Incidental Mutation 'R7540:Zfp160'
| ID |
583865 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp160
|
| Ensembl Gene |
ENSMUSG00000067942 |
| Gene Name |
zinc finger protein 160 |
| Synonyms |
6720480D16Rik, 6720480D16Rik |
| MMRRC Submission |
045612-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7540 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
21229203-21249119 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 21245922 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 157
(Y157*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086191
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088811]
[ENSMUST00000231482]
[ENSMUST00000232320]
[ENSMUST00000232354]
[ENSMUST00000232473]
[ENSMUST00000232595]
[ENSMUST00000232663]
|
| AlphaFold |
E9Q459 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000088811
AA Change: Y157*
|
| SMART Domains |
Protein: ENSMUSP00000086191
Gene: ENSMUSG00000067942
AA Change: Y157*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
1.91e-29 |
SMART |
|
low complexity region
|
100 |
110 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
146 |
168 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
174 |
196 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
202 |
224 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
1.72e-4 |
SMART |
|
ZnF_C2H2
|
286 |
308 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
314 |
336 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
398 |
420 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
426 |
448 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
454 |
476 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
482 |
504 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
510 |
532 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
538 |
560 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
566 |
588 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
594 |
616 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
622 |
644 |
1.13e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231482
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232320
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000232354
AA Change: Y157*
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232473
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232595
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232663
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
98% (48/49) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 48 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930516K23Rik |
T |
C |
7: 103,708,470 (GRCm39) |
E113G |
probably damaging |
Het |
| Adamts8 |
A |
G |
9: 30,870,360 (GRCm39) |
E650G |
probably damaging |
Het |
| Adgrg7 |
G |
A |
16: 56,570,792 (GRCm39) |
T412M |
probably damaging |
Het |
| Ank2 |
C |
T |
3: 126,781,808 (GRCm39) |
V7I |
possibly damaging |
Het |
| Bpifb1 |
G |
A |
2: 154,055,031 (GRCm39) |
V308M |
probably damaging |
Het |
| C3 |
A |
G |
17: 57,513,220 (GRCm39) |
S1476P |
probably benign |
Het |
| Dgkb |
A |
T |
12: 38,031,789 (GRCm39) |
|
probably benign |
Het |
| Fmn1 |
A |
G |
2: 113,359,655 (GRCm39) |
|
probably null |
Het |
| Foxb1 |
G |
A |
9: 69,667,141 (GRCm39) |
Q130* |
probably null |
Het |
| Gemin5 |
C |
T |
11: 58,021,228 (GRCm39) |
|
probably null |
Het |
| Ghr |
T |
A |
15: 3,349,396 (GRCm39) |
D594V |
possibly damaging |
Het |
| Gm10272 |
A |
C |
10: 77,542,460 (GRCm39) |
M1L |
unknown |
Het |
| Gpr161 |
G |
A |
1: 165,146,404 (GRCm39) |
V447M |
probably damaging |
Het |
| Hspg2 |
T |
A |
4: 137,268,751 (GRCm39) |
S2157T |
possibly damaging |
Het |
| Irs1 |
A |
G |
1: 82,265,723 (GRCm39) |
V831A |
not run |
Het |
| Itga8 |
T |
A |
2: 12,115,848 (GRCm39) |
I1014L |
possibly damaging |
Het |
| Iws1 |
T |
A |
18: 32,213,536 (GRCm39) |
S321R |
possibly damaging |
Het |
| Kctd19 |
G |
T |
8: 106,113,567 (GRCm39) |
P702Q |
probably benign |
Het |
| Man2c1 |
G |
A |
9: 57,047,559 (GRCm39) |
D739N |
probably damaging |
Het |
| Mboat4 |
T |
A |
8: 34,591,178 (GRCm39) |
L205Q |
probably damaging |
Het |
| Meis3 |
C |
A |
7: 15,911,418 (GRCm39) |
Y38* |
probably null |
Het |
| Mroh7 |
G |
T |
4: 106,577,595 (GRCm39) |
T361K |
possibly damaging |
Het |
| Msantd5f2 |
C |
T |
4: 73,586,648 (GRCm39) |
|
probably benign |
Het |
| Myl6b |
T |
A |
10: 128,332,149 (GRCm39) |
K106* |
probably null |
Het |
| Naaa |
T |
A |
5: 92,411,583 (GRCm39) |
T241S |
probably benign |
Het |
| Neurog3 |
T |
G |
10: 61,969,756 (GRCm39) |
I172S |
probably benign |
Het |
| Nub1 |
T |
G |
5: 24,906,527 (GRCm39) |
I351R |
probably damaging |
Het |
| Or2t47 |
C |
A |
11: 58,442,457 (GRCm39) |
V203L |
possibly damaging |
Het |
| Or3a1c |
A |
T |
11: 74,046,414 (GRCm39) |
R145W |
probably benign |
Het |
| Or6c207 |
A |
T |
10: 129,105,003 (GRCm39) |
F63Y |
probably benign |
Het |
| Osbp2 |
T |
C |
11: 3,667,944 (GRCm39) |
K18E |
probably damaging |
Het |
| Pcdh8 |
A |
T |
14: 80,008,543 (GRCm39) |
W7R |
probably benign |
Het |
| Pcsk7 |
G |
T |
9: 45,838,971 (GRCm39) |
|
probably null |
Het |
| Plin4 |
G |
A |
17: 56,411,883 (GRCm39) |
T716I |
probably damaging |
Het |
| Prkcb |
G |
A |
7: 122,167,357 (GRCm39) |
V356I |
probably damaging |
Het |
| Pus7 |
G |
A |
5: 23,965,244 (GRCm39) |
T304I |
probably damaging |
Het |
| Rmnd1 |
A |
G |
10: 4,353,989 (GRCm39) |
V402A |
probably damaging |
Het |
| Slmap |
T |
C |
14: 26,181,346 (GRCm39) |
E329G |
probably damaging |
Het |
| Sytl3 |
T |
C |
17: 6,949,346 (GRCm39) |
|
probably benign |
Het |
| Tg |
A |
G |
15: 66,561,776 (GRCm39) |
I1087V |
probably benign |
Het |
| Tmco1 |
A |
G |
1: 167,153,572 (GRCm39) |
T162A |
|
Het |
| Tti1 |
G |
A |
2: 157,849,916 (GRCm39) |
T441I |
probably benign |
Het |
| Tubgcp6 |
G |
T |
15: 88,986,526 (GRCm39) |
Q1366K |
possibly damaging |
Het |
| Ush1g |
T |
C |
11: 115,209,399 (GRCm39) |
K265R |
probably benign |
Het |
| Zdhhc8 |
A |
G |
16: 18,045,674 (GRCm39) |
V209A |
probably damaging |
Het |
| Zfp423 |
A |
T |
8: 88,414,695 (GRCm39) |
C1208S |
possibly damaging |
Het |
| Zfyve26 |
A |
T |
12: 79,315,450 (GRCm39) |
V1342E |
probably damaging |
Het |
| Zmym1 |
A |
T |
4: 126,942,550 (GRCm39) |
C613S |
probably benign |
Het |
|
| Other mutations in Zfp160 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00714:Zfp160
|
APN |
17 |
21,246,964 (GRCm39) |
missense |
probably benign |
|
|
IGL01019:Zfp160
|
APN |
17 |
21,241,088 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02430:Zfp160
|
APN |
17 |
21,245,792 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0412:Zfp160
|
UTSW |
17 |
21,247,139 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0600:Zfp160
|
UTSW |
17 |
21,247,268 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2146:Zfp160
|
UTSW |
17 |
21,247,244 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2157:Zfp160
|
UTSW |
17 |
21,241,090 (GRCm39) |
missense |
probably benign |
0.23 |
|
R2411:Zfp160
|
UTSW |
17 |
21,246,007 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2904:Zfp160
|
UTSW |
17 |
21,245,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4249:Zfp160
|
UTSW |
17 |
21,246,000 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4896:Zfp160
|
UTSW |
17 |
21,240,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5106:Zfp160
|
UTSW |
17 |
21,247,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5342:Zfp160
|
UTSW |
17 |
21,240,995 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5352:Zfp160
|
UTSW |
17 |
21,247,114 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6193:Zfp160
|
UTSW |
17 |
21,247,124 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6230:Zfp160
|
UTSW |
17 |
21,246,707 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6753:Zfp160
|
UTSW |
17 |
21,240,996 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6928:Zfp160
|
UTSW |
17 |
21,261,724 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7040:Zfp160
|
UTSW |
17 |
21,246,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7255:Zfp160
|
UTSW |
17 |
21,245,749 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7497:Zfp160
|
UTSW |
17 |
21,246,455 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7510:Zfp160
|
UTSW |
17 |
21,246,655 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7627:Zfp160
|
UTSW |
17 |
21,247,270 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8169:Zfp160
|
UTSW |
17 |
21,247,298 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8240:Zfp160
|
UTSW |
17 |
21,246,350 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8330:Zfp160
|
UTSW |
17 |
21,246,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8367:Zfp160
|
UTSW |
17 |
21,245,804 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8802:Zfp160
|
UTSW |
17 |
21,246,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9183:Zfp160
|
UTSW |
17 |
21,240,354 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9556:Zfp160
|
UTSW |
17 |
21,247,031 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9695:Zfp160
|
UTSW |
17 |
21,245,746 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Z1177:Zfp160
|
UTSW |
17 |
21,247,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTAATGAAGCTAAGTCCATCAGC -3'
(R):5'- TCTCACCAGTATGGATTCTTCGATG -3'
Sequencing Primer
(F):5'- AAGTCCATCAGCAGTGGTTC -3'
(R):5'- CGATGACTCTTAAGGTGTGAATTC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation