Incidental Mutation 'R7559:Opcml'
ID 584958
Institutional Source Beutler Lab
Gene Symbol Opcml
Ensembl Gene ENSMUSG00000062257
Gene Name opioid binding protein/cell adhesion molecule-like
Synonyms 2900075O15Rik, B930023M13Rik, Obcam, LOC235104
MMRRC Submission 045653-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R7559 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 27702071-28836706 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 28814620 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 291 (T291S)
Ref Sequence ENSEMBL: ENSMUSP00000110898 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073822] [ENSMUST00000115243]
AlphaFold G5E8G3
Predicted Effect probably benign
Transcript: ENSMUST00000073822
AA Change: T299S

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000073493
Gene: ENSMUSG00000062257
AA Change: T299S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IG 42 133 2.94e-10 SMART
IGc2 148 209 2.91e-14 SMART
IGc2 235 303 2e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115243
AA Change: T291S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000110898
Gene: ENSMUSG00000062257
AA Change: T291S

DomainStartEndE-ValueType
IG 35 126 2.94e-10 SMART
IGc2 141 201 1.36e-14 SMART
IGc2 227 295 2e-12 SMART
Meta Mutation Damage Score 0.0801 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 99% (68/69)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adap1 C A 5: 139,265,295 (GRCm39) R206L probably damaging Het
Adcy3 A G 12: 4,248,440 (GRCm39) K501E probably benign Het
Agl T C 3: 116,545,764 (GRCm39) D679G Het
Ankrd10 A T 8: 11,662,548 (GRCm39) V395D probably damaging Het
Ano5 A G 7: 51,224,636 (GRCm39) I531V probably damaging Het
Apol9a T A 15: 77,288,761 (GRCm39) H202L possibly damaging Het
Atp6v1c2 A C 12: 17,351,215 (GRCm39) I105M probably benign Het
Cfap57 C T 4: 118,472,128 (GRCm39) V84I probably benign Het
Coro1b T C 19: 4,200,220 (GRCm39) probably null Het
D930020B18Rik A G 10: 121,492,131 (GRCm39) probably benign Het
Dcst2 T C 3: 89,276,021 (GRCm39) F384S possibly damaging Het
Ddx39a T A 8: 84,447,595 (GRCm39) F147I possibly damaging Het
Drosha A G 15: 12,842,508 (GRCm39) E393G probably damaging Het
Etfdh T C 3: 79,530,886 (GRCm39) Y45C probably damaging Het
Fam20c G T 5: 138,778,954 (GRCm39) E287D possibly damaging Het
Flnc T A 6: 29,459,009 (GRCm39) D2463E probably damaging Het
Flt4 A T 11: 49,535,198 (GRCm39) I1209F possibly damaging Het
Foxp1 T C 6: 98,922,521 (GRCm39) D437G unknown Het
Fras1 T C 5: 96,888,713 (GRCm39) V2753A possibly damaging Het
Ftsj3 T C 11: 106,143,813 (GRCm39) D277G possibly damaging Het
Gad1 T C 2: 70,394,256 (GRCm39) probably null Het
Gal3st2c A G 1: 93,937,075 (GRCm39) Y340C probably damaging Het
Gbp9 A G 5: 105,232,975 (GRCm39) F226L probably damaging Het
Gm11992 C T 11: 9,002,747 (GRCm39) P37S possibly damaging Het
Gm19668 G T 10: 77,634,572 (GRCm39) C132* probably null Het
Hdac3 A T 18: 38,078,569 (GRCm39) F139I possibly damaging Het
Hectd4 A G 5: 121,453,573 (GRCm39) probably null Het
Helz T A 11: 107,491,104 (GRCm39) S162T possibly damaging Het
Hspb6 C A 7: 30,253,712 (GRCm39) S75Y probably damaging Het
Il17rb T A 14: 29,719,000 (GRCm39) I361F probably damaging Het
Iqsec3 A T 6: 121,364,739 (GRCm39) V850D probably damaging Het
Knl1 A G 2: 118,924,487 (GRCm39) E1840G possibly damaging Het
Lamc3 A G 2: 31,812,380 (GRCm39) K939R probably benign Het
Lmo7 C T 14: 102,124,662 (GRCm39) R496* probably null Het
Lsm14a A T 7: 34,052,826 (GRCm39) C374* probably null Het
Luc7l T C 17: 26,474,089 (GRCm39) L49P probably damaging Het
Mdga2 A C 12: 66,520,003 (GRCm39) C988G probably damaging Het
Mtf1 T C 4: 124,713,999 (GRCm39) V136A probably damaging Het
Myo7b T A 18: 32,116,413 (GRCm39) I1016F probably benign Het
Nadsyn1 C A 7: 143,361,804 (GRCm39) A306S probably benign Het
Naip5 T C 13: 100,356,204 (GRCm39) Q1137R probably benign Het
Naip5 G T 13: 100,356,205 (GRCm39) Q1137K not run Het
Nr4a1 T C 15: 101,168,780 (GRCm39) V272A probably damaging Het
Or13a24 T A 7: 140,154,356 (GRCm39) C97S probably damaging Het
Or52u1 C A 7: 104,237,087 (GRCm39) H25Q probably damaging Het
Or56b1b C T 7: 108,164,763 (GRCm39) A80T probably damaging Het
Osbp2 C G 11: 3,662,493 (GRCm39) K196N probably damaging Het
Otoa T C 7: 120,743,149 (GRCm39) V792A probably damaging Het
Pcmtd1 A G 1: 7,239,766 (GRCm39) D245G probably damaging Het
Pcnx1 T C 12: 82,039,896 (GRCm39) V1428A unknown Het
Pik3r4 A G 9: 105,555,352 (GRCm39) H1103R probably benign Het
Pjvk C T 2: 76,486,154 (GRCm39) H185Y probably benign Het
Pkd1l3 T C 8: 110,351,072 (GRCm39) V639A probably benign Het
Pklr T C 3: 89,050,365 (GRCm39) S405P probably damaging Het
Pla2g12a T A 3: 129,672,569 (GRCm39) Y68N probably damaging Het
Proz A G 8: 13,113,455 (GRCm39) H92R probably benign Het
Sec23ip G T 7: 128,379,074 (GRCm39) V844F possibly damaging Het
Sema3f A G 9: 107,561,777 (GRCm39) V520A possibly damaging Het
Serpinb12 A G 1: 106,881,453 (GRCm39) I197V probably damaging Het
Sim2 A T 16: 93,910,218 (GRCm39) I207F possibly damaging Het
Slc15a2 C T 16: 36,572,259 (GRCm39) V702I probably benign Het
Slc35f4 T C 14: 49,541,732 (GRCm39) I341V probably benign Het
Spam1 A G 6: 24,800,452 (GRCm39) Y397C probably damaging Het
Spire1 A T 18: 67,634,187 (GRCm39) M417K probably benign Het
Srcap T C 7: 127,129,722 (GRCm39) S515P unknown Het
Tfrc T A 16: 32,440,235 (GRCm39) probably null Het
Topors A G 4: 40,261,401 (GRCm39) S628P unknown Het
Trim71 T C 9: 114,342,110 (GRCm39) Y724C probably damaging Het
Ttn C T 2: 76,623,199 (GRCm39) V15413I probably damaging Het
Vmn1r21 A T 6: 57,821,227 (GRCm39) N72K probably damaging Het
Vmn2r80 A T 10: 79,030,459 (GRCm39) M762L probably benign Het
Wdr62 A G 7: 29,970,198 (GRCm39) I203T probably damaging Het
Other mutations in Opcml
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00864:Opcml APN 9 28,812,887 (GRCm39) missense probably damaging 1.00
IGL00864:Opcml APN 9 28,812,886 (GRCm39) missense probably damaging 1.00
IGL00956:Opcml APN 9 28,586,624 (GRCm39) missense possibly damaging 0.86
IGL02391:Opcml APN 9 28,586,560 (GRCm39) missense probably damaging 0.96
IGL03210:Opcml APN 9 28,812,833 (GRCm39) missense probably damaging 0.99
R0373:Opcml UTSW 9 28,724,694 (GRCm39) missense possibly damaging 0.48
R1037:Opcml UTSW 9 28,814,595 (GRCm39) missense probably damaging 1.00
R1564:Opcml UTSW 9 28,814,612 (GRCm39) missense probably damaging 1.00
R2094:Opcml UTSW 9 28,812,886 (GRCm39) missense probably damaging 1.00
R2268:Opcml UTSW 9 28,814,651 (GRCm39) missense possibly damaging 0.91
R2426:Opcml UTSW 9 28,814,663 (GRCm39) critical splice donor site probably null
R2938:Opcml UTSW 9 27,702,682 (GRCm39) start codon destroyed probably null 0.00
R3746:Opcml UTSW 9 28,812,826 (GRCm39) missense possibly damaging 0.54
R4058:Opcml UTSW 9 28,812,884 (GRCm39) missense probably damaging 1.00
R4173:Opcml UTSW 9 28,814,654 (GRCm39) missense probably benign
R4882:Opcml UTSW 9 28,812,886 (GRCm39) missense probably damaging 1.00
R5335:Opcml UTSW 9 28,586,621 (GRCm39) missense possibly damaging 0.88
R7058:Opcml UTSW 9 28,586,507 (GRCm39) nonsense probably null
R8050:Opcml UTSW 9 28,724,640 (GRCm39) missense probably damaging 0.97
R8250:Opcml UTSW 9 28,586,566 (GRCm39) missense probably damaging 1.00
R8350:Opcml UTSW 9 28,813,463 (GRCm39) missense probably benign 0.00
R8772:Opcml UTSW 9 27,702,707 (GRCm39) missense probably benign 0.04
R8879:Opcml UTSW 9 28,813,447 (GRCm39) missense probably damaging 1.00
R9355:Opcml UTSW 9 28,814,650 (GRCm39) missense probably benign 0.00
R9364:Opcml UTSW 9 28,814,624 (GRCm39) missense probably damaging 1.00
R9385:Opcml UTSW 9 28,586,459 (GRCm39) missense possibly damaging 0.62
Z1177:Opcml UTSW 9 28,315,673 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CATCCTTTGAGTGCCTGCTG -3'
(R):5'- ACCTTGGACACATGACTGC -3'

Sequencing Primer
(F):5'- GAGTGCCTGCTGCTTCTCTTG -3'
(R):5'- GCCAGGAGGAGGATCTTAGC -3'
Posted On 2019-10-17