Incidental Mutation 'R7494:Or2t46'
ID 580997
Institutional Source Beutler Lab
Gene Symbol Or2t46
Ensembl Gene ENSMUSG00000060765
Gene Name olfactory receptor family 2 subfamily T member 46
Synonyms MOR275-11_p, Olfr325, GA_x6K02T2NKPP-844642-843680, MOR275-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R7494 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 58471663-58472703 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58472038 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 123 (S123P)
Ref Sequence ENSEMBL: ENSMUSP00000145386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169428] [ENSMUST00000203418]
AlphaFold Q5NCD2
Predicted Effect probably damaging
Transcript: ENSMUST00000169428
AA Change: S123P

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000131257
Gene: ENSMUSG00000060765
AA Change: S123P

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 2.3e-46 PFAM
Pfam:7TM_GPCR_Srsx 39 290 1.4e-6 PFAM
Pfam:7tm_1 45 294 1.6e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203418
AA Change: S123P

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000145386
Gene: ENSMUSG00000060765
AA Change: S123P

DomainStartEndE-ValueType
Pfam:7tm_4 35 130 7.6e-14 PFAM
Pfam:7TM_GPCR_Srsx 36 130 1.1e-4 PFAM
Pfam:7tm_1 45 130 2.6e-16 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 G A 11: 110,099,571 (GRCm39) T992I possibly damaging Het
Adamts10 T A 17: 33,768,352 (GRCm39) C841* probably null Het
AI661453 C T 17: 47,779,105 (GRCm39) P944S unknown Het
Als2 G A 1: 59,222,325 (GRCm39) probably null Het
Anapc2 A G 2: 25,166,376 (GRCm39) E381G possibly damaging Het
Ank3 T C 10: 69,824,756 (GRCm39) Y1142H Het
Apip A T 2: 102,922,896 (GRCm39) N238I probably benign Het
Cblc A T 7: 19,526,737 (GRCm39) V165D possibly damaging Het
Cep295nl T A 11: 118,224,758 (GRCm39) M29L probably benign Het
Clec12a A G 6: 129,330,362 (GRCm39) I47V possibly damaging Het
Dpp9 T C 17: 56,507,619 (GRCm39) Y350C probably damaging Het
Enpp2 C T 15: 54,773,554 (GRCm39) G56R probably damaging Het
Epsti1 G T 14: 78,166,194 (GRCm39) E82D probably benign Het
Eri2 C A 7: 119,385,304 (GRCm39) C399F probably damaging Het
Ern1 T C 11: 106,298,361 (GRCm39) T672A probably damaging Het
Fbxo21 T A 5: 118,138,388 (GRCm39) C445S possibly damaging Het
Folh1 G T 7: 86,368,907 (GRCm39) T740K probably damaging Het
Gapt A G 13: 110,490,262 (GRCm39) Y134H probably damaging Het
Gm19410 T C 8: 36,262,684 (GRCm39) S874P probably damaging Het
Gm2431 G A 7: 141,811,547 (GRCm39) P119L unknown Het
Gzmc G A 14: 56,469,785 (GRCm39) Q172* probably null Het
Hoxa1 C A 6: 52,134,571 (GRCm39) V211F probably damaging Het
Hyou1 G T 9: 44,300,706 (GRCm39) R925L probably benign Het
Ift70a1 A C 2: 75,810,242 (GRCm39) F614V probably damaging Het
Ilvbl A G 10: 78,414,857 (GRCm39) Y240C possibly damaging Het
Lama1 T A 17: 68,118,441 (GRCm39) F2551Y Het
Lrrtm3 A G 10: 63,924,958 (GRCm39) Y70H probably damaging Het
Naa38 T A 11: 69,287,126 (GRCm39) C69S probably damaging Het
Or12e7 T A 2: 87,287,912 (GRCm39) N134K probably damaging Het
Or8k25 A T 2: 86,243,592 (GRCm39) I268N probably benign Het
Panx3 A G 9: 37,572,608 (GRCm39) L314P probably damaging Het
Polr2f T C 15: 79,028,865 (GRCm39) probably null Het
Prkcd C A 14: 30,331,150 (GRCm39) R75L probably benign Het
Psap A C 10: 60,135,275 (GRCm39) L313F probably benign Het
Psen1 T A 12: 83,775,017 (GRCm39) C263S probably benign Het
Ptma GGAAGAAG GGAAGAAGAAG 1: 86,457,261 (GRCm39) probably benign Het
Pura T A 18: 36,420,942 (GRCm39) M243K probably damaging Het
Sec16b T C 1: 157,388,369 (GRCm39) S579P probably benign Het
Septin1 T A 7: 126,814,122 (GRCm39) E338V probably damaging Het
Sgms1 A G 19: 32,107,091 (GRCm39) F255L probably benign Het
Slc4a2 A G 5: 24,637,862 (GRCm39) T353A possibly damaging Het
Smg6 T C 11: 74,820,449 (GRCm39) V240A probably benign Het
Sntg2 T G 12: 30,279,633 (GRCm39) D340A possibly damaging Het
Sun1 C T 5: 139,221,475 (GRCm39) P553S probably benign Het
Tas2r140 T C 6: 40,468,254 (GRCm39) V28A probably damaging Het
Tfcp2l1 T C 1: 118,592,686 (GRCm39) F323S probably damaging Het
Thoc2l T C 5: 104,666,284 (GRCm39) Y269H possibly damaging Het
Tpcn2 G A 7: 144,832,586 (GRCm39) T90I possibly damaging Het
Ttn A T 2: 76,720,321 (GRCm39) Y6968* probably null Het
Vmn2r44 A T 7: 8,386,122 (GRCm39) L39* probably null Het
Other mutations in Or2t46
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Or2t46 APN 11 58,472,636 (GRCm39) missense probably benign
IGL01922:Or2t46 APN 11 58,471,899 (GRCm39) missense probably benign 0.01
IGL02440:Or2t46 APN 11 58,472,035 (GRCm39) missense probably damaging 1.00
IGL02456:Or2t46 APN 11 58,472,024 (GRCm39) missense possibly damaging 0.48
IGL03088:Or2t46 APN 11 58,472,653 (GRCm39) utr 3 prime probably benign
IGL03328:Or2t46 APN 11 58,472,539 (GRCm39) missense probably damaging 1.00
R0604:Or2t46 UTSW 11 58,472,174 (GRCm39) missense probably damaging 0.99
R1698:Or2t46 UTSW 11 58,472,077 (GRCm39) missense probably damaging 1.00
R2473:Or2t46 UTSW 11 58,472,401 (GRCm39) missense probably damaging 1.00
R2888:Or2t46 UTSW 11 58,471,988 (GRCm39) missense possibly damaging 0.96
R4133:Or2t46 UTSW 11 58,471,901 (GRCm39) missense probably damaging 0.97
R4710:Or2t46 UTSW 11 58,472,548 (GRCm39) missense probably damaging 1.00
R4715:Or2t46 UTSW 11 58,472,255 (GRCm39) missense probably damaging 1.00
R4898:Or2t46 UTSW 11 58,472,546 (GRCm39) missense probably damaging 1.00
R4939:Or2t46 UTSW 11 58,472,037 (GRCm39) missense probably damaging 1.00
R4977:Or2t46 UTSW 11 58,472,455 (GRCm39) missense possibly damaging 0.57
R5389:Or2t46 UTSW 11 58,471,825 (GRCm39) missense possibly damaging 0.78
R5393:Or2t46 UTSW 11 58,471,825 (GRCm39) missense possibly damaging 0.78
R6137:Or2t46 UTSW 11 58,471,894 (GRCm39) missense probably benign
R6302:Or2t46 UTSW 11 58,472,464 (GRCm39) missense probably benign
R6655:Or2t46 UTSW 11 58,472,036 (GRCm39) missense probably damaging 1.00
R6927:Or2t46 UTSW 11 58,472,491 (GRCm39) missense possibly damaging 0.81
R7451:Or2t46 UTSW 11 58,472,516 (GRCm39) missense probably damaging 1.00
R7626:Or2t46 UTSW 11 58,471,999 (GRCm39) missense probably damaging 0.97
R7724:Or2t46 UTSW 11 58,472,208 (GRCm39) missense probably benign 0.01
R7874:Or2t46 UTSW 11 58,472,573 (GRCm39) missense possibly damaging 0.93
R8217:Or2t46 UTSW 11 58,471,792 (GRCm39) missense probably benign 0.00
R8252:Or2t46 UTSW 11 58,471,958 (GRCm39) missense probably damaging 1.00
R8992:Or2t46 UTSW 11 58,471,738 (GRCm39) missense probably benign 0.00
R9376:Or2t46 UTSW 11 58,472,636 (GRCm39) missense probably benign
R9439:Or2t46 UTSW 11 58,472,104 (GRCm39) missense probably benign 0.38
Z1177:Or2t46 UTSW 11 58,472,137 (GRCm39) missense probably damaging 1.00
Z1186:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1186:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1187:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1188:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1189:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1190:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1191:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1192:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGGTACTCTCTGACACCCAC -3'
(R):5'- TGTCACAGCAGGAACCTCAC -3'

Sequencing Primer
(F):5'- GTACTCTCTGACACCCACCTTCAC -3'
(R):5'- CCTCACAGAAGAAGTGATGGATCTC -3'
Posted On 2019-10-17