Incidental Mutation 'R0620:Siglec1'
| ID |
58578 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Siglec1
|
| Ensembl Gene |
ENSMUSG00000027322 |
| Gene Name |
sialic acid binding Ig-like lectin 1, sialoadhesin |
| Synonyms |
Sn, CD169, Siglec-1 |
| MMRRC Submission |
038809-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.076)
|
| Stock # |
R0620 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
130911140-130928685 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 130916188 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Methionine
at position 1254
(T1254M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028794
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028794]
[ENSMUST00000110227]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000028794
AA Change: T1254M
PolyPhen 2
Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000028794
Gene: ENSMUSG00000027322
AA Change: T1254M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
9.4e-18 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
IG_like
|
1549 |
1624 |
1.21e-1 |
SMART |
|
transmembrane domain
|
1647 |
1669 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110227
AA Change: T1254M
PolyPhen 2
Score 0.281 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000105856
Gene: ENSMUSG00000027322
AA Change: T1254M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
7e-17 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.1316 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 99.0%
- 10x: 97.8%
- 20x: 96.1%
|
| Validation Efficiency |
100% (74/74) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts9 |
T |
C |
6: 92,835,094 (GRCm39) |
T679A |
possibly damaging |
Het |
| Ahr |
T |
C |
12: 35,558,193 (GRCm39) |
T276A |
probably benign |
Het |
| Akap9 |
A |
T |
5: 4,114,136 (GRCm39) |
Q3138H |
probably damaging |
Het |
| Armt1 |
T |
A |
10: 4,382,689 (GRCm39) |
F7I |
probably benign |
Het |
| B3galt2 |
A |
G |
1: 143,521,878 (GRCm39) |
R5G |
probably damaging |
Het |
| Bod1l |
T |
C |
5: 41,958,576 (GRCm39) |
N2750S |
probably benign |
Het |
| Cadps2 |
T |
A |
6: 23,583,395 (GRCm39) |
E365V |
probably damaging |
Het |
| Cd200r3 |
T |
A |
16: 44,778,080 (GRCm39) |
|
probably null |
Het |
| Cemip2 |
T |
A |
19: 21,795,335 (GRCm39) |
S743T |
probably benign |
Het |
| Cst7 |
T |
A |
2: 150,417,806 (GRCm39) |
|
probably benign |
Het |
| Defb30 |
A |
T |
14: 63,287,212 (GRCm39) |
|
probably benign |
Het |
| Dido1 |
C |
T |
2: 180,301,644 (GRCm39) |
G2087S |
probably benign |
Het |
| Dio2 |
A |
G |
12: 90,704,845 (GRCm39) |
Y72H |
probably benign |
Het |
| Dnah11 |
C |
T |
12: 117,951,204 (GRCm39) |
E3035K |
probably damaging |
Het |
| Dnajb13 |
T |
C |
7: 100,152,456 (GRCm39) |
K287E |
possibly damaging |
Het |
| Dnajc11 |
G |
A |
4: 152,058,085 (GRCm39) |
V244I |
possibly damaging |
Het |
| Ect2 |
C |
T |
3: 27,193,801 (GRCm39) |
A226T |
probably damaging |
Het |
| Ercc8 |
G |
A |
13: 108,310,595 (GRCm39) |
|
probably null |
Het |
| Fam120b |
T |
A |
17: 15,623,189 (GRCm39) |
M389K |
probably benign |
Het |
| Fam151a |
A |
G |
4: 106,605,128 (GRCm39) |
M497V |
probably benign |
Het |
| Fam186b |
C |
A |
15: 99,178,009 (GRCm39) |
G439V |
probably benign |
Het |
| Fank1 |
A |
G |
7: 133,478,494 (GRCm39) |
Y185C |
probably damaging |
Het |
| Gart |
T |
C |
16: 91,427,490 (GRCm39) |
|
probably benign |
Het |
| Glb1l |
T |
C |
1: 75,176,364 (GRCm39) |
Y572C |
probably damaging |
Het |
| Gm11563 |
C |
T |
11: 99,549,263 (GRCm39) |
A164T |
unknown |
Het |
| Gnb4 |
C |
T |
3: 32,645,356 (GRCm39) |
V112I |
probably benign |
Het |
| Gsdmc3 |
T |
A |
15: 63,731,542 (GRCm39) |
D330V |
probably damaging |
Het |
| H2-DMa |
C |
T |
17: 34,356,934 (GRCm39) |
T144M |
probably damaging |
Het |
| Haus6 |
A |
T |
4: 86,501,751 (GRCm39) |
F707I |
possibly damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,469,767 (GRCm39) |
T4971S |
probably benign |
Het |
| Ints6 |
A |
T |
14: 62,934,208 (GRCm39) |
F766L |
probably benign |
Het |
| Kdm5d |
T |
A |
Y: 927,330 (GRCm39) |
M650K |
probably damaging |
Het |
| Kif21b |
T |
C |
1: 136,087,166 (GRCm39) |
F881S |
possibly damaging |
Het |
| Klrk1 |
C |
A |
6: 129,591,598 (GRCm39) |
Q176H |
possibly damaging |
Het |
| Ky |
T |
C |
9: 102,414,820 (GRCm39) |
V244A |
probably benign |
Het |
| Mia2 |
T |
A |
12: 59,201,205 (GRCm39) |
L191M |
possibly damaging |
Het |
| Miga2 |
T |
A |
2: 30,271,756 (GRCm39) |
|
probably benign |
Het |
| Mtss2 |
C |
T |
8: 111,464,580 (GRCm39) |
P322S |
probably damaging |
Het |
| Nalcn |
A |
G |
14: 123,536,553 (GRCm39) |
|
probably benign |
Het |
| Ncbp3 |
T |
A |
11: 72,940,671 (GRCm39) |
|
probably benign |
Het |
| Nprl3 |
G |
A |
11: 32,184,876 (GRCm39) |
L378F |
probably damaging |
Het |
| Ntrk2 |
A |
T |
13: 58,994,635 (GRCm39) |
M184L |
probably benign |
Het |
| Or11g1 |
G |
T |
14: 50,651,154 (GRCm39) |
C51F |
probably benign |
Het |
| Or9e1 |
T |
G |
11: 58,732,269 (GRCm39) |
C110G |
probably damaging |
Het |
| Osbpl9 |
T |
C |
4: 108,940,325 (GRCm39) |
E287G |
probably damaging |
Het |
| Parva |
T |
C |
7: 112,175,618 (GRCm39) |
F250L |
probably damaging |
Het |
| Pcdhb11 |
C |
T |
18: 37,554,864 (GRCm39) |
Q65* |
probably null |
Het |
| Phtf1 |
A |
G |
3: 103,901,081 (GRCm39) |
T377A |
probably damaging |
Het |
| Pkp4 |
G |
A |
2: 59,152,987 (GRCm39) |
V612I |
possibly damaging |
Het |
| Plscr2 |
C |
A |
9: 92,169,707 (GRCm39) |
S52R |
probably benign |
Het |
| Pnisr |
C |
T |
4: 21,874,092 (GRCm39) |
|
probably benign |
Het |
| Pole2 |
A |
C |
12: 69,256,653 (GRCm39) |
S291A |
probably damaging |
Het |
| Ppp2r5d |
A |
G |
17: 46,994,944 (GRCm39) |
F586L |
probably benign |
Het |
| Prrx1 |
G |
A |
1: 163,085,385 (GRCm39) |
R182C |
probably damaging |
Het |
| Ptprs |
A |
G |
17: 56,736,103 (GRCm39) |
I110T |
possibly damaging |
Het |
| Rasgrf2 |
G |
A |
13: 92,067,936 (GRCm39) |
|
probably benign |
Het |
| Resf1 |
A |
T |
6: 149,229,873 (GRCm39) |
Q973L |
probably damaging |
Het |
| Riox2 |
T |
C |
16: 59,312,255 (GRCm39) |
V464A |
probably benign |
Het |
| Robo2 |
A |
G |
16: 73,764,690 (GRCm39) |
V646A |
possibly damaging |
Het |
| Ros1 |
T |
A |
10: 51,994,444 (GRCm39) |
I1279F |
probably damaging |
Het |
| Snx7 |
T |
C |
3: 117,640,324 (GRCm39) |
N62D |
probably damaging |
Het |
| Sp100 |
G |
A |
1: 85,587,588 (GRCm39) |
|
probably null |
Het |
| Stil |
A |
T |
4: 114,864,356 (GRCm39) |
I86L |
possibly damaging |
Het |
| Tbc1d16 |
T |
A |
11: 119,099,864 (GRCm39) |
D170V |
probably benign |
Het |
| Trappc13 |
G |
A |
13: 104,297,589 (GRCm39) |
T105M |
probably damaging |
Het |
| Trhr |
T |
A |
15: 44,092,896 (GRCm39) |
S378T |
probably benign |
Het |
| Ttc7b |
T |
C |
12: 100,466,332 (GRCm39) |
|
probably null |
Het |
| Vegfc |
A |
T |
8: 54,610,174 (GRCm39) |
Y110F |
probably benign |
Het |
| Vmn1r184 |
C |
A |
7: 25,966,602 (GRCm39) |
P116H |
possibly damaging |
Het |
| Vmn2r5 |
A |
T |
3: 64,411,235 (GRCm39) |
C444* |
probably null |
Het |
| Zfp341 |
A |
G |
2: 154,476,193 (GRCm39) |
E460G |
possibly damaging |
Het |
| Zfp819 |
T |
A |
7: 43,265,868 (GRCm39) |
V41E |
probably benign |
Het |
|
| Other mutations in Siglec1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00482:Siglec1
|
APN |
2 |
130,921,245 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01092:Siglec1
|
APN |
2 |
130,921,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01115:Siglec1
|
APN |
2 |
130,916,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01324:Siglec1
|
APN |
2 |
130,927,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01330:Siglec1
|
APN |
2 |
130,916,925 (GRCm39) |
nonsense |
probably null |
|
|
IGL01330:Siglec1
|
APN |
2 |
130,925,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01558:Siglec1
|
APN |
2 |
130,920,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01632:Siglec1
|
APN |
2 |
130,925,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01768:Siglec1
|
APN |
2 |
130,916,314 (GRCm39) |
missense |
probably benign |
|
|
IGL02399:Siglec1
|
APN |
2 |
130,913,098 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02558:Siglec1
|
APN |
2 |
130,916,915 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02794:Siglec1
|
APN |
2 |
130,917,889 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02839:Siglec1
|
APN |
2 |
130,926,852 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
aggressor
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
boris
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
espia
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
hoodlum
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
microfische
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
K3955:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0038:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4576001:Siglec1
|
UTSW |
2 |
130,920,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4677001:Siglec1
|
UTSW |
2 |
130,914,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Siglec1
|
UTSW |
2 |
130,916,980 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0243:Siglec1
|
UTSW |
2 |
130,927,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Siglec1
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
R0379:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Siglec1
|
UTSW |
2 |
130,921,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0560:Siglec1
|
UTSW |
2 |
130,912,266 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0621:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0853:Siglec1
|
UTSW |
2 |
130,926,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1079:Siglec1
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
R1169:Siglec1
|
UTSW |
2 |
130,916,747 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Siglec1
|
UTSW |
2 |
130,922,384 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1293:Siglec1
|
UTSW |
2 |
130,915,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1533:Siglec1
|
UTSW |
2 |
130,918,078 (GRCm39) |
missense |
probably benign |
|
|
R1717:Siglec1
|
UTSW |
2 |
130,925,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1717:Siglec1
|
UTSW |
2 |
130,915,876 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1744:Siglec1
|
UTSW |
2 |
130,923,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1852:Siglec1
|
UTSW |
2 |
130,923,420 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1941:Siglec1
|
UTSW |
2 |
130,920,051 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2011:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2128:Siglec1
|
UTSW |
2 |
130,922,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Siglec1
|
UTSW |
2 |
130,913,257 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2403:Siglec1
|
UTSW |
2 |
130,916,395 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2449:Siglec1
|
UTSW |
2 |
130,920,645 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2885:Siglec1
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4213:Siglec1
|
UTSW |
2 |
130,916,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Siglec1
|
UTSW |
2 |
130,927,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4679:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4715:Siglec1
|
UTSW |
2 |
130,916,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4782:Siglec1
|
UTSW |
2 |
130,917,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4896:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4993:Siglec1
|
UTSW |
2 |
130,915,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5004:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5004:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5105:Siglec1
|
UTSW |
2 |
130,922,320 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5137:Siglec1
|
UTSW |
2 |
130,923,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Siglec1
|
UTSW |
2 |
130,927,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5311:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5600:Siglec1
|
UTSW |
2 |
130,927,503 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5682:Siglec1
|
UTSW |
2 |
130,925,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5732:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5870:Siglec1
|
UTSW |
2 |
130,914,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5898:Siglec1
|
UTSW |
2 |
130,915,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Siglec1
|
UTSW |
2 |
130,919,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6488:Siglec1
|
UTSW |
2 |
130,923,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6920:Siglec1
|
UTSW |
2 |
130,919,997 (GRCm39) |
nonsense |
probably null |
|
|
R7064:Siglec1
|
UTSW |
2 |
130,925,834 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7270:Siglec1
|
UTSW |
2 |
130,923,471 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7355:Siglec1
|
UTSW |
2 |
130,922,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7400:Siglec1
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7470:Siglec1
|
UTSW |
2 |
130,917,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7568:Siglec1
|
UTSW |
2 |
130,914,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7781:Siglec1
|
UTSW |
2 |
130,923,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7853:Siglec1
|
UTSW |
2 |
130,923,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Siglec1
|
UTSW |
2 |
130,913,083 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8191:Siglec1
|
UTSW |
2 |
130,927,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8274:Siglec1
|
UTSW |
2 |
130,925,830 (GRCm39) |
missense |
probably benign |
|
|
R8345:Siglec1
|
UTSW |
2 |
130,920,498 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8670:Siglec1
|
UTSW |
2 |
130,923,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8814:Siglec1
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9102:Siglec1
|
UTSW |
2 |
130,915,389 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9311:Siglec1
|
UTSW |
2 |
130,916,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Siglec1
|
UTSW |
2 |
130,925,390 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Siglec1
|
UTSW |
2 |
130,916,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Siglec1
|
UTSW |
2 |
130,915,246 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9683:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9799:Siglec1
|
UTSW |
2 |
130,915,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0024:Siglec1
|
UTSW |
2 |
130,922,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,922,444 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,920,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCCATTGTGAAACCAGGCATAGAG -3'
(R):5'- GTGGTAGTTCCAGCACCATGTGAAG -3'
Sequencing Primer
(F):5'- GTCCTCGCAGGTCACTG -3'
(R):5'- GCAAACTGGTCTCTGTGTAAC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation