Incidental Mutation 'R7653:Zfp366'
ID 580500
Institutional Source Beutler Lab
Gene Symbol Zfp366
Ensembl Gene ENSMUSG00000050919
Gene Name zinc finger protein 366
Synonyms DC-SCRIPT
MMRRC Submission 045730-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.331) question?
Stock # R7653 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 99321331-99383540 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99365709 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 290 (L290P)
Ref Sequence ENSEMBL: ENSMUSP00000060040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056558]
AlphaFold Q6NS86
Predicted Effect probably damaging
Transcript: ENSMUST00000056558
AA Change: L290P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000060040
Gene: ENSMUSG00000050919
AA Change: L290P

DomainStartEndE-ValueType
low complexity region 159 175 N/A INTRINSIC
low complexity region 183 196 N/A INTRINSIC
ZnF_C2H2 250 272 1.18e-2 SMART
ZnF_C2H2 278 300 4.05e-1 SMART
ZnF_C2H2 306 328 1.79e-2 SMART
ZnF_C2H2 334 356 1.53e-1 SMART
ZnF_C2H2 362 384 1.89e-1 SMART
ZnF_C2H2 390 412 1.22e-4 SMART
ZnF_C2H2 418 440 1.36e-2 SMART
ZnF_C2H2 446 468 1.1e-2 SMART
ZnF_C2H2 474 496 8.34e-3 SMART
ZnF_C2H2 502 524 5.42e-2 SMART
ZnF_C2H2 530 553 2.4e-3 SMART
low complexity region 615 623 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit perimembranous and muscular ventricular septal defects (VSD), and overriding aorta. Short snout, micrognathia, micropthalmia, hypoplastic thymus, and hydronephrosis are also observed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730049H05Rik A T 6: 92,805,050 (GRCm39) Q70L unknown Het
Adamts12 T A 15: 11,257,115 (GRCm39) N489K probably benign Het
Alms1 A G 6: 85,597,577 (GRCm39) D801G possibly damaging Het
Apex1 T G 14: 51,163,995 (GRCm39) N173K probably damaging Het
Arhgap32 A T 9: 32,168,441 (GRCm39) N808I probably benign Het
Arhgef28 T C 13: 98,105,821 (GRCm39) Y706C probably benign Het
Atg2b A T 12: 105,602,731 (GRCm39) F1604Y possibly damaging Het
Atm A T 9: 53,401,602 (GRCm39) Y1422* probably null Het
Bace2 T A 16: 97,237,852 (GRCm39) V38E Het
Birc6 C A 17: 74,954,729 (GRCm39) L3442I possibly damaging Het
C6 T A 15: 4,844,244 (GRCm39) S889T Het
Calcrl A T 2: 84,175,529 (GRCm39) L275* probably null Het
Casp6 T C 3: 129,705,872 (GRCm39) Y180H probably benign Het
Cd5 T C 19: 10,703,910 (GRCm39) M51V probably benign Het
Cdhr1 G T 14: 36,804,158 (GRCm39) P500Q probably benign Het
Celsr3 G A 9: 108,712,269 (GRCm39) W1732* probably null Het
Ces2g T C 8: 105,689,285 (GRCm39) V87A probably damaging Het
Chil6 T C 3: 106,301,641 (GRCm39) N153S possibly damaging Het
Chrna5 A T 9: 54,909,718 (GRCm39) D113V probably benign Het
Cimip2b T G 4: 43,427,273 (GRCm39) probably null Het
Cox20 A G 1: 178,150,164 (GRCm39) T113A probably benign Het
Cryl1 T C 14: 57,541,148 (GRCm39) I179V probably benign Het
Dennd3 A G 15: 73,434,275 (GRCm39) T982A probably damaging Het
Drosha G A 15: 12,859,522 (GRCm39) V577I probably benign Het
Dync2h1 A G 9: 7,117,570 (GRCm39) S2240P probably benign Het
Eif1ad14 T A 12: 87,886,248 (GRCm39) D127V unknown Het
Fbxl5 C T 5: 43,916,116 (GRCm39) S432N probably benign Het
Fez1 T A 9: 36,772,146 (GRCm39) S150R probably benign Het
Gabrb2 T G 11: 42,378,039 (GRCm39) M85R probably damaging Het
Lhx4 A G 1: 155,580,617 (GRCm39) V203A probably damaging Het
Med23 G A 10: 24,780,282 (GRCm39) D977N probably damaging Het
Mplkip T C 13: 17,870,367 (GRCm39) F100L probably damaging Het
Ncoa7 C T 10: 30,570,239 (GRCm39) G240E probably damaging Het
Nedd4 A G 9: 72,650,910 (GRCm39) E827G probably damaging Het
Nfatc2 A G 2: 168,413,065 (GRCm39) F207L probably benign Het
Nr2f1 A T 13: 78,343,716 (GRCm39) S183T probably benign Het
Ocel1 A G 8: 71,824,560 (GRCm39) E81G probably benign Het
Or10aa3 T C 1: 173,878,488 (GRCm39) V183A probably benign Het
Or10g3b C A 14: 52,586,889 (GRCm39) G205* probably null Het
Or4n4b C T 14: 50,536,604 (GRCm39) G54E possibly damaging Het
Pcdh8 G A 14: 80,005,086 (GRCm39) P980S probably benign Het
Pex26 A T 6: 121,170,510 (GRCm39) Q285L possibly damaging Het
Pgap6 T A 17: 26,339,423 (GRCm39) M579K probably damaging Het
Plce1 A T 19: 38,737,763 (GRCm39) N1603I probably benign Het
Poli A T 18: 70,642,698 (GRCm39) C501S probably benign Het
Ppp4r4 C T 12: 103,550,404 (GRCm39) T276I probably damaging Het
Rbpj T A 5: 53,747,693 (GRCm39) M1K probably null Het
Recql4 T A 15: 76,587,982 (GRCm39) M1204L probably benign Het
Ribc2 T C 15: 85,025,876 (GRCm39) I284T probably benign Het
Rreb1 C A 13: 38,114,362 (GRCm39) Q574K probably benign Het
Scn9a A T 2: 66,357,424 (GRCm39) L959Q probably damaging Het
Shank1 C A 7: 43,969,093 (GRCm39) H329Q unknown Het
Soat2 A T 15: 102,071,013 (GRCm39) D469V probably damaging Het
Spag7 T A 11: 70,555,691 (GRCm39) H82L probably damaging Het
Sptb T C 12: 76,675,271 (GRCm39) I248V probably benign Het
Tacr3 A G 3: 134,566,843 (GRCm39) I239V probably benign Het
Tbc1d1 T C 5: 64,414,133 (GRCm39) F165L probably benign Het
Tchhl1 A G 3: 93,378,451 (GRCm39) E385G probably benign Het
Tecta C T 9: 42,248,532 (GRCm39) D1957N probably damaging Het
Tenm2 T C 11: 35,938,174 (GRCm39) I1501V probably benign Het
Tet2 G T 3: 133,192,146 (GRCm39) Q763K probably benign Het
Timd6 A C 11: 46,475,200 (GRCm39) S132R probably benign Het
Tox3 G A 8: 90,975,617 (GRCm39) T338I probably damaging Het
Usp30 G A 5: 114,259,730 (GRCm39) D479N probably damaging Het
Vmn1r27 T C 6: 58,192,785 (GRCm39) D73G possibly damaging Het
Vmn1r27 A T 6: 58,192,879 (GRCm39) S42T probably benign Het
Vmn2r120 A T 17: 57,816,258 (GRCm39) V699D possibly damaging Het
Vwa2 A T 19: 56,897,767 (GRCm39) T691S probably benign Het
Wdr31 T A 4: 62,381,666 (GRCm39) Q55L probably benign Het
Xdh A G 17: 74,204,040 (GRCm39) F1107L probably benign Het
Zfp184 A G 13: 22,143,887 (GRCm39) H531R probably damaging Het
Other mutations in Zfp366
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Zfp366 APN 13 99,383,080 (GRCm39) utr 3 prime probably benign
IGL01626:Zfp366 APN 13 99,364,920 (GRCm39) missense probably damaging 0.99
IGL02227:Zfp366 APN 13 99,370,696 (GRCm39) missense possibly damaging 0.85
IGL03074:Zfp366 APN 13 99,382,913 (GRCm39) missense probably benign
R0126:Zfp366 UTSW 13 99,365,129 (GRCm39) missense probably benign 0.14
R0145:Zfp366 UTSW 13 99,366,048 (GRCm39) missense probably damaging 1.00
R0234:Zfp366 UTSW 13 99,370,768 (GRCm39) missense probably damaging 1.00
R0234:Zfp366 UTSW 13 99,370,768 (GRCm39) missense probably damaging 1.00
R0376:Zfp366 UTSW 13 99,370,759 (GRCm39) missense probably benign 0.00
R0537:Zfp366 UTSW 13 99,365,786 (GRCm39) missense probably damaging 1.00
R0637:Zfp366 UTSW 13 99,365,474 (GRCm39) missense probably damaging 0.99
R0838:Zfp366 UTSW 13 99,365,118 (GRCm39) missense possibly damaging 0.73
R1386:Zfp366 UTSW 13 99,383,063 (GRCm39) missense probably damaging 0.98
R1422:Zfp366 UTSW 13 99,365,804 (GRCm39) missense probably damaging 1.00
R1669:Zfp366 UTSW 13 99,366,069 (GRCm39) missense probably damaging 0.99
R1839:Zfp366 UTSW 13 99,365,000 (GRCm39) missense probably damaging 0.98
R3751:Zfp366 UTSW 13 99,365,352 (GRCm39) missense probably damaging 1.00
R4782:Zfp366 UTSW 13 99,382,991 (GRCm39) missense probably damaging 1.00
R4908:Zfp366 UTSW 13 99,370,609 (GRCm39) missense possibly damaging 0.68
R4992:Zfp366 UTSW 13 99,366,003 (GRCm39) missense possibly damaging 0.62
R5040:Zfp366 UTSW 13 99,364,875 (GRCm39) missense probably damaging 1.00
R5086:Zfp366 UTSW 13 99,365,451 (GRCm39) missense probably benign 0.00
R5186:Zfp366 UTSW 13 99,382,676 (GRCm39) missense probably benign 0.00
R5249:Zfp366 UTSW 13 99,366,117 (GRCm39) missense probably damaging 1.00
R5450:Zfp366 UTSW 13 99,366,093 (GRCm39) missense probably damaging 1.00
R6838:Zfp366 UTSW 13 99,382,685 (GRCm39) missense possibly damaging 0.83
R6838:Zfp366 UTSW 13 99,365,015 (GRCm39) missense possibly damaging 0.93
R7250:Zfp366 UTSW 13 99,366,076 (GRCm39) missense probably damaging 1.00
R7378:Zfp366 UTSW 13 99,366,023 (GRCm39) missense probably damaging 1.00
R7571:Zfp366 UTSW 13 99,382,895 (GRCm39) missense probably benign 0.03
R7624:Zfp366 UTSW 13 99,382,804 (GRCm39) missense probably benign
R8367:Zfp366 UTSW 13 99,380,551 (GRCm39) missense possibly damaging 0.95
R9510:Zfp366 UTSW 13 99,365,874 (GRCm39) missense probably damaging 1.00
R9658:Zfp366 UTSW 13 99,365,435 (GRCm39) missense probably benign 0.13
R9734:Zfp366 UTSW 13 99,365,352 (GRCm39) missense probably damaging 1.00
Z1176:Zfp366 UTSW 13 99,382,858 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GATCGACGACAGCTACTACG -3'
(R):5'- GCACTCCACACAAATGTTTTCG -3'

Sequencing Primer
(F):5'- CGACAGCTACTACGTGGATGTG -3'
(R):5'- ACAAATGTTTTCGCGCCCG -3'
Posted On 2019-10-07