Incidental Mutation 'R7563:Or5m10'
ID 585236
Institutional Source Beutler Lab
Gene Symbol Or5m10
Ensembl Gene ENSMUSG00000050128
Gene Name olfactory receptor family 5 subfamily M member 10
Synonyms GA_x6K02T2Q125-47363965-47364900, MOR196-3, Olfr1023
MMRRC Submission 045655-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R7563 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85717146-85718081 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85717482 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 113 (Y113N)
Ref Sequence ENSEMBL: ENSMUSP00000149138 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056408] [ENSMUST00000213441]
AlphaFold A2ASU6
Predicted Effect probably damaging
Transcript: ENSMUST00000056408
AA Change: Y113N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000059849
Gene: ENSMUSG00000050128
AA Change: Y113N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2.6e-7 PFAM
Pfam:7tm_1 41 290 2.4e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213441
AA Change: Y113N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 A G 4: 144,184,464 (GRCm39) I98T probably damaging Het
Ahnak T C 19: 8,988,529 (GRCm39) I3271T probably damaging Het
Aox1 G A 1: 58,086,304 (GRCm39) V70I probably benign Het
Ap1g2 A G 14: 55,337,206 (GRCm39) S710P probably damaging Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Cacna1e T C 1: 154,347,162 (GRCm39) K1064E probably benign Het
Capn11 T A 17: 45,944,891 (GRCm39) I459F probably damaging Het
Ccnc A G 4: 21,732,220 (GRCm39) I48V probably damaging Het
Ces1d T A 8: 93,904,667 (GRCm39) I358F probably benign Het
Clgn A T 8: 84,147,185 (GRCm39) N379I probably damaging Het
Cym T C 3: 107,121,548 (GRCm39) Y248C probably damaging Het
Epha8 T C 4: 136,666,100 (GRCm39) D352G possibly damaging Het
Eya2 T C 2: 165,558,050 (GRCm39) probably null Het
Fam219a A C 4: 41,569,208 (GRCm39) V10G probably benign Het
Fbxl5 C T 5: 43,978,891 (GRCm39) V20I probably benign Het
Fbxl9 A G 8: 106,042,388 (GRCm39) C147R probably benign Het
Fscb T C 12: 64,520,059 (GRCm39) E469G possibly damaging Het
Glt8d2 A T 10: 82,496,659 (GRCm39) probably null Het
Grep1 A T 17: 23,936,302 (GRCm39) F8L probably benign Het
Helt T C 8: 46,746,630 (GRCm39) probably benign Het
Igkv8-27 G T 6: 70,148,887 (GRCm39) T89K probably benign Het
Ipo5 T A 14: 121,183,567 (GRCm39) H1048Q probably benign Het
Kalrn T C 16: 34,212,464 (GRCm39) D28G probably damaging Het
Kcnh4 G A 11: 100,632,680 (GRCm39) P936S probably benign Het
Klrd1 A G 6: 129,570,701 (GRCm39) I37M possibly damaging Het
Kmt2e T C 5: 23,705,271 (GRCm39) V1267A probably damaging Het
Marchf1 A T 8: 66,920,965 (GRCm39) Q214L probably damaging Het
Mlip G T 9: 77,020,279 (GRCm39) H52N probably damaging Het
Oas1e T C 5: 120,927,021 (GRCm39) R229G probably benign Het
Ogfr T A 2: 180,234,300 (GRCm39) probably null Het
Or4g16 T C 2: 111,137,134 (GRCm39) F195L probably benign Het
Pde4d T C 13: 110,087,541 (GRCm39) I636T probably benign Het
Pex5l C T 3: 33,008,625 (GRCm39) V426I probably damaging Het
Pmfbp1 A G 8: 110,252,006 (GRCm39) K384E possibly damaging Het
Pramel22 A T 4: 143,380,675 (GRCm39) Y449* probably null Het
Prl6a1 T G 13: 27,498,221 (GRCm39) probably null Het
Prss23 A T 7: 89,159,038 (GRCm39) W344R probably damaging Het
Ptar1 T A 19: 23,697,680 (GRCm39) D397E probably benign Het
Qrsl1 G A 10: 43,752,513 (GRCm39) R437C probably damaging Het
Rab6a G T 7: 100,257,404 (GRCm39) probably benign Het
Samd14 C A 11: 94,912,239 (GRCm39) S205R probably benign Het
Sel1l3 T C 5: 53,343,326 (GRCm39) Y322C probably damaging Het
Slc30a5 A T 13: 100,940,480 (GRCm39) L669I probably benign Het
Ssc4d A G 5: 135,991,887 (GRCm39) L419P probably damaging Het
Tbc1d2b A T 9: 90,101,063 (GRCm39) Y642* probably null Het
Tbc1d2b A C 9: 90,108,301 (GRCm39) F417V probably benign Het
Top2a T C 11: 98,907,005 (GRCm39) D212G probably damaging Het
Trim39 A T 17: 36,571,807 (GRCm39) V317E probably damaging Het
Uncx G A 5: 139,530,261 (GRCm39) R113H probably damaging Het
Usp4 A G 9: 108,256,543 (GRCm39) S655G probably benign Het
Vmn2r114 C T 17: 23,510,000 (GRCm39) V827I probably benign Het
Vmn2r28 T A 7: 5,491,200 (GRCm39) N349I probably benign Het
Vmn2r3 A G 3: 64,182,770 (GRCm39) W310R possibly damaging Het
Xirp2 T C 2: 67,340,245 (GRCm39) W829R probably damaging Het
Zfp574 C A 7: 24,780,777 (GRCm39) H600N possibly damaging Het
Other mutations in Or5m10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01536:Or5m10 APN 2 85,717,944 (GRCm39) missense probably damaging 1.00
IGL01622:Or5m10 APN 2 85,717,306 (GRCm39) missense probably benign 0.01
IGL01623:Or5m10 APN 2 85,717,306 (GRCm39) missense probably benign 0.01
IGL01977:Or5m10 APN 2 85,717,711 (GRCm39) missense probably damaging 1.00
IGL02057:Or5m10 APN 2 85,717,275 (GRCm39) missense probably benign 0.00
IGL02555:Or5m10 APN 2 85,717,742 (GRCm39) missense probably benign 0.34
IGL03133:Or5m10 APN 2 85,717,478 (GRCm39) missense probably damaging 1.00
IGL03180:Or5m10 APN 2 85,717,740 (GRCm39) missense probably benign 0.00
R0415:Or5m10 UTSW 2 85,717,782 (GRCm39) missense possibly damaging 0.94
R1476:Or5m10 UTSW 2 85,717,592 (GRCm39) nonsense probably null
R1544:Or5m10 UTSW 2 85,717,615 (GRCm39) missense probably damaging 1.00
R2058:Or5m10 UTSW 2 85,717,296 (GRCm39) missense possibly damaging 0.48
R4096:Or5m10 UTSW 2 85,717,767 (GRCm39) missense probably damaging 0.98
R5055:Or5m10 UTSW 2 85,717,585 (GRCm39) missense probably benign 0.12
R5703:Or5m10 UTSW 2 85,717,783 (GRCm39) missense probably benign 0.06
R6297:Or5m10 UTSW 2 85,717,159 (GRCm39) missense probably benign 0.35
R7041:Or5m10 UTSW 2 85,717,965 (GRCm39) missense probably benign 0.01
R7070:Or5m10 UTSW 2 85,718,034 (GRCm39) missense probably benign 0.13
R7777:Or5m10 UTSW 2 85,717,951 (GRCm39) missense possibly damaging 0.83
R7913:Or5m10 UTSW 2 85,718,074 (GRCm39) missense probably damaging 0.96
R9060:Or5m10 UTSW 2 85,717,920 (GRCm39) missense probably benign 0.06
R9789:Or5m10 UTSW 2 85,717,338 (GRCm39) missense probably damaging 1.00
S24628:Or5m10 UTSW 2 85,717,782 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- ACACTGGCAGGAAACTTGTTC -3'
(R):5'- TTCATGGGAGCCACAGAAAG -3'

Sequencing Primer
(F):5'- GTGCTGATCAGGACCAATTCC -3'
(R):5'- GCCACAGAAAGACAGGTGG -3'
Posted On 2019-10-17