Incidental Mutation 'R7533:Cfap74'
ID 583407
Institutional Source Beutler Lab
Gene Symbol Cfap74
Ensembl Gene ENSMUSG00000078490
Gene Name cilia and flagella associated protein 74
Synonyms 2010015L04Rik
MMRRC Submission 045605-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7533 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 155493647-155551280 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 155500200 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 15 (D15E)
Ref Sequence ENSEMBL: ENSMUSP00000131899 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000123952] [ENSMUST00000151083]
AlphaFold Q3UY96
Predicted Effect
SMART Domains Protein: ENSMUSP00000131899
Gene: ENSMUSG00000078490
AA Change: D15E

DomainStartEndE-ValueType
low complexity region 44 59 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000123626
Gene: ENSMUSG00000078490
AA Change: D15E

DomainStartEndE-ValueType
low complexity region 44 59 N/A INTRINSIC
coiled coil region 134 162 N/A INTRINSIC
coiled coil region 333 378 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (36/36)
Allele List at MGI

All alleles(7) : Targeted(2) Gene trapped(5)

Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agr2 T C 12: 36,046,128 (GRCm39) probably null Het
Alpk2 A T 18: 65,437,674 (GRCm39) S1240T probably damaging Het
Atp8b2 G A 3: 89,852,831 (GRCm39) L144F Het
Cck T C 9: 121,319,201 (GRCm39) D94G probably damaging Het
Ccser1 A T 6: 61,615,474 (GRCm39) T659S probably benign Het
Commd5 G A 15: 76,784,776 (GRCm39) A58T probably benign Het
Dctn2 A G 10: 127,103,347 (GRCm39) D34G possibly damaging Het
Ecpas T C 4: 58,809,411 (GRCm39) I1654M probably benign Het
Epha6 T C 16: 60,025,925 (GRCm39) T506A probably damaging Het
Fat4 A C 3: 39,061,406 (GRCm39) I4330L probably benign Het
Fcho2 G T 13: 98,921,307 (GRCm39) Q193K probably benign Het
Hace1 A T 10: 45,587,570 (GRCm39) I890L probably benign Het
Igsf11 T G 16: 38,829,236 (GRCm39) N102K probably benign Het
Il7r G A 15: 9,508,047 (GRCm39) S425L probably benign Het
Itga3 G T 11: 94,937,344 (GRCm39) Q1011K probably benign Het
Kif3c T A 12: 3,416,510 (GRCm39) I177N probably damaging Het
Neb G A 2: 52,114,578 (GRCm39) A1048V Het
Neu4 C T 1: 93,950,122 (GRCm39) T27M probably benign Het
Or52b3 T C 7: 102,203,718 (GRCm39) S76P probably damaging Het
P4htm T C 9: 108,474,136 (GRCm39) H134R probably benign Het
Padi6 T C 4: 140,458,506 (GRCm39) D462G probably damaging Het
Pi4ka T C 16: 17,115,525 (GRCm39) D1375G Het
Ptgr1 C T 4: 58,971,011 (GRCm39) R247H possibly damaging Het
Rad50 T C 11: 53,589,746 (GRCm39) N152D probably damaging Het
Serpina1c T A 12: 103,863,566 (GRCm39) K211N probably damaging Het
Sgsh T C 11: 119,238,696 (GRCm39) E256G probably damaging Het
Tnrc6b T C 15: 80,811,942 (GRCm39) probably null Het
Ube3d A G 9: 86,304,990 (GRCm39) F284S probably damaging Het
Usp13 A G 3: 32,973,091 (GRCm39) D757G probably damaging Het
Vmn1r173 C T 7: 23,402,071 (GRCm39) A102V probably benign Het
Vmn2r29 G T 7: 7,244,656 (GRCm39) A406D probably damaging Het
Wdfy3 G A 5: 102,030,354 (GRCm39) R2385C probably benign Het
Zfp112 A T 7: 23,824,752 (GRCm39) K244M possibly damaging Het
Zfp61 T C 7: 23,990,504 (GRCm39) Q549R probably benign Het
Other mutations in Cfap74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01607:Cfap74 APN 4 155,503,443 (GRCm39) missense possibly damaging 0.95
paranoid UTSW 4 155,538,481 (GRCm39) utr 5 prime probably benign
sensibile UTSW 4 155,525,743 (GRCm39) missense probably null 0.03
touchy UTSW 4 155,547,529 (GRCm39) missense probably benign 0.27
FR4304:Cfap74 UTSW 4 155,500,217 (GRCm39) missense possibly damaging 0.93
P0007:Cfap74 UTSW 4 155,506,685 (GRCm39) missense possibly damaging 0.83
PIT4434001:Cfap74 UTSW 4 155,548,421 (GRCm39) missense unknown
R0025:Cfap74 UTSW 4 155,510,572 (GRCm39) missense probably benign 0.22
R0034:Cfap74 UTSW 4 155,545,344 (GRCm39) splice site probably benign
R0193:Cfap74 UTSW 4 155,510,572 (GRCm39) missense probably benign 0.22
R0306:Cfap74 UTSW 4 155,549,896 (GRCm39) unclassified probably benign
R0427:Cfap74 UTSW 4 155,525,734 (GRCm39) missense probably benign 0.02
R0905:Cfap74 UTSW 4 155,503,153 (GRCm39) critical splice donor site probably null
R1116:Cfap74 UTSW 4 155,518,453 (GRCm39) missense probably benign 0.15
R1548:Cfap74 UTSW 4 155,518,502 (GRCm39) missense probably benign 0.45
R1950:Cfap74 UTSW 4 155,511,887 (GRCm39) critical splice donor site probably null
R2009:Cfap74 UTSW 4 155,504,724 (GRCm39) missense possibly damaging 0.77
R2029:Cfap74 UTSW 4 155,526,538 (GRCm39) missense possibly damaging 0.74
R2135:Cfap74 UTSW 4 155,514,408 (GRCm39) missense probably damaging 1.00
R2135:Cfap74 UTSW 4 155,514,397 (GRCm39) missense probably damaging 0.97
R2154:Cfap74 UTSW 4 155,513,753 (GRCm39) missense possibly damaging 0.94
R2413:Cfap74 UTSW 4 155,503,081 (GRCm39) missense possibly damaging 0.76
R2418:Cfap74 UTSW 4 155,540,166 (GRCm39) utr 5 prime probably benign
R2930:Cfap74 UTSW 4 155,522,627 (GRCm39) missense probably damaging 0.97
R3965:Cfap74 UTSW 4 155,531,174 (GRCm39) missense probably damaging 1.00
R4078:Cfap74 UTSW 4 155,540,128 (GRCm39) missense probably damaging 0.98
R4238:Cfap74 UTSW 4 155,547,529 (GRCm39) missense probably benign 0.27
R4239:Cfap74 UTSW 4 155,547,529 (GRCm39) missense probably benign 0.27
R4240:Cfap74 UTSW 4 155,547,529 (GRCm39) missense probably benign 0.27
R4491:Cfap74 UTSW 4 155,513,628 (GRCm39) missense probably benign 0.22
R4731:Cfap74 UTSW 4 155,548,059 (GRCm39) intron probably benign
R5333:Cfap74 UTSW 4 155,521,197 (GRCm39) missense probably damaging 0.99
R5362:Cfap74 UTSW 4 155,522,623 (GRCm39) missense probably damaging 0.98
R5425:Cfap74 UTSW 4 155,540,149 (GRCm39) utr 5 prime probably benign
R5468:Cfap74 UTSW 4 155,510,498 (GRCm39) missense probably benign 0.27
R5839:Cfap74 UTSW 4 155,507,207 (GRCm39) critical splice donor site probably null
R6010:Cfap74 UTSW 4 155,538,495 (GRCm39) missense possibly damaging 0.83
R6284:Cfap74 UTSW 4 155,536,253 (GRCm39) missense probably damaging 0.96
R6323:Cfap74 UTSW 4 155,548,395 (GRCm39) missense possibly damaging 0.54
R6389:Cfap74 UTSW 4 155,507,793 (GRCm39) missense possibly damaging 0.69
R6513:Cfap74 UTSW 4 155,525,743 (GRCm39) missense probably null 0.03
R6527:Cfap74 UTSW 4 155,506,722 (GRCm39) splice site probably null
R6785:Cfap74 UTSW 4 155,538,481 (GRCm39) utr 5 prime probably benign
R6980:Cfap74 UTSW 4 155,550,809 (GRCm39) unclassified probably benign
R7039:Cfap74 UTSW 4 155,538,565 (GRCm39) critical splice donor site probably null
R7077:Cfap74 UTSW 4 155,540,134 (GRCm39) missense unknown
R7116:Cfap74 UTSW 4 155,539,518 (GRCm39) missense unknown
R7202:Cfap74 UTSW 4 155,510,654 (GRCm39) splice site probably null
R7227:Cfap74 UTSW 4 155,545,405 (GRCm39) nonsense probably null
R7228:Cfap74 UTSW 4 155,549,507 (GRCm39) missense unknown
R7261:Cfap74 UTSW 4 155,549,831 (GRCm39) missense unknown
R7315:Cfap74 UTSW 4 155,547,476 (GRCm39) missense unknown
R7337:Cfap74 UTSW 4 155,544,472 (GRCm39) missense unknown
R7354:Cfap74 UTSW 4 155,549,804 (GRCm39) missense unknown
R7673:Cfap74 UTSW 4 155,547,513 (GRCm39) missense unknown
R7798:Cfap74 UTSW 4 155,507,079 (GRCm39) missense
R7829:Cfap74 UTSW 4 155,513,694 (GRCm39) missense
R7897:Cfap74 UTSW 4 155,514,351 (GRCm39) missense
R8099:Cfap74 UTSW 4 155,539,489 (GRCm39) missense unknown
R8126:Cfap74 UTSW 4 155,511,831 (GRCm39) missense
R8769:Cfap74 UTSW 4 155,503,105 (GRCm39) missense
R8873:Cfap74 UTSW 4 155,539,465 (GRCm39) missense unknown
R8893:Cfap74 UTSW 4 155,531,152 (GRCm39) missense unknown
R8900:Cfap74 UTSW 4 155,521,187 (GRCm39) missense
R8954:Cfap74 UTSW 4 155,521,187 (GRCm39) missense
R8957:Cfap74 UTSW 4 155,521,187 (GRCm39) missense
R8982:Cfap74 UTSW 4 155,521,187 (GRCm39) missense
R9008:Cfap74 UTSW 4 155,503,121 (GRCm39) missense
R9406:Cfap74 UTSW 4 155,510,626 (GRCm39) nonsense probably null
R9606:Cfap74 UTSW 4 155,509,133 (GRCm39) missense
R9641:Cfap74 UTSW 4 155,549,054 (GRCm39) missense unknown
R9647:Cfap74 UTSW 4 155,549,373 (GRCm39) missense unknown
R9655:Cfap74 UTSW 4 155,522,665 (GRCm39) missense
R9761:Cfap74 UTSW 4 155,550,844 (GRCm39) missense unknown
R9797:Cfap74 UTSW 4 155,514,402 (GRCm39) missense
T0970:Cfap74 UTSW 4 155,547,574 (GRCm39) splice site probably null
X0066:Cfap74 UTSW 4 155,548,421 (GRCm39) missense probably damaging 1.00
Z1176:Cfap74 UTSW 4 155,510,575 (GRCm39) missense
Z1177:Cfap74 UTSW 4 155,539,370 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- TGATTACTGGGACCCTGGGTAC -3'
(R):5'- AAGTCTGTAGCCTGAAGGGATG -3'

Sequencing Primer
(F):5'- GTACATGGCTCTGCACCCTTAAG -3'
(R):5'- CCAGGTCACATTCAAAGGATTG -3'
Posted On 2019-10-17