Incidental Mutation 'R7484:Slc22a28'
ID 580031
Institutional Source Beutler Lab
Gene Symbol Slc22a28
Ensembl Gene ENSMUSG00000063590
Gene Name solute carrier family 22, member 28
Synonyms Gm5631
MMRRC Submission 045558-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.299) question?
Stock # R7484 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 8039574-8109346 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 8048492 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Isoleucine at position 385 (S385I)
Ref Sequence ENSEMBL: ENSMUSP00000067114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065651]
AlphaFold B2RT89
Predicted Effect probably benign
Transcript: ENSMUST00000065651
AA Change: S385I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000067114
Gene: ENSMUSG00000063590
AA Change: S385I

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:Sugar_tr 99 527 1.4e-26 PFAM
Pfam:MFS_1 140 375 1.1e-15 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (65/66)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm5 A G 4: 144,504,521 (GRCm39) L210P probably damaging Het
Acacb G A 5: 114,356,923 (GRCm39) V1285I probably damaging Het
Acly A T 11: 100,386,789 (GRCm39) I591N probably damaging Het
Acr T A 15: 89,457,427 (GRCm39) V225E probably damaging Het
Actr8 A G 14: 29,714,925 (GRCm39) D580G probably damaging Het
Adamts12 C A 15: 11,345,734 (GRCm39) Q1592K probably benign Het
Aire T C 10: 77,878,404 (GRCm39) E138G probably damaging Het
Apob C T 12: 8,056,884 (GRCm39) Q1789* probably null Het
Cbx5 A C 15: 103,114,256 (GRCm39) probably null Het
Cd300lb A T 11: 114,819,345 (GRCm39) W95R probably damaging Het
Cdc16 A G 8: 13,827,605 (GRCm39) T504A probably benign Het
Cenpf A G 1: 189,389,018 (GRCm39) S1605P probably damaging Het
Ckap2l A G 2: 129,114,455 (GRCm39) V596A possibly damaging Het
Cntn1 T C 15: 92,151,922 (GRCm39) W454R probably benign Het
Crat C T 2: 30,294,577 (GRCm39) R497Q probably benign Het
Csf2rb A G 15: 78,223,099 (GRCm39) T104A possibly damaging Het
Cyp4a12b A G 4: 115,289,760 (GRCm39) D209G possibly damaging Het
Ddx23 T C 15: 98,546,570 (GRCm39) E533G probably damaging Het
Dscaml1 A G 9: 45,660,744 (GRCm39) probably null Het
Eif3l T G 15: 78,968,336 (GRCm39) C202G probably benign Het
Ephx4 T G 5: 107,577,612 (GRCm39) M312R probably damaging Het
Erich6 A T 3: 58,534,112 (GRCm39) probably null Het
Far2 G A 6: 148,075,411 (GRCm39) D424N probably damaging Het
Fat1 C A 8: 45,489,221 (GRCm39) N3497K probably damaging Het
Fstl3 G A 10: 79,615,865 (GRCm39) C117Y probably damaging Het
Fyb2 A T 4: 104,870,499 (GRCm39) H700L probably benign Het
Gm8356 T A 14: 17,691,282 (GRCm39) M128L probably benign Het
Golim4 G T 3: 75,805,442 (GRCm39) probably null Het
Grm1 T G 10: 10,622,403 (GRCm39) D440A probably benign Het
Gtf2a1 A G 12: 91,529,747 (GRCm39) V322A probably benign Het
Hid1 T C 11: 115,243,407 (GRCm39) probably null Het
Igfals G A 17: 25,098,962 (GRCm39) V18M possibly damaging Het
Klk1b24 G T 7: 43,839,688 (GRCm39) probably null Het
Lmbr1 T C 5: 29,551,850 (GRCm39) probably benign Het
Lrrc40 T C 3: 157,746,194 (GRCm39) S90P probably benign Het
Mapk9 T C 11: 49,763,663 (GRCm39) Y185H probably damaging Het
Marveld2 C T 13: 100,748,068 (GRCm39) G337D probably damaging Het
Mga G T 2: 119,776,710 (GRCm39) R1539L probably damaging Het
Mllt6 T A 11: 97,563,442 (GRCm39) S342T probably benign Het
Ms4a6c T C 19: 11,449,893 (GRCm39) probably null Het
Muc16 T A 9: 18,558,064 (GRCm39) H2743L unknown Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Or10ag60 T C 2: 87,438,281 (GRCm39) F183S probably damaging Het
Or2l13 A G 16: 19,305,753 (GRCm39) H55R possibly damaging Het
Plcd3 T G 11: 102,962,545 (GRCm39) K635N probably damaging Het
Prkch T A 12: 73,632,301 (GRCm39) probably null Het
Rb1cc1 T C 1: 6,344,441 (GRCm39) V1570A probably damaging Het
Rp1 T C 1: 4,415,704 (GRCm39) N1803D probably benign Het
Rufy3 T A 5: 88,746,331 (GRCm39) V72E probably benign Het
Secisbp2l G A 2: 125,613,452 (GRCm39) Q181* probably null Het
Sgcb A G 5: 73,797,188 (GRCm39) F191L possibly damaging Het
Sgsh T A 11: 119,237,183 (GRCm39) D477V probably damaging Het
Shoc1 A T 4: 59,062,286 (GRCm39) V924E probably damaging Het
Slc26a3 T C 12: 31,497,787 (GRCm39) V47A probably benign Het
Slco2a1 A T 9: 102,945,185 (GRCm39) I187F probably damaging Het
Sltm T C 9: 70,481,179 (GRCm39) S344P unknown Het
Sort1 A G 3: 108,246,141 (GRCm39) T373A probably damaging Het
Stab1 A G 14: 30,882,274 (GRCm39) F474L probably benign Het
Tbc1d5 G T 17: 51,224,573 (GRCm39) A326E possibly damaging Het
Tcstv4 A T 13: 120,770,017 (GRCm39) K112N probably damaging Het
Vwa8 A C 14: 79,219,674 (GRCm39) probably null Het
Wdr70 G A 15: 7,951,562 (GRCm39) T425I probably benign Het
Zfp30 T C 7: 29,492,231 (GRCm39) Y243H probably benign Het
Zfp974 A T 7: 27,611,559 (GRCm39) N55K possibly damaging Het
Zftraf1 A G 15: 76,530,435 (GRCm39) L295P probably damaging Het
Other mutations in Slc22a28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Slc22a28 APN 19 8,107,567 (GRCm39) missense possibly damaging 0.89
IGL00515:Slc22a28 APN 19 8,094,428 (GRCm39) missense probably benign 0.34
IGL01025:Slc22a28 APN 19 8,094,272 (GRCm39) splice site probably benign
IGL02697:Slc22a28 APN 19 8,094,491 (GRCm39) missense probably benign 0.06
PIT4378001:Slc22a28 UTSW 19 8,049,279 (GRCm39) missense probably damaging 0.96
R0744:Slc22a28 UTSW 19 8,094,197 (GRCm39) missense possibly damaging 0.94
R0836:Slc22a28 UTSW 19 8,094,197 (GRCm39) missense possibly damaging 0.94
R1398:Slc22a28 UTSW 19 8,107,566 (GRCm39) nonsense probably null
R1456:Slc22a28 UTSW 19 8,049,223 (GRCm39) missense possibly damaging 0.50
R1603:Slc22a28 UTSW 19 8,040,674 (GRCm39) missense probably damaging 1.00
R1993:Slc22a28 UTSW 19 8,094,488 (GRCm39) missense possibly damaging 0.79
R2254:Slc22a28 UTSW 19 8,041,858 (GRCm39) missense probably benign
R2262:Slc22a28 UTSW 19 8,048,573 (GRCm39) missense probably benign 0.00
R4078:Slc22a28 UTSW 19 8,078,777 (GRCm39) missense probably benign 0.15
R4165:Slc22a28 UTSW 19 8,040,773 (GRCm39) missense possibly damaging 0.95
R4612:Slc22a28 UTSW 19 8,078,770 (GRCm39) missense probably damaging 1.00
R4947:Slc22a28 UTSW 19 8,108,816 (GRCm39) missense probably benign 0.03
R5573:Slc22a28 UTSW 19 8,048,462 (GRCm39) missense possibly damaging 0.50
R5611:Slc22a28 UTSW 19 8,040,698 (GRCm39) missense probably damaging 1.00
R5621:Slc22a28 UTSW 19 8,048,376 (GRCm39) missense probably benign 0.00
R5671:Slc22a28 UTSW 19 8,108,795 (GRCm39) missense probably damaging 1.00
R6063:Slc22a28 UTSW 19 8,094,386 (GRCm39) missense probably benign 0.01
R6358:Slc22a28 UTSW 19 8,049,253 (GRCm39) missense probably damaging 0.99
R6385:Slc22a28 UTSW 19 8,078,844 (GRCm39) missense probably damaging 0.99
R6680:Slc22a28 UTSW 19 8,078,757 (GRCm39) missense probably benign 0.07
R6767:Slc22a28 UTSW 19 8,094,409 (GRCm39) missense probably damaging 1.00
R6865:Slc22a28 UTSW 19 8,041,856 (GRCm39) nonsense probably null
R6947:Slc22a28 UTSW 19 8,041,875 (GRCm39) missense possibly damaging 0.58
R7049:Slc22a28 UTSW 19 8,049,270 (GRCm39) missense probably benign
R7269:Slc22a28 UTSW 19 8,094,491 (GRCm39) missense probably benign 0.06
R7823:Slc22a28 UTSW 19 8,041,890 (GRCm39) missense probably benign 0.38
R7856:Slc22a28 UTSW 19 8,040,698 (GRCm39) missense probably damaging 1.00
R7980:Slc22a28 UTSW 19 8,078,837 (GRCm39) missense probably damaging 0.99
R8323:Slc22a28 UTSW 19 8,108,788 (GRCm39) missense probably damaging 1.00
R8404:Slc22a28 UTSW 19 8,108,793 (GRCm39) nonsense probably null
R8435:Slc22a28 UTSW 19 8,048,565 (GRCm39) missense probably benign 0.13
R8529:Slc22a28 UTSW 19 8,040,778 (GRCm39) missense probably benign 0.01
R9149:Slc22a28 UTSW 19 8,049,205 (GRCm39) missense probably benign 0.00
R9727:Slc22a28 UTSW 19 8,108,818 (GRCm39) missense probably benign
R9782:Slc22a28 UTSW 19 8,041,813 (GRCm39) missense probably null 1.00
Z1088:Slc22a28 UTSW 19 8,039,763 (GRCm39) missense probably damaging 0.96
Z1176:Slc22a28 UTSW 19 8,039,748 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGTTTCCAGCATGGCAACC -3'
(R):5'- CGATGTGATCACTCATTACACAATG -3'

Sequencing Primer
(F):5'- CCAGCATGGCAACCAGAAATTATTTG -3'
(R):5'- TCATTACACAATGATTCTTGGTAGC -3'
Posted On 2019-10-07