benign |
Het |
Ak8 |
T |
G |
2: 28,625,677 (GRCm39) |
I240S |
probably damaging |
Het |
Akap13 |
T |
C |
7: 75,264,744 (GRCm39) |
V174A |
probably damaging |
Het |
Alppl2 |
G |
A |
1: 87,017,095 (GRCm39) |
T66I |
probably damaging |
Het |
Ankrd61 |
T |
A |
5: 143,831,697 (GRCm39) |
I36F |
probably damaging |
Het |
Antxrl |
T |
A |
14: 33,780,758 (GRCm39) |
|
probably null |
Het |
Arhgef2 |
G |
C |
3: 88,541,743 (GRCm39) |
V244L |
probably damaging |
Het |
Arid1a |
A |
G |
4: 133,416,481 (GRCm39) |
I1098T |
unknown |
Het |
Atr |
T |
C |
9: 95,756,830 (GRCm39) |
V903A |
possibly damaging |
Het |
B3gnt6 |
C |
A |
7: 97,842,899 (GRCm39) |
A354S |
probably benign |
Het |
Bnc1 |
A |
T |
7: 81,624,114 (GRCm39) |
I371N |
probably damaging |
Het |
Camsap1 |
A |
T |
2: 25,823,659 (GRCm39) |
S1464T |
probably damaging |
Het |
Cand2 |
G |
A |
6: 115,780,766 (GRCm39) |
E1217K |
probably damaging |
Het |
Cass4 |
T |
C |
2: 172,274,331 (GRCm39) |
I728T |
probably damaging |
Het |
Ccdc88a |
A |
T |
11: 29,443,752 (GRCm39) |
M1378L |
probably damaging |
Het |
Ccdc9 |
C |
A |
7: 16,012,384 (GRCm39) |
W266L |
probably damaging |
Het |
Cct6b |
C |
A |
11: 82,627,914 (GRCm39) |
|
probably null |
Het |
Cd177 |
T |
C |
7: 24,456,111 (GRCm39) |
E219G |
probably benign |
Het |
Cdkal1 |
A |
T |
13: 29,538,667 (GRCm39) |
Y497* |
probably null |
Het |
Chmp2a |
T |
C |
7: 12,766,371 (GRCm39) |
E107G |
probably damaging |
Het |
Chrna2 |
T |
G |
14: 66,386,757 (GRCm39) |
V301G |
probably benign |
Het |
Chrna7 |
A |
G |
7: 62,749,391 (GRCm39) |
C364R |
probably benign |
Het |
Cltc |
G |
T |
11: 86,603,439 (GRCm39) |
L796I |
probably benign |
Het |
Col12a1 |
T |
C |
9: 79,610,658 (GRCm39) |
T249A |
probably damaging |
Het |
Col13a1 |
G |
A |
10: 61,723,129 (GRCm39) |
Q270* |
probably null |
Het |
Col6a1 |
C |
T |
10: 76,545,569 (GRCm39) |
V968M |
probably benign |
Het |
Copb1 |
C |
A |
7: 113,832,517 (GRCm39) |
V511F |
probably benign |
Het |
Daw1 |
C |
G |
1: 83,174,981 (GRCm39) |
S160R |
probably damaging |
Het |
Ddx46 |
A |
G |
13: 55,787,590 (GRCm39) |
|
probably benign |
Het |
Depdc7 |
T |
C |
2: 104,552,332 (GRCm39) |
K492E |
possibly damaging |
Het |
Dmbt1 |
C |
T |
7: 130,699,383 (GRCm39) |
A1004V |
possibly damaging |
Het |
Dnah7b |
G |
A |
1: 46,280,152 (GRCm39) |
V2694I |
probably benign |
Het |
Dnhd1 |
T |
A |
7: 105,300,831 (GRCm39) |
F63I |
probably benign |
Het |
Edc4 |
C |
A |
8: 106,617,424 (GRCm39) |
A1052E |
possibly damaging |
Het |
Eif2s2 |
T |
A |
2: 154,726,278 (GRCm39) |
K129M |
probably damaging |
Het |
Emx2 |
A |
G |
19: 59,452,460 (GRCm39) |
D248G |
probably damaging |
Het |
Erich6b |
T |
C |
14: 75,896,449 (GRCm39) |
|
probably benign |
Het |
Exoc3l4 |
A |
G |
12: 111,394,400 (GRCm39) |
K507E |
probably benign |
Het |
Fanci |
T |
A |
7: 79,055,953 (GRCm39) |
V195E |
probably damaging |
Het |
Fgfr2 |
T |
G |
7: 129,828,969 (GRCm39) |
|
probably benign |
Het |
Frem1 |
A |
G |
4: 82,890,402 (GRCm39) |
S1007P |
probably damaging |
Het |
Fry |
T |
C |
5: 150,419,817 (GRCm39) |
I993T |
possibly damaging |
Het |
Fst |
A |
G |
13: 114,591,038 (GRCm39) |
S244P |
possibly damaging |
Het |
Gcc1 |
T |
C |
6: 28,421,009 (GRCm39) |
T103A |
probably damaging |
Het |
Gdf2 |
C |
T |
14: 33,663,178 (GRCm39) |
P24L |
probably damaging |
Het |
Gja3 |
T |
C |
14: 57,274,219 (GRCm39) |
D51G |
possibly damaging |
Het |
Gm10305 |
A |
G |
4: 99,161,313 (GRCm39) |
D74G |
unknown |
Het |
Gm12689 |
G |
T |
4: 99,184,258 (GRCm39) |
G37V |
unknown |
Het |
Gm5424 |
C |
T |
10: 61,907,313 (GRCm39) |
|
noncoding transcript |
Het |
Hephl1 |
T |
C |
9: 14,995,820 (GRCm39) |
E434G |
probably benign |
Het |
Hoatz |
T |
A |
9: 51,013,253 (GRCm39) |
R6S |
probably benign |
Het |
Htatip2 |
T |
C |
7: 49,423,059 (GRCm39) |
C205R |
possibly damaging |
Het |
Igf2r |
T |
C |
17: 12,936,161 (GRCm39) |
|
probably null |
Het |
Ints2 |
T |
C |
11: 86,124,022 (GRCm39) |
I589V |
probably benign |
Het |
Kcnma1 |
T |
C |
14: 23,559,852 (GRCm39) |
|
probably benign |
Het |
Kif11 |
A |
G |
19: 37,401,565 (GRCm39) |
|
probably benign |
Het |
Kif13a |
A |
G |
13: 46,932,364 (GRCm39) |
|
probably benign |
Het |
Kif18a |
T |
A |
2: 109,128,667 (GRCm39) |
|
probably benign |
Het |
Klhl29 |
T |
C |
12: 5,144,883 (GRCm39) |
T406A |
probably benign |
Het |
Litaf |
A |
T |
16: 10,784,276 (GRCm39) |
|
probably benign |
Het |
Lmntd1 |
T |
A |
6: 145,375,726 (GRCm39) |
I71F |
probably benign |
Het |
Lrit3 |
A |
C |
3: 129,582,204 (GRCm39) |
C594W |
probably damaging |
Het |
Lrp6 |
T |
A |
6: 134,456,738 (GRCm39) |
Q842L |
possibly damaging |
Het |
Lrrcc1 |
T |
A |
3: 14,605,179 (GRCm39) |
|
probably benign |
Het |
Macf1 |
A |
T |
4: 123,349,317 (GRCm39) |
L1829* |
probably null |
Het |
Mapk1ip1 |
T |
C |
7: 138,437,684 (GRCm39) |
T249A |
possibly damaging |
Het |
Mfap4 |
T |
C |
11: 61,378,006 (GRCm39) |
F173L |
probably damaging |
Het |
Mfsd9 |
C |
A |
1: 40,829,634 (GRCm39) |
|
probably benign |
Het |
Mgat4b |
T |
C |
11: 50,121,590 (GRCm39) |
S69P |
probably damaging |
Het |
Mki67 |
A |
T |
7: 135,306,117 (GRCm39) |
V620D |
probably damaging |
Het |
Moxd1 |
C |
T |
10: 24,128,852 (GRCm39) |
T201I |
probably damaging |
Het |
Msh4 |
G |
C |
3: 153,572,057 (GRCm39) |
D774E |
probably benign |
Het |
Myg1 |
C |
T |
15: 102,240,284 (GRCm39) |
R37C |
probably benign |
Het |
Myrf |
C |
A |
19: 10,206,246 (GRCm39) |
A57S |
probably benign |
Het |
Ndst1 |
G |
A |
18: 60,833,431 (GRCm39) |
|
probably benign |
Het |
Nedd4l |
A |
T |
18: 65,341,574 (GRCm39) |
|
probably benign |
Het |
Neil2 |
T |
A |
14: 63,420,849 (GRCm39) |
I281F |
possibly damaging |
Het |
Nfatc2 |
T |
A |
2: 168,432,035 (GRCm39) |
D26V |
probably benign |
Het |
Nt5c |
A |
G |
11: 115,381,540 (GRCm39) |
|
probably null |
Het |
Or13a24 |
T |
G |
7: 140,154,420 (GRCm39) |
M118R |
probably damaging |
Het |
Or2w1b |
G |
T |
13: 21,300,078 (GRCm39) |
C72F |
probably damaging |
Het |
Or2z8 |
T |
A |
8: 72,812,166 (GRCm39) |
I214N |
probably damaging |
Het |
Or5ac20 |
A |
G |
16: 59,104,570 (GRCm39) |
C97R |
possibly damaging |
Het |
Or5t15 |
T |
C |
2: 86,681,311 (GRCm39) |
T244A |
probably benign |
Het |
Ovch2 |
A |
G |
7: 107,381,228 (GRCm39) |
S557P |
probably benign |
Het |
Pik3cg |
A |
G |
12: 32,255,202 (GRCm39) |
S262P |
probably benign |
Het |
Pla2g6 |
T |
A |
15: 79,190,596 (GRCm39) |
H322L |
probably damaging |
Het |
Plch1 |
A |
T |
3: 63,606,640 (GRCm39) |
L1079Q |
probably benign |
Het |
Plekhg4 |
T |
A |
8: 106,105,934 (GRCm39) |
V777D |
probably damaging |
Het |
Plekhg5 |
A |
G |
4: 152,196,876 (GRCm39) |
D747G |
possibly damaging |
Het |
Poln |
C |
A |
5: 34,276,302 (GRCm39) |
V318F |
possibly damaging |
Het |
Pou5f2 |
T |
A |
13: 78,173,873 (GRCm39) |
S272T |
probably benign |
Het |
Ppp1r3e |
T |
G |
14: 55,114,073 (GRCm39) |
S200R |
possibly damaging |
Het |
Prl7d1 |
G |
A |
13: 27,894,165 (GRCm39) |
P135S |
probably benign |
Het |
Ptgs2 |
G |
A |
1: 149,980,288 (GRCm39) |
V409I |
probably benign |
Het |
Ptk2b |
T |
C |
14: 66,415,200 (GRCm39) |
T276A |
probably damaging |
Het |
Ptpn3 |
T |
C |
4: 57,204,921 (GRCm39) |
T747A |
probably damaging |
Het |
Qrfpr |
A |
G |
3: 36,276,138 (GRCm39) |
I84T |
probably damaging |
Het |
Rab44 |
A |
G |
17: 29,358,118 (GRCm39) |
D102G |
possibly damaging |
Het |
Rimoc1 |
A |
G |
15: 4,015,971 (GRCm39) |
|
probably benign |
Het |
Rnf125 |
A |
T |
18: 21,112,140 (GRCm39) |
D57V |
possibly damaging |
Het |
Rnf145 |
T |
C |
11: 44,450,851 (GRCm39) |
F392L |
probably damaging |
Het |
Rttn |
A |
G |
18: 89,007,670 (GRCm39) |
N435S |
probably benign |
Het |
Scn8a |
A |
G |
15: 100,933,418 (GRCm39) |
T1500A |
probably damaging |
Het |
Sgsm1 |
A |
G |
5: 113,432,989 (GRCm39) |
|
probably benign |
Het |
Sgsm3 |
A |
T |
15: 80,895,937 (GRCm39) |
*751C |
probably null |
Het |
Slc35c2 |
A |
C |
2: 165,122,849 (GRCm39) |
L145R |
probably damaging |
Het |
Slc4a7 |
A |
T |
14: 14,757,382 (GRCm38) |
E396V |
probably damaging |
Het |
Smarca4 |
G |
C |
9: 21,570,280 (GRCm39) |
|
probably benign |
Het |
Snapc3 |
T |
A |
4: 83,336,039 (GRCm39) |
V17D |
probably damaging |
Het |
Snta1 |
G |
T |
2: 154,218,992 (GRCm39) |
Q448K |
probably benign |
Het |
Sptbn2 |
A |
G |
19: 4,790,014 (GRCm39) |
D1334G |
probably benign |
Het |
Stard5 |
A |
G |
7: 83,281,965 (GRCm39) |
R41G |
probably damaging |
Het |
Stxbp5 |
T |
A |
10: 9,660,102 (GRCm39) |
N731I |
probably benign |
Het |
Tmem135 |
T |
A |
7: 88,792,996 (GRCm39) |
K413* |
probably null |
Het |
Tmem38a |
G |
A |
8: 73,333,862 (GRCm39) |
V114I |
probably benign |
Het |
Tpr |
A |
G |
1: 150,298,282 (GRCm39) |
T1057A |
probably damaging |
Het |
Ttc23l |
A |
T |
15: 10,540,066 (GRCm39) |
L139Q |
probably damaging |
Het |
Ttn |
T |
A |
2: 76,585,640 (GRCm39) |
|
probably null |
Het |
Tuba3b |
A |
G |
6: 145,565,302 (GRCm39) |
T257A |
probably damaging |
Het |
Tubgcp6 |
A |
C |
15: 88,985,190 (GRCm39) |
Y1633D |
probably damaging |
Het |
Txnl1 |
C |
T |
18: 63,804,644 (GRCm39) |
|
probably benign |
Het |
Unc13b |
A |
G |
4: 43,182,849 (GRCm39) |
Q3186R |
possibly damaging |
Het |
Vmn2r75 |
T |
A |
7: 85,812,478 (GRCm39) |
S514C |
probably null |
Het |
Whrn |
G |
A |
4: 63,337,726 (GRCm39) |
T545I |
probably damaging |
Het |
Zdhhc20 |
T |
C |
14: 58,095,097 (GRCm39) |
H154R |
probably damaging |
Het |
Zfp462 |
A |
T |
4: 55,007,563 (GRCm39) |
M1L |
possibly damaging |
Het |
Zfp831 |
A |
G |
2: 174,487,083 (GRCm39) |
K586R |
possibly damaging |
Het |
Zfp990 |
A |
T |
4: 145,263,872 (GRCm39) |
H290L |
possibly damaging |
Het |
Zfpm1 |
C |
T |
8: 123,063,613 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Itgae |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00424:Itgae
|
APN |
11 |
73,036,461 (GRCm39) |
missense |
probably benign |
0.17 |
IGL00472:Itgae
|
APN |
11 |
73,004,520 (GRCm39) |
missense |
probably benign |
0.06 |
IGL00821:Itgae
|
APN |
11 |
73,013,974 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01625:Itgae
|
APN |
11 |
73,010,263 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01639:Itgae
|
APN |
11 |
73,010,204 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01743:Itgae
|
APN |
11 |
73,002,585 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01911:Itgae
|
APN |
11 |
73,006,963 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01949:Itgae
|
APN |
11 |
73,009,010 (GRCm39) |
missense |
probably benign |
0.29 |
IGL02149:Itgae
|
APN |
11 |
72,994,720 (GRCm39) |
missense |
probably benign |
0.04 |
IGL02179:Itgae
|
APN |
11 |
73,024,844 (GRCm39) |
missense |
probably benign |
0.06 |
IGL02231:Itgae
|
APN |
11 |
72,981,448 (GRCm39) |
missense |
possibly damaging |
0.88 |
IGL02292:Itgae
|
APN |
11 |
73,009,361 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02378:Itgae
|
APN |
11 |
73,008,947 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02525:Itgae
|
APN |
11 |
73,021,777 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02576:Itgae
|
APN |
11 |
73,009,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02729:Itgae
|
APN |
11 |
73,009,029 (GRCm39) |
splice site |
probably benign |
|
IGL02859:Itgae
|
APN |
11 |
73,005,693 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03074:Itgae
|
APN |
11 |
73,016,136 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03107:Itgae
|
APN |
11 |
73,004,427 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03264:Itgae
|
APN |
11 |
73,006,400 (GRCm39) |
missense |
possibly damaging |
0.73 |
IGL03272:Itgae
|
APN |
11 |
73,024,680 (GRCm39) |
splice site |
probably null |
|
IGL03352:Itgae
|
APN |
11 |
73,022,556 (GRCm39) |
missense |
probably damaging |
1.00 |
R0134:Itgae
|
UTSW |
11 |
73,002,168 (GRCm39) |
missense |
probably benign |
0.00 |
R0225:Itgae
|
UTSW |
11 |
73,002,168 (GRCm39) |
missense |
probably benign |
0.00 |
R0320:Itgae
|
UTSW |
11 |
73,021,825 (GRCm39) |
missense |
possibly damaging |
0.74 |
R0344:Itgae
|
UTSW |
11 |
73,008,973 (GRCm39) |
missense |
probably benign |
0.13 |
R0403:Itgae
|
UTSW |
11 |
73,014,009 (GRCm39) |
missense |
possibly damaging |
0.89 |
R0833:Itgae
|
UTSW |
11 |
73,020,032 (GRCm39) |
missense |
probably benign |
0.02 |
R0836:Itgae
|
UTSW |
11 |
73,020,032 (GRCm39) |
missense |
probably benign |
0.02 |
R0973:Itgae
|
UTSW |
11 |
73,029,335 (GRCm39) |
nonsense |
probably null |
|
R1231:Itgae
|
UTSW |
11 |
73,010,205 (GRCm39) |
missense |
probably benign |
0.02 |
R1389:Itgae
|
UTSW |
11 |
73,016,188 (GRCm39) |
missense |
probably damaging |
1.00 |
R1433:Itgae
|
UTSW |
11 |
73,006,418 (GRCm39) |
missense |
probably damaging |
1.00 |
R1534:Itgae
|
UTSW |
11 |
73,036,431 (GRCm39) |
missense |
possibly damaging |
0.58 |
R1833:Itgae
|
UTSW |
11 |
73,007,988 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1914:Itgae
|
UTSW |
11 |
73,009,469 (GRCm39) |
splice site |
probably benign |
|
R1915:Itgae
|
UTSW |
11 |
73,009,469 (GRCm39) |
splice site |
probably benign |
|
R2061:Itgae
|
UTSW |
11 |
73,009,448 (GRCm39) |
missense |
probably benign |
0.00 |
R2380:Itgae
|
UTSW |
11 |
73,036,395 (GRCm39) |
missense |
probably benign |
0.00 |
R2435:Itgae
|
UTSW |
11 |
73,012,763 (GRCm39) |
nonsense |
probably null |
|
R2680:Itgae
|
UTSW |
11 |
73,005,752 (GRCm39) |
missense |
probably damaging |
1.00 |
R2886:Itgae
|
UTSW |
11 |
73,031,513 (GRCm39) |
missense |
probably benign |
0.04 |
R3873:Itgae
|
UTSW |
11 |
73,004,442 (GRCm39) |
missense |
probably damaging |
1.00 |
R3923:Itgae
|
UTSW |
11 |
73,006,969 (GRCm39) |
missense |
probably damaging |
0.99 |
R4010:Itgae
|
UTSW |
11 |
73,002,165 (GRCm39) |
missense |
probably benign |
0.00 |
R4059:Itgae
|
UTSW |
11 |
73,002,960 (GRCm39) |
missense |
probably benign |
|
R4212:Itgae
|
UTSW |
11 |
73,010,178 (GRCm39) |
missense |
probably benign |
|
R4213:Itgae
|
UTSW |
11 |
73,010,178 (GRCm39) |
missense |
probably benign |
|
R4691:Itgae
|
UTSW |
11 |
73,010,345 (GRCm39) |
nonsense |
probably null |
|
R4736:Itgae
|
UTSW |
11 |
73,005,706 (GRCm39) |
missense |
possibly damaging |
0.79 |
R5152:Itgae
|
UTSW |
11 |
73,021,821 (GRCm39) |
missense |
probably damaging |
1.00 |
R5201:Itgae
|
UTSW |
11 |
73,001,382 (GRCm39) |
missense |
probably benign |
0.00 |
R5307:Itgae
|
UTSW |
11 |
73,036,464 (GRCm39) |
missense |
probably benign |
0.00 |
R5362:Itgae
|
UTSW |
11 |
73,002,675 (GRCm39) |
missense |
probably damaging |
1.00 |
R5448:Itgae
|
UTSW |
11 |
73,024,734 (GRCm39) |
critical splice donor site |
probably null |
|
R5645:Itgae
|
UTSW |
11 |
73,020,074 (GRCm39) |
missense |
probably damaging |
1.00 |
R5672:Itgae
|
UTSW |
11 |
73,036,377 (GRCm39) |
missense |
possibly damaging |
0.96 |
R6079:Itgae
|
UTSW |
11 |
73,006,400 (GRCm39) |
missense |
possibly damaging |
0.73 |
R6138:Itgae
|
UTSW |
11 |
73,006,400 (GRCm39) |
missense |
possibly damaging |
0.73 |
R6226:Itgae
|
UTSW |
11 |
73,031,583 (GRCm39) |
missense |
probably benign |
0.11 |
R6244:Itgae
|
UTSW |
11 |
73,036,427 (GRCm39) |
missense |
probably damaging |
0.96 |
R6326:Itgae
|
UTSW |
11 |
73,022,519 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6332:Itgae
|
UTSW |
11 |
73,002,228 (GRCm39) |
splice site |
probably null |
|
R6502:Itgae
|
UTSW |
11 |
73,036,418 (GRCm39) |
missense |
probably benign |
0.10 |
R6825:Itgae
|
UTSW |
11 |
73,009,322 (GRCm39) |
missense |
possibly damaging |
0.89 |
R7016:Itgae
|
UTSW |
11 |
73,010,342 (GRCm39) |
missense |
probably damaging |
0.99 |
R7020:Itgae
|
UTSW |
11 |
73,002,195 (GRCm39) |
missense |
probably damaging |
1.00 |
R7069:Itgae
|
UTSW |
11 |
73,006,969 (GRCm39) |
missense |
probably damaging |
0.99 |
R7132:Itgae
|
UTSW |
11 |
73,002,184 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7473:Itgae
|
UTSW |
11 |
73,031,504 (GRCm39) |
missense |
possibly damaging |
0.87 |
R7599:Itgae
|
UTSW |
11 |
73,012,786 (GRCm39) |
missense |
possibly damaging |
0.62 |
R7637:Itgae
|
UTSW |
11 |
73,004,457 (GRCm39) |
missense |
probably damaging |
1.00 |
R7763:Itgae
|
UTSW |
11 |
73,014,095 (GRCm39) |
critical splice donor site |
probably null |
|
R7829:Itgae
|
UTSW |
11 |
73,029,618 (GRCm39) |
missense |
probably benign |
|
R7860:Itgae
|
UTSW |
11 |
73,011,099 (GRCm39) |
critical splice acceptor site |
probably null |
|
R7978:Itgae
|
UTSW |
11 |
73,024,913 (GRCm39) |
missense |
probably damaging |
0.98 |
R8197:Itgae
|
UTSW |
11 |
73,011,210 (GRCm39) |
missense |
probably benign |
|
R8911:Itgae
|
UTSW |
11 |
73,004,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R9155:Itgae
|
UTSW |
11 |
73,016,089 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9284:Itgae
|
UTSW |
11 |
73,012,752 (GRCm39) |
missense |
probably benign |
0.25 |
R9355:Itgae
|
UTSW |
11 |
73,006,906 (GRCm39) |
missense |
probably damaging |
1.00 |
R9414:Itgae
|
UTSW |
11 |
73,002,629 (GRCm39) |
missense |
possibly damaging |
0.59 |
R9595:Itgae
|
UTSW |
11 |
73,016,182 (GRCm39) |
missense |
probably damaging |
0.99 |
R9618:Itgae
|
UTSW |
11 |
73,011,171 (GRCm39) |
missense |
possibly damaging |
0.78 |
U15987:Itgae
|
UTSW |
11 |
73,006,400 (GRCm39) |
missense |
possibly damaging |
0.73 |
X0024:Itgae
|
UTSW |
11 |
73,002,202 (GRCm39) |
missense |
probably benign |
0.01 |
Z1186:Itgae
|
UTSW |
11 |
72,994,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
Z1186:Itgae
|
UTSW |
11 |
73,024,953 (GRCm39) |
missense |
probably benign |
0.36 |
Z1186:Itgae
|
UTSW |
11 |
73,012,783 (GRCm39) |
missense |
probably benign |
0.00 |
Z1186:Itgae
|
UTSW |
11 |
73,012,757 (GRCm39) |
missense |
probably benign |
0.00 |
Z1186:Itgae
|
UTSW |
11 |
73,008,913 (GRCm39) |
missense |
probably benign |
0.01 |
Z1186:Itgae
|
UTSW |
11 |
73,006,466 (GRCm39) |
missense |
probably benign |
|
Z1186:Itgae
|
UTSW |
11 |
72,994,786 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1187:Itgae
|
UTSW |
11 |
72,994,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
Z1187:Itgae
|
UTSW |
11 |
72,994,786 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1187:Itgae
|
UTSW |
11 |
73,006,466 (GRCm39) |
missense |
probably benign |
|
Z1187:Itgae
|
UTSW |
11 |
73,008,913 (GRCm39) |
missense |
probably benign |
0.01 |
Z1187:Itgae
|
UTSW |
11 |
73,012,757 (GRCm39) |
missense |
probably benign |
0.00 |
Z1187:Itgae
|
UTSW |
11 |
73,012,783 (GRCm39) |
missense |
probably benign |
0.00 |
Z1187:Itgae
|
UTSW |
11 |
73,024,953 (GRCm39) |
missense |
probably benign |
0.36 |
Z1188:Itgae
|
UTSW |
11 |
72,994,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
Z1188:Itgae
|
UTSW |
11 |
73,024,953 (GRCm39) |
missense |
probably benign |
0.36 |
Z1188:Itgae
|
UTSW |
11 |
73,012,783 (GRCm39) |
missense |
probably benign |
0.00 |
Z1188:Itgae
|
UTSW |
11 |
73,012,757 (GRCm39) |
missense |
probably benign |
0.00 |
Z1188:Itgae
|
UTSW |
11 |
73,008,913 (GRCm39) |
missense |
probably benign |
0.01 |
Z1188:Itgae
|
UTSW |
11 |
73,006,466 (GRCm39) |
missense |
probably benign |
|
Z1188:Itgae
|
UTSW |
11 |
72,994,786 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1189:Itgae
|
UTSW |
11 |
72,994,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
Z1189:Itgae
|
UTSW |
11 |
73,024,953 (GRCm39) |
missense |
probably benign |
0.36 |
Z1189:Itgae
|
UTSW |
11 |
73,012,783 (GRCm39) |
missense |
probably benign |
0.00 |
Z1189:Itgae
|
UTSW |
11 |
73,012,757 (GRCm39) |
missense |
probably benign |
0.00 |
Z1189:Itgae
|
UTSW |
11 |
73,008,913 (GRCm39) |
missense |
probably benign |
0.01 |
Z1189:Itgae
|
UTSW |
11 |
73,006,466 (GRCm39) |
missense |
probably benign |
|
Z1189:Itgae
|
UTSW |
11 |
72,994,786 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1190:Itgae
|
UTSW |
11 |
73,024,953 (GRCm39) |
missense |
probably benign |
0.36 |
Z1190:Itgae
|
UTSW |
11 |
73,012,783 (GRCm39) |
missense |
probably benign |
0.00 |
Z1190:Itgae
|
UTSW |
11 |
73,012,757 (GRCm39) |
missense |
probably benign |
0.00 |
Z1190:Itgae
|
UTSW |
11 |
73,008,913 (GRCm39) |
missense |
probably benign |
0.01 |
Z1190:Itgae
|
UTSW |
11 |
73,006,466 (GRCm39) |
missense |
probably benign |
|
Z1190:Itgae
|
UTSW |
11 |
72,994,786 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1190:Itgae
|
UTSW |
11 |
72,994,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
Z1191:Itgae
|
UTSW |
11 |
73,024,953 (GRCm39) |
missense |
probably benign |
0.36 |
Z1191:Itgae
|
UTSW |
11 |
73,012,783 (GRCm39) |
missense |
probably benign |
0.00 |
Z1191:Itgae
|
UTSW |
11 |
73,012,757 (GRCm39) |
missense |
probably benign |
0.00 |
Z1191:Itgae
|
UTSW |
11 |
73,008,913 (GRCm39) |
missense |
probably benign |
0.01 |
Z1191:Itgae
|
UTSW |
11 |
73,006,466 (GRCm39) |
missense |
probably benign |
|
Z1191:Itgae
|
UTSW |
11 |
72,994,786 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1191:Itgae
|
UTSW |
11 |
72,994,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
Z1192:Itgae
|
UTSW |
11 |
73,012,783 (GRCm39) |
missense |
probably benign |
0.00 |
Z1192:Itgae
|
UTSW |
11 |
73,012,757 (GRCm39) |
missense |
probably benign |
0.00 |
Z1192:Itgae
|
UTSW |
11 |
73,008,913 (GRCm39) |
missense |
probably benign |
0.01 |
Z1192:Itgae
|
UTSW |
11 |
73,006,466 (GRCm39) |
missense |
probably benign |
|
Z1192:Itgae
|
UTSW |
11 |
72,994,786 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1192:Itgae
|
UTSW |
11 |
72,994,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
Z1192:Itgae
|
UTSW |
11 |
73,024,953 (GRCm39) |
missense |
probably benign |
0.36 |
|
Predicted Primers |
PCR Primer
(F):5'- TGTGTGATGCAAATCCGCCCTC -3'
(R):5'- ACCAGGACTCATCTCAGTGGTCTC -3'
Sequencing Primer
(F):5'- CAAATCCGCCCTCTTCCG -3'
(R):5'- TTCAGCCAGTGAGCTATGC -3'
|
Posted On |
2013-07-11 |