Incidental Mutation 'R0616:Pde4dip'
| ID |
58300 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pde4dip
|
| Ensembl Gene |
ENSMUSG00000038170 |
| Gene Name |
phosphodiesterase 4D interacting protein (myomegalin) |
| Synonyms |
Usmg4, D3Bwg1078e, D130016K21Rik, 9430063L05Rik, 4732458A06Rik |
| MMRRC Submission |
038805-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0616 (G1)
|
| Quality Score |
218 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
97597144-97796023 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 97654849 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Methionine
at position 859
(I859M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088254
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045243]
[ENSMUST00000090750]
[ENSMUST00000107038]
[ENSMUST00000168438]
[ENSMUST00000175751]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000045243
AA Change: I902M
PolyPhen 2
Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000040905
Gene: ENSMUSG00000038170
AA Change: I902M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
72 |
90 |
N/A |
INTRINSIC |
|
low complexity region
|
159 |
170 |
N/A |
INTRINSIC |
|
coiled coil region
|
399 |
451 |
N/A |
INTRINSIC |
|
SCOP:d1gw5a_
|
613 |
839 |
3e-3 |
SMART |
|
coiled coil region
|
909 |
985 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1099 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090750
AA Change: I859M
PolyPhen 2
Score 0.093 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000088254
Gene: ENSMUSG00000038170
AA Change: I859M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Cnn_1N
|
124 |
196 |
3.2e-26 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
4.03e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
6.59e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
4.03e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
6.59e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1780 |
N/A |
INTRINSIC |
|
low complexity region
|
1836 |
1851 |
N/A |
INTRINSIC |
|
low complexity region
|
1860 |
1874 |
N/A |
INTRINSIC |
|
low complexity region
|
1940 |
1951 |
N/A |
INTRINSIC |
|
coiled coil region
|
1962 |
2138 |
N/A |
INTRINSIC |
|
coiled coil region
|
2162 |
2197 |
N/A |
INTRINSIC |
|
coiled coil region
|
2387 |
2431 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107038
AA Change: I805M
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000102653
Gene: ENSMUSG00000038170
AA Change: I805M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Microtub_assoc
|
70 |
144 |
7.8e-32 |
PFAM |
|
low complexity region
|
150 |
165 |
N/A |
INTRINSIC |
|
coiled coil region
|
228 |
271 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
343 |
384 |
5.54e-5 |
PROSPERO |
|
low complexity region
|
513 |
524 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
566 |
607 |
5.54e-5 |
PROSPERO |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168438
AA Change: I859M
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000131170
Gene: ENSMUSG00000038170
AA Change: I859M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Microtub_assoc
|
124 |
198 |
1.4e-31 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
3.56e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
5.83e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
3.56e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
5.83e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1769 |
N/A |
INTRINSIC |
|
low complexity region
|
1785 |
1800 |
N/A |
INTRINSIC |
|
low complexity region
|
1809 |
1823 |
N/A |
INTRINSIC |
|
low complexity region
|
1889 |
1900 |
N/A |
INTRINSIC |
|
coiled coil region
|
1911 |
2087 |
N/A |
INTRINSIC |
|
coiled coil region
|
2111 |
2146 |
N/A |
INTRINSIC |
|
coiled coil region
|
2336 |
2380 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175751
|
| SMART Domains |
Protein: ENSMUSP00000134832
Gene: ENSMUSG00000038170
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-AD
|
4 |
78 |
4.3e-8 |
PFAM |
|
low complexity region
|
159 |
170 |
N/A |
INTRINSIC |
|
coiled coil region
|
399 |
451 |
N/A |
INTRINSIC |
|
coiled coil region
|
513 |
538 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.5%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit partial (in utero or perinatal) lethality, hyperactivity, and increased vertical activity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
G |
T |
1: 71,341,830 (GRCm39) |
Q1044K |
probably damaging |
Het |
| Abi3bp |
A |
T |
16: 56,474,433 (GRCm39) |
T723S |
probably damaging |
Het |
| Ackr3 |
G |
A |
1: 90,142,191 (GRCm39) |
V217I |
probably benign |
Het |
| Acnat2 |
A |
G |
4: 49,380,269 (GRCm39) |
S370P |
probably damaging |
Het |
| Arap1 |
A |
G |
7: 101,050,857 (GRCm39) |
R1152G |
possibly damaging |
Het |
| Arhgap15 |
G |
A |
2: 44,006,729 (GRCm39) |
|
probably null |
Het |
| Arhgap5 |
C |
T |
12: 52,563,848 (GRCm39) |
T273I |
possibly damaging |
Het |
| Armh4 |
G |
T |
14: 50,011,113 (GRCm39) |
T198K |
possibly damaging |
Het |
| C1s2 |
T |
C |
6: 124,605,723 (GRCm39) |
E332G |
probably damaging |
Het |
| Camp |
G |
A |
9: 109,677,707 (GRCm39) |
R88W |
probably benign |
Het |
| Cdkl2 |
A |
G |
5: 92,156,863 (GRCm39) |
M564T |
probably benign |
Het |
| Ceacam20 |
A |
G |
7: 19,704,321 (GRCm39) |
H124R |
probably benign |
Het |
| Cep19 |
C |
T |
16: 31,922,829 (GRCm39) |
R32C |
probably damaging |
Het |
| Cep295 |
G |
A |
9: 15,243,618 (GRCm39) |
Q1565* |
probably null |
Het |
| Chd3 |
T |
C |
11: 69,236,313 (GRCm39) |
E1932G |
probably damaging |
Het |
| Cibar1 |
G |
A |
4: 12,168,234 (GRCm39) |
R210* |
probably null |
Het |
| Cnr2 |
G |
T |
4: 135,644,873 (GRCm39) |
W317L |
probably benign |
Het |
| Cntnap5a |
C |
T |
1: 116,508,279 (GRCm39) |
H1264Y |
possibly damaging |
Het |
| Depdc7 |
T |
A |
2: 104,557,650 (GRCm39) |
N200I |
probably benign |
Het |
| Dock4 |
T |
C |
12: 40,754,414 (GRCm39) |
S468P |
probably benign |
Het |
| Dscc1 |
C |
A |
15: 54,946,966 (GRCm39) |
C253F |
probably benign |
Het |
| Fam217a |
C |
A |
13: 35,097,666 (GRCm39) |
S55I |
probably benign |
Het |
| Farp1 |
G |
A |
14: 121,514,434 (GRCm39) |
R921H |
probably damaging |
Het |
| Fat4 |
A |
G |
3: 38,997,019 (GRCm39) |
D1746G |
probably damaging |
Het |
| Fbxw5 |
T |
C |
2: 25,392,517 (GRCm39) |
F100L |
probably damaging |
Het |
| Gli3 |
C |
A |
13: 15,836,991 (GRCm39) |
T458K |
possibly damaging |
Het |
| Gm4841 |
T |
C |
18: 60,404,009 (GRCm39) |
Y28C |
probably benign |
Het |
| Gprc5d |
T |
C |
6: 135,093,430 (GRCm39) |
E159G |
probably benign |
Het |
| Grm4 |
A |
T |
17: 27,653,538 (GRCm39) |
I757N |
probably damaging |
Het |
| Hagh |
A |
G |
17: 25,076,551 (GRCm39) |
Y94C |
probably damaging |
Het |
| Hycc1 |
T |
C |
5: 24,191,770 (GRCm39) |
T44A |
probably damaging |
Het |
| Itpkb |
T |
C |
1: 180,249,301 (GRCm39) |
I892T |
probably damaging |
Het |
| Kcmf1 |
T |
C |
6: 72,827,467 (GRCm39) |
I58V |
probably benign |
Het |
| Khdrbs2 |
A |
G |
1: 32,506,856 (GRCm39) |
I167V |
possibly damaging |
Het |
| Kmt2c |
A |
G |
5: 25,504,250 (GRCm39) |
I275T |
probably benign |
Het |
| Lingo4 |
A |
G |
3: 94,310,388 (GRCm39) |
K442R |
probably benign |
Het |
| Mak |
T |
C |
13: 41,195,661 (GRCm39) |
N382D |
probably benign |
Het |
| Maob |
G |
A |
X: 16,576,402 (GRCm39) |
T480I |
possibly damaging |
Het |
| Mcoln1 |
A |
G |
8: 3,565,025 (GRCm39) |
E573G |
probably benign |
Het |
| Ms4a6b |
G |
A |
19: 11,504,262 (GRCm39) |
|
probably null |
Het |
| Muc5ac |
A |
G |
7: 141,349,981 (GRCm39) |
M576V |
probably benign |
Het |
| Nme8 |
T |
A |
13: 19,875,029 (GRCm39) |
D126V |
probably benign |
Het |
| Npy2r |
T |
A |
3: 82,448,670 (GRCm39) |
D35V |
possibly damaging |
Het |
| Nrxn1 |
T |
C |
17: 90,670,285 (GRCm39) |
D193G |
probably damaging |
Het |
| Or2g7 |
A |
C |
17: 38,378,131 (GRCm39) |
E23A |
probably damaging |
Het |
| Or2y1e |
T |
C |
11: 49,218,583 (GRCm39) |
L115P |
probably damaging |
Het |
| Or4c10b |
T |
A |
2: 89,711,935 (GRCm39) |
V255E |
probably benign |
Het |
| Or4d5 |
A |
T |
9: 40,012,283 (GRCm39) |
F168I |
probably damaging |
Het |
| Or52b4i |
T |
A |
7: 102,191,761 (GRCm39) |
M206K |
possibly damaging |
Het |
| Or6d14 |
A |
G |
6: 116,533,889 (GRCm39) |
I168V |
probably benign |
Het |
| Or8b3b |
A |
T |
9: 38,584,776 (GRCm39) |
M1K |
probably null |
Het |
| Or8c17 |
G |
T |
9: 38,180,630 (GRCm39) |
V266L |
probably benign |
Het |
| Or8g18 |
G |
A |
9: 39,148,946 (GRCm39) |
T258M |
probably benign |
Het |
| Pabpc2 |
A |
T |
18: 39,906,792 (GRCm39) |
H19L |
possibly damaging |
Het |
| Pcdhb9 |
A |
T |
18: 37,535,028 (GRCm39) |
K341* |
probably null |
Het |
| Pfkfb2 |
T |
C |
1: 130,634,159 (GRCm39) |
|
probably null |
Het |
| Pigg |
C |
T |
5: 108,461,951 (GRCm39) |
T94M |
probably damaging |
Het |
| Pik3c2b |
T |
C |
1: 133,028,569 (GRCm39) |
F1353L |
probably damaging |
Het |
| Prg4 |
T |
C |
1: 150,336,462 (GRCm39) |
D87G |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,508,271 (GRCm39) |
D974V |
probably damaging |
Het |
| Prmt3 |
A |
G |
7: 49,437,076 (GRCm39) |
Y217C |
probably damaging |
Het |
| Proser1 |
A |
G |
3: 53,382,118 (GRCm39) |
T192A |
probably damaging |
Het |
| Rab3d |
G |
A |
9: 21,826,060 (GRCm39) |
T118M |
probably damaging |
Het |
| Rb1cc1 |
A |
G |
1: 6,314,486 (GRCm39) |
K386R |
possibly damaging |
Het |
| Rcn2 |
A |
G |
9: 55,963,534 (GRCm39) |
D221G |
probably benign |
Het |
| Rhbdl3 |
T |
G |
11: 80,222,687 (GRCm39) |
H245Q |
probably damaging |
Het |
| Ribc1 |
T |
C |
X: 150,788,787 (GRCm39) |
E204G |
probably damaging |
Het |
| Rpap1 |
G |
A |
2: 119,608,601 (GRCm39) |
L254F |
probably damaging |
Het |
| Rrp12 |
A |
G |
19: 41,880,988 (GRCm39) |
F148L |
possibly damaging |
Het |
| Rusf1 |
A |
T |
7: 127,871,803 (GRCm39) |
|
probably null |
Het |
| Setdb1 |
A |
T |
3: 95,249,109 (GRCm39) |
I333K |
probably damaging |
Het |
| Simc1 |
A |
G |
13: 54,694,845 (GRCm39) |
I1210V |
probably benign |
Het |
| Smchd1 |
T |
A |
17: 71,686,569 (GRCm39) |
D1379V |
probably benign |
Het |
| Snap29 |
A |
T |
16: 17,240,370 (GRCm39) |
K159* |
probably null |
Het |
| Spdye4c |
A |
T |
2: 128,436,132 (GRCm39) |
K176M |
possibly damaging |
Het |
| Stk31 |
T |
A |
6: 49,400,419 (GRCm39) |
W415R |
probably damaging |
Het |
| Supt6 |
C |
T |
11: 78,100,321 (GRCm39) |
R1497Q |
probably damaging |
Het |
| Tenm3 |
A |
G |
8: 48,729,191 (GRCm39) |
I1605T |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,676,967 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
G |
2: 76,728,011 (GRCm39) |
|
probably benign |
Het |
| Ucp3 |
A |
T |
7: 100,129,368 (GRCm39) |
T68S |
probably benign |
Het |
| Ugt2b36 |
T |
C |
5: 87,237,336 (GRCm39) |
N316D |
probably benign |
Het |
| Usp4 |
T |
G |
9: 108,244,003 (GRCm39) |
S247A |
probably benign |
Het |
| Utp20 |
A |
T |
10: 88,606,613 (GRCm39) |
V1653D |
probably benign |
Het |
| Vmn1r183 |
A |
G |
7: 23,754,250 (GRCm39) |
I18V |
probably benign |
Het |
| Vmn1r237 |
A |
G |
17: 21,534,885 (GRCm39) |
M203V |
probably damaging |
Het |
| Vmn1r61 |
A |
T |
7: 5,613,998 (GRCm39) |
F105L |
possibly damaging |
Het |
| Zfp462 |
T |
C |
4: 55,011,951 (GRCm39) |
C158R |
probably damaging |
Het |
| Zfyve16 |
C |
G |
13: 92,657,637 (GRCm39) |
R758P |
probably damaging |
Het |
|
| Other mutations in Pde4dip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00332:Pde4dip
|
APN |
3 |
97,674,593 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00543:Pde4dip
|
APN |
3 |
97,664,940 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL00979:Pde4dip
|
APN |
3 |
97,655,074 (GRCm39) |
splice site |
probably benign |
|
|
IGL01483:Pde4dip
|
APN |
3 |
97,661,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02122:Pde4dip
|
APN |
3 |
97,674,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02398:Pde4dip
|
APN |
3 |
97,674,097 (GRCm39) |
missense |
probably benign |
|
|
IGL02814:Pde4dip
|
APN |
3 |
97,674,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02826:Pde4dip
|
APN |
3 |
97,674,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D3080:Pde4dip
|
UTSW |
3 |
97,674,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0077:Pde4dip
|
UTSW |
3 |
97,660,442 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Pde4dip
|
UTSW |
3 |
97,674,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0277:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0304:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0676:Pde4dip
|
UTSW |
3 |
97,624,413 (GRCm39) |
splice site |
probably benign |
|
|
R1166:Pde4dip
|
UTSW |
3 |
97,620,512 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Pde4dip
|
UTSW |
3 |
97,631,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1550:Pde4dip
|
UTSW |
3 |
97,627,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1700:Pde4dip
|
UTSW |
3 |
97,610,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1704:Pde4dip
|
UTSW |
3 |
97,661,576 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1769:Pde4dip
|
UTSW |
3 |
97,603,246 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1934:Pde4dip
|
UTSW |
3 |
97,600,007 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1980:Pde4dip
|
UTSW |
3 |
97,664,312 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2088:Pde4dip
|
UTSW |
3 |
97,661,749 (GRCm39) |
missense |
probably null |
1.00 |
|
R2143:Pde4dip
|
UTSW |
3 |
97,795,835 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2149:Pde4dip
|
UTSW |
3 |
97,700,152 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2156:Pde4dip
|
UTSW |
3 |
97,631,534 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2158:Pde4dip
|
UTSW |
3 |
97,664,937 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2240:Pde4dip
|
UTSW |
3 |
97,631,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2249:Pde4dip
|
UTSW |
3 |
97,700,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2256:Pde4dip
|
UTSW |
3 |
97,625,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2680:Pde4dip
|
UTSW |
3 |
97,608,933 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2921:Pde4dip
|
UTSW |
3 |
97,626,885 (GRCm39) |
missense |
probably benign |
|
|
R3407:Pde4dip
|
UTSW |
3 |
97,661,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3736:Pde4dip
|
UTSW |
3 |
97,631,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3787:Pde4dip
|
UTSW |
3 |
97,622,868 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3883:Pde4dip
|
UTSW |
3 |
97,620,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4437:Pde4dip
|
UTSW |
3 |
97,673,885 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4528:Pde4dip
|
UTSW |
3 |
97,624,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Pde4dip
|
UTSW |
3 |
97,661,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4600:Pde4dip
|
UTSW |
3 |
97,603,260 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4653:Pde4dip
|
UTSW |
3 |
97,674,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4678:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4679:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Pde4dip
|
UTSW |
3 |
97,750,993 (GRCm39) |
nonsense |
probably null |
|
|
R4770:Pde4dip
|
UTSW |
3 |
97,674,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4841:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Pde4dip
|
UTSW |
3 |
97,616,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Pde4dip
|
UTSW |
3 |
97,622,644 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4943:Pde4dip
|
UTSW |
3 |
97,662,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5131:Pde4dip
|
UTSW |
3 |
97,616,830 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5408:Pde4dip
|
UTSW |
3 |
97,704,052 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5583:Pde4dip
|
UTSW |
3 |
97,654,892 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5677:Pde4dip
|
UTSW |
3 |
97,748,964 (GRCm39) |
nonsense |
probably null |
|
|
R5689:Pde4dip
|
UTSW |
3 |
97,599,683 (GRCm39) |
nonsense |
probably null |
|
|
R5696:Pde4dip
|
UTSW |
3 |
97,616,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5860:Pde4dip
|
UTSW |
3 |
97,631,504 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6279:Pde4dip
|
UTSW |
3 |
97,606,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6341:Pde4dip
|
UTSW |
3 |
97,602,227 (GRCm39) |
missense |
probably benign |
|
|
R6440:Pde4dip
|
UTSW |
3 |
97,674,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Pde4dip
|
UTSW |
3 |
97,617,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6489:Pde4dip
|
UTSW |
3 |
97,662,907 (GRCm39) |
nonsense |
probably null |
|
|
R6706:Pde4dip
|
UTSW |
3 |
97,648,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6722:Pde4dip
|
UTSW |
3 |
97,625,555 (GRCm39) |
nonsense |
probably null |
|
|
R6798:Pde4dip
|
UTSW |
3 |
97,795,850 (GRCm39) |
missense |
probably benign |
|
|
R6804:Pde4dip
|
UTSW |
3 |
97,700,564 (GRCm39) |
nonsense |
probably null |
|
|
R6862:Pde4dip
|
UTSW |
3 |
97,674,340 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6957:Pde4dip
|
UTSW |
3 |
97,731,649 (GRCm39) |
splice site |
probably null |
|
|
R6983:Pde4dip
|
UTSW |
3 |
97,625,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7014:Pde4dip
|
UTSW |
3 |
97,622,738 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7025:Pde4dip
|
UTSW |
3 |
97,631,499 (GRCm39) |
nonsense |
probably null |
|
|
R7136:Pde4dip
|
UTSW |
3 |
97,601,379 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7178:Pde4dip
|
UTSW |
3 |
97,622,946 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7269:Pde4dip
|
UTSW |
3 |
97,674,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Pde4dip
|
UTSW |
3 |
97,666,198 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7354:Pde4dip
|
UTSW |
3 |
97,626,646 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7357:Pde4dip
|
UTSW |
3 |
97,622,857 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7360:Pde4dip
|
UTSW |
3 |
97,625,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7371:Pde4dip
|
UTSW |
3 |
97,664,587 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7432:Pde4dip
|
UTSW |
3 |
97,602,408 (GRCm39) |
missense |
probably benign |
|
|
R7536:Pde4dip
|
UTSW |
3 |
97,664,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7542:Pde4dip
|
UTSW |
3 |
97,673,971 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7609:Pde4dip
|
UTSW |
3 |
97,622,881 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7650:Pde4dip
|
UTSW |
3 |
97,606,423 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7800:Pde4dip
|
UTSW |
3 |
97,622,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Pde4dip
|
UTSW |
3 |
97,622,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Pde4dip
|
UTSW |
3 |
97,622,539 (GRCm39) |
nonsense |
probably null |
|
|
R8120:Pde4dip
|
UTSW |
3 |
97,614,254 (GRCm39) |
missense |
probably null |
0.94 |
|
R8139:Pde4dip
|
UTSW |
3 |
97,604,309 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8144:Pde4dip
|
UTSW |
3 |
97,622,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Pde4dip
|
UTSW |
3 |
97,674,848 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8294:Pde4dip
|
UTSW |
3 |
97,674,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8406:Pde4dip
|
UTSW |
3 |
97,606,428 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8911:Pde4dip
|
UTSW |
3 |
97,650,917 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8912:Pde4dip
|
UTSW |
3 |
97,617,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8960:Pde4dip
|
UTSW |
3 |
97,700,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8993:Pde4dip
|
UTSW |
3 |
97,673,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9031:Pde4dip
|
UTSW |
3 |
97,599,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9032:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9085:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9103:Pde4dip
|
UTSW |
3 |
97,749,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9163:Pde4dip
|
UTSW |
3 |
97,659,123 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9182:Pde4dip
|
UTSW |
3 |
97,602,314 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9185:Pde4dip
|
UTSW |
3 |
97,666,132 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9286:Pde4dip
|
UTSW |
3 |
97,607,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9357:Pde4dip
|
UTSW |
3 |
97,625,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9415:Pde4dip
|
UTSW |
3 |
97,660,468 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9500:Pde4dip
|
UTSW |
3 |
97,795,896 (GRCm39) |
missense |
unknown |
|
|
R9595:Pde4dip
|
UTSW |
3 |
97,602,207 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9689:Pde4dip
|
UTSW |
3 |
97,649,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Pde4dip
|
UTSW |
3 |
97,603,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGTCTCCAGATTTCAGGGCAATCC -3'
(R):5'- CAGACGTTCATCTCTAACCAGCCAG -3'
Sequencing Primer
(F):5'- TTTCAGGGCAATCCAAATCGG -3'
(R):5'- CGATCAAGTAAGAACTCTAGACTCTG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation