Incidental Mutation 'R7336:Clasp2'
ID |
580618 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Clasp2
|
Ensembl Gene |
ENSMUSG00000033392 |
Gene Name |
CLIP associating protein 2 |
Synonyms |
CLASP2alpha, 1500004F14Rik, CLASP2gamma, CLASP2, CLASP2beta, 8030404L10Rik |
MMRRC Submission |
045426-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R7336 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
9 |
Chromosomal Location |
113570541-113748750 bp(+) (GRCm39) |
Type of Mutation |
splice site (3 bp from exon) |
DNA Base Change (assembly) |
A to G
at 113705421 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000149670
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000111838]
[ENSMUST00000163895]
[ENSMUST00000166734]
[ENSMUST00000213663]
[ENSMUST00000214522]
[ENSMUST00000215022]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably null
Transcript: ENSMUST00000111838
|
SMART Domains |
Protein: ENSMUSP00000107469 Gene: ENSMUSG00000033392
Domain | Start | End | E-Value | Type |
TOG
|
90 |
323 |
1.17e-8 |
SMART |
low complexity region
|
382 |
395 |
N/A |
INTRINSIC |
low complexity region
|
459 |
472 |
N/A |
INTRINSIC |
low complexity region
|
473 |
484 |
N/A |
INTRINSIC |
low complexity region
|
562 |
572 |
N/A |
INTRINSIC |
low complexity region
|
614 |
634 |
N/A |
INTRINSIC |
TOG
|
640 |
877 |
2.03e-1 |
SMART |
low complexity region
|
995 |
1009 |
N/A |
INTRINSIC |
TOG
|
1043 |
1274 |
1.49e-24 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000163895
|
SMART Domains |
Protein: ENSMUSP00000128460 Gene: ENSMUSG00000033392
Domain | Start | End | E-Value | Type |
TOG
|
90 |
323 |
1.17e-8 |
SMART |
low complexity region
|
382 |
395 |
N/A |
INTRINSIC |
low complexity region
|
459 |
472 |
N/A |
INTRINSIC |
low complexity region
|
473 |
484 |
N/A |
INTRINSIC |
low complexity region
|
583 |
593 |
N/A |
INTRINSIC |
low complexity region
|
635 |
655 |
N/A |
INTRINSIC |
TOG
|
661 |
898 |
2.03e-1 |
SMART |
low complexity region
|
1016 |
1030 |
N/A |
INTRINSIC |
TOG
|
1064 |
1295 |
1.49e-24 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000166734
|
SMART Domains |
Protein: ENSMUSP00000130201 Gene: ENSMUSG00000033392
Domain | Start | End | E-Value | Type |
TOG
|
90 |
323 |
1.17e-8 |
SMART |
low complexity region
|
382 |
395 |
N/A |
INTRINSIC |
low complexity region
|
459 |
472 |
N/A |
INTRINSIC |
low complexity region
|
473 |
484 |
N/A |
INTRINSIC |
low complexity region
|
562 |
572 |
N/A |
INTRINSIC |
low complexity region
|
614 |
634 |
N/A |
INTRINSIC |
TOG
|
640 |
878 |
7.51e-1 |
SMART |
low complexity region
|
996 |
1010 |
N/A |
INTRINSIC |
TOG
|
1044 |
1275 |
1.49e-24 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000213663
|
Predicted Effect |
probably null
Transcript: ENSMUST00000214522
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000215022
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
99% (80/81) |
MGI Phenotype |
PHENOTYPE: Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 79 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl2fm1 |
G |
A |
3: 59,840,174 (GRCm39) |
|
probably null |
Het |
Abca15 |
A |
T |
7: 119,987,456 (GRCm39) |
Q1247H |
possibly damaging |
Het |
Acsf2 |
G |
C |
11: 94,462,476 (GRCm39) |
Q180E |
probably benign |
Het |
Adamts8 |
A |
G |
9: 30,873,363 (GRCm39) |
D856G |
probably benign |
Het |
Agrn |
A |
T |
4: 156,259,371 (GRCm39) |
C828* |
probably null |
Het |
Ankub1 |
T |
C |
3: 57,573,108 (GRCm39) |
T205A |
probably benign |
Het |
Atm |
A |
T |
9: 53,373,803 (GRCm39) |
Y2150N |
possibly damaging |
Het |
Barhl1 |
A |
G |
2: 28,799,855 (GRCm39) |
F257L |
probably benign |
Het |
Bcat2 |
T |
A |
7: 45,224,909 (GRCm39) |
C27S |
probably benign |
Het |
Bod1l |
G |
A |
5: 41,978,867 (GRCm39) |
R816C |
probably damaging |
Het |
Btg3 |
A |
G |
16: 78,161,695 (GRCm39) |
Y172H |
probably benign |
Het |
Cacna1d |
T |
C |
14: 29,767,239 (GRCm39) |
D1940G |
probably benign |
Het |
Catsperg2 |
T |
A |
7: 29,406,026 (GRCm39) |
N624I |
possibly damaging |
Het |
Ccdc146 |
A |
G |
5: 21,508,110 (GRCm39) |
V646A |
probably benign |
Het |
Ccp110 |
C |
T |
7: 118,321,433 (GRCm39) |
P363S |
probably damaging |
Het |
Cct4 |
C |
A |
11: 22,951,564 (GRCm39) |
T377K |
possibly damaging |
Het |
Cemip2 |
C |
A |
19: 21,803,509 (GRCm39) |
Y847* |
probably null |
Het |
Cep350 |
T |
A |
1: 155,738,022 (GRCm39) |
H2607L |
probably benign |
Het |
Cfap46 |
A |
G |
7: 139,200,020 (GRCm39) |
F1954L |
unknown |
Het |
Chat |
C |
T |
14: 32,145,213 (GRCm39) |
|
probably null |
Het |
Cldn9 |
T |
C |
17: 23,901,989 (GRCm39) |
D212G |
probably benign |
Het |
Cp |
G |
A |
3: 20,018,696 (GRCm39) |
|
probably null |
Het |
Cyfip1 |
T |
A |
7: 55,576,148 (GRCm39) |
I1108N |
possibly damaging |
Het |
Dnah14 |
A |
G |
1: 181,625,299 (GRCm39) |
D4060G |
probably damaging |
Het |
Dpyd |
A |
G |
3: 118,858,570 (GRCm39) |
T595A |
probably damaging |
Het |
Eps8 |
G |
A |
6: 137,486,211 (GRCm39) |
R434C |
possibly damaging |
Het |
Fasl |
A |
G |
1: 161,615,557 (GRCm39) |
Y100H |
probably damaging |
Het |
Fkbp9 |
A |
T |
6: 56,826,712 (GRCm39) |
N104I |
probably damaging |
Het |
Frmd4a |
A |
G |
2: 4,478,025 (GRCm39) |
T65A |
possibly damaging |
Het |
Gm1110 |
T |
C |
9: 26,825,653 (GRCm39) |
N102S |
probably damaging |
Het |
Gm2381 |
T |
C |
7: 42,471,804 (GRCm39) |
Q25R |
possibly damaging |
Het |
Gtpbp2 |
A |
G |
17: 46,472,239 (GRCm39) |
Y58C |
probably damaging |
Het |
H2-T3 |
C |
A |
17: 36,498,237 (GRCm39) |
K269N |
probably damaging |
Het |
Icosl |
C |
A |
10: 77,909,707 (GRCm39) |
Y217* |
probably null |
Het |
Il17rd |
G |
T |
14: 26,809,503 (GRCm39) |
R153L |
probably benign |
Het |
Kif17 |
C |
A |
4: 138,025,617 (GRCm39) |
T973K |
possibly damaging |
Het |
Klk1b16 |
A |
G |
7: 43,790,907 (GRCm39) |
I236M |
probably benign |
Het |
Lgmn |
G |
A |
12: 102,389,998 (GRCm39) |
|
probably benign |
Het |
Lmbr1l |
T |
C |
15: 98,811,468 (GRCm39) |
D54G |
possibly damaging |
Het |
Lrrc49 |
A |
T |
9: 60,584,474 (GRCm39) |
I196N |
possibly damaging |
Het |
Maml1 |
C |
T |
11: 50,157,276 (GRCm39) |
A300T |
possibly damaging |
Het |
Mapkap1 |
A |
T |
2: 34,423,829 (GRCm39) |
Q293L |
possibly damaging |
Het |
Mki67 |
T |
C |
7: 135,315,568 (GRCm39) |
T69A |
probably benign |
Het |
Mlph |
G |
A |
1: 90,849,705 (GRCm39) |
|
probably null |
Het |
Myh1 |
A |
T |
11: 67,111,435 (GRCm39) |
M1625L |
probably benign |
Het |
Myh3 |
G |
T |
11: 66,981,847 (GRCm39) |
R781L |
probably benign |
Het |
Nckap5 |
A |
T |
1: 125,953,786 (GRCm39) |
I922K |
probably benign |
Het |
Nlrp5 |
T |
A |
7: 23,117,059 (GRCm39) |
M261K |
probably damaging |
Het |
Or1e1d-ps1 |
G |
A |
11: 73,819,663 (GRCm39) |
M204I |
probably benign |
Het |
Or4f47 |
A |
T |
2: 111,972,514 (GRCm39) |
S75C |
possibly damaging |
Het |
Or5af1 |
T |
A |
11: 58,722,750 (GRCm39) |
Y257N |
probably damaging |
Het |
Or8g52 |
A |
G |
9: 39,630,906 (GRCm39) |
N128D |
probably benign |
Het |
Pak1 |
T |
A |
7: 97,538,179 (GRCm39) |
V262E |
probably benign |
Het |
Pigw |
A |
T |
11: 84,767,930 (GRCm39) |
D466E |
probably damaging |
Het |
Pira2 |
A |
T |
7: 3,847,344 (GRCm39) |
L115Q |
probably damaging |
Het |
Rbm15 |
A |
C |
3: 107,240,432 (GRCm39) |
|
probably benign |
Het |
Rfx1 |
A |
G |
8: 84,800,385 (GRCm39) |
|
probably benign |
Het |
Rfx7 |
A |
G |
9: 72,500,639 (GRCm39) |
Y133C |
probably damaging |
Het |
Serpinb9d |
T |
A |
13: 33,384,702 (GRCm39) |
D226E |
probably benign |
Het |
Sgk3 |
G |
A |
1: 9,954,701 (GRCm39) |
A271T |
possibly damaging |
Het |
Sh2d5 |
T |
A |
4: 137,984,150 (GRCm39) |
C173S |
probably benign |
Het |
Skint8 |
T |
C |
4: 111,796,769 (GRCm39) |
V291A |
probably benign |
Het |
Slc22a27 |
T |
A |
19: 7,904,054 (GRCm39) |
N28Y |
probably benign |
Het |
Slc25a54 |
G |
A |
3: 109,023,751 (GRCm39) |
V449I |
probably benign |
Het |
Slc39a9 |
T |
C |
12: 80,726,316 (GRCm39) |
F255S |
probably damaging |
Het |
Spata31d1c |
C |
T |
13: 65,183,942 (GRCm39) |
H495Y |
probably damaging |
Het |
Stab2 |
G |
A |
10: 86,805,049 (GRCm39) |
Q310* |
probably null |
Het |
Supt16 |
C |
A |
14: 52,408,948 (GRCm39) |
A809S |
possibly damaging |
Het |
Tenm3 |
A |
T |
8: 48,689,212 (GRCm39) |
M2125K |
possibly damaging |
Het |
Tex2 |
G |
A |
11: 106,439,685 (GRCm39) |
T565M |
unknown |
Het |
Tll1 |
G |
A |
8: 64,478,176 (GRCm39) |
A859V |
probably damaging |
Het |
Tmem106c |
C |
T |
15: 97,867,512 (GRCm39) |
T232I |
possibly damaging |
Het |
Trim65 |
T |
G |
11: 116,019,116 (GRCm39) |
D141A |
probably benign |
Het |
Trim80 |
T |
C |
11: 115,332,042 (GRCm39) |
F78S |
probably damaging |
Het |
Txnrd1 |
T |
A |
10: 82,709,051 (GRCm39) |
I83N |
probably benign |
Het |
Vnn3 |
G |
A |
10: 23,727,806 (GRCm39) |
G72D |
probably benign |
Het |
Wasl |
G |
T |
6: 24,619,686 (GRCm39) |
P278Q |
unknown |
Het |
Wdr62 |
A |
T |
7: 29,943,342 (GRCm39) |
L951Q |
probably damaging |
Het |
Zfp760 |
C |
T |
17: 21,942,814 (GRCm39) |
T663I |
unknown |
Het |
|
Other mutations in Clasp2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00772:Clasp2
|
APN |
9 |
113,735,060 (GRCm39) |
splice site |
probably benign |
|
IGL00885:Clasp2
|
APN |
9 |
113,740,484 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01314:Clasp2
|
APN |
9 |
113,735,195 (GRCm39) |
missense |
possibly damaging |
0.89 |
IGL01344:Clasp2
|
APN |
9 |
113,642,360 (GRCm39) |
splice site |
probably null |
|
IGL01567:Clasp2
|
APN |
9 |
113,709,164 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02238:Clasp2
|
APN |
9 |
113,709,088 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02299:Clasp2
|
APN |
9 |
113,709,057 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02323:Clasp2
|
APN |
9 |
113,697,794 (GRCm39) |
splice site |
probably benign |
|
IGL02635:Clasp2
|
APN |
9 |
113,737,910 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02645:Clasp2
|
APN |
9 |
113,719,129 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02976:Clasp2
|
APN |
9 |
113,735,204 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03190:Clasp2
|
APN |
9 |
113,673,208 (GRCm39) |
nonsense |
probably null |
|
IGL03219:Clasp2
|
APN |
9 |
113,677,545 (GRCm39) |
splice site |
probably benign |
|
PIT4810001:Clasp2
|
UTSW |
9 |
113,735,135 (GRCm39) |
missense |
probably damaging |
1.00 |
R0067:Clasp2
|
UTSW |
9 |
113,689,209 (GRCm39) |
splice site |
probably benign |
|
R0067:Clasp2
|
UTSW |
9 |
113,689,209 (GRCm39) |
splice site |
probably benign |
|
R0421:Clasp2
|
UTSW |
9 |
113,683,370 (GRCm39) |
missense |
probably benign |
0.02 |
R0432:Clasp2
|
UTSW |
9 |
113,738,487 (GRCm39) |
missense |
probably benign |
0.00 |
R0458:Clasp2
|
UTSW |
9 |
113,735,292 (GRCm39) |
splice site |
probably null |
|
R0865:Clasp2
|
UTSW |
9 |
113,740,568 (GRCm39) |
missense |
possibly damaging |
0.57 |
R0972:Clasp2
|
UTSW |
9 |
113,676,773 (GRCm39) |
missense |
possibly damaging |
0.58 |
R1037:Clasp2
|
UTSW |
9 |
113,725,702 (GRCm39) |
splice site |
probably benign |
|
R1925:Clasp2
|
UTSW |
9 |
113,735,265 (GRCm39) |
missense |
possibly damaging |
0.88 |
R2015:Clasp2
|
UTSW |
9 |
113,740,568 (GRCm39) |
missense |
possibly damaging |
0.57 |
R2066:Clasp2
|
UTSW |
9 |
113,735,225 (GRCm39) |
missense |
possibly damaging |
0.86 |
R2330:Clasp2
|
UTSW |
9 |
113,705,372 (GRCm39) |
missense |
probably damaging |
1.00 |
R2568:Clasp2
|
UTSW |
9 |
113,707,832 (GRCm39) |
missense |
probably benign |
|
R3011:Clasp2
|
UTSW |
9 |
113,730,581 (GRCm39) |
missense |
probably damaging |
1.00 |
R3879:Clasp2
|
UTSW |
9 |
113,719,029 (GRCm39) |
missense |
probably damaging |
0.98 |
R3915:Clasp2
|
UTSW |
9 |
113,737,805 (GRCm39) |
missense |
probably damaging |
0.99 |
R3928:Clasp2
|
UTSW |
9 |
113,735,173 (GRCm39) |
missense |
probably benign |
0.28 |
R4323:Clasp2
|
UTSW |
9 |
113,719,027 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4571:Clasp2
|
UTSW |
9 |
113,676,789 (GRCm39) |
missense |
probably damaging |
1.00 |
R4975:Clasp2
|
UTSW |
9 |
113,732,984 (GRCm39) |
missense |
probably damaging |
1.00 |
R5445:Clasp2
|
UTSW |
9 |
113,733,014 (GRCm39) |
missense |
probably damaging |
1.00 |
R5564:Clasp2
|
UTSW |
9 |
113,641,836 (GRCm39) |
critical splice donor site |
probably null |
|
R5697:Clasp2
|
UTSW |
9 |
113,689,190 (GRCm39) |
missense |
probably benign |
0.01 |
R5780:Clasp2
|
UTSW |
9 |
113,679,220 (GRCm39) |
missense |
probably damaging |
0.99 |
R5787:Clasp2
|
UTSW |
9 |
113,691,310 (GRCm39) |
missense |
probably damaging |
1.00 |
R6011:Clasp2
|
UTSW |
9 |
113,705,315 (GRCm39) |
missense |
probably benign |
0.07 |
R6026:Clasp2
|
UTSW |
9 |
113,740,646 (GRCm39) |
missense |
probably benign |
0.13 |
R6090:Clasp2
|
UTSW |
9 |
113,681,803 (GRCm39) |
missense |
probably benign |
0.06 |
R6262:Clasp2
|
UTSW |
9 |
113,705,420 (GRCm39) |
critical splice donor site |
probably null |
|
R6427:Clasp2
|
UTSW |
9 |
113,721,512 (GRCm39) |
missense |
probably damaging |
1.00 |
R6464:Clasp2
|
UTSW |
9 |
113,602,785 (GRCm39) |
missense |
probably damaging |
1.00 |
R6586:Clasp2
|
UTSW |
9 |
113,642,332 (GRCm39) |
missense |
probably damaging |
1.00 |
R6628:Clasp2
|
UTSW |
9 |
113,725,788 (GRCm39) |
missense |
probably damaging |
1.00 |
R6745:Clasp2
|
UTSW |
9 |
113,704,338 (GRCm39) |
nonsense |
probably null |
|
R7032:Clasp2
|
UTSW |
9 |
113,683,391 (GRCm39) |
missense |
probably benign |
0.04 |
R7165:Clasp2
|
UTSW |
9 |
113,615,467 (GRCm39) |
splice site |
probably null |
|
R7221:Clasp2
|
UTSW |
9 |
113,681,825 (GRCm39) |
missense |
probably damaging |
0.99 |
R7583:Clasp2
|
UTSW |
9 |
113,737,755 (GRCm39) |
missense |
probably benign |
0.02 |
R7774:Clasp2
|
UTSW |
9 |
113,677,804 (GRCm39) |
splice site |
probably null |
|
R7895:Clasp2
|
UTSW |
9 |
113,733,016 (GRCm39) |
missense |
probably benign |
0.03 |
R8084:Clasp2
|
UTSW |
9 |
113,676,823 (GRCm39) |
missense |
probably benign |
0.16 |
R8109:Clasp2
|
UTSW |
9 |
113,740,588 (GRCm39) |
missense |
probably damaging |
1.00 |
R8171:Clasp2
|
UTSW |
9 |
113,732,974 (GRCm39) |
missense |
possibly damaging |
0.88 |
R8230:Clasp2
|
UTSW |
9 |
113,721,482 (GRCm39) |
missense |
possibly damaging |
0.73 |
R8810:Clasp2
|
UTSW |
9 |
113,728,649 (GRCm39) |
missense |
probably damaging |
1.00 |
R8879:Clasp2
|
UTSW |
9 |
113,602,773 (GRCm39) |
missense |
probably benign |
0.39 |
R8888:Clasp2
|
UTSW |
9 |
113,732,936 (GRCm39) |
missense |
possibly damaging |
0.54 |
R8889:Clasp2
|
UTSW |
9 |
113,709,251 (GRCm39) |
missense |
probably damaging |
1.00 |
R8892:Clasp2
|
UTSW |
9 |
113,709,251 (GRCm39) |
missense |
probably damaging |
1.00 |
R8922:Clasp2
|
UTSW |
9 |
113,725,728 (GRCm39) |
nonsense |
probably null |
|
R9042:Clasp2
|
UTSW |
9 |
113,735,065 (GRCm39) |
missense |
probably benign |
|
R9195:Clasp2
|
UTSW |
9 |
113,671,045 (GRCm39) |
missense |
probably benign |
0.06 |
R9355:Clasp2
|
UTSW |
9 |
113,664,309 (GRCm39) |
missense |
probably damaging |
1.00 |
R9481:Clasp2
|
UTSW |
9 |
113,670,669 (GRCm39) |
missense |
probably damaging |
1.00 |
R9502:Clasp2
|
UTSW |
9 |
113,737,866 (GRCm39) |
missense |
probably benign |
0.01 |
R9523:Clasp2
|
UTSW |
9 |
113,705,372 (GRCm39) |
missense |
probably damaging |
0.98 |
R9525:Clasp2
|
UTSW |
9 |
113,740,677 (GRCm39) |
missense |
probably damaging |
1.00 |
R9653:Clasp2
|
UTSW |
9 |
113,670,993 (GRCm39) |
missense |
probably benign |
0.01 |
R9699:Clasp2
|
UTSW |
9 |
113,738,614 (GRCm39) |
critical splice donor site |
probably null |
|
R9738:Clasp2
|
UTSW |
9 |
113,590,665 (GRCm39) |
nonsense |
probably null |
|
R9775:Clasp2
|
UTSW |
9 |
113,725,740 (GRCm39) |
missense |
probably benign |
|
X0022:Clasp2
|
UTSW |
9 |
113,681,740 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Clasp2
|
UTSW |
9 |
113,737,863 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1177:Clasp2
|
UTSW |
9 |
113,599,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CCCTTGCATTATTACAGTTGTGAC -3'
(R):5'- TGCCATACAGTCAGTACACTACAG -3'
Sequencing Primer
(F):5'- GTGACTGTCTAAAAGTTGTTCTCC -3'
(R):5'- ACCTAGTTAAGATTACTGGAACTGAC -3'
|
Posted On |
2019-10-14 |