Incidental Mutation 'R7533:Kif3c'
ID |
583424 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Kif3c
|
Ensembl Gene |
ENSMUSG00000020668 |
Gene Name |
kinesin family member 3C |
Synonyms |
N-4 kinesin |
MMRRC Submission |
045605-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.333)
|
Stock # |
R7533 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
12 |
Chromosomal Location |
3415132-3456494 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 3416510 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Asparagine
at position 177
(I177N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000020999
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020999]
[ENSMUST00000220210]
|
AlphaFold |
O35066 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000020999
AA Change: I177N
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000020999 Gene: ENSMUSG00000020668 AA Change: I177N
Domain | Start | End | E-Value | Type |
KISc
|
8 |
375 |
5.43e-171 |
SMART |
low complexity region
|
404 |
421 |
N/A |
INTRINSIC |
low complexity region
|
435 |
443 |
N/A |
INTRINSIC |
low complexity region
|
486 |
505 |
N/A |
INTRINSIC |
Blast:KISc
|
508 |
579 |
3e-8 |
BLAST |
low complexity region
|
580 |
602 |
N/A |
INTRINSIC |
Blast:KISc
|
603 |
666 |
1e-16 |
BLAST |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000220210
AA Change: I177N
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
Validation Efficiency |
100% (36/36) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene display a normal phenotype. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 34 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Agr2 |
T |
C |
12: 36,046,128 (GRCm39) |
|
probably null |
Het |
Alpk2 |
A |
T |
18: 65,437,674 (GRCm39) |
S1240T |
probably damaging |
Het |
Atp8b2 |
G |
A |
3: 89,852,831 (GRCm39) |
L144F |
|
Het |
Cck |
T |
C |
9: 121,319,201 (GRCm39) |
D94G |
probably damaging |
Het |
Ccser1 |
A |
T |
6: 61,615,474 (GRCm39) |
T659S |
probably benign |
Het |
Cfap74 |
C |
A |
4: 155,500,200 (GRCm39) |
D15E |
|
Het |
Commd5 |
G |
A |
15: 76,784,776 (GRCm39) |
A58T |
probably benign |
Het |
Dctn2 |
A |
G |
10: 127,103,347 (GRCm39) |
D34G |
possibly damaging |
Het |
Ecpas |
T |
C |
4: 58,809,411 (GRCm39) |
I1654M |
probably benign |
Het |
Epha6 |
T |
C |
16: 60,025,925 (GRCm39) |
T506A |
probably damaging |
Het |
Fat4 |
A |
C |
3: 39,061,406 (GRCm39) |
I4330L |
probably benign |
Het |
Fcho2 |
G |
T |
13: 98,921,307 (GRCm39) |
Q193K |
probably benign |
Het |
Hace1 |
A |
T |
10: 45,587,570 (GRCm39) |
I890L |
probably benign |
Het |
Igsf11 |
T |
G |
16: 38,829,236 (GRCm39) |
N102K |
probably benign |
Het |
Il7r |
G |
A |
15: 9,508,047 (GRCm39) |
S425L |
probably benign |
Het |
Itga3 |
G |
T |
11: 94,937,344 (GRCm39) |
Q1011K |
probably benign |
Het |
Neb |
G |
A |
2: 52,114,578 (GRCm39) |
A1048V |
|
Het |
Neu4 |
C |
T |
1: 93,950,122 (GRCm39) |
T27M |
probably benign |
Het |
Or52b3 |
T |
C |
7: 102,203,718 (GRCm39) |
S76P |
probably damaging |
Het |
P4htm |
T |
C |
9: 108,474,136 (GRCm39) |
H134R |
probably benign |
Het |
Padi6 |
T |
C |
4: 140,458,506 (GRCm39) |
D462G |
probably damaging |
Het |
Pi4ka |
T |
C |
16: 17,115,525 (GRCm39) |
D1375G |
|
Het |
Ptgr1 |
C |
T |
4: 58,971,011 (GRCm39) |
R247H |
possibly damaging |
Het |
Rad50 |
T |
C |
11: 53,589,746 (GRCm39) |
N152D |
probably damaging |
Het |
Serpina1c |
T |
A |
12: 103,863,566 (GRCm39) |
K211N |
probably damaging |
Het |
Sgsh |
T |
C |
11: 119,238,696 (GRCm39) |
E256G |
probably damaging |
Het |
Tnrc6b |
T |
C |
15: 80,811,942 (GRCm39) |
|
probably null |
Het |
Ube3d |
A |
G |
9: 86,304,990 (GRCm39) |
F284S |
probably damaging |
Het |
Usp13 |
A |
G |
3: 32,973,091 (GRCm39) |
D757G |
probably damaging |
Het |
Vmn1r173 |
C |
T |
7: 23,402,071 (GRCm39) |
A102V |
probably benign |
Het |
Vmn2r29 |
G |
T |
7: 7,244,656 (GRCm39) |
A406D |
probably damaging |
Het |
Wdfy3 |
G |
A |
5: 102,030,354 (GRCm39) |
R2385C |
probably benign |
Het |
Zfp112 |
A |
T |
7: 23,824,752 (GRCm39) |
K244M |
possibly damaging |
Het |
Zfp61 |
T |
C |
7: 23,990,504 (GRCm39) |
Q549R |
probably benign |
Het |
|
Other mutations in Kif3c |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0049:Kif3c
|
UTSW |
12 |
3,417,090 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0049:Kif3c
|
UTSW |
12 |
3,417,090 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0189:Kif3c
|
UTSW |
12 |
3,415,989 (GRCm39) |
missense |
probably benign |
0.10 |
R0727:Kif3c
|
UTSW |
12 |
3,416,776 (GRCm39) |
missense |
probably benign |
0.01 |
R0885:Kif3c
|
UTSW |
12 |
3,415,981 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
R1796:Kif3c
|
UTSW |
12 |
3,417,299 (GRCm39) |
missense |
probably benign |
0.01 |
R2229:Kif3c
|
UTSW |
12 |
3,416,671 (GRCm39) |
missense |
probably benign |
0.01 |
R4728:Kif3c
|
UTSW |
12 |
3,415,873 (GRCm39) |
start gained |
probably benign |
|
R4870:Kif3c
|
UTSW |
12 |
3,451,735 (GRCm39) |
missense |
probably damaging |
1.00 |
R5586:Kif3c
|
UTSW |
12 |
3,439,656 (GRCm39) |
missense |
probably benign |
0.41 |
R5662:Kif3c
|
UTSW |
12 |
3,417,031 (GRCm39) |
missense |
probably damaging |
0.99 |
R6969:Kif3c
|
UTSW |
12 |
3,416,114 (GRCm39) |
missense |
probably benign |
0.30 |
R7216:Kif3c
|
UTSW |
12 |
3,416,126 (GRCm39) |
missense |
probably benign |
0.06 |
R7372:Kif3c
|
UTSW |
12 |
3,437,592 (GRCm39) |
missense |
probably benign |
0.03 |
R8373:Kif3c
|
UTSW |
12 |
3,416,089 (GRCm39) |
missense |
probably benign |
0.44 |
R8917:Kif3c
|
UTSW |
12 |
3,416,690 (GRCm39) |
missense |
probably damaging |
1.00 |
R9005:Kif3c
|
UTSW |
12 |
3,451,706 (GRCm39) |
missense |
probably damaging |
1.00 |
R9348:Kif3c
|
UTSW |
12 |
3,417,505 (GRCm39) |
missense |
probably benign |
0.00 |
X0052:Kif3c
|
UTSW |
12 |
3,417,027 (GRCm39) |
missense |
probably benign |
0.30 |
X0064:Kif3c
|
UTSW |
12 |
3,416,868 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Kif3c
|
UTSW |
12 |
3,417,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGACCTACACCATGCAGGG -3'
(R):5'- ATATGATCCTGGCCATCAGAGC -3'
Sequencing Primer
(F):5'- AGAGCTCCGCGGGGTTATC -3'
(R):5'- GCCACGCTCACTGCACTC -3'
|
Posted On |
2019-10-17 |