Incidental Mutation 'R7491:Arhgef28'
| ID |
580788 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef28
|
| Ensembl Gene |
ENSMUSG00000021662 |
| Gene Name |
Rho guanine nucleotide exchange factor 28 |
| Synonyms |
Rgnef, 9230110L08Rik, Rho specific exchange factor, RhoGEF, RIP2, D13Bwg1089e, p190RhoGEF |
| MMRRC Submission |
045565-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7491 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
98035977-98342947 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 98081194 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 1221
(N1221S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105053
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109426]
[ENSMUST00000225884]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109426
AA Change: N1221S
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000105053
Gene: ENSMUSG00000021662
AA Change: N1221S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
530 |
568 |
N/A |
INTRINSIC |
|
low complexity region
|
634 |
650 |
N/A |
INTRINSIC |
|
C1
|
652 |
698 |
1.65e-11 |
SMART |
|
RhoGEF
|
850 |
1040 |
1.11e-65 |
SMART |
|
PH
|
1084 |
1187 |
1.08e-9 |
SMART |
|
low complexity region
|
1267 |
1281 |
N/A |
INTRINSIC |
|
coiled coil region
|
1469 |
1522 |
N/A |
INTRINSIC |
|
low complexity region
|
1647 |
1663 |
N/A |
INTRINSIC |
|
low complexity region
|
1682 |
1693 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000225884
AA Change: N1221S
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are born at lower than expected Mendelian ratios and exhibit a reduction in overall size that becomes negligible by 8 weeks of age. Mouse embryonic fibroblasts display defects in cell migration and focal adhesion formation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933409G03Rik |
G |
T |
2: 68,445,099 (GRCm39) |
|
probably null |
Het |
| 5730522E02Rik |
A |
T |
11: 25,719,014 (GRCm39) |
V44E |
unknown |
Het |
| Adcy9 |
A |
G |
16: 4,236,673 (GRCm39) |
L246S |
possibly damaging |
Het |
| Adk |
C |
T |
14: 21,284,997 (GRCm39) |
H123Y |
probably damaging |
Het |
| Adra1b |
T |
A |
11: 43,726,794 (GRCm39) |
D41V |
probably benign |
Het |
| Ankib1 |
T |
G |
5: 3,751,911 (GRCm39) |
K710Q |
probably damaging |
Het |
| Aoc2 |
T |
A |
11: 101,219,203 (GRCm39) |
V542D |
probably benign |
Het |
| BC028528 |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
3: 95,795,448 (GRCm39) |
|
probably benign |
Het |
| BC028528 |
CACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGT |
CACTGGTTCTGTGGTTACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGT |
3: 95,795,450 (GRCm39) |
|
probably benign |
Het |
| Bmal1 |
T |
C |
7: 112,898,631 (GRCm39) |
V353A |
probably benign |
Het |
| Cacna1a |
C |
A |
8: 85,285,922 (GRCm39) |
R856S |
possibly damaging |
Het |
| Cacna1c |
T |
C |
6: 118,590,304 (GRCm39) |
M1559V |
|
Het |
| Cdh10 |
G |
C |
15: 19,013,445 (GRCm39) |
E682Q |
probably damaging |
Het |
| Celsr1 |
T |
C |
15: 85,916,719 (GRCm39) |
D418G |
possibly damaging |
Het |
| Cfap44 |
T |
C |
16: 44,291,111 (GRCm39) |
L1537P |
probably damaging |
Het |
| Clca3a2 |
A |
G |
3: 144,519,340 (GRCm39) |
S279P |
probably damaging |
Het |
| Col2a1 |
C |
T |
15: 97,874,040 (GRCm39) |
V1449I |
not run |
Het |
| Cpt2 |
A |
G |
4: 107,764,339 (GRCm39) |
F475S |
probably damaging |
Het |
| Cpxm1 |
T |
C |
2: 130,235,487 (GRCm39) |
T502A |
probably benign |
Het |
| Creb3l2 |
G |
T |
6: 37,356,794 (GRCm39) |
T91N |
probably benign |
Het |
| D630045J12Rik |
A |
T |
6: 38,119,601 (GRCm39) |
S1714T |
possibly damaging |
Het |
| Dennd1c |
C |
A |
17: 57,379,379 (GRCm39) |
V246F |
probably damaging |
Het |
| Dse |
A |
G |
10: 34,028,561 (GRCm39) |
V843A |
probably benign |
Het |
| Ern2 |
C |
A |
7: 121,769,756 (GRCm39) |
W810L |
probably damaging |
Het |
| Fer1l6 |
G |
A |
15: 58,472,281 (GRCm39) |
D906N |
probably damaging |
Het |
| Fry |
A |
G |
5: 150,389,791 (GRCm39) |
E140G |
|
Het |
| Galnt7 |
A |
G |
8: 58,005,552 (GRCm39) |
V227A |
probably damaging |
Het |
| Gas2l3 |
A |
G |
10: 89,249,763 (GRCm39) |
S452P |
probably benign |
Het |
| Gm40460 |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
7: 141,794,450 (GRCm39) |
|
probably benign |
Het |
| Gm826 |
A |
T |
2: 160,153,942 (GRCm39) |
S34T |
unknown |
Het |
| Gzmk |
A |
T |
13: 113,308,535 (GRCm39) |
I222N |
probably benign |
Het |
| Hivep3 |
A |
T |
4: 119,956,027 (GRCm39) |
T1448S |
probably benign |
Het |
| Hk1 |
T |
C |
10: 62,131,524 (GRCm39) |
D278G |
probably damaging |
Het |
| Ipo7 |
C |
A |
7: 109,638,401 (GRCm39) |
Q223K |
possibly damaging |
Het |
| Itga9 |
T |
A |
9: 118,598,179 (GRCm39) |
I571N |
probably damaging |
Het |
| Itgb6 |
T |
C |
2: 60,450,720 (GRCm39) |
Y573C |
probably damaging |
Het |
| Kmt2c |
T |
A |
5: 25,489,562 (GRCm39) |
H4459L |
probably damaging |
Het |
| Limch1 |
T |
G |
5: 67,211,580 (GRCm39) |
S894R |
probably damaging |
Het |
| Lrit2 |
A |
T |
14: 36,790,867 (GRCm39) |
Q182L |
possibly damaging |
Het |
| Mlph |
A |
T |
1: 90,867,100 (GRCm39) |
H374L |
possibly damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,121,374 (GRCm39) |
H748R |
probably damaging |
Het |
| Mrpl58 |
T |
C |
11: 115,301,092 (GRCm39) |
V134A |
possibly damaging |
Het |
| Nae1 |
A |
T |
8: 105,244,871 (GRCm39) |
D353E |
probably benign |
Het |
| Naip5 |
A |
C |
13: 100,353,579 (GRCm39) |
F1227V |
probably benign |
Het |
| Nln |
A |
T |
13: 104,205,831 (GRCm39) |
F108I |
probably damaging |
Het |
| Nop16 |
C |
T |
13: 54,736,417 (GRCm39) |
V94I |
probably benign |
Het |
| Nt5c1b |
A |
T |
12: 10,424,903 (GRCm39) |
T150S |
probably benign |
Het |
| Or10d4b |
T |
G |
9: 39,535,268 (GRCm39) |
I281S |
possibly damaging |
Het |
| Pcdha4 |
T |
C |
18: 37,087,689 (GRCm39) |
V624A |
probably damaging |
Het |
| Pcdhga8 |
T |
C |
18: 37,860,483 (GRCm39) |
I513T |
probably benign |
Het |
| Prc1 |
A |
T |
7: 79,959,239 (GRCm39) |
|
probably null |
Het |
| Prpf4 |
T |
A |
4: 62,336,113 (GRCm39) |
F280Y |
probably damaging |
Het |
| Ptprd |
T |
C |
4: 76,051,392 (GRCm39) |
E43G |
probably benign |
Het |
| Pum1 |
T |
A |
4: 130,446,485 (GRCm39) |
D181E |
probably benign |
Het |
| Rab7 |
A |
G |
6: 87,990,624 (GRCm39) |
S17P |
probably damaging |
Het |
| Rgs1 |
T |
C |
1: 144,121,134 (GRCm39) |
Y179C |
probably damaging |
Het |
| Rrm1 |
T |
C |
7: 102,103,764 (GRCm39) |
C238R |
probably damaging |
Het |
| Rusc2 |
T |
A |
4: 43,426,528 (GRCm39) |
L1484Q |
probably damaging |
Het |
| Sall3 |
C |
T |
18: 81,015,920 (GRCm39) |
M669I |
probably benign |
Het |
| Saxo1 |
A |
C |
4: 86,363,644 (GRCm39) |
F280V |
probably benign |
Het |
| Scn2a |
T |
C |
2: 65,532,352 (GRCm39) |
S655P |
probably damaging |
Het |
| Senp6 |
G |
T |
9: 80,031,010 (GRCm39) |
E571* |
probably null |
Het |
| Sin3b |
C |
G |
8: 73,473,069 (GRCm39) |
T463S |
probably damaging |
Het |
| Sirt7 |
C |
A |
11: 120,509,837 (GRCm39) |
R349L |
probably benign |
Het |
| Skor1 |
T |
C |
9: 63,053,730 (GRCm39) |
T80A |
probably damaging |
Het |
| Slc12a9 |
C |
A |
5: 137,321,082 (GRCm39) |
A478S |
probably damaging |
Het |
| Slc25a23 |
T |
A |
17: 57,359,822 (GRCm39) |
R310* |
probably null |
Het |
| Slco6c1 |
A |
T |
1: 97,055,579 (GRCm39) |
H107Q |
probably benign |
Het |
| Slit2 |
A |
G |
5: 48,377,336 (GRCm39) |
E455G |
probably benign |
Het |
| Smo |
G |
C |
6: 29,736,119 (GRCm39) |
G37A |
probably damaging |
Het |
| St6galnac1 |
T |
C |
11: 116,660,010 (GRCm39) |
K101R |
probably benign |
Het |
| Stat1 |
C |
A |
1: 52,191,530 (GRCm39) |
N628K |
probably benign |
Het |
| Syn2 |
A |
T |
6: 115,231,615 (GRCm39) |
Y302F |
probably benign |
Het |
| Tapt1 |
T |
G |
5: 44,345,978 (GRCm39) |
Q324P |
probably damaging |
Het |
| Tgoln1 |
C |
T |
6: 72,593,403 (GRCm39) |
A26T |
unknown |
Het |
| Timm13 |
T |
A |
10: 80,736,378 (GRCm39) |
T43S |
probably benign |
Het |
| Tnfrsf19 |
G |
A |
14: 61,242,654 (GRCm39) |
P77S |
possibly damaging |
Het |
| Trem3 |
T |
G |
17: 48,564,969 (GRCm39) |
F157V |
probably benign |
Het |
| Trgv3 |
T |
A |
13: 19,427,016 (GRCm39) |
M1K |
probably null |
Het |
| Trim33 |
T |
A |
3: 103,233,464 (GRCm39) |
S420T |
probably benign |
Het |
| Trip11 |
T |
C |
12: 101,851,694 (GRCm39) |
K790R |
probably damaging |
Het |
| Trnt1 |
A |
G |
6: 106,755,865 (GRCm39) |
T307A |
probably benign |
Het |
| Tshz1 |
T |
C |
18: 84,033,766 (GRCm39) |
Y214C |
probably damaging |
Het |
| Vmn2r105 |
T |
A |
17: 20,448,827 (GRCm39) |
T117S |
probably benign |
Het |
| Vmn2r45 |
A |
G |
7: 8,484,342 (GRCm39) |
Y488H |
probably benign |
Het |
| Vwa8 |
A |
T |
14: 79,320,254 (GRCm39) |
K1088N |
probably benign |
Het |
| Wdr35 |
T |
C |
12: 9,036,000 (GRCm39) |
V257A |
probably benign |
Het |
| Zfp189 |
T |
A |
4: 49,521,569 (GRCm39) |
S3T |
probably benign |
Het |
| Zscan22 |
G |
A |
7: 12,640,833 (GRCm39) |
C359Y |
probably damaging |
Het |
| Zscan4-ps2 |
A |
T |
7: 11,251,812 (GRCm39) |
R283* |
probably null |
Het |
|
| Other mutations in Arhgef28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00426:Arhgef28
|
APN |
13 |
98,124,785 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL00945:Arhgef28
|
APN |
13 |
98,103,907 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01099:Arhgef28
|
APN |
13 |
98,090,480 (GRCm39) |
splice site |
probably benign |
|
|
IGL01328:Arhgef28
|
APN |
13 |
98,106,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01396:Arhgef28
|
APN |
13 |
98,090,401 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02067:Arhgef28
|
APN |
13 |
98,213,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02147:Arhgef28
|
APN |
13 |
98,097,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02285:Arhgef28
|
APN |
13 |
98,187,536 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02439:Arhgef28
|
APN |
13 |
98,067,647 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02499:Arhgef28
|
APN |
13 |
98,090,291 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02532:Arhgef28
|
APN |
13 |
98,166,391 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02634:Arhgef28
|
APN |
13 |
98,187,566 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02902:Arhgef28
|
APN |
13 |
98,083,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03067:Arhgef28
|
APN |
13 |
98,124,794 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03081:Arhgef28
|
APN |
13 |
98,165,881 (GRCm39) |
splice site |
probably benign |
|
|
IGL03106:Arhgef28
|
APN |
13 |
98,094,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03195:Arhgef28
|
APN |
13 |
98,088,071 (GRCm39) |
splice site |
probably null |
|
|
IGL03325:Arhgef28
|
APN |
13 |
98,036,324 (GRCm39) |
missense |
probably benign |
0.03 |
|
H8786:Arhgef28
|
UTSW |
13 |
98,083,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0027:Arhgef28
|
UTSW |
13 |
98,082,204 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0027:Arhgef28
|
UTSW |
13 |
98,082,204 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0062:Arhgef28
|
UTSW |
13 |
98,093,150 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0062:Arhgef28
|
UTSW |
13 |
98,093,150 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0090:Arhgef28
|
UTSW |
13 |
98,211,618 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0096:Arhgef28
|
UTSW |
13 |
98,067,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Arhgef28
|
UTSW |
13 |
98,067,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0537:Arhgef28
|
UTSW |
13 |
98,094,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0617:Arhgef28
|
UTSW |
13 |
98,106,863 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0711:Arhgef28
|
UTSW |
13 |
98,067,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Arhgef28
|
UTSW |
13 |
98,075,987 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0790:Arhgef28
|
UTSW |
13 |
98,117,914 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1240:Arhgef28
|
UTSW |
13 |
98,066,000 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1365:Arhgef28
|
UTSW |
13 |
98,211,632 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1456:Arhgef28
|
UTSW |
13 |
98,211,510 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1490:Arhgef28
|
UTSW |
13 |
98,114,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1496:Arhgef28
|
UTSW |
13 |
98,102,054 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1660:Arhgef28
|
UTSW |
13 |
98,117,884 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1671:Arhgef28
|
UTSW |
13 |
98,067,542 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1747:Arhgef28
|
UTSW |
13 |
98,073,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1792:Arhgef28
|
UTSW |
13 |
98,067,694 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1864:Arhgef28
|
UTSW |
13 |
98,130,640 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1887:Arhgef28
|
UTSW |
13 |
98,282,081 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1924:Arhgef28
|
UTSW |
13 |
98,073,324 (GRCm39) |
splice site |
probably benign |
|
|
R1987:Arhgef28
|
UTSW |
13 |
98,103,604 (GRCm39) |
missense |
probably benign |
|
|
R2215:Arhgef28
|
UTSW |
13 |
98,187,529 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2342:Arhgef28
|
UTSW |
13 |
98,130,537 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2495:Arhgef28
|
UTSW |
13 |
98,165,881 (GRCm39) |
splice site |
probably benign |
|
|
R3897:Arhgef28
|
UTSW |
13 |
98,093,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3922:Arhgef28
|
UTSW |
13 |
98,130,452 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4063:Arhgef28
|
UTSW |
13 |
98,130,575 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4086:Arhgef28
|
UTSW |
13 |
98,103,712 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4543:Arhgef28
|
UTSW |
13 |
98,211,508 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Arhgef28
|
UTSW |
13 |
98,114,650 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4735:Arhgef28
|
UTSW |
13 |
98,036,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4953:Arhgef28
|
UTSW |
13 |
98,066,062 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5069:Arhgef28
|
UTSW |
13 |
98,211,714 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5558:Arhgef28
|
UTSW |
13 |
98,097,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5573:Arhgef28
|
UTSW |
13 |
98,065,999 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5594:Arhgef28
|
UTSW |
13 |
98,076,000 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5937:Arhgef28
|
UTSW |
13 |
98,076,051 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Arhgef28
|
UTSW |
13 |
98,073,368 (GRCm39) |
nonsense |
probably null |
|
|
R6015:Arhgef28
|
UTSW |
13 |
98,211,530 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6193:Arhgef28
|
UTSW |
13 |
98,121,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6209:Arhgef28
|
UTSW |
13 |
98,065,917 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6306:Arhgef28
|
UTSW |
13 |
98,121,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6393:Arhgef28
|
UTSW |
13 |
98,130,527 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6562:Arhgef28
|
UTSW |
13 |
98,124,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6646:Arhgef28
|
UTSW |
13 |
98,076,002 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6655:Arhgef28
|
UTSW |
13 |
98,036,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6707:Arhgef28
|
UTSW |
13 |
98,211,624 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6707:Arhgef28
|
UTSW |
13 |
98,073,224 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6751:Arhgef28
|
UTSW |
13 |
98,211,755 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6940:Arhgef28
|
UTSW |
13 |
98,102,038 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7018:Arhgef28
|
UTSW |
13 |
98,101,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7030:Arhgef28
|
UTSW |
13 |
98,124,769 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7120:Arhgef28
|
UTSW |
13 |
98,081,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7266:Arhgef28
|
UTSW |
13 |
98,101,960 (GRCm39) |
missense |
probably benign |
|
|
R7353:Arhgef28
|
UTSW |
13 |
98,211,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Arhgef28
|
UTSW |
13 |
98,133,370 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7500:Arhgef28
|
UTSW |
13 |
98,115,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7653:Arhgef28
|
UTSW |
13 |
98,105,821 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7813:Arhgef28
|
UTSW |
13 |
98,082,189 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7989:Arhgef28
|
UTSW |
13 |
98,036,243 (GRCm39) |
missense |
probably benign |
|
|
R8064:Arhgef28
|
UTSW |
13 |
98,115,002 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8221:Arhgef28
|
UTSW |
13 |
98,282,064 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8293:Arhgef28
|
UTSW |
13 |
98,079,029 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8328:Arhgef28
|
UTSW |
13 |
98,187,517 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8348:Arhgef28
|
UTSW |
13 |
98,190,375 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8432:Arhgef28
|
UTSW |
13 |
98,088,091 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8843:Arhgef28
|
UTSW |
13 |
98,130,557 (GRCm39) |
missense |
probably benign |
|
|
R8859:Arhgef28
|
UTSW |
13 |
98,082,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8954:Arhgef28
|
UTSW |
13 |
98,066,141 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8987:Arhgef28
|
UTSW |
13 |
98,190,472 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9253:Arhgef28
|
UTSW |
13 |
98,124,779 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9351:Arhgef28
|
UTSW |
13 |
98,130,576 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9381:Arhgef28
|
UTSW |
13 |
98,036,269 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9395:Arhgef28
|
UTSW |
13 |
98,103,692 (GRCm39) |
frame shift |
probably null |
|
|
R9466:Arhgef28
|
UTSW |
13 |
98,124,825 (GRCm39) |
missense |
|
|
|
R9529:Arhgef28
|
UTSW |
13 |
98,213,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9641:Arhgef28
|
UTSW |
13 |
98,078,983 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9662:Arhgef28
|
UTSW |
13 |
98,065,969 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9744:Arhgef28
|
UTSW |
13 |
98,094,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9776:Arhgef28
|
UTSW |
13 |
98,133,415 (GRCm39) |
missense |
probably benign |
0.19 |
|
Z1088:Arhgef28
|
UTSW |
13 |
98,082,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Arhgef28
|
UTSW |
13 |
98,036,264 (GRCm39) |
missense |
probably benign |
0.43 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCCTGTAAACTCGGTCTCAG -3'
(R):5'- CACAGGTCGCAATCACAAGG -3'
Sequencing Primer
(F):5'- ACCAAATCGTTTCCAGGGG -3'
(R):5'- GGGAATTTGAATCTCTACCACCC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation