Incidental Mutation 'R7521:Tdrp'
ID 582666
Institutional Source Beutler Lab
Gene Symbol Tdrp
Ensembl Gene ENSMUSG00000050052
Gene Name testis development related protein
Synonyms 2610019F03Rik
MMRRC Submission 045593-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7521 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 14002008-14025032 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 14003831 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 169 (Q169*)
Ref Sequence ENSEMBL: ENSMUSP00000058371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062613] [ENSMUST00000145695] [ENSMUST00000210414]
AlphaFold Q8C5P7
Predicted Effect probably null
Transcript: ENSMUST00000062613
AA Change: Q169*
SMART Domains Protein: ENSMUSP00000058371
Gene: ENSMUSG00000050052
AA Change: Q169*

DomainStartEndE-ValueType
low complexity region 8 22 N/A INTRINSIC
Pfam:TDRP 35 182 1.8e-72 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145695
SMART Domains Protein: ENSMUSP00000114338
Gene: ENSMUSG00000050052

DomainStartEndE-ValueType
low complexity region 8 22 N/A INTRINSIC
low complexity region 23 37 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000210414
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 A G 17: 31,283,543 (GRCm39) N76S probably benign Het
Ahnak T C 19: 8,979,715 (GRCm39) V333A possibly damaging Het
Arid1b GGCGGC GGCGGCAGCGGC 17: 5,046,135 (GRCm39) probably benign Het
Arid1b GGGCGGCGGCGGCGGCGGCGGCGG GGGCGGCGGCGGCGGCGGCGGCGGCGGCGG 17: 5,046,119 (GRCm39) probably benign Het
Arid1b A G 17: 5,392,865 (GRCm39) T2079A probably benign Het
Clca3a2 A G 3: 144,507,674 (GRCm39) *190R probably null Het
Cntnap3 G T 13: 64,919,815 (GRCm39) Q681K probably benign Het
Coro7 T C 16: 4,449,346 (GRCm39) D689G probably benign Het
Dnah9 A T 11: 65,880,663 (GRCm39) S2645T probably damaging Het
Dnm3 A T 1: 161,962,113 (GRCm39) L32H probably damaging Het
Dtx4 T C 19: 12,469,861 (GRCm39) K89E probably benign Het
Exph5 T A 9: 53,285,377 (GRCm39) N819K possibly damaging Het
Fpgt A G 3: 154,792,765 (GRCm39) S421P possibly damaging Het
Gbp5 T C 3: 142,206,382 (GRCm39) V22A probably benign Het
Gpatch1 C T 7: 34,993,213 (GRCm39) R544Q probably damaging Het
Grm5 T A 7: 87,723,480 (GRCm39) L590Q possibly damaging Het
Hc T C 2: 34,935,344 (GRCm39) D172G possibly damaging Het
Ifi209 A T 1: 173,470,261 (GRCm39) N283I probably damaging Het
Igsf11 C T 16: 38,829,274 (GRCm39) T115M probably damaging Het
Il17rd T A 14: 26,816,823 (GRCm39) M320K probably benign Het
Kdm5a T A 6: 120,409,148 (GRCm39) C1610* probably null Het
Mast3 T A 8: 71,241,412 (GRCm39) I175L probably benign Het
Mif A T 10: 75,695,942 (GRCm39) S21T possibly damaging Het
Mindy2 T C 9: 70,514,792 (GRCm39) Q542R probably benign Het
Nalcn T A 14: 123,530,870 (GRCm39) E1389D probably damaging Het
Or55b3 C T 7: 102,126,402 (GRCm39) R225H possibly damaging Het
Or5k8 T C 16: 58,644,257 (GRCm39) I272V probably benign Het
Or5t16 T A 2: 86,818,954 (GRCm39) T189S probably damaging Het
Or7e177 T C 9: 20,212,036 (GRCm39) I181T probably benign Het
Pcsk5 T A 19: 17,432,196 (GRCm39) D1473V probably benign Het
Phax C T 18: 56,708,990 (GRCm39) Q185* probably null Het
Ppp2r2b T A 18: 43,192,242 (GRCm39) S22C probably benign Het
Prss40 A G 1: 34,597,090 (GRCm39) F153L probably benign Het
Slc22a2 T C 17: 12,805,710 (GRCm39) S154P probably benign Het
Speer4a1 G A 5: 26,241,763 (GRCm39) T121I probably damaging Het
Tacc1 A G 8: 25,665,268 (GRCm39) V488A possibly damaging Het
Tmem30b C T 12: 73,592,092 (GRCm39) R341H probably benign Het
Other mutations in Tdrp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02980:Tdrp UTSW 8 14,003,918 (GRCm39) missense probably damaging 0.98
R1905:Tdrp UTSW 8 14,004,079 (GRCm39) missense probably damaging 0.99
R4760:Tdrp UTSW 8 14,024,527 (GRCm39) splice site probably benign
R4906:Tdrp UTSW 8 14,003,845 (GRCm39) missense possibly damaging 0.95
R5065:Tdrp UTSW 8 14,003,791 (GRCm39) missense probably damaging 1.00
R5086:Tdrp UTSW 8 14,024,590 (GRCm39) missense possibly damaging 0.72
R5245:Tdrp UTSW 8 14,024,479 (GRCm39) intron probably benign
R7172:Tdrp UTSW 8 14,024,579 (GRCm39) nonsense probably null
R7890:Tdrp UTSW 8 14,005,727 (GRCm39) missense probably damaging 0.98
R9000:Tdrp UTSW 8 14,003,989 (GRCm39) missense probably benign
R9029:Tdrp UTSW 8 14,003,840 (GRCm39) missense possibly damaging 0.52
R9112:Tdrp UTSW 8 14,005,796 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACCAGATGTCACCCGGAAG -3'
(R):5'- GGAGCCTCCCAAACTTACTG -3'

Sequencing Primer
(F):5'- AGATGTCACCCGGAAGCCATG -3'
(R):5'- CAAACTTACTGCTGAAGACGTGGTC -3'
Posted On 2019-10-17