Incidental Mutation 'R0634:Mgst1'
ID 58141
Institutional Source Beutler Lab
Gene Symbol Mgst1
Ensembl Gene ENSMUSG00000008540
Gene Name microsomal glutathione S-transferase 1
Synonyms 1500002K10Rik
MMRRC Submission 038823-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R0634 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 138117525-138133753 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 138133329 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 37 (T37S)
Ref Sequence ENSEMBL: ENSMUSP00000145306 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000008684] [ENSMUST00000118091] [ENSMUST00000120230] [ENSMUST00000120302] [ENSMUST00000120939] [ENSMUST00000140932] [ENSMUST00000204628]
AlphaFold Q91VS7
Predicted Effect probably damaging
Transcript: ENSMUST00000008684
AA Change: T141S

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000008684
Gene: ENSMUSG00000008540
AA Change: T141S

DomainStartEndE-ValueType
Pfam:MAPEG 16 150 9.2e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000118091
AA Change: T215S

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000112923
Gene: ENSMUSG00000008540
AA Change: T215S

DomainStartEndE-ValueType
Pfam:MAPEG 90 224 1.9e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000120230
AA Change: T141S

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113859
Gene: ENSMUSG00000008540
AA Change: T141S

DomainStartEndE-ValueType
Pfam:MAPEG 16 150 9.2e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000120302
AA Change: T141S

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113257
Gene: ENSMUSG00000008540
AA Change: T141S

DomainStartEndE-ValueType
Pfam:MAPEG 16 150 9.2e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120939
SMART Domains Protein: ENSMUSP00000112646
Gene: ENSMUSG00000008540

DomainStartEndE-ValueType
PDB:2H8A|A 2 74 1e-45 PDB
Predicted Effect probably damaging
Transcript: ENSMUST00000140932
AA Change: T37S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145306
Gene: ENSMUSG00000008540
AA Change: T37S

DomainStartEndE-ValueType
Pfam:MAPEG 1 46 2.9e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204628
Meta Mutation Damage Score 0.3297 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.9%
  • 20x: 96.2%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,264,491 (GRCm39) I2958V possibly damaging Het
Adam21 C A 12: 81,607,126 (GRCm39) W212L probably benign Het
Adcy2 A C 13: 68,876,064 (GRCm39) H479Q possibly damaging Het
Adcy4 T C 14: 56,019,054 (GRCm39) R168G probably benign Het
Adrm1b C T 3: 92,336,116 (GRCm39) W125* probably null Het
Atp13a2 T C 4: 140,734,240 (GRCm39) probably benign Het
C1ra G A 6: 124,494,464 (GRCm39) E304K possibly damaging Het
Cc2d2a A C 5: 43,838,723 (GRCm39) probably benign Het
Cenpe T C 3: 134,952,588 (GRCm39) L1426P probably damaging Het
Cntn1 A T 15: 92,212,444 (GRCm39) R869* probably null Het
Creb3l2 A T 6: 37,311,283 (GRCm39) probably benign Het
Crybg2 G A 4: 133,802,615 (GRCm39) probably benign Het
Csmd1 A T 8: 16,276,405 (GRCm39) F800I probably damaging Het
Dock6 G A 9: 21,752,823 (GRCm39) T330I probably damaging Het
Ets2 G A 16: 95,517,200 (GRCm39) E311K possibly damaging Het
Fbxo22 A T 9: 55,122,244 (GRCm39) Q141L probably benign Het
Fer C T 17: 64,342,503 (GRCm39) T223M probably benign Het
Gtf3c1 A T 7: 125,256,649 (GRCm39) probably benign Het
Gtf3c2 G A 5: 31,317,150 (GRCm39) R684* probably null Het
Hs6st3 T A 14: 120,106,474 (GRCm39) L294* probably null Het
Ighg2c T G 12: 113,251,584 (GRCm39) E181A unknown Het
Igkv6-15 A T 6: 70,383,763 (GRCm39) probably benign Het
Irag2 A T 6: 145,120,354 (GRCm39) H523L probably damaging Het
Map2k6 C T 11: 110,385,169 (GRCm39) R178* probably null Het
Meikin T A 11: 54,281,309 (GRCm39) D126E probably benign Het
Mrc2 G A 11: 105,238,518 (GRCm39) V1222M probably benign Het
Myom2 C A 8: 15,169,216 (GRCm39) probably benign Het
Negr1 A G 3: 156,721,903 (GRCm39) K159R possibly damaging Het
Nptx1 T C 11: 119,434,127 (GRCm39) T320A possibly damaging Het
Or12j3 A T 7: 139,953,310 (GRCm39) V71E possibly damaging Het
Or4p21 A T 2: 88,276,961 (GRCm39) M107K probably benign Het
Or5p66 T C 7: 107,885,503 (GRCm39) I277V probably benign Het
Pes1 C T 11: 3,927,794 (GRCm39) probably benign Het
Pes1 T G 11: 3,927,795 (GRCm39) probably benign Het
Pkhd1 A T 1: 20,187,698 (GRCm39) Y3537N probably damaging Het
Poteg G A 8: 27,963,615 (GRCm39) G289R probably benign Het
Pramel29 A G 4: 143,935,910 (GRCm39) probably null Het
Rassf5 T C 1: 131,172,693 (GRCm39) R59G probably damaging Het
Reln A T 5: 22,223,867 (GRCm39) W961R probably damaging Het
Rhot2 G A 17: 26,061,002 (GRCm39) H168Y possibly damaging Het
Ripk3 G T 14: 56,025,848 (GRCm39) probably benign Het
Samm50 A G 15: 84,098,372 (GRCm39) silent Het
Sap30bp T C 11: 115,848,229 (GRCm39) I117T probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Sipa1l2 A T 8: 126,149,363 (GRCm39) L1632* probably null Het
Sirt7 T C 11: 120,512,955 (GRCm39) probably benign Het
Smg8 T C 11: 86,976,934 (GRCm39) T216A possibly damaging Het
Sox9 A G 11: 112,675,768 (GRCm39) Y319C probably damaging Het
Sspn G A 6: 145,906,877 (GRCm39) A27T possibly damaging Het
Suco A G 1: 161,666,373 (GRCm39) V509A possibly damaging Het
Svep1 C T 4: 58,070,661 (GRCm39) C2375Y possibly damaging Het
Trbv21 T A 6: 41,179,984 (GRCm39) probably benign Het
Uimc1 C T 13: 55,208,079 (GRCm39) E455K possibly damaging Het
Upk3b A G 5: 136,068,930 (GRCm39) T100A possibly damaging Het
Usp47 A G 7: 111,707,862 (GRCm39) N1303D probably damaging Het
Vav1 A T 17: 57,610,862 (GRCm39) D476V probably benign Het
Vmn1r68 A G 7: 10,261,162 (GRCm39) V312A probably benign Het
Wdr62 A G 7: 29,969,599 (GRCm39) V287A probably damaging Het
Zcchc4 C T 5: 52,940,550 (GRCm39) P40S probably benign Het
Zfp326 T A 5: 106,034,069 (GRCm39) Y26* probably null Het
Zfp592 A G 7: 80,687,819 (GRCm39) H915R probably damaging Het
Other mutations in Mgst1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Mgst1 APN 6 138,124,766 (GRCm39) missense probably damaging 0.99
R0319:Mgst1 UTSW 6 138,133,155 (GRCm39) missense possibly damaging 0.81
R0613:Mgst1 UTSW 6 138,133,243 (GRCm39) missense probably damaging 1.00
R0730:Mgst1 UTSW 6 138,124,667 (GRCm39) missense probably benign 0.03
R0862:Mgst1 UTSW 6 138,124,749 (GRCm39) missense probably damaging 1.00
R4447:Mgst1 UTSW 6 138,118,662 (GRCm39) intron probably benign
R4569:Mgst1 UTSW 6 138,133,213 (GRCm39) missense probably damaging 0.99
R4644:Mgst1 UTSW 6 138,133,368 (GRCm39) missense probably damaging 1.00
R4701:Mgst1 UTSW 6 138,127,836 (GRCm39) missense probably damaging 1.00
R4930:Mgst1 UTSW 6 138,130,507 (GRCm39) missense probably benign 0.00
R5688:Mgst1 UTSW 6 138,118,798 (GRCm39) intron probably benign
R6307:Mgst1 UTSW 6 138,127,827 (GRCm39) missense probably benign 0.44
R6468:Mgst1 UTSW 6 138,118,585 (GRCm39) splice site probably null
R6697:Mgst1 UTSW 6 138,124,751 (GRCm39) missense probably damaging 1.00
R6741:Mgst1 UTSW 6 138,127,836 (GRCm39) missense probably damaging 1.00
R6755:Mgst1 UTSW 6 138,124,770 (GRCm39) missense probably damaging 0.99
R6791:Mgst1 UTSW 6 138,118,805 (GRCm39) intron probably benign
R7295:Mgst1 UTSW 6 138,124,754 (GRCm39) missense probably benign 0.11
R7440:Mgst1 UTSW 6 138,127,842 (GRCm39) missense probably benign
R7532:Mgst1 UTSW 6 138,130,504 (GRCm39) missense probably benign 0.29
R8486:Mgst1 UTSW 6 138,120,026 (GRCm39) missense probably benign 0.00
R8954:Mgst1 UTSW 6 138,119,967 (GRCm39) intron probably benign
R9326:Mgst1 UTSW 6 138,120,023 (GRCm39) missense probably benign 0.29
R9784:Mgst1 UTSW 6 138,124,799 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCAAGTTTCAAGCCACCCTTAGC -3'
(R):5'- GCTCCTTTCACGCATTAAAACCTCAG -3'

Sequencing Primer
(F):5'- tagctaATCTTGACTCAAACCCATTC -3'
(R):5'- CCTCAGAAAGAGTTTGAATCCACTG -3'
Posted On 2013-07-11