Incidental Mutation 'R7561:Zfp786'
ID 585113
Institutional Source Beutler Lab
Gene Symbol Zfp786
Ensembl Gene ENSMUSG00000051499
Gene Name zinc finger protein 786
Synonyms A730012O14Rik
MMRRC Submission 045654-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R7561 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 47796200-47807801 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 47796667 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 757 (R757L)
Ref Sequence ENSEMBL: ENSMUSP00000057495 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058844]
AlphaFold Q8BV42
Predicted Effect probably benign
Transcript: ENSMUST00000058844
AA Change: R757L

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000057495
Gene: ENSMUSG00000051499
AA Change: R757L

DomainStartEndE-ValueType
KRAB 9 69 2.6e-22 SMART
low complexity region 156 164 N/A INTRINSIC
ZnF_C2H2 240 262 5.34e-1 SMART
ZnF_C2H2 268 295 1.41e2 SMART
ZnF_C2H2 420 440 1.21e2 SMART
ZnF_C2H2 448 470 3.52e-1 SMART
ZnF_C2H2 476 498 1.89e-1 SMART
ZnF_C2H2 504 526 1.69e-3 SMART
ZnF_C2H2 532 554 5.59e-4 SMART
ZnF_C2H2 560 582 4.79e-3 SMART
ZnF_C2H2 588 610 3.69e-4 SMART
ZnF_C2H2 616 638 3.63e-3 SMART
ZnF_C2H2 644 665 5.92e0 SMART
ZnF_C2H2 671 693 2.57e-3 SMART
ZnF_C2H2 699 721 1.38e-3 SMART
ZnF_C2H2 727 749 1.45e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik C A 13: 77,341,314 (GRCm39) N314K probably benign Het
A430005L14Rik T A 4: 154,045,097 (GRCm39) I80N probably benign Het
Abca2 A G 2: 25,336,707 (GRCm39) H2271R probably damaging Het
Acad8 T C 9: 26,890,538 (GRCm39) I257V probably benign Het
Acot12 A T 13: 91,918,243 (GRCm39) T179S probably damaging Het
Adcy10 A G 1: 165,386,741 (GRCm39) R1155G possibly damaging Het
Adcy9 C T 16: 4,236,028 (GRCm39) C461Y probably damaging Het
Adgrf1 G A 17: 43,622,000 (GRCm39) V746I possibly damaging Het
Agbl1 C A 7: 76,348,509 (GRCm39) Q869K unknown Het
AI837181 T G 19: 5,476,491 (GRCm39) V218G probably damaging Het
Alg9 T C 9: 50,754,074 (GRCm39) S585P possibly damaging Het
Arhgef38 T C 3: 132,866,489 (GRCm39) Q216R Het
Asb4 A T 6: 5,430,968 (GRCm39) H401L possibly damaging Het
Atg7 G T 6: 114,650,002 (GRCm39) A60S possibly damaging Het
Atp10a T A 7: 58,476,881 (GRCm39) C1199S probably damaging Het
Blm G A 7: 80,152,276 (GRCm39) A557V probably damaging Het
Cbln1 A T 8: 88,198,624 (GRCm39) M82K probably benign Het
Ccdc183 T G 2: 25,501,529 (GRCm39) I293L probably benign Het
Col6a3 A G 1: 90,703,463 (GRCm39) S3035P unknown Het
Cux2 A T 5: 122,017,931 (GRCm39) S206T probably benign Het
Cyfip2 T C 11: 46,161,425 (GRCm39) D355G probably benign Het
Dhrs2 A G 14: 55,474,698 (GRCm39) H111R probably benign Het
Eif3b T G 5: 140,428,109 (GRCm39) D781E probably benign Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Fermt1 A T 2: 132,758,008 (GRCm39) I469N probably benign Het
Fgf20 G T 8: 40,732,975 (GRCm39) N154K possibly damaging Het
Fndc10 T A 4: 155,779,328 (GRCm39) V124E probably damaging Het
Fra10ac1 T C 19: 38,210,324 (GRCm39) D13G probably damaging Het
Gpatch1 A G 7: 35,008,800 (GRCm39) S74P probably damaging Het
Gramd1b G A 9: 40,312,911 (GRCm39) T19I unknown Het
Grm8 T C 6: 27,429,524 (GRCm39) T457A probably benign Het
Gucy2g C A 19: 55,194,772 (GRCm39) V882L probably benign Het
Hectd4 G A 5: 121,429,288 (GRCm39) R811H possibly damaging Het
Hk1 C T 10: 62,116,807 (GRCm39) probably null Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Il10ra T A 9: 45,167,117 (GRCm39) D480V probably benign Het
Il18rap A T 1: 40,563,537 (GRCm39) H22L probably benign Het
Inpp5a T A 7: 139,147,338 (GRCm39) I321N probably damaging Het
Insyn1 A G 9: 58,406,687 (GRCm39) D199G probably damaging Het
Kat2b T G 17: 53,948,286 (GRCm39) L352R probably benign Het
Katnip C T 7: 125,441,894 (GRCm39) S627L probably benign Het
Kcna1 A T 6: 126,619,108 (GRCm39) V404E probably damaging Het
Mcm3ap T A 10: 76,328,712 (GRCm39) V1110E possibly damaging Het
Moxd2 C T 6: 40,864,337 (GRCm39) R31H probably damaging Het
Mpdz A T 4: 81,225,388 (GRCm39) N1368K probably damaging Het
Mpzl3 G T 9: 44,966,610 (GRCm39) V24F probably benign Het
Mybph G A 1: 134,121,465 (GRCm39) probably null Het
Ncam1 G T 9: 49,476,242 (GRCm39) D282E probably damaging Het
Ntrk2 G A 13: 59,009,202 (GRCm39) C331Y probably benign Het
Nwd2 T A 5: 63,964,434 (GRCm39) C1339* probably null Het
Or3a1d T C 11: 74,238,436 (GRCm39) probably benign Het
Or5b98 T C 19: 12,931,403 (GRCm39) V150A probably benign Het
Or8k33 T C 2: 86,383,661 (GRCm39) D269G probably benign Het
Osbpl6 C A 2: 76,416,498 (GRCm39) T672N probably damaging Het
Pds5b T C 5: 150,662,783 (GRCm39) probably null Het
Perm1 A G 4: 156,303,217 (GRCm39) N587S probably benign Het
Pex7 A T 10: 19,770,012 (GRCm39) C165* probably null Het
Pik3r4 A G 9: 105,564,446 (GRCm39) T1347A possibly damaging Het
Pitpnm3 T C 11: 71,942,008 (GRCm39) D933G probably benign Het
Rnf213 T A 11: 119,332,545 (GRCm39) F2586I Het
Scn10a A G 9: 119,523,390 (GRCm39) M1T probably null Het
Sdhaf3 T A 6: 6,956,079 (GRCm39) L18Q not run Het
Septin7 A G 9: 25,209,151 (GRCm39) E256G possibly damaging Het
Slc35b2 A G 17: 45,877,727 (GRCm39) T236A probably damaging Het
Slc4a4 G A 5: 89,347,556 (GRCm39) G766R probably damaging Het
Slco6c1 G T 1: 97,000,691 (GRCm39) S537Y probably damaging Het
Srp68 T C 11: 116,139,593 (GRCm39) E452G probably damaging Het
Taf2 A T 15: 54,919,229 (GRCm39) M382K probably benign Het
Tas2r131 A G 6: 132,933,921 (GRCm39) L296P probably benign Het
Tlr9 A G 9: 106,103,148 (GRCm39) E813G probably benign Het
Trmt44 T C 5: 35,715,336 (GRCm39) E659G possibly damaging Het
Ttc21b G A 2: 66,047,548 (GRCm39) A849V possibly damaging Het
Unc45a G T 7: 79,981,334 (GRCm39) S489R possibly damaging Het
Xrn1 T C 9: 95,881,511 (GRCm39) V795A probably benign Het
Zbtb22 A T 17: 34,136,952 (GRCm39) T366S probably benign Het
Zcchc10 T A 11: 53,215,545 (GRCm39) H6Q probably benign Het
Zfp60 A G 7: 27,447,955 (GRCm39) K208E probably damaging Het
Zfp780b A T 7: 27,664,037 (GRCm39) C173S possibly damaging Het
Zfp936 G A 7: 42,839,339 (GRCm39) A269T probably damaging Het
Zfp976 T C 7: 42,265,701 (GRCm39) Y29C probably damaging Het
Other mutations in Zfp786
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00593:Zfp786 APN 6 47,796,605 (GRCm39) makesense probably null
IGL02442:Zfp786 APN 6 47,798,301 (GRCm39) missense probably benign 0.00
IGL02674:Zfp786 APN 6 47,797,427 (GRCm39) missense probably benign 0.22
IGL02814:Zfp786 APN 6 47,796,775 (GRCm39) missense probably damaging 1.00
IGL03072:Zfp786 APN 6 47,798,177 (GRCm39) missense probably benign 0.01
IGL03294:Zfp786 APN 6 47,798,258 (GRCm39) nonsense probably null
IGL03393:Zfp786 APN 6 47,798,458 (GRCm39) missense possibly damaging 0.88
3-1:Zfp786 UTSW 6 47,797,379 (GRCm39) missense probably damaging 1.00
PIT4581001:Zfp786 UTSW 6 47,796,756 (GRCm39) missense probably damaging 1.00
R1071:Zfp786 UTSW 6 47,798,239 (GRCm39) missense possibly damaging 0.91
R1426:Zfp786 UTSW 6 47,802,013 (GRCm39) missense probably benign 0.17
R1976:Zfp786 UTSW 6 47,796,691 (GRCm39) missense probably damaging 1.00
R2114:Zfp786 UTSW 6 47,803,931 (GRCm39) missense probably damaging 1.00
R2115:Zfp786 UTSW 6 47,803,931 (GRCm39) missense probably damaging 1.00
R2117:Zfp786 UTSW 6 47,803,931 (GRCm39) missense probably damaging 1.00
R2176:Zfp786 UTSW 6 47,797,905 (GRCm39) missense possibly damaging 0.65
R2304:Zfp786 UTSW 6 47,797,633 (GRCm39) missense probably damaging 1.00
R3110:Zfp786 UTSW 6 47,797,160 (GRCm39) missense probably damaging 1.00
R3112:Zfp786 UTSW 6 47,797,160 (GRCm39) missense probably damaging 1.00
R3623:Zfp786 UTSW 6 47,798,357 (GRCm39) missense probably benign 0.00
R4654:Zfp786 UTSW 6 47,797,868 (GRCm39) missense probably benign 0.01
R4741:Zfp786 UTSW 6 47,797,625 (GRCm39) missense probably damaging 1.00
R4927:Zfp786 UTSW 6 47,797,087 (GRCm39) missense probably benign 0.43
R4936:Zfp786 UTSW 6 47,798,202 (GRCm39) nonsense probably null
R5084:Zfp786 UTSW 6 47,796,953 (GRCm39) missense probably benign 0.00
R5445:Zfp786 UTSW 6 47,796,619 (GRCm39) missense probably damaging 1.00
R6662:Zfp786 UTSW 6 47,803,920 (GRCm39) missense probably damaging 1.00
R7290:Zfp786 UTSW 6 47,796,929 (GRCm39) missense probably damaging 1.00
R8038:Zfp786 UTSW 6 47,798,188 (GRCm39) missense probably benign 0.01
R8090:Zfp786 UTSW 6 47,796,943 (GRCm39) missense probably damaging 1.00
R8250:Zfp786 UTSW 6 47,797,729 (GRCm39) missense possibly damaging 0.85
R8438:Zfp786 UTSW 6 47,796,934 (GRCm39) missense probably damaging 1.00
R8516:Zfp786 UTSW 6 47,797,477 (GRCm39) missense probably damaging 1.00
R8868:Zfp786 UTSW 6 47,802,015 (GRCm39) missense probably damaging 0.99
R9596:Zfp786 UTSW 6 47,797,406 (GRCm39) nonsense probably null
R9788:Zfp786 UTSW 6 47,797,816 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GAGCCCCTCTGTTCCTAAAAC -3'
(R):5'- CCAAGCAATCTAAACTCGTGG -3'

Sequencing Primer
(F):5'- GTTCCTAAAACCTGCTTCCCAGTAG -3'
(R):5'- GCTTCCGATTGAAAGCTCAG -3'
Posted On 2019-10-17