Incidental Mutation 'R7559:Vmn2r80'
| ID |
584963 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r80
|
| Ensembl Gene |
ENSMUSG00000091888 |
| Gene Name |
vomeronasal 2, receptor 80 |
| Synonyms |
EG624765 |
| MMRRC Submission |
045653-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
R7559 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
78984650-79030767 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 79030459 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 762
(M762L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132299
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165834]
|
| AlphaFold |
E9Q1L0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165834
AA Change: M762L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000132299
Gene: ENSMUSG00000091888
AA Change: M762L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
79 |
474 |
1.5e-36 |
PFAM |
|
Pfam:NCD3G
|
517 |
570 |
7.9e-22 |
PFAM |
|
Pfam:7tm_3
|
603 |
838 |
6.2e-49 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
99% (68/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adap1 |
C |
A |
5: 139,265,295 (GRCm39) |
R206L |
probably damaging |
Het |
| Adcy3 |
A |
G |
12: 4,248,440 (GRCm39) |
K501E |
probably benign |
Het |
| Agl |
T |
C |
3: 116,545,764 (GRCm39) |
D679G |
|
Het |
| Ankrd10 |
A |
T |
8: 11,662,548 (GRCm39) |
V395D |
probably damaging |
Het |
| Ano5 |
A |
G |
7: 51,224,636 (GRCm39) |
I531V |
probably damaging |
Het |
| Apol9a |
T |
A |
15: 77,288,761 (GRCm39) |
H202L |
possibly damaging |
Het |
| Atp6v1c2 |
A |
C |
12: 17,351,215 (GRCm39) |
I105M |
probably benign |
Het |
| Cfap57 |
C |
T |
4: 118,472,128 (GRCm39) |
V84I |
probably benign |
Het |
| Coro1b |
T |
C |
19: 4,200,220 (GRCm39) |
|
probably null |
Het |
| D930020B18Rik |
A |
G |
10: 121,492,131 (GRCm39) |
|
probably benign |
Het |
| Dcst2 |
T |
C |
3: 89,276,021 (GRCm39) |
F384S |
possibly damaging |
Het |
| Ddx39a |
T |
A |
8: 84,447,595 (GRCm39) |
F147I |
possibly damaging |
Het |
| Drosha |
A |
G |
15: 12,842,508 (GRCm39) |
E393G |
probably damaging |
Het |
| Etfdh |
T |
C |
3: 79,530,886 (GRCm39) |
Y45C |
probably damaging |
Het |
| Fam20c |
G |
T |
5: 138,778,954 (GRCm39) |
E287D |
possibly damaging |
Het |
| Flnc |
T |
A |
6: 29,459,009 (GRCm39) |
D2463E |
probably damaging |
Het |
| Flt4 |
A |
T |
11: 49,535,198 (GRCm39) |
I1209F |
possibly damaging |
Het |
| Foxp1 |
T |
C |
6: 98,922,521 (GRCm39) |
D437G |
unknown |
Het |
| Fras1 |
T |
C |
5: 96,888,713 (GRCm39) |
V2753A |
possibly damaging |
Het |
| Ftsj3 |
T |
C |
11: 106,143,813 (GRCm39) |
D277G |
possibly damaging |
Het |
| Gad1 |
T |
C |
2: 70,394,256 (GRCm39) |
|
probably null |
Het |
| Gal3st2c |
A |
G |
1: 93,937,075 (GRCm39) |
Y340C |
probably damaging |
Het |
| Gbp9 |
A |
G |
5: 105,232,975 (GRCm39) |
F226L |
probably damaging |
Het |
| Gm11992 |
C |
T |
11: 9,002,747 (GRCm39) |
P37S |
possibly damaging |
Het |
| Gm19668 |
G |
T |
10: 77,634,572 (GRCm39) |
C132* |
probably null |
Het |
| Hdac3 |
A |
T |
18: 38,078,569 (GRCm39) |
F139I |
possibly damaging |
Het |
| Hectd4 |
A |
G |
5: 121,453,573 (GRCm39) |
|
probably null |
Het |
| Helz |
T |
A |
11: 107,491,104 (GRCm39) |
S162T |
possibly damaging |
Het |
| Hspb6 |
C |
A |
7: 30,253,712 (GRCm39) |
S75Y |
probably damaging |
Het |
| Il17rb |
T |
A |
14: 29,719,000 (GRCm39) |
I361F |
probably damaging |
Het |
| Iqsec3 |
A |
T |
6: 121,364,739 (GRCm39) |
V850D |
probably damaging |
Het |
| Knl1 |
A |
G |
2: 118,924,487 (GRCm39) |
E1840G |
possibly damaging |
Het |
| Lamc3 |
A |
G |
2: 31,812,380 (GRCm39) |
K939R |
probably benign |
Het |
| Lmo7 |
C |
T |
14: 102,124,662 (GRCm39) |
R496* |
probably null |
Het |
| Lsm14a |
A |
T |
7: 34,052,826 (GRCm39) |
C374* |
probably null |
Het |
| Luc7l |
T |
C |
17: 26,474,089 (GRCm39) |
L49P |
probably damaging |
Het |
| Mdga2 |
A |
C |
12: 66,520,003 (GRCm39) |
C988G |
probably damaging |
Het |
| Mtf1 |
T |
C |
4: 124,713,999 (GRCm39) |
V136A |
probably damaging |
Het |
| Myo7b |
T |
A |
18: 32,116,413 (GRCm39) |
I1016F |
probably benign |
Het |
| Nadsyn1 |
C |
A |
7: 143,361,804 (GRCm39) |
A306S |
probably benign |
Het |
| Naip5 |
T |
C |
13: 100,356,204 (GRCm39) |
Q1137R |
probably benign |
Het |
| Naip5 |
G |
T |
13: 100,356,205 (GRCm39) |
Q1137K |
not run |
Het |
| Nr4a1 |
T |
C |
15: 101,168,780 (GRCm39) |
V272A |
probably damaging |
Het |
| Opcml |
A |
T |
9: 28,814,620 (GRCm39) |
T291S |
probably benign |
Het |
| Or13a24 |
T |
A |
7: 140,154,356 (GRCm39) |
C97S |
probably damaging |
Het |
| Or52u1 |
C |
A |
7: 104,237,087 (GRCm39) |
H25Q |
probably damaging |
Het |
| Or56b1b |
C |
T |
7: 108,164,763 (GRCm39) |
A80T |
probably damaging |
Het |
| Osbp2 |
C |
G |
11: 3,662,493 (GRCm39) |
K196N |
probably damaging |
Het |
| Otoa |
T |
C |
7: 120,743,149 (GRCm39) |
V792A |
probably damaging |
Het |
| Pcmtd1 |
A |
G |
1: 7,239,766 (GRCm39) |
D245G |
probably damaging |
Het |
| Pcnx1 |
T |
C |
12: 82,039,896 (GRCm39) |
V1428A |
unknown |
Het |
| Pik3r4 |
A |
G |
9: 105,555,352 (GRCm39) |
H1103R |
probably benign |
Het |
| Pjvk |
C |
T |
2: 76,486,154 (GRCm39) |
H185Y |
probably benign |
Het |
| Pkd1l3 |
T |
C |
8: 110,351,072 (GRCm39) |
V639A |
probably benign |
Het |
| Pklr |
T |
C |
3: 89,050,365 (GRCm39) |
S405P |
probably damaging |
Het |
| Pla2g12a |
T |
A |
3: 129,672,569 (GRCm39) |
Y68N |
probably damaging |
Het |
| Proz |
A |
G |
8: 13,113,455 (GRCm39) |
H92R |
probably benign |
Het |
| Sec23ip |
G |
T |
7: 128,379,074 (GRCm39) |
V844F |
possibly damaging |
Het |
| Sema3f |
A |
G |
9: 107,561,777 (GRCm39) |
V520A |
possibly damaging |
Het |
| Serpinb12 |
A |
G |
1: 106,881,453 (GRCm39) |
I197V |
probably damaging |
Het |
| Sim2 |
A |
T |
16: 93,910,218 (GRCm39) |
I207F |
possibly damaging |
Het |
| Slc15a2 |
C |
T |
16: 36,572,259 (GRCm39) |
V702I |
probably benign |
Het |
| Slc35f4 |
T |
C |
14: 49,541,732 (GRCm39) |
I341V |
probably benign |
Het |
| Spam1 |
A |
G |
6: 24,800,452 (GRCm39) |
Y397C |
probably damaging |
Het |
| Spire1 |
A |
T |
18: 67,634,187 (GRCm39) |
M417K |
probably benign |
Het |
| Srcap |
T |
C |
7: 127,129,722 (GRCm39) |
S515P |
unknown |
Het |
| Tfrc |
T |
A |
16: 32,440,235 (GRCm39) |
|
probably null |
Het |
| Topors |
A |
G |
4: 40,261,401 (GRCm39) |
S628P |
unknown |
Het |
| Trim71 |
T |
C |
9: 114,342,110 (GRCm39) |
Y724C |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,623,199 (GRCm39) |
V15413I |
probably damaging |
Het |
| Vmn1r21 |
A |
T |
6: 57,821,227 (GRCm39) |
N72K |
probably damaging |
Het |
| Wdr62 |
A |
G |
7: 29,970,198 (GRCm39) |
I203T |
probably damaging |
Het |
|
| Other mutations in Vmn2r80 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01084:Vmn2r80
|
APN |
10 |
79,030,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01325:Vmn2r80
|
APN |
10 |
79,030,081 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01611:Vmn2r80
|
APN |
10 |
79,007,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01799:Vmn2r80
|
APN |
10 |
79,007,385 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01877:Vmn2r80
|
APN |
10 |
79,007,334 (GRCm39) |
splice site |
probably null |
|
|
IGL02673:Vmn2r80
|
APN |
10 |
79,005,318 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02756:Vmn2r80
|
APN |
10 |
79,030,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02820:Vmn2r80
|
APN |
10 |
79,007,439 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03382:Vmn2r80
|
APN |
10 |
79,005,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0071:Vmn2r80
|
UTSW |
10 |
79,007,566 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0071:Vmn2r80
|
UTSW |
10 |
79,007,566 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0129:Vmn2r80
|
UTSW |
10 |
79,005,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0325:Vmn2r80
|
UTSW |
10 |
78,984,773 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0567:Vmn2r80
|
UTSW |
10 |
79,030,665 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1510:Vmn2r80
|
UTSW |
10 |
79,005,553 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1519:Vmn2r80
|
UTSW |
10 |
79,030,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1520:Vmn2r80
|
UTSW |
10 |
79,030,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1627:Vmn2r80
|
UTSW |
10 |
79,030,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1709:Vmn2r80
|
UTSW |
10 |
79,030,223 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2116:Vmn2r80
|
UTSW |
10 |
79,030,558 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2237:Vmn2r80
|
UTSW |
10 |
79,004,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2308:Vmn2r80
|
UTSW |
10 |
79,007,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2893:Vmn2r80
|
UTSW |
10 |
78,984,699 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3408:Vmn2r80
|
UTSW |
10 |
79,004,227 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4502:Vmn2r80
|
UTSW |
10 |
78,984,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4685:Vmn2r80
|
UTSW |
10 |
79,030,162 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4851:Vmn2r80
|
UTSW |
10 |
79,030,156 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4947:Vmn2r80
|
UTSW |
10 |
79,030,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5112:Vmn2r80
|
UTSW |
10 |
79,030,292 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5217:Vmn2r80
|
UTSW |
10 |
79,004,980 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5226:Vmn2r80
|
UTSW |
10 |
79,029,874 (GRCm39) |
missense |
probably benign |
0.36 |
|
R5512:Vmn2r80
|
UTSW |
10 |
79,004,066 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5618:Vmn2r80
|
UTSW |
10 |
78,984,755 (GRCm39) |
missense |
probably benign |
|
|
R5959:Vmn2r80
|
UTSW |
10 |
79,005,313 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6104:Vmn2r80
|
UTSW |
10 |
78,984,854 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6110:Vmn2r80
|
UTSW |
10 |
79,017,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6270:Vmn2r80
|
UTSW |
10 |
79,030,159 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6508:Vmn2r80
|
UTSW |
10 |
79,030,290 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6843:Vmn2r80
|
UTSW |
10 |
79,005,502 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6894:Vmn2r80
|
UTSW |
10 |
79,005,438 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7048:Vmn2r80
|
UTSW |
10 |
79,030,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vmn2r80
|
UTSW |
10 |
79,030,654 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7262:Vmn2r80
|
UTSW |
10 |
79,005,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7622:Vmn2r80
|
UTSW |
10 |
79,030,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8003:Vmn2r80
|
UTSW |
10 |
78,984,711 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8207:Vmn2r80
|
UTSW |
10 |
79,030,150 (GRCm39) |
nonsense |
probably null |
|
|
R8330:Vmn2r80
|
UTSW |
10 |
79,007,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8337:Vmn2r80
|
UTSW |
10 |
78,984,707 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8354:Vmn2r80
|
UTSW |
10 |
78,984,710 (GRCm39) |
missense |
probably benign |
|
|
R8688:Vmn2r80
|
UTSW |
10 |
79,004,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8903:Vmn2r80
|
UTSW |
10 |
79,017,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Vmn2r80
|
UTSW |
10 |
79,005,378 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9125:Vmn2r80
|
UTSW |
10 |
78,984,760 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9147:Vmn2r80
|
UTSW |
10 |
79,030,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9148:Vmn2r80
|
UTSW |
10 |
79,030,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9187:Vmn2r80
|
UTSW |
10 |
79,030,438 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9218:Vmn2r80
|
UTSW |
10 |
79,030,270 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9553:Vmn2r80
|
UTSW |
10 |
78,984,743 (GRCm39) |
missense |
probably benign |
|
|
R9612:Vmn2r80
|
UTSW |
10 |
79,030,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9677:Vmn2r80
|
UTSW |
10 |
78,984,672 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9769:Vmn2r80
|
UTSW |
10 |
79,005,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r80
|
UTSW |
10 |
79,030,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r80
|
UTSW |
10 |
79,030,232 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
Z1176:Vmn2r80
|
UTSW |
10 |
79,005,311 (GRCm39) |
missense |
not run |
|
|
Z1176:Vmn2r80
|
UTSW |
10 |
79,030,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r80
|
UTSW |
10 |
79,005,311 (GRCm39) |
missense |
not run |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGATGGTTGCTGACATCACAG -3'
(R):5'- GAATGCTTGCACTGGAAGCC -3'
Sequencing Primer
(F):5'- GCTGACATCACAGGTCCCTAAATTTG -3'
(R):5'- GCCAAGGTAGAGAATATTTCCATAGC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation