Incidental Mutation 'R7509:Irak2'
ID 581951
Institutional Source Beutler Lab
Gene Symbol Irak2
Ensembl Gene ENSMUSG00000060477
Gene Name interleukin-1 receptor-associated kinase 2
Synonyms 6330415L08Rik, IRAK-2
MMRRC Submission 045582-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7509 (G1)
Quality Score 217.468
Status Validated
Chromosome 6
Chromosomal Location 113615428-113671987 bp(+) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) AC to ACC at 113667859 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000055073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059286] [ENSMUST00000089022] [ENSMUST00000089023]
AlphaFold Q8CFA1
Predicted Effect probably null
Transcript: ENSMUST00000059286
SMART Domains Protein: ENSMUSP00000055073
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
Pfam:Death 14 94 4.8e-16 PFAM
Pfam:Pkinase 208 473 4.8e-28 PFAM
Pfam:Pkinase_Tyr 208 482 1.6e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000089022
SMART Domains Protein: ENSMUSP00000086416
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
Pfam:Death 14 93 3.9e-16 PFAM
Pfam:Pkinase 160 425 1.3e-30 PFAM
Pfam:Pkinase_Tyr 160 436 1e-20 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000089023
SMART Domains Protein: ENSMUSP00000086417
Gene: ENSMUSG00000060477

DomainStartEndE-ValueType
PDB:3MOP|N 2 35 3e-13 PDB
Pfam:Pkinase 147 412 1.2e-30 PFAM
Pfam:Pkinase_Tyr 147 419 9.8e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm5 A G 7: 119,133,611 (GRCm39) S259G probably benign Het
Adamts16 G T 13: 70,935,283 (GRCm39) N436K probably damaging Het
Asb3 T A 11: 30,948,507 (GRCm39) M61K probably benign Het
Catspere2 A G 1: 177,905,078 (GRCm39) T163A possibly damaging Het
Ccser2 A G 14: 36,660,602 (GRCm39) L517P probably damaging Het
Cd226 A G 18: 89,265,195 (GRCm39) T158A probably benign Het
Chd6 A T 2: 160,855,074 (GRCm39) I778N probably damaging Het
Cnga4 T C 7: 105,056,097 (GRCm39) V336A probably benign Het
Cpd C T 11: 76,688,702 (GRCm39) V857I probably benign Het
Cpm A G 10: 117,495,745 (GRCm39) Y78C probably damaging Het
Cst7 A T 2: 150,419,624 (GRCm39) T97S probably benign Het
Cttnbp2nl T C 3: 104,940,046 (GRCm39) K8E possibly damaging Het
Erbb4 A T 1: 68,289,739 (GRCm39) D767E possibly damaging Het
Esyt2 T C 12: 116,329,496 (GRCm39) S685P probably damaging Het
Fam110d A C 4: 133,979,424 (GRCm39) V18G probably damaging Het
Gcfc2 T C 6: 81,930,256 (GRCm39) L641P probably damaging Het
Gcnt4 T A 13: 97,083,678 (GRCm39) F325I probably benign Het
Glg1 T G 8: 111,985,675 (GRCm39) S52R probably benign Het
Gm10577 G A 4: 100,877,848 (GRCm39) L16F unknown Het
Gm14326 C T 2: 177,587,493 (GRCm39) G501D probably benign Het
Gm1587 G A 14: 78,034,464 (GRCm39) P35S unknown Het
Gpd1 G A 15: 99,619,967 (GRCm39) S255N probably damaging Het
Helb T A 10: 119,925,719 (GRCm39) H886L probably damaging Het
Hgsnat A G 8: 26,445,754 (GRCm39) V380A probably damaging Het
Hmbs T A 9: 44,248,208 (GRCm39) R125S Het
Hsd17b4 A T 18: 50,297,749 (GRCm39) Y346F probably damaging Het
Inpp4a T C 1: 37,426,911 (GRCm39) L624P probably damaging Het
Itga11 C T 9: 62,689,222 (GRCm39) T1129I probably benign Het
Itih4 G A 14: 30,617,404 (GRCm39) V575I probably benign Het
Kcnn2 A G 18: 45,816,187 (GRCm39) T473A probably benign Het
Kidins220 T C 12: 25,032,360 (GRCm39) V31A probably damaging Het
Lrch1 G A 14: 75,185,048 (GRCm39) T18I probably benign Het
Ly6e T C 15: 74,830,135 (GRCm39) F30L probably damaging Het
Med13l A G 5: 118,886,995 (GRCm39) D1632G probably damaging Het
Mei4 T A 9: 81,907,630 (GRCm39) L320Q probably damaging Het
Mlip T G 9: 77,088,678 (GRCm39) T197P probably damaging Het
Mon2 G A 10: 122,868,457 (GRCm39) A532V probably benign Het
Myh1 C T 11: 67,101,287 (GRCm39) P688S probably benign Het
Ncapg G A 5: 45,853,450 (GRCm39) D900N probably benign Het
Neurl1b C G 17: 26,657,720 (GRCm39) H219Q probably benign Het
Ntn4 A G 10: 93,546,430 (GRCm39) N361S probably benign Het
Nudt16l1 T A 16: 4,757,082 (GRCm39) H26Q probably damaging Het
Obscn G A 11: 58,942,455 (GRCm39) T4348I probably benign Het
Or10d4b T A 9: 39,534,623 (GRCm39) I66N probably damaging Het
Or8c20 T A 9: 38,260,868 (GRCm39) M157K probably benign Het
Pcdh7 T A 5: 57,877,529 (GRCm39) D361E probably damaging Het
Pcdhb7 C A 18: 37,475,074 (GRCm39) T70K possibly damaging Het
Pcdhga3 T A 18: 37,808,910 (GRCm39) Y454* probably null Het
Pigc A T 1: 161,798,545 (GRCm39) T176S probably benign Het
Pola2 A T 19: 6,011,194 (GRCm39) S43R probably benign Het
Pole A T 5: 110,478,571 (GRCm39) probably benign Het
Polq C A 16: 36,880,705 (GRCm39) D956E probably benign Het
Polq T A 16: 36,880,706 (GRCm39) C957S probably benign Het
Ppp3cc G A 14: 70,504,131 (GRCm39) T107I probably damaging Het
Prss39 C A 1: 34,539,280 (GRCm39) H173Q possibly damaging Het
Reep4 A G 14: 70,785,928 (GRCm39) D256G probably benign Het
Rfc3 A G 5: 151,570,975 (GRCm39) V107A probably damaging Het
Slc19a3 A G 1: 83,003,981 (GRCm39) L40P probably damaging Het
Slc29a4 C T 5: 142,704,261 (GRCm39) P305L probably benign Het
Strada C A 11: 106,077,920 (GRCm39) V15F unknown Het
Suco A T 1: 161,672,903 (GRCm39) S440T probably damaging Het
Svep1 A T 4: 58,090,683 (GRCm39) C1595S probably benign Het
Synpo G T 18: 60,736,566 (GRCm39) T460K probably damaging Het
Tagap A T 17: 8,147,568 (GRCm39) I93F probably damaging Het
Tmtc3 A T 10: 100,301,956 (GRCm39) F331Y probably damaging Het
Tnpo1 A C 13: 99,006,751 (GRCm39) I225M probably benign Het
Tollip A T 7: 141,445,878 (GRCm39) M70K probably benign Het
Trpm7 A T 2: 126,691,842 (GRCm39) I171N probably damaging Het
Ttc41 G T 10: 86,549,296 (GRCm39) E163D probably damaging Het
Vmn2r17 A T 5: 109,575,695 (GRCm39) T189S probably benign Het
Vmn2r20 C T 6: 123,362,382 (GRCm39) V801I probably benign Het
Vmn2r82 G A 10: 79,231,842 (GRCm39) V614I possibly damaging Het
Vmn2r96 G A 17: 18,802,995 (GRCm39) E302K probably benign Het
Vwf T C 6: 125,619,132 (GRCm39) F1270S Het
Wdr3 A T 3: 100,058,503 (GRCm39) F367L probably benign Het
Zfp592 A G 7: 80,688,088 (GRCm39) S1005G probably damaging Het
Other mutations in Irak2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Irak2 APN 6 113,655,636 (GRCm39) missense probably benign 0.41
IGL03026:Irak2 APN 6 113,653,612 (GRCm39) missense probably damaging 1.00
R0047:Irak2 UTSW 6 113,655,699 (GRCm39) missense probably benign 0.43
R0047:Irak2 UTSW 6 113,649,914 (GRCm39) splice site probably benign
R0658:Irak2 UTSW 6 113,615,525 (GRCm39) missense probably damaging 1.00
R1120:Irak2 UTSW 6 113,652,720 (GRCm39) unclassified probably benign
R2143:Irak2 UTSW 6 113,649,788 (GRCm39) missense probably benign 0.03
R2190:Irak2 UTSW 6 113,663,904 (GRCm39) missense probably damaging 1.00
R2342:Irak2 UTSW 6 113,670,632 (GRCm39) missense probably benign 0.08
R2507:Irak2 UTSW 6 113,624,639 (GRCm39) missense probably damaging 1.00
R3160:Irak2 UTSW 6 113,649,721 (GRCm39) missense probably benign 0.18
R3162:Irak2 UTSW 6 113,649,721 (GRCm39) missense probably benign 0.18
R4231:Irak2 UTSW 6 113,667,817 (GRCm39) missense probably damaging 0.98
R4604:Irak2 UTSW 6 113,649,848 (GRCm39) missense probably damaging 1.00
R4772:Irak2 UTSW 6 113,670,683 (GRCm39) missense probably damaging 1.00
R4940:Irak2 UTSW 6 113,670,691 (GRCm39) missense probably benign 0.41
R5082:Irak2 UTSW 6 113,649,805 (GRCm39) missense probably damaging 1.00
R5118:Irak2 UTSW 6 113,642,772 (GRCm39) missense probably benign 0.00
R5194:Irak2 UTSW 6 113,667,751 (GRCm39) missense probably benign 0.00
R5604:Irak2 UTSW 6 113,667,792 (GRCm39) missense possibly damaging 0.91
R5928:Irak2 UTSW 6 113,653,587 (GRCm39) missense probably damaging 1.00
R6479:Irak2 UTSW 6 113,663,902 (GRCm39) missense probably damaging 0.99
R7102:Irak2 UTSW 6 113,663,810 (GRCm39) missense probably damaging 1.00
R7153:Irak2 UTSW 6 113,655,670 (GRCm39) missense probably benign 0.34
R7199:Irak2 UTSW 6 113,650,045 (GRCm39) missense probably damaging 0.99
R7694:Irak2 UTSW 6 113,667,859 (GRCm39) missense probably damaging 1.00
R7716:Irak2 UTSW 6 113,667,859 (GRCm39) frame shift probably null
R8414:Irak2 UTSW 6 113,663,903 (GRCm39) missense probably benign 0.08
R8750:Irak2 UTSW 6 113,663,783 (GRCm39) missense probably benign 0.01
R8870:Irak2 UTSW 6 113,663,902 (GRCm39) missense probably damaging 0.99
R8959:Irak2 UTSW 6 113,624,702 (GRCm39) missense probably damaging 0.98
R9324:Irak2 UTSW 6 113,615,604 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CAGCTTTAGTGTCAGCGACTG -3'
(R):5'- TGGCCTAAGTTAGGGTCACAGG -3'

Sequencing Primer
(F):5'- CGACTGATACGGCTGCTTGTC -3'
(R):5'- CCAAGCTTACCGTTCTGGG -3'
Posted On 2019-10-17