Incidental Mutation 'R0616:Prg4'
| ID |
58283 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Prg4
|
| Ensembl Gene |
ENSMUSG00000006014 |
| Gene Name |
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) |
| Synonyms |
MSF, SZP, lubricin, DOL54 |
| MMRRC Submission |
038805-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.125)
|
| Stock # |
R0616 (G1)
|
| Quality Score |
184 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
150325163-150341916 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 150336462 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 87
(D87G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128943
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006171]
[ENSMUST00000111901]
[ENSMUST00000111902]
[ENSMUST00000159035]
[ENSMUST00000161320]
[ENSMUST00000161611]
[ENSMUST00000162367]
[ENSMUST00000164600]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000006171
AA Change: D87G
PolyPhen 2
Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000006171
Gene: ENSMUSG00000006014
AA Change: D87G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
4.21e-12 |
SMART |
|
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
|
HX
|
169 |
211 |
1.67e-7 |
SMART |
|
HX
|
213 |
256 |
3.76e-10 |
SMART |
|
Blast:HX
|
369 |
422 |
2e-27 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111901
AA Change: D87G
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000107532
Gene: ENSMUSG00000006014
AA Change: D87G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
4.21e-12 |
SMART |
|
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
221 |
N/A |
INTRINSIC |
|
low complexity region
|
241 |
535 |
N/A |
INTRINSIC |
|
low complexity region
|
570 |
623 |
N/A |
INTRINSIC |
|
HX
|
711 |
753 |
1.67e-7 |
SMART |
|
HX
|
755 |
798 |
3.76e-10 |
SMART |
|
Blast:HX
|
911 |
964 |
5e-27 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000111902
AA Change: D46G
PolyPhen 2
Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000107533
Gene: ENSMUSG00000006014
AA Change: D46G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
25 |
67 |
2.71e-15 |
SMART |
|
low complexity region
|
69 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
86 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
171 |
N/A |
INTRINSIC |
|
low complexity region
|
188 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
268 |
N/A |
INTRINSIC |
|
low complexity region
|
288 |
582 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
588 |
614 |
2.72e-5 |
PROSPERO |
|
low complexity region
|
617 |
670 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
680 |
706 |
2.72e-5 |
PROSPERO |
|
HX
|
758 |
800 |
1.67e-7 |
SMART |
|
HX
|
802 |
845 |
3.76e-10 |
SMART |
|
Blast:HX
|
958 |
1011 |
4e-27 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159035
AA Change: D46G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124410
Gene: ENSMUSG00000006014
AA Change: D46G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
25 |
67 |
2.71e-15 |
SMART |
|
low complexity region
|
69 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
88 |
99 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000161320
AA Change: D46G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124801
Gene: ENSMUSG00000006014
AA Change: D46G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
25 |
67 |
3.83e-15 |
SMART |
|
low complexity region
|
69 |
83 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
148 |
179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000161611
AA Change: D87G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125677
Gene: ENSMUSG00000006014
AA Change: D87G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
2.77e-12 |
SMART |
|
low complexity region
|
110 |
122 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
184 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
212 |
N/A |
INTRINSIC |
|
low complexity region
|
229 |
239 |
N/A |
INTRINSIC |
|
internal_repeat_3
|
244 |
271 |
7.42e-5 |
PROSPERO |
|
low complexity region
|
277 |
309 |
N/A |
INTRINSIC |
|
Pfam:Cornifin
|
578 |
691 |
2.2e-9 |
PFAM |
|
internal_repeat_3
|
796 |
825 |
7.42e-5 |
PROSPERO |
|
internal_repeat_2
|
797 |
823 |
1.24e-5 |
PROSPERO |
|
low complexity region
|
826 |
879 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
889 |
915 |
1.24e-5 |
PROSPERO |
|
HX
|
967 |
1009 |
1.67e-7 |
SMART |
|
HX
|
1011 |
1054 |
3.76e-10 |
SMART |
|
Blast:HX
|
1167 |
1220 |
6e-27 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000162367
AA Change: D87G
PolyPhen 2
Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000125551
Gene: ENSMUSG00000006014
AA Change: D87G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
4.21e-12 |
SMART |
|
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
|
HX
|
169 |
211 |
1.67e-7 |
SMART |
|
HX
|
213 |
256 |
3.76e-10 |
SMART |
|
Blast:HX
|
369 |
422 |
2e-27 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164600
AA Change: D87G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000128943
Gene: ENSMUSG00000006014
AA Change: D87G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
2.77e-12 |
SMART |
|
low complexity region
|
110 |
122 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
184 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
212 |
N/A |
INTRINSIC |
|
low complexity region
|
229 |
239 |
N/A |
INTRINSIC |
|
internal_repeat_3
|
244 |
271 |
7.42e-5 |
PROSPERO |
|
low complexity region
|
277 |
309 |
N/A |
INTRINSIC |
|
Pfam:Cornifin
|
404 |
497 |
2.4e-14 |
PFAM |
|
Pfam:Cornifin
|
468 |
584 |
3.2e-15 |
PFAM |
|
Pfam:Cornifin
|
550 |
648 |
3.3e-16 |
PFAM |
|
Pfam:Cornifin
|
625 |
722 |
2.1e-15 |
PFAM |
|
Pfam:Cornifin
|
647 |
743 |
7.8e-16 |
PFAM |
|
Pfam:Cornifin
|
706 |
822 |
1.4e-12 |
PFAM |
|
low complexity region
|
826 |
879 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
889 |
915 |
1.24e-5 |
PROSPERO |
|
HX
|
967 |
1009 |
1.67e-7 |
SMART |
|
HX
|
1011 |
1054 |
3.76e-10 |
SMART |
|
Blast:HX
|
1167 |
1220 |
6e-27 |
BLAST |
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.5%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Aging homozygous null mice develop a hopping gait, irregular endochondral growth plates, altered cartilage surface, camptodactyly, progressive synovial hyperplasia and, ultimately, joint failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
G |
T |
1: 71,341,830 (GRCm39) |
Q1044K |
probably damaging |
Het |
| Abi3bp |
A |
T |
16: 56,474,433 (GRCm39) |
T723S |
probably damaging |
Het |
| Ackr3 |
G |
A |
1: 90,142,191 (GRCm39) |
V217I |
probably benign |
Het |
| Acnat2 |
A |
G |
4: 49,380,269 (GRCm39) |
S370P |
probably damaging |
Het |
| Arap1 |
A |
G |
7: 101,050,857 (GRCm39) |
R1152G |
possibly damaging |
Het |
| Arhgap15 |
G |
A |
2: 44,006,729 (GRCm39) |
|
probably null |
Het |
| Arhgap5 |
C |
T |
12: 52,563,848 (GRCm39) |
T273I |
possibly damaging |
Het |
| Armh4 |
G |
T |
14: 50,011,113 (GRCm39) |
T198K |
possibly damaging |
Het |
| C1s2 |
T |
C |
6: 124,605,723 (GRCm39) |
E332G |
probably damaging |
Het |
| Camp |
G |
A |
9: 109,677,707 (GRCm39) |
R88W |
probably benign |
Het |
| Cdkl2 |
A |
G |
5: 92,156,863 (GRCm39) |
M564T |
probably benign |
Het |
| Ceacam20 |
A |
G |
7: 19,704,321 (GRCm39) |
H124R |
probably benign |
Het |
| Cep19 |
C |
T |
16: 31,922,829 (GRCm39) |
R32C |
probably damaging |
Het |
| Cep295 |
G |
A |
9: 15,243,618 (GRCm39) |
Q1565* |
probably null |
Het |
| Chd3 |
T |
C |
11: 69,236,313 (GRCm39) |
E1932G |
probably damaging |
Het |
| Cibar1 |
G |
A |
4: 12,168,234 (GRCm39) |
R210* |
probably null |
Het |
| Cnr2 |
G |
T |
4: 135,644,873 (GRCm39) |
W317L |
probably benign |
Het |
| Cntnap5a |
C |
T |
1: 116,508,279 (GRCm39) |
H1264Y |
possibly damaging |
Het |
| Depdc7 |
T |
A |
2: 104,557,650 (GRCm39) |
N200I |
probably benign |
Het |
| Dock4 |
T |
C |
12: 40,754,414 (GRCm39) |
S468P |
probably benign |
Het |
| Dscc1 |
C |
A |
15: 54,946,966 (GRCm39) |
C253F |
probably benign |
Het |
| Fam217a |
C |
A |
13: 35,097,666 (GRCm39) |
S55I |
probably benign |
Het |
| Farp1 |
G |
A |
14: 121,514,434 (GRCm39) |
R921H |
probably damaging |
Het |
| Fat4 |
A |
G |
3: 38,997,019 (GRCm39) |
D1746G |
probably damaging |
Het |
| Fbxw5 |
T |
C |
2: 25,392,517 (GRCm39) |
F100L |
probably damaging |
Het |
| Gli3 |
C |
A |
13: 15,836,991 (GRCm39) |
T458K |
possibly damaging |
Het |
| Gm4841 |
T |
C |
18: 60,404,009 (GRCm39) |
Y28C |
probably benign |
Het |
| Gprc5d |
T |
C |
6: 135,093,430 (GRCm39) |
E159G |
probably benign |
Het |
| Grm4 |
A |
T |
17: 27,653,538 (GRCm39) |
I757N |
probably damaging |
Het |
| Hagh |
A |
G |
17: 25,076,551 (GRCm39) |
Y94C |
probably damaging |
Het |
| Hycc1 |
T |
C |
5: 24,191,770 (GRCm39) |
T44A |
probably damaging |
Het |
| Itpkb |
T |
C |
1: 180,249,301 (GRCm39) |
I892T |
probably damaging |
Het |
| Kcmf1 |
T |
C |
6: 72,827,467 (GRCm39) |
I58V |
probably benign |
Het |
| Khdrbs2 |
A |
G |
1: 32,506,856 (GRCm39) |
I167V |
possibly damaging |
Het |
| Kmt2c |
A |
G |
5: 25,504,250 (GRCm39) |
I275T |
probably benign |
Het |
| Lingo4 |
A |
G |
3: 94,310,388 (GRCm39) |
K442R |
probably benign |
Het |
| Mak |
T |
C |
13: 41,195,661 (GRCm39) |
N382D |
probably benign |
Het |
| Maob |
G |
A |
X: 16,576,402 (GRCm39) |
T480I |
possibly damaging |
Het |
| Mcoln1 |
A |
G |
8: 3,565,025 (GRCm39) |
E573G |
probably benign |
Het |
| Ms4a6b |
G |
A |
19: 11,504,262 (GRCm39) |
|
probably null |
Het |
| Muc5ac |
A |
G |
7: 141,349,981 (GRCm39) |
M576V |
probably benign |
Het |
| Nme8 |
T |
A |
13: 19,875,029 (GRCm39) |
D126V |
probably benign |
Het |
| Npy2r |
T |
A |
3: 82,448,670 (GRCm39) |
D35V |
possibly damaging |
Het |
| Nrxn1 |
T |
C |
17: 90,670,285 (GRCm39) |
D193G |
probably damaging |
Het |
| Or2g7 |
A |
C |
17: 38,378,131 (GRCm39) |
E23A |
probably damaging |
Het |
| Or2y1e |
T |
C |
11: 49,218,583 (GRCm39) |
L115P |
probably damaging |
Het |
| Or4c10b |
T |
A |
2: 89,711,935 (GRCm39) |
V255E |
probably benign |
Het |
| Or4d5 |
A |
T |
9: 40,012,283 (GRCm39) |
F168I |
probably damaging |
Het |
| Or52b4i |
T |
A |
7: 102,191,761 (GRCm39) |
M206K |
possibly damaging |
Het |
| Or6d14 |
A |
G |
6: 116,533,889 (GRCm39) |
I168V |
probably benign |
Het |
| Or8b3b |
A |
T |
9: 38,584,776 (GRCm39) |
M1K |
probably null |
Het |
| Or8c17 |
G |
T |
9: 38,180,630 (GRCm39) |
V266L |
probably benign |
Het |
| Or8g18 |
G |
A |
9: 39,148,946 (GRCm39) |
T258M |
probably benign |
Het |
| Pabpc2 |
A |
T |
18: 39,906,792 (GRCm39) |
H19L |
possibly damaging |
Het |
| Pcdhb9 |
A |
T |
18: 37,535,028 (GRCm39) |
K341* |
probably null |
Het |
| Pde4dip |
T |
C |
3: 97,654,849 (GRCm39) |
I859M |
probably benign |
Het |
| Pfkfb2 |
T |
C |
1: 130,634,159 (GRCm39) |
|
probably null |
Het |
| Pigg |
C |
T |
5: 108,461,951 (GRCm39) |
T94M |
probably damaging |
Het |
| Pik3c2b |
T |
C |
1: 133,028,569 (GRCm39) |
F1353L |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,508,271 (GRCm39) |
D974V |
probably damaging |
Het |
| Prmt3 |
A |
G |
7: 49,437,076 (GRCm39) |
Y217C |
probably damaging |
Het |
| Proser1 |
A |
G |
3: 53,382,118 (GRCm39) |
T192A |
probably damaging |
Het |
| Rab3d |
G |
A |
9: 21,826,060 (GRCm39) |
T118M |
probably damaging |
Het |
| Rb1cc1 |
A |
G |
1: 6,314,486 (GRCm39) |
K386R |
possibly damaging |
Het |
| Rcn2 |
A |
G |
9: 55,963,534 (GRCm39) |
D221G |
probably benign |
Het |
| Rhbdl3 |
T |
G |
11: 80,222,687 (GRCm39) |
H245Q |
probably damaging |
Het |
| Ribc1 |
T |
C |
X: 150,788,787 (GRCm39) |
E204G |
probably damaging |
Het |
| Rpap1 |
G |
A |
2: 119,608,601 (GRCm39) |
L254F |
probably damaging |
Het |
| Rrp12 |
A |
G |
19: 41,880,988 (GRCm39) |
F148L |
possibly damaging |
Het |
| Rusf1 |
A |
T |
7: 127,871,803 (GRCm39) |
|
probably null |
Het |
| Setdb1 |
A |
T |
3: 95,249,109 (GRCm39) |
I333K |
probably damaging |
Het |
| Simc1 |
A |
G |
13: 54,694,845 (GRCm39) |
I1210V |
probably benign |
Het |
| Smchd1 |
T |
A |
17: 71,686,569 (GRCm39) |
D1379V |
probably benign |
Het |
| Snap29 |
A |
T |
16: 17,240,370 (GRCm39) |
K159* |
probably null |
Het |
| Spdye4c |
A |
T |
2: 128,436,132 (GRCm39) |
K176M |
possibly damaging |
Het |
| Stk31 |
T |
A |
6: 49,400,419 (GRCm39) |
W415R |
probably damaging |
Het |
| Supt6 |
C |
T |
11: 78,100,321 (GRCm39) |
R1497Q |
probably damaging |
Het |
| Tenm3 |
A |
G |
8: 48,729,191 (GRCm39) |
I1605T |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,676,967 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
G |
2: 76,728,011 (GRCm39) |
|
probably benign |
Het |
| Ucp3 |
A |
T |
7: 100,129,368 (GRCm39) |
T68S |
probably benign |
Het |
| Ugt2b36 |
T |
C |
5: 87,237,336 (GRCm39) |
N316D |
probably benign |
Het |
| Usp4 |
T |
G |
9: 108,244,003 (GRCm39) |
S247A |
probably benign |
Het |
| Utp20 |
A |
T |
10: 88,606,613 (GRCm39) |
V1653D |
probably benign |
Het |
| Vmn1r183 |
A |
G |
7: 23,754,250 (GRCm39) |
I18V |
probably benign |
Het |
| Vmn1r237 |
A |
G |
17: 21,534,885 (GRCm39) |
M203V |
probably damaging |
Het |
| Vmn1r61 |
A |
T |
7: 5,613,998 (GRCm39) |
F105L |
possibly damaging |
Het |
| Zfp462 |
T |
C |
4: 55,011,951 (GRCm39) |
C158R |
probably damaging |
Het |
| Zfyve16 |
C |
G |
13: 92,657,637 (GRCm39) |
R758P |
probably damaging |
Het |
|
| Other mutations in Prg4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Prg4
|
APN |
1 |
150,327,671 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02033:Prg4
|
APN |
1 |
150,331,619 (GRCm39) |
intron |
probably benign |
|
|
IGL02154:Prg4
|
APN |
1 |
150,330,613 (GRCm39) |
intron |
probably benign |
|
|
IGL03111:Prg4
|
APN |
1 |
150,327,653 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03177:Prg4
|
APN |
1 |
150,331,354 (GRCm39) |
intron |
probably benign |
|
|
IGL03260:Prg4
|
APN |
1 |
150,331,378 (GRCm39) |
intron |
probably benign |
|
|
IGL03281:Prg4
|
APN |
1 |
150,325,839 (GRCm39) |
splice site |
probably benign |
|
|
R0046:Prg4
|
UTSW |
1 |
150,331,837 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0046:Prg4
|
UTSW |
1 |
150,331,837 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0196:Prg4
|
UTSW |
1 |
150,330,243 (GRCm39) |
intron |
probably benign |
|
|
R0233:Prg4
|
UTSW |
1 |
150,329,298 (GRCm39) |
splice site |
probably benign |
|
|
R0255:Prg4
|
UTSW |
1 |
150,331,558 (GRCm39) |
intron |
probably benign |
|
|
R1016:Prg4
|
UTSW |
1 |
150,330,442 (GRCm39) |
intron |
probably benign |
|
|
R1826:Prg4
|
UTSW |
1 |
150,327,760 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1862:Prg4
|
UTSW |
1 |
150,336,420 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1863:Prg4
|
UTSW |
1 |
150,336,420 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1922:Prg4
|
UTSW |
1 |
150,325,750 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Prg4
|
UTSW |
1 |
150,331,774 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3765:Prg4
|
UTSW |
1 |
150,327,122 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3855:Prg4
|
UTSW |
1 |
150,327,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3894:Prg4
|
UTSW |
1 |
150,330,510 (GRCm39) |
intron |
probably benign |
|
|
R3895:Prg4
|
UTSW |
1 |
150,330,510 (GRCm39) |
intron |
probably benign |
|
|
R3912:Prg4
|
UTSW |
1 |
150,327,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3935:Prg4
|
UTSW |
1 |
150,333,908 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4050:Prg4
|
UTSW |
1 |
150,330,510 (GRCm39) |
intron |
probably benign |
|
|
R4475:Prg4
|
UTSW |
1 |
150,330,610 (GRCm39) |
intron |
probably benign |
|
|
R4794:Prg4
|
UTSW |
1 |
150,330,297 (GRCm39) |
intron |
probably benign |
|
|
R4910:Prg4
|
UTSW |
1 |
150,331,574 (GRCm39) |
intron |
probably benign |
|
|
R4911:Prg4
|
UTSW |
1 |
150,331,574 (GRCm39) |
intron |
probably benign |
|
|
R4993:Prg4
|
UTSW |
1 |
150,336,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5378:Prg4
|
UTSW |
1 |
150,330,977 (GRCm39) |
intron |
probably benign |
|
|
R5381:Prg4
|
UTSW |
1 |
150,330,204 (GRCm39) |
intron |
probably benign |
|
|
R5452:Prg4
|
UTSW |
1 |
150,331,519 (GRCm39) |
intron |
probably benign |
|
|
R5870:Prg4
|
UTSW |
1 |
150,331,300 (GRCm39) |
nonsense |
probably null |
|
|
R5888:Prg4
|
UTSW |
1 |
150,328,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5929:Prg4
|
UTSW |
1 |
150,329,880 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6058:Prg4
|
UTSW |
1 |
150,327,197 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6059:Prg4
|
UTSW |
1 |
150,325,748 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6232:Prg4
|
UTSW |
1 |
150,331,567 (GRCm39) |
intron |
probably benign |
|
|
R6272:Prg4
|
UTSW |
1 |
150,330,517 (GRCm39) |
intron |
probably benign |
|
|
R6459:Prg4
|
UTSW |
1 |
150,330,052 (GRCm39) |
intron |
probably benign |
|
|
R6659:Prg4
|
UTSW |
1 |
150,336,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6663:Prg4
|
UTSW |
1 |
150,330,852 (GRCm39) |
intron |
probably benign |
|
|
R6882:Prg4
|
UTSW |
1 |
150,329,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6970:Prg4
|
UTSW |
1 |
150,331,657 (GRCm39) |
intron |
probably benign |
|
|
R7078:Prg4
|
UTSW |
1 |
150,334,014 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7102:Prg4
|
UTSW |
1 |
150,328,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7264:Prg4
|
UTSW |
1 |
150,329,818 (GRCm39) |
missense |
not run |
|
|
R7487:Prg4
|
UTSW |
1 |
150,331,656 (GRCm39) |
missense |
unknown |
|
|
R7531:Prg4
|
UTSW |
1 |
150,330,786 (GRCm39) |
missense |
unknown |
|
|
R7651:Prg4
|
UTSW |
1 |
150,330,696 (GRCm39) |
missense |
unknown |
|
|
R7701:Prg4
|
UTSW |
1 |
150,333,293 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8072:Prg4
|
UTSW |
1 |
150,331,774 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8168:Prg4
|
UTSW |
1 |
150,331,601 (GRCm39) |
missense |
unknown |
|
|
R8248:Prg4
|
UTSW |
1 |
150,330,877 (GRCm39) |
missense |
unknown |
|
|
R8436:Prg4
|
UTSW |
1 |
150,331,318 (GRCm39) |
missense |
unknown |
|
|
R8460:Prg4
|
UTSW |
1 |
150,331,692 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8514:Prg4
|
UTSW |
1 |
150,330,396 (GRCm39) |
missense |
unknown |
|
|
R8904:Prg4
|
UTSW |
1 |
150,331,810 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9072:Prg4
|
UTSW |
1 |
150,331,288 (GRCm39) |
missense |
unknown |
|
|
R9073:Prg4
|
UTSW |
1 |
150,331,288 (GRCm39) |
missense |
unknown |
|
|
R9274:Prg4
|
UTSW |
1 |
150,331,924 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9337:Prg4
|
UTSW |
1 |
150,327,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9488:Prg4
|
UTSW |
1 |
150,327,024 (GRCm39) |
missense |
probably benign |
|
|
R9613:Prg4
|
UTSW |
1 |
150,331,660 (GRCm39) |
missense |
unknown |
|
|
R9670:Prg4
|
UTSW |
1 |
150,326,618 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0024:Prg4
|
UTSW |
1 |
150,330,243 (GRCm39) |
intron |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AACTCTGTCTGCTGTGTGTTAGCC -3'
(R):5'- CTGCCTCTGTTAGGACATCATGCC -3'
Sequencing Primer
(F):5'- TGTTAGCCATCAGGGAAGCC -3'
(R):5'- GTGCTCCAAATTCCAAATAGGAGAC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation