Incidental Mutation 'R7486:Robo4'
| ID |
580175 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo4
|
| Ensembl Gene |
ENSMUSG00000032125 |
| Gene Name |
roundabout guidance receptor 4 |
| Synonyms |
Magic roundabout, 1200012D01Rik |
| MMRRC Submission |
045560-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.224)
|
| Stock # |
R7486 (G1)
|
| Quality Score |
223.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
37313198-37325319 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 37316870 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 395
(V395A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150722
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102895]
[ENSMUST00000115046]
[ENSMUST00000115048]
[ENSMUST00000156972]
[ENSMUST00000214185]
|
| AlphaFold |
Q8C310 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102895
AA Change: V395A
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000099959
Gene: ENSMUSG00000032125
AA Change: V395A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
748 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
871 |
880 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115046
AA Change: V395A
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000110698
Gene: ENSMUSG00000032125
AA Change: V395A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
484 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
546 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
756 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
834 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
925 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000110700
Gene: ENSMUSG00000032125
AA Change: V284A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
695 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
769 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
806 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
887 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156972
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000214185
AA Change: V395A
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam21 |
T |
C |
12: 81,605,657 (GRCm39) |
I702V |
probably benign |
Het |
| Adgre5 |
T |
C |
8: 84,450,515 (GRCm39) |
E815G |
probably damaging |
Het |
| Adgrl2 |
A |
G |
3: 148,523,330 (GRCm39) |
V298A |
|
Het |
| Akp3 |
A |
G |
1: 87,053,201 (GRCm39) |
D91G |
probably damaging |
Het |
| Ano8 |
A |
G |
8: 71,937,642 (GRCm39) |
|
probably null |
Het |
| Blvra |
T |
C |
2: 126,929,243 (GRCm39) |
S136P |
unknown |
Het |
| Cacul1 |
T |
A |
19: 60,568,868 (GRCm39) |
M97L |
probably benign |
Het |
| Ccdc80 |
T |
C |
16: 44,946,542 (GRCm39) |
V827A |
probably damaging |
Het |
| Cep68 |
T |
C |
11: 20,192,166 (GRCm39) |
E11G |
probably benign |
Het |
| Cfap221 |
A |
T |
1: 119,851,322 (GRCm39) |
V813E |
possibly damaging |
Het |
| Chd6 |
A |
G |
2: 160,791,923 (GRCm39) |
V2478A |
probably damaging |
Het |
| Chmp6 |
T |
C |
11: 119,807,783 (GRCm39) |
F148S |
probably benign |
Het |
| Clca3a2 |
T |
A |
3: 144,503,362 (GRCm39) |
I863F |
probably damaging |
Het |
| Cnnm2 |
T |
C |
19: 46,750,513 (GRCm39) |
V101A |
possibly damaging |
Het |
| Cpne8 |
A |
T |
15: 90,400,109 (GRCm39) |
|
probably null |
Het |
| Dmbt1 |
T |
G |
7: 130,668,192 (GRCm39) |
C483G |
unknown |
Het |
| Dnah7b |
G |
A |
1: 46,329,894 (GRCm39) |
G3246D |
probably damaging |
Het |
| Dnajc3 |
C |
A |
14: 119,209,816 (GRCm39) |
T297K |
probably benign |
Het |
| Dpm3 |
A |
G |
3: 89,174,034 (GRCm39) |
|
probably null |
Het |
| Eef2k |
A |
G |
7: 120,457,793 (GRCm39) |
N51D |
probably benign |
Het |
| Erc1 |
G |
A |
6: 119,571,907 (GRCm39) |
Q1022* |
probably null |
Het |
| Ercc5 |
T |
A |
1: 44,187,224 (GRCm39) |
M1K |
probably null |
Het |
| Fam114a2 |
C |
T |
11: 57,404,515 (GRCm39) |
G83D |
probably damaging |
Het |
| Fat4 |
C |
A |
3: 39,011,576 (GRCm39) |
Y2225* |
probably null |
Het |
| Frk |
G |
A |
10: 34,423,292 (GRCm39) |
W123* |
probably null |
Het |
| Gm11568 |
T |
A |
11: 99,749,292 (GRCm39) |
C166S |
unknown |
Het |
| Gpr153 |
A |
G |
4: 152,366,858 (GRCm39) |
D337G |
probably benign |
Het |
| Gpt2 |
T |
C |
8: 86,252,235 (GRCm39) |
F517L |
probably damaging |
Het |
| Gsg1 |
C |
T |
6: 135,214,427 (GRCm39) |
E361K |
probably benign |
Het |
| Hsfy2 |
G |
A |
1: 56,676,130 (GRCm39) |
R136* |
probably null |
Het |
| Insm1 |
G |
A |
2: 146,065,738 (GRCm39) |
R518H |
probably damaging |
Het |
| Kank1 |
G |
A |
19: 25,388,193 (GRCm39) |
C622Y |
probably damaging |
Het |
| Katnb1 |
T |
A |
8: 95,825,357 (GRCm39) |
S640R |
probably damaging |
Het |
| Kcnmb4 |
A |
G |
10: 116,254,180 (GRCm39) |
V199A |
probably benign |
Het |
| Lamb1 |
T |
G |
12: 31,337,441 (GRCm39) |
S391A |
probably benign |
Het |
| Larp7-ps |
A |
T |
4: 92,079,506 (GRCm39) |
V105E |
probably benign |
Het |
| Macf1 |
T |
G |
4: 123,303,374 (GRCm39) |
D376A |
probably benign |
Het |
| Map7d1 |
C |
A |
4: 126,128,179 (GRCm39) |
R614L |
unknown |
Het |
| Mcm8 |
C |
T |
2: 132,681,440 (GRCm39) |
R667W |
probably damaging |
Het |
| Med13l |
C |
T |
5: 118,866,539 (GRCm39) |
T531I |
probably benign |
Het |
| Mstn |
G |
T |
1: 53,103,128 (GRCm39) |
A155S |
probably damaging |
Het |
| Mycbp2 |
C |
T |
14: 103,434,690 (GRCm39) |
R2251K |
probably damaging |
Het |
| Myo19 |
T |
C |
11: 84,796,463 (GRCm39) |
S692P |
probably benign |
Het |
| Nipbl |
A |
T |
15: 8,325,120 (GRCm39) |
N2514K |
probably benign |
Het |
| Nkd2 |
T |
A |
13: 73,995,561 (GRCm39) |
|
probably benign |
Het |
| Nox3 |
T |
A |
17: 3,720,219 (GRCm39) |
Y322F |
probably damaging |
Het |
| Nt5dc1 |
A |
G |
10: 34,275,805 (GRCm39) |
Y135H |
probably benign |
Het |
| Oog3 |
T |
A |
4: 143,884,742 (GRCm39) |
H398L |
probably benign |
Het |
| Or10g9 |
T |
A |
9: 39,912,181 (GRCm39) |
Y114F |
probably benign |
Het |
| Or12j4 |
C |
T |
7: 140,045,947 (GRCm39) |
|
probably benign |
Het |
| Or1e29 |
T |
C |
11: 73,667,847 (GRCm39) |
Y102C |
probably damaging |
Het |
| Otogl |
A |
G |
10: 107,657,849 (GRCm39) |
L1027P |
probably damaging |
Het |
| Pcdh20 |
T |
A |
14: 88,706,050 (GRCm39) |
I417F |
possibly damaging |
Het |
| Pcdha12 |
T |
A |
18: 37,154,610 (GRCm39) |
V443E |
probably damaging |
Het |
| Pcdhga2 |
A |
G |
18: 37,803,461 (GRCm39) |
D435G |
probably benign |
Het |
| Pcnt |
G |
T |
10: 76,254,270 (GRCm39) |
T853K |
probably benign |
Het |
| Pcnt |
T |
C |
10: 76,254,271 (GRCm39) |
T853A |
probably benign |
Het |
| Pgghg |
T |
A |
7: 140,522,393 (GRCm39) |
S57R |
probably benign |
Het |
| Ppm1m |
T |
C |
9: 106,073,810 (GRCm39) |
D301G |
probably damaging |
Het |
| Ppp6r1 |
A |
G |
7: 4,642,899 (GRCm39) |
V519A |
probably benign |
Het |
| Prss41 |
ACAGCAGCAGCAGCAGCAGCA |
ACAGCAGCAGCAGCAGCA |
17: 24,063,072 (GRCm39) |
|
probably benign |
Het |
| Rasa3 |
C |
T |
8: 13,640,201 (GRCm39) |
|
probably null |
Het |
| Scrib |
A |
G |
15: 75,929,499 (GRCm39) |
S1123P |
probably damaging |
Het |
| Setd1b |
A |
G |
5: 123,301,655 (GRCm39) |
K45E |
probably benign |
Het |
| Slc14a1 |
T |
C |
18: 78,154,739 (GRCm39) |
S216G |
probably benign |
Het |
| Slc25a45 |
A |
G |
19: 5,934,997 (GRCm39) |
Y282C |
probably damaging |
Het |
| Slc6a5 |
T |
C |
7: 49,567,078 (GRCm39) |
S255P |
possibly damaging |
Het |
| Smc2 |
A |
T |
4: 52,462,861 (GRCm39) |
Q617L |
possibly damaging |
Het |
| Spo11 |
G |
A |
2: 172,825,870 (GRCm39) |
D103N |
probably benign |
Het |
| Tcf20 |
A |
T |
15: 82,737,935 (GRCm39) |
M1172K |
possibly damaging |
Het |
| Tesc |
T |
A |
5: 118,184,382 (GRCm39) |
S21T |
probably benign |
Het |
| Tie1 |
C |
A |
4: 118,337,101 (GRCm39) |
|
probably null |
Het |
| Trim24 |
T |
G |
6: 37,934,774 (GRCm39) |
|
probably null |
Het |
| Trpm7 |
A |
G |
2: 126,673,115 (GRCm39) |
|
probably null |
Het |
| Unc13d |
T |
C |
11: 115,965,259 (GRCm39) |
D193G |
possibly damaging |
Het |
| Upk3a |
A |
T |
15: 84,902,225 (GRCm39) |
|
probably null |
Het |
| Vmn2r25 |
T |
C |
6: 123,800,101 (GRCm39) |
N747S |
probably damaging |
Het |
| Wipf1 |
GCCTCCTCCTCCTCCTCCTCCTCC |
GCCTCCTCCTCCTCCTCCTCC |
2: 73,270,418 (GRCm39) |
|
probably benign |
Het |
| Zbtb2 |
G |
A |
10: 4,319,025 (GRCm39) |
Q334* |
probably null |
Het |
| Zfp653 |
T |
C |
9: 21,967,824 (GRCm39) |
N494D |
probably damaging |
Het |
| Zfp865 |
A |
G |
7: 5,034,259 (GRCm39) |
D748G |
possibly damaging |
Het |
| Zzef1 |
T |
C |
11: 72,755,612 (GRCm39) |
S1014P |
possibly damaging |
Het |
|
| Other mutations in Robo4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Robo4
|
APN |
9 |
37,322,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Robo4
|
APN |
9 |
37,319,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00491:Robo4
|
APN |
9 |
37,317,231 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL00792:Robo4
|
APN |
9 |
37,319,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Robo4
|
APN |
9 |
37,317,296 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01287:Robo4
|
APN |
9 |
37,324,336 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02289:Robo4
|
APN |
9 |
37,319,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02486:Robo4
|
APN |
9 |
37,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02851:Robo4
|
APN |
9 |
37,324,678 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02898:Robo4
|
APN |
9 |
37,319,472 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02965:Robo4
|
APN |
9 |
37,321,765 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03071:Robo4
|
APN |
9 |
37,315,580 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Robo4
|
APN |
9 |
37,315,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Robo4
|
UTSW |
9 |
37,317,106 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Robo4
|
UTSW |
9 |
37,322,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0068:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Robo4
|
UTSW |
9 |
37,316,062 (GRCm39) |
splice site |
probably benign |
|
|
R1005:Robo4
|
UTSW |
9 |
37,319,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Robo4
|
UTSW |
9 |
37,324,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1183:Robo4
|
UTSW |
9 |
37,319,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1254:Robo4
|
UTSW |
9 |
37,322,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1398:Robo4
|
UTSW |
9 |
37,319,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1505:Robo4
|
UTSW |
9 |
37,314,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Robo4
|
UTSW |
9 |
37,314,739 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1834:Robo4
|
UTSW |
9 |
37,324,355 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1899:Robo4
|
UTSW |
9 |
37,315,366 (GRCm39) |
splice site |
probably benign |
|
|
R2203:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2204:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2351:Robo4
|
UTSW |
9 |
37,322,956 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2448:Robo4
|
UTSW |
9 |
37,313,958 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2847:Robo4
|
UTSW |
9 |
37,315,772 (GRCm39) |
nonsense |
probably null |
|
|
R2851:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2852:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2877:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3123:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3124:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3125:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3805:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3806:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3892:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3905:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R3938:Robo4
|
UTSW |
9 |
37,313,313 (GRCm39) |
start gained |
probably benign |
|
|
R4261:Robo4
|
UTSW |
9 |
37,316,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4434:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4435:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4561:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4562:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Robo4
|
UTSW |
9 |
37,316,118 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4695:Robo4
|
UTSW |
9 |
37,314,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Robo4
|
UTSW |
9 |
37,313,856 (GRCm39) |
missense |
probably benign |
|
|
R5000:Robo4
|
UTSW |
9 |
37,319,664 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5056:Robo4
|
UTSW |
9 |
37,316,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5279:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5285:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5347:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5348:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5361:Robo4
|
UTSW |
9 |
37,324,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5403:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5404:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5488:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5489:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5490:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5494:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5629:Robo4
|
UTSW |
9 |
37,319,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5736:Robo4
|
UTSW |
9 |
37,316,093 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5796:Robo4
|
UTSW |
9 |
37,322,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Robo4
|
UTSW |
9 |
37,322,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6178:Robo4
|
UTSW |
9 |
37,316,926 (GRCm39) |
nonsense |
probably null |
|
|
R6189:Robo4
|
UTSW |
9 |
37,314,829 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6365:Robo4
|
UTSW |
9 |
37,322,008 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6528:Robo4
|
UTSW |
9 |
37,315,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6887:Robo4
|
UTSW |
9 |
37,313,363 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7196:Robo4
|
UTSW |
9 |
37,314,001 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7408:Robo4
|
UTSW |
9 |
37,322,277 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7419:Robo4
|
UTSW |
9 |
37,314,105 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7707:Robo4
|
UTSW |
9 |
37,324,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7839:Robo4
|
UTSW |
9 |
37,322,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8079:Robo4
|
UTSW |
9 |
37,313,931 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8081:Robo4
|
UTSW |
9 |
37,316,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8280:Robo4
|
UTSW |
9 |
37,315,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R8547:Robo4
|
UTSW |
9 |
37,315,674 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8735:Robo4
|
UTSW |
9 |
37,319,577 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8836:Robo4
|
UTSW |
9 |
37,317,130 (GRCm39) |
missense |
unknown |
|
|
R8889:Robo4
|
UTSW |
9 |
37,314,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Robo4
|
UTSW |
9 |
37,315,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Robo4
|
UTSW |
9 |
37,313,206 (GRCm39) |
start gained |
probably benign |
|
|
R9375:Robo4
|
UTSW |
9 |
37,316,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9621:Robo4
|
UTSW |
9 |
37,317,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACTTGTCCTGGGTGTAATGTAACAG -3'
(R):5'- GCCTTTCCCTCACCTAAAAGG -3'
Sequencing Primer
(F):5'- GTCCTGGGTGTAATGTAACAGATTAC -3'
(R):5'- TTTCCCTCACCTAAAAGGAGGCAG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation