Incidental Mutation 'R7436:Dzip3'
ID 580579
Institutional Source Beutler Lab
Gene Symbol Dzip3
Ensembl Gene ENSMUSG00000064061
Gene Name DAZ interacting protein 3, zinc finger
Synonyms 2A-HUB, 2310047C04Rik, 6430549P11Rik
MMRRC Submission 045512-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7436 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 48744591-48814505 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 48772352 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 439 (H439L)
Ref Sequence ENSEMBL: ENSMUSP00000113344 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114516] [ENSMUST00000121869]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000114516
SMART Domains Protein: ENSMUSP00000110161
Gene: ENSMUSG00000064061

DomainStartEndE-ValueType
low complexity region 451 472 N/A INTRINSIC
coiled coil region 548 568 N/A INTRINSIC
coiled coil region 599 650 N/A INTRINSIC
low complexity region 743 754 N/A INTRINSIC
low complexity region 883 891 N/A INTRINSIC
RING 938 977 2.09e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000121869
AA Change: H439L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113344
Gene: ENSMUSG00000064061
AA Change: H439L

DomainStartEndE-ValueType
low complexity region 657 678 N/A INTRINSIC
coiled coil region 754 774 N/A INTRINSIC
coiled coil region 805 856 N/A INTRINSIC
low complexity region 949 960 N/A INTRINSIC
low complexity region 1089 1097 N/A INTRINSIC
RING 1144 1183 2.09e-7 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 97% (66/68)
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-indcued allele exhibit embryonic lethality. [provided by MGI curators]
Allele List at MGI

All alleles(23) : Gene trapped(23)

Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700024B05Rik A G 14: 41,805,178 (GRCm39) probably null Het
2310034C09Rik A G 16: 88,556,242 (GRCm39) Y152C probably benign Het
Acads C A 5: 115,249,057 (GRCm39) Q365H probably damaging Het
Akap1 A G 11: 88,736,354 (GRCm39) S103P probably damaging Het
Ampd1 T A 3: 102,981,435 (GRCm39) probably null Het
Apoa1 T A 9: 46,141,100 (GRCm39) probably null Het
Asb16 A G 11: 102,163,481 (GRCm39) D157G possibly damaging Het
Bank1 T C 3: 135,761,561 (GRCm39) N748D possibly damaging Het
BC034090 C A 1: 155,102,127 (GRCm39) G46W probably damaging Het
Ccdc202 A T 14: 96,120,027 (GRCm39) K261N probably benign Het
Ccdc73 T A 2: 104,782,214 (GRCm39) V190E probably damaging Het
Cracd GCGCGAGGCCGAGAGGCAGGAGGAGGAAGCAAGACAACGCGAGGCCGAGAGGCAGG GCGCGAGGCCGAGAGGCAGG 5: 77,004,801 (GRCm39) probably benign Het
Cyb561a3 A G 19: 10,559,696 (GRCm39) Y7C probably damaging Het
Cyp2t4 A T 7: 26,857,668 (GRCm39) D427V probably damaging Het
Cyp4f14 T C 17: 33,128,131 (GRCm39) T295A probably benign Het
D430041D05Rik T C 2: 104,087,447 (GRCm39) T510A probably benign Het
Dennd6a G T 14: 26,300,865 (GRCm39) E26* probably null Het
Dusp10 T C 1: 183,801,418 (GRCm39) I395T probably damaging Het
Heatr5b T A 17: 79,075,962 (GRCm39) D1452V probably benign Het
Hsd3b2 A G 3: 98,619,112 (GRCm39) F278L probably benign Het
Hspg2 T A 4: 137,242,975 (GRCm39) M702K probably damaging Het
Hydin T C 8: 111,310,546 (GRCm39) F4081L probably damaging Het
Ido1 T G 8: 25,076,932 (GRCm39) T209P probably benign Het
Ift122 C T 6: 115,903,263 (GRCm39) R1176C probably benign Het
Ipo8 T C 6: 148,691,303 (GRCm39) Y689C probably benign Het
Macf1 C T 4: 123,350,436 (GRCm39) R3809Q probably benign Het
Manea T C 4: 26,328,228 (GRCm39) Y271C probably damaging Het
Mroh2b A G 15: 4,971,036 (GRCm39) T1014A probably benign Het
Nek5 A G 8: 22,598,056 (GRCm39) F200L probably damaging Het
Nipal1 A G 5: 72,824,984 (GRCm39) I226V probably benign Het
Nipsnap3a A T 4: 52,994,159 (GRCm39) N80I probably damaging Het
Nmur1 G A 1: 86,314,100 (GRCm39) P389S probably benign Het
Or10d5 G T 9: 39,861,349 (GRCm39) C239* probably null Het
Or1p1 T C 11: 74,179,511 (GRCm39) L13P possibly damaging Het
Or8u10 T C 2: 85,915,251 (GRCm39) Y290C probably damaging Het
Patl2 A C 2: 121,958,006 (GRCm39) V84G probably benign Het
Pcdhb4 T C 18: 37,442,328 (GRCm39) V546A probably damaging Het
Phf20l1 G T 15: 66,469,599 (GRCm39) S168I possibly damaging Het
Phgdh T C 3: 98,247,045 (GRCm39) N35S probably benign Het
Pigw A T 11: 84,768,789 (GRCm39) M180K probably damaging Het
Pkhd1 G T 1: 20,270,925 (GRCm39) H3209Q probably benign Het
Plbd2 A G 5: 120,624,861 (GRCm39) F436L probably damaging Het
Plch2 T C 4: 155,068,553 (GRCm39) T1358A probably benign Het
Poll C T 19: 45,541,496 (GRCm39) V491M probably damaging Het
Polr1e A G 4: 45,024,553 (GRCm39) probably null Het
Ppp1r35 G A 5: 137,778,279 (GRCm39) W258* probably null Het
Ptpdc1 A T 13: 48,740,142 (GRCm39) F430I probably benign Het
Ptprh T C 7: 4,555,742 (GRCm39) E739G probably damaging Het
Ramp2 T C 11: 101,138,765 (GRCm39) V148A possibly damaging Het
Rapgef6 T C 11: 54,501,747 (GRCm39) probably null Het
Rbm5 A G 9: 107,627,593 (GRCm39) probably null Het
Rnf39 A T 17: 37,254,241 (GRCm39) S88C probably benign Het
Rpl12 A G 2: 32,853,836 (GRCm39) I155V probably benign Het
Scart2 A T 7: 139,841,520 (GRCm39) T275S probably benign Het
Senp5 C T 16: 31,794,847 (GRCm39) E596K unknown Het
Serpinb9d A G 13: 33,379,916 (GRCm39) Y85C probably benign Het
Serpinf1 T A 11: 75,307,142 (GRCm39) Y65F probably benign Het
Snrnp200 G A 2: 127,068,404 (GRCm39) probably null Het
Spatc1 A T 15: 76,152,568 (GRCm39) Q66L probably benign Het
Tet3 TGGCCCAGGCCCAGGC TGGCCCAGGCCCAGGCCCAGGC 6: 83,345,211 (GRCm39) probably benign Het
Traf3ip1 A G 1: 91,439,110 (GRCm39) D342G probably benign Het
Txk T A 5: 72,853,922 (GRCm39) T472S probably damaging Het
Ube2j2 T C 4: 156,041,788 (GRCm39) V249A probably damaging Het
Utrn A C 10: 12,315,535 (GRCm39) N3025K possibly damaging Het
Vmn1r17 T A 6: 57,337,862 (GRCm39) M168L probably benign Het
Vmn1r77 T A 7: 11,775,694 (GRCm39) S157T probably benign Het
Zfp977 A G 7: 42,229,884 (GRCm39) S214P probably benign Het
Zscan10 T C 17: 23,828,979 (GRCm39) L507P possibly damaging Het
Other mutations in Dzip3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00825:Dzip3 APN 16 48,748,778 (GRCm39) missense probably damaging 1.00
IGL00931:Dzip3 APN 16 48,755,860 (GRCm39) critical splice donor site probably null
IGL01109:Dzip3 APN 16 48,750,037 (GRCm39) missense probably benign 0.27
IGL01121:Dzip3 APN 16 48,765,244 (GRCm39) missense probably benign 0.10
IGL01328:Dzip3 APN 16 48,792,621 (GRCm39) missense probably damaging 1.00
IGL01729:Dzip3 APN 16 48,748,726 (GRCm39) missense possibly damaging 0.78
IGL02044:Dzip3 APN 16 48,768,790 (GRCm39) missense possibly damaging 0.90
IGL02051:Dzip3 APN 16 48,792,617 (GRCm39) missense probably benign 0.01
IGL02115:Dzip3 APN 16 48,768,848 (GRCm39) missense probably benign 0.00
IGL02125:Dzip3 APN 16 48,747,959 (GRCm39) missense probably damaging 1.00
IGL02136:Dzip3 APN 16 48,747,945 (GRCm39) missense possibly damaging 0.94
IGL02244:Dzip3 APN 16 48,801,351 (GRCm39) missense probably benign 0.01
IGL02253:Dzip3 APN 16 48,765,287 (GRCm39) missense probably benign 0.34
IGL02412:Dzip3 APN 16 48,778,820 (GRCm39) missense probably benign 0.00
IGL02452:Dzip3 APN 16 48,758,900 (GRCm39) splice site probably benign
IGL02481:Dzip3 APN 16 48,795,914 (GRCm39) splice site probably benign
IGL02499:Dzip3 APN 16 48,754,213 (GRCm39) missense probably damaging 1.00
IGL02511:Dzip3 APN 16 48,757,343 (GRCm39) missense possibly damaging 0.75
IGL02519:Dzip3 APN 16 48,748,759 (GRCm39) missense probably damaging 1.00
IGL02610:Dzip3 APN 16 48,772,016 (GRCm39) missense probably damaging 1.00
IGL03129:Dzip3 APN 16 48,762,446 (GRCm39) missense possibly damaging 0.51
IGL03342:Dzip3 APN 16 48,749,986 (GRCm39) missense probably damaging 0.98
IGL03493:Dzip3 APN 16 48,772,059 (GRCm39) missense probably benign 0.32
corvette UTSW 16 48,747,903 (GRCm39) critical splice donor site probably null
dazwick UTSW 16 48,778,828 (GRCm39) missense possibly damaging 0.90
1mM(1):Dzip3 UTSW 16 48,771,920 (GRCm39) missense probably damaging 1.00
PIT4651001:Dzip3 UTSW 16 48,765,241 (GRCm39) missense probably benign
R0313:Dzip3 UTSW 16 48,757,424 (GRCm39) missense probably damaging 0.99
R0483:Dzip3 UTSW 16 48,768,076 (GRCm39) missense possibly damaging 0.94
R0504:Dzip3 UTSW 16 48,780,006 (GRCm39) splice site probably benign
R0744:Dzip3 UTSW 16 48,780,038 (GRCm39) missense probably damaging 1.00
R0800:Dzip3 UTSW 16 48,774,171 (GRCm39) splice site probably benign
R0927:Dzip3 UTSW 16 48,795,840 (GRCm39) missense probably damaging 0.99
R0931:Dzip3 UTSW 16 48,771,921 (GRCm39) missense probably damaging 1.00
R1170:Dzip3 UTSW 16 48,781,571 (GRCm39) missense probably damaging 1.00
R1203:Dzip3 UTSW 16 48,772,180 (GRCm39) missense probably damaging 1.00
R1205:Dzip3 UTSW 16 48,772,044 (GRCm39) missense probably damaging 1.00
R1442:Dzip3 UTSW 16 48,765,985 (GRCm39) missense probably benign 0.19
R1526:Dzip3 UTSW 16 48,757,369 (GRCm39) missense probably damaging 1.00
R1560:Dzip3 UTSW 16 48,771,903 (GRCm39) splice site probably null
R1585:Dzip3 UTSW 16 48,798,241 (GRCm39) splice site probably benign
R1682:Dzip3 UTSW 16 48,778,780 (GRCm39) critical splice donor site probably null
R1957:Dzip3 UTSW 16 48,747,956 (GRCm39) missense probably damaging 1.00
R2472:Dzip3 UTSW 16 48,774,150 (GRCm39) missense possibly damaging 0.85
R2571:Dzip3 UTSW 16 48,792,581 (GRCm39) splice site probably null
R3040:Dzip3 UTSW 16 48,748,687 (GRCm39) missense probably damaging 1.00
R3081:Dzip3 UTSW 16 48,747,921 (GRCm39) missense probably damaging 1.00
R3615:Dzip3 UTSW 16 48,757,426 (GRCm39) missense probably damaging 1.00
R3616:Dzip3 UTSW 16 48,757,426 (GRCm39) missense probably damaging 1.00
R3786:Dzip3 UTSW 16 48,795,906 (GRCm39) missense probably benign 0.08
R3851:Dzip3 UTSW 16 48,770,376 (GRCm39) missense possibly damaging 0.94
R4097:Dzip3 UTSW 16 48,778,852 (GRCm39) nonsense probably null
R4371:Dzip3 UTSW 16 48,763,818 (GRCm39) critical splice donor site probably null
R4612:Dzip3 UTSW 16 48,772,403 (GRCm39) nonsense probably null
R4671:Dzip3 UTSW 16 48,799,953 (GRCm39) nonsense probably null
R4695:Dzip3 UTSW 16 48,771,924 (GRCm39) missense probably damaging 1.00
R4696:Dzip3 UTSW 16 48,746,332 (GRCm39) unclassified probably benign
R4769:Dzip3 UTSW 16 48,758,837 (GRCm39) missense probably damaging 0.97
R5063:Dzip3 UTSW 16 48,774,117 (GRCm39) nonsense probably null
R5321:Dzip3 UTSW 16 48,778,038 (GRCm39) missense possibly damaging 0.95
R5764:Dzip3 UTSW 16 48,747,724 (GRCm39) intron probably benign
R6020:Dzip3 UTSW 16 48,772,205 (GRCm39) missense probably damaging 1.00
R6218:Dzip3 UTSW 16 48,778,828 (GRCm39) missense possibly damaging 0.90
R6300:Dzip3 UTSW 16 48,772,170 (GRCm39) missense probably damaging 1.00
R6365:Dzip3 UTSW 16 48,751,636 (GRCm39) missense probably damaging 0.96
R6778:Dzip3 UTSW 16 48,802,446 (GRCm39) missense probably benign 0.00
R6915:Dzip3 UTSW 16 48,762,488 (GRCm39) missense possibly damaging 0.72
R7047:Dzip3 UTSW 16 48,802,489 (GRCm39) missense probably benign 0.04
R7059:Dzip3 UTSW 16 48,801,305 (GRCm39) missense probably benign 0.34
R7095:Dzip3 UTSW 16 48,748,153 (GRCm39) missense probably benign
R7227:Dzip3 UTSW 16 48,771,932 (GRCm39) missense probably damaging 0.99
R7319:Dzip3 UTSW 16 48,747,903 (GRCm39) critical splice donor site probably null
R7469:Dzip3 UTSW 16 48,765,242 (GRCm39) missense probably benign
R7526:Dzip3 UTSW 16 48,795,837 (GRCm39) missense probably damaging 0.99
R7964:Dzip3 UTSW 16 48,772,268 (GRCm39) missense probably damaging 1.00
R8131:Dzip3 UTSW 16 48,754,156 (GRCm39) critical splice donor site probably null
R8188:Dzip3 UTSW 16 48,772,499 (GRCm39) missense probably damaging 1.00
R8209:Dzip3 UTSW 16 48,798,307 (GRCm39) missense probably damaging 1.00
R8750:Dzip3 UTSW 16 48,801,338 (GRCm39) missense probably damaging 0.99
R8758:Dzip3 UTSW 16 48,798,300 (GRCm39) missense probably damaging 1.00
R8784:Dzip3 UTSW 16 48,751,628 (GRCm39) missense probably damaging 0.99
R9086:Dzip3 UTSW 16 48,781,493 (GRCm39) missense possibly damaging 0.81
R9157:Dzip3 UTSW 16 48,748,124 (GRCm39) missense probably benign
R9170:Dzip3 UTSW 16 48,772,401 (GRCm39) missense possibly damaging 0.74
R9762:Dzip3 UTSW 16 48,748,707 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGATCAGAAGATGGTGGTTCC -3'
(R):5'- CCTTAGGGTGCAATGTGAGAG -3'

Sequencing Primer
(F):5'- GGTGGTTCCATATCCCAGC -3'
(R):5'- CCTTAGGGTGCAATGTGAGAGACTAC -3'
Posted On 2019-10-07