Incidental Mutation 'R7516:Vmn2r85'
| ID |
582475 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r85
|
| Ensembl Gene |
ENSMUSG00000092048 |
| Gene Name |
vomeronasal 2, receptor 85 |
| Synonyms |
EG623734 |
| MMRRC Submission |
045589-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
R7516 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130253658-130266615 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 130254852 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 611
(T611S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128792
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171811]
|
| AlphaFold |
G3UW56 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171811
AA Change: T611S
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: T611S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
9e-26 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.1e-18 |
PFAM |
|
Pfam:7tm_3
|
595 |
831 |
3.7e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam28 |
T |
A |
14: 68,868,125 (GRCm39) |
I407F |
probably damaging |
Het |
| Agbl1 |
A |
G |
7: 76,075,669 (GRCm39) |
Y437C |
probably damaging |
Het |
| Alkbh5 |
T |
C |
11: 60,429,979 (GRCm39) |
V244A |
probably damaging |
Het |
| Arap1 |
T |
C |
7: 101,058,538 (GRCm39) |
F1390L |
probably benign |
Het |
| Asph |
T |
C |
4: 9,630,940 (GRCm39) |
D136G |
possibly damaging |
Het |
| Atp8a2 |
A |
T |
14: 60,094,516 (GRCm39) |
Y841N |
probably damaging |
Het |
| Cald1 |
A |
T |
6: 34,686,492 (GRCm39) |
|
probably benign |
Het |
| Capn11 |
A |
G |
17: 45,949,766 (GRCm39) |
I400T |
possibly damaging |
Het |
| Cdh18 |
T |
A |
15: 23,259,684 (GRCm39) |
|
probably null |
Het |
| Ces2h |
T |
A |
8: 105,743,458 (GRCm39) |
L204Q |
probably damaging |
Het |
| Chrna3 |
G |
A |
9: 54,922,653 (GRCm39) |
A385V |
probably benign |
Het |
| Clca4a |
A |
T |
3: 144,672,009 (GRCm39) |
L311Q |
probably damaging |
Het |
| Clip1 |
A |
G |
5: 123,721,448 (GRCm39) |
V1149A |
probably benign |
Het |
| Clip3 |
T |
A |
7: 29,998,268 (GRCm39) |
V238D |
possibly damaging |
Het |
| Col12a1 |
A |
G |
9: 79,520,192 (GRCm39) |
|
probably null |
Het |
| Coro2a |
A |
G |
4: 46,562,992 (GRCm39) |
V54A |
probably benign |
Het |
| Crem |
T |
C |
18: 3,299,141 (GRCm39) |
|
probably null |
Het |
| Dennd5b |
T |
C |
6: 148,969,878 (GRCm39) |
I192V |
probably benign |
Het |
| Dst |
A |
G |
1: 34,209,560 (GRCm39) |
N1209S |
probably benign |
Het |
| Ero1a |
T |
A |
14: 45,525,480 (GRCm39) |
M385L |
probably benign |
Het |
| Fam13a |
A |
T |
6: 58,932,248 (GRCm39) |
V375D |
probably damaging |
Het |
| Fgfbp3 |
T |
A |
19: 36,896,324 (GRCm39) |
Y98F |
possibly damaging |
Het |
| Frem3 |
T |
C |
8: 81,338,712 (GRCm39) |
V335A |
probably damaging |
Het |
| Gm19410 |
T |
A |
8: 36,263,433 (GRCm39) |
D951E |
probably benign |
Het |
| Gpatch1 |
T |
C |
7: 35,007,625 (GRCm39) |
D145G |
probably benign |
Het |
| H60c |
G |
T |
10: 3,209,746 (GRCm39) |
C180* |
probably null |
Het |
| Hmcn1 |
T |
C |
1: 150,498,718 (GRCm39) |
T4054A |
probably benign |
Het |
| Hrg |
A |
G |
16: 22,780,048 (GRCm39) |
Y442C |
unknown |
Het |
| Hspg2 |
C |
T |
4: 137,269,931 (GRCm39) |
R2327C |
possibly damaging |
Het |
| Klhl31 |
G |
T |
9: 77,558,429 (GRCm39) |
A382S |
probably damaging |
Het |
| Knl1 |
T |
C |
2: 118,901,179 (GRCm39) |
V960A |
probably damaging |
Het |
| Lztr1 |
C |
T |
16: 17,327,525 (GRCm39) |
A76V |
possibly damaging |
Het |
| Me3 |
G |
T |
7: 89,497,183 (GRCm39) |
E395* |
probably null |
Het |
| Morc2b |
G |
A |
17: 33,356,435 (GRCm39) |
H446Y |
probably benign |
Het |
| Mroh7 |
A |
T |
4: 106,548,316 (GRCm39) |
M1054K |
probably benign |
Het |
| Ms4a6b |
T |
C |
19: 11,506,907 (GRCm39) |
V232A |
probably benign |
Het |
| Nmt2 |
C |
A |
2: 3,313,767 (GRCm39) |
D224E |
probably damaging |
Het |
| Nox4 |
C |
A |
7: 86,970,905 (GRCm39) |
R261S |
probably benign |
Het |
| Obscn |
T |
A |
11: 59,015,416 (GRCm39) |
K1019* |
probably null |
Het |
| Or4a15 |
T |
A |
2: 89,193,719 (GRCm39) |
N18I |
probably benign |
Het |
| Or4g7 |
T |
A |
2: 111,309,282 (GRCm39) |
V51D |
probably benign |
Het |
| Or5p67 |
G |
A |
7: 107,922,223 (GRCm39) |
S220F |
probably damaging |
Het |
| Or8k24 |
C |
T |
2: 86,216,328 (GRCm39) |
V145I |
probably benign |
Het |
| Pcdha11 |
A |
T |
18: 37,144,671 (GRCm39) |
N254I |
probably damaging |
Het |
| Pck2 |
T |
A |
14: 55,779,913 (GRCm39) |
I54N |
probably benign |
Het |
| Pkd1l3 |
T |
A |
8: 110,361,861 (GRCm39) |
W978R |
probably damaging |
Het |
| Plxna4 |
T |
C |
6: 32,214,703 (GRCm39) |
T593A |
probably benign |
Het |
| Podn |
G |
A |
4: 107,879,321 (GRCm39) |
R266W |
probably damaging |
Het |
| Ptpn22 |
A |
G |
3: 103,792,854 (GRCm39) |
D335G |
probably benign |
Het |
| Pxn |
A |
G |
5: 115,644,922 (GRCm39) |
D3G |
unknown |
Het |
| Rapgefl1 |
T |
G |
11: 98,736,960 (GRCm39) |
V320G |
probably benign |
Het |
| Rel |
A |
G |
11: 23,692,785 (GRCm39) |
I416T |
probably benign |
Het |
| Sema5b |
A |
G |
16: 35,471,540 (GRCm39) |
N378D |
probably benign |
Het |
| Sh3bp4 |
C |
A |
1: 89,073,368 (GRCm39) |
L739M |
probably damaging |
Het |
| Skint2 |
A |
T |
4: 112,483,168 (GRCm39) |
D191V |
probably damaging |
Het |
| Slc3a1 |
T |
C |
17: 85,371,190 (GRCm39) |
Y581H |
probably damaging |
Het |
| Smcr8 |
G |
T |
11: 60,670,814 (GRCm39) |
C654F |
probably benign |
Het |
| Spta1 |
A |
C |
1: 174,025,349 (GRCm39) |
Q738P |
probably damaging |
Het |
| Sptlc3 |
C |
A |
2: 139,431,438 (GRCm39) |
A320D |
probably benign |
Het |
| Thnsl2 |
T |
A |
6: 71,108,990 (GRCm39) |
K274* |
probably null |
Het |
| Tmed2 |
T |
A |
5: 124,685,055 (GRCm39) |
I68K |
possibly damaging |
Het |
| Tmtc4 |
G |
A |
14: 123,180,735 (GRCm39) |
A326V |
possibly damaging |
Het |
| Tnks2 |
T |
A |
19: 36,849,064 (GRCm39) |
S179T |
possibly damaging |
Het |
| Trim34b |
G |
T |
7: 103,978,918 (GRCm39) |
C55F |
probably damaging |
Het |
| Trpm4 |
T |
A |
7: 44,954,444 (GRCm39) |
E1129V |
probably damaging |
Het |
| Tvp23b |
T |
C |
11: 62,782,867 (GRCm39) |
S188P |
possibly damaging |
Het |
| Usp1 |
A |
G |
4: 98,822,356 (GRCm39) |
T557A |
probably damaging |
Het |
| Vmn2r66 |
C |
T |
7: 84,661,176 (GRCm39) |
C18Y |
possibly damaging |
Het |
| Vps13c |
T |
C |
9: 67,862,289 (GRCm39) |
S2969P |
possibly damaging |
Het |
| Wdr74 |
T |
A |
19: 8,713,554 (GRCm39) |
C62* |
probably null |
Het |
| Wfikkn1 |
A |
T |
17: 26,097,020 (GRCm39) |
C435S |
probably damaging |
Het |
| Zbtb45 |
A |
T |
7: 12,740,269 (GRCm39) |
F449I |
probably damaging |
Het |
|
| Other mutations in Vmn2r85 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01160:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01298:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01361:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02185:Vmn2r85
|
APN |
10 |
130,254,561 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02505:Vmn2r85
|
APN |
10 |
130,261,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02607:Vmn2r85
|
APN |
10 |
130,262,290 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02755:Vmn2r85
|
APN |
10 |
130,261,381 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03188:Vmn2r85
|
APN |
10 |
130,254,612 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03366:Vmn2r85
|
APN |
10 |
130,262,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03397:Vmn2r85
|
APN |
10 |
130,261,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r85
|
UTSW |
10 |
130,261,572 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0066:Vmn2r85
|
UTSW |
10 |
130,261,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0128:Vmn2r85
|
UTSW |
10 |
130,255,054 (GRCm39) |
splice site |
probably benign |
|
|
R0130:Vmn2r85
|
UTSW |
10 |
130,255,054 (GRCm39) |
splice site |
probably benign |
|
|
R0503:Vmn2r85
|
UTSW |
10 |
130,258,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0827:Vmn2r85
|
UTSW |
10 |
130,265,387 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1432:Vmn2r85
|
UTSW |
10 |
130,261,155 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1521:Vmn2r85
|
UTSW |
10 |
130,261,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2029:Vmn2r85
|
UTSW |
10 |
130,261,443 (GRCm39) |
nonsense |
probably null |
|
|
R2034:Vmn2r85
|
UTSW |
10 |
130,262,242 (GRCm39) |
splice site |
probably benign |
|
|
R2852:Vmn2r85
|
UTSW |
10 |
130,255,035 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2853:Vmn2r85
|
UTSW |
10 |
130,255,035 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3084:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3085:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3430:Vmn2r85
|
UTSW |
10 |
130,254,758 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3694:Vmn2r85
|
UTSW |
10 |
130,254,171 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3932:Vmn2r85
|
UTSW |
10 |
130,254,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4207:Vmn2r85
|
UTSW |
10 |
130,254,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4628:Vmn2r85
|
UTSW |
10 |
130,261,235 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4814:Vmn2r85
|
UTSW |
10 |
130,254,567 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4948:Vmn2r85
|
UTSW |
10 |
130,254,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Vmn2r85
|
UTSW |
10 |
130,261,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4959:Vmn2r85
|
UTSW |
10 |
130,257,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Vmn2r85
|
UTSW |
10 |
130,258,574 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5643:Vmn2r85
|
UTSW |
10 |
130,262,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6061:Vmn2r85
|
UTSW |
10 |
130,261,531 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6115:Vmn2r85
|
UTSW |
10 |
130,258,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6190:Vmn2r85
|
UTSW |
10 |
130,261,330 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6518:Vmn2r85
|
UTSW |
10 |
130,265,281 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6533:Vmn2r85
|
UTSW |
10 |
130,262,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6610:Vmn2r85
|
UTSW |
10 |
130,261,838 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6809:Vmn2r85
|
UTSW |
10 |
130,261,795 (GRCm39) |
missense |
probably benign |
|
|
R6962:Vmn2r85
|
UTSW |
10 |
130,261,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7075:Vmn2r85
|
UTSW |
10 |
130,258,557 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7104:Vmn2r85
|
UTSW |
10 |
130,262,376 (GRCm39) |
missense |
probably benign |
|
|
R7424:Vmn2r85
|
UTSW |
10 |
130,254,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7537:Vmn2r85
|
UTSW |
10 |
130,258,735 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7768:Vmn2r85
|
UTSW |
10 |
130,254,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8078:Vmn2r85
|
UTSW |
10 |
130,265,364 (GRCm39) |
nonsense |
probably null |
|
|
R8115:Vmn2r85
|
UTSW |
10 |
130,261,820 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8262:Vmn2r85
|
UTSW |
10 |
130,254,738 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8395:Vmn2r85
|
UTSW |
10 |
130,261,797 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8409:Vmn2r85
|
UTSW |
10 |
130,261,257 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8547:Vmn2r85
|
UTSW |
10 |
130,261,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8875:Vmn2r85
|
UTSW |
10 |
130,254,171 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9035:Vmn2r85
|
UTSW |
10 |
130,261,479 (GRCm39) |
missense |
probably benign |
|
|
R9040:Vmn2r85
|
UTSW |
10 |
130,254,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9115:Vmn2r85
|
UTSW |
10 |
130,254,153 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Vmn2r85
|
UTSW |
10 |
130,265,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9245:Vmn2r85
|
UTSW |
10 |
130,261,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r85
|
UTSW |
10 |
130,255,033 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9405:Vmn2r85
|
UTSW |
10 |
130,261,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9502:Vmn2r85
|
UTSW |
10 |
130,261,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9520:Vmn2r85
|
UTSW |
10 |
130,254,993 (GRCm39) |
missense |
probably benign |
|
|
R9653:Vmn2r85
|
UTSW |
10 |
130,261,694 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Vmn2r85
|
UTSW |
10 |
130,261,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r85
|
UTSW |
10 |
130,254,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GACCACAGTTATTGTTTTGGCC -3'
(R):5'- AGGGTTTATTGACATTTGCCAGC -3'
Sequencing Primer
(F):5'- GTTTTGGCCAACACTGTAGAAAC -3'
(R):5'- TGACATTTGCCAGCAGATATGG -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation