Mutagenetix > Incidental Mutation

Incidental Mutation 'R0624:Tnxb'

58845

Institutional Source

Beutler Lab

Gene Symbol

Tnxb

Ensembl Gene

ENSMUSG00000033327

Gene Name

tenascin XB

Synonyms

Tnx, TN-MHC

MMRRC Submission

038813-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0624 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

34879431-34938789 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 34902522 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Proline at position 1002 (H1002P)

Ref Sequence

ENSEMBL: ENSMUSP00000127487 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087399] [ENSMUST00000168533]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000087399
AA Change: H1125P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000084661
Gene: ENSMUSG00000033327
AA Change: H1125P

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	33	44	N/A	INTRINSIC
low complexity region	69	89	N/A	INTRINSIC
low complexity region	92	103	N/A	INTRINSIC
EGF	173	201	1.59e1	SMART
EGF	204	232	7.41e0	SMART
EGF	235	263	2.64e1	SMART
EGF	266	294	2.64e1	SMART
EGF	297	325	9.13e0	SMART
EGF	328	356	2.07e1	SMART
EGF_like	359	387	3.16e1	SMART
EGF_like	390	418	4.64e1	SMART
EGF_like	421	449	3.29e1	SMART
EGF_like	452	480	7.09e1	SMART
EGF	483	511	1.15e1	SMART
EGF	514	542	1.91e1	SMART
EGF_like	545	573	4.11e1	SMART
EGF	576	604	7.95e0	SMART
EGF	607	635	1.23e1	SMART
EGF_like	638	666	4.93e1	SMART
EGF_like	674	702	5.24e1	SMART
EGF	705	733	2.29e1	SMART
FN3	736	816	4.12e-3	SMART
FN3	827	904	1.21e-9	SMART
FN3	1047	1126	3.97e-5	SMART
FN3	1142	1223	3.62e-8	SMART
low complexity region	1230	1241	N/A	INTRINSIC
FN3	1242	1320	2.31e-6	SMART
FN3	1351	1431	8.77e-7	SMART
FN3	1460	1539	3.01e-5	SMART
FN3	1556	1636	2.76e-4	SMART
FN3	1657	1736	5.78e-7	SMART
FN3	1752	1832	4.7e-7	SMART
FN3	1851	1929	1.95e-4	SMART
FN3	1955	2034	4.56e-5	SMART
FN3	2066	2145	2.23e-8	SMART
FN3	2164	2244	7.75e-8	SMART
FN3	2279	2358	8.5e-5	SMART
FN3	2387	2467	2.94e-8	SMART
FN3	2501	2580	1.7e-4	SMART
low complexity region	2588	2598	N/A	INTRINSIC
FN3	2607	2687	6.75e-8	SMART
FN3	2716	2795	7.4e-5	SMART
FN3	2822	2902	1.35e-7	SMART
FN3	2931	3010	5.61e-5	SMART
FN3	3026	3106	6.01e-5	SMART
FN3	3120	3199	6.45e-5	SMART
FN3	3214	3293	9.54e-8	SMART
FN3	3316	3396	2.81e-5	SMART
FN3	3416	3502	1.98e-5	SMART
FN3	3518	3596	5.65e-10	SMART
FN3	3607	3682	7.63e-7	SMART
FN3	3695	3770	6.54e-6	SMART
FBG	3787	3997	8.88e-125	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000168533
AA Change: H1002P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000127487
Gene: ENSMUSG00000033327
AA Change: H1002P

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	33	44	N/A	INTRINSIC
low complexity region	69	89	N/A	INTRINSIC
low complexity region	92	103	N/A	INTRINSIC
EGF	173	201	1.59e1	SMART
EGF	204	232	7.41e0	SMART
EGF	235	263	2.64e1	SMART
EGF	266	294	2.64e1	SMART
EGF	297	325	9.13e0	SMART
EGF	328	356	2.07e1	SMART
EGF_like	359	387	3.16e1	SMART
EGF_like	390	418	4.64e1	SMART
EGF_like	421	449	3.29e1	SMART
EGF_like	452	480	7.09e1	SMART
EGF	483	511	1.15e1	SMART
EGF	514	542	1.91e1	SMART
EGF_like	545	573	4.11e1	SMART
EGF	576	604	7.95e0	SMART
EGF	607	635	1.23e1	SMART
EGF_like	638	666	4.93e1	SMART
EGF_like	674	702	5.24e1	SMART
EGF	705	733	2.29e1	SMART
FN3	736	816	4.12e-3	SMART
FN3	827	904	1.21e-9	SMART
FN3	924	1003	3.97e-5	SMART
FN3	1019	1100	3.62e-8	SMART
low complexity region	1107	1118	N/A	INTRINSIC
FN3	1119	1197	2.31e-6	SMART
FN3	1228	1308	8.77e-7	SMART
FN3	1337	1416	3.01e-5	SMART
FN3	1433	1513	2.76e-4	SMART
FN3	1534	1613	5.78e-7	SMART
FN3	1629	1709	4.7e-7	SMART
FN3	1728	1806	1.95e-4	SMART
FN3	1832	1911	4.56e-5	SMART
FN3	1943	2022	2.23e-8	SMART
FN3	2051	2130	5.61e-5	SMART
FN3	2146	2226	6.01e-5	SMART
FN3	2240	2319	6.45e-5	SMART
FN3	2334	2413	9.54e-8	SMART
FN3	2436	2516	2.81e-5	SMART
FN3	2536	2622	1.98e-5	SMART
FN3	2638	2716	5.65e-10	SMART
FN3	2727	2802	7.63e-7	SMART
FN3	2815	2890	6.54e-6	SMART
FBG	2907	3117	8.88e-125	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000179962

Meta Mutation Damage Score

0.3700

Coding Region Coverage

1x: 99.4%
3x: 99.0%
10x: 97.8%
20x: 96.2%

Validation Efficiency

98% (88/90)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	T	A	11: 110,030,446 (GRCm39)	D767V	probably damaging	Het
Add1	T	A	5: 34,763,197 (GRCm39)	N128K	probably damaging	Het
Ado	A	T	10: 67,384,058 (GRCm39)	D182E	probably benign	Het
Anapc4	T	A	5: 53,002,761 (GRCm39)		probably benign	Het
Ano10	A	G	9: 122,088,661 (GRCm39)		probably benign	Het
Apba2	A	G	7: 64,364,263 (GRCm39)		probably null	Het
Apc2	A	G	10: 80,150,417 (GRCm39)	T1795A	probably benign	Het
Atp4a	A	G	7: 30,418,424 (GRCm39)	N571D	probably benign	Het
Birc6	A	G	17: 74,887,344 (GRCm39)	N891D	probably benign	Het
Bltp2	G	A	11: 78,159,283 (GRCm39)	E494K	probably damaging	Het
Car3	G	T	3: 14,931,864 (GRCm39)	M78I	probably benign	Het
Cc2d2a	A	T	5: 43,887,371 (GRCm39)	H1267L	probably benign	Het
Cdk18	A	G	1: 132,046,610 (GRCm39)	L192P	probably damaging	Het
Cdk9	A	T	2: 32,599,836 (GRCm39)	Y134N	probably damaging	Het
Ceacam5	A	T	7: 17,448,888 (GRCm39)	T85S	probably benign	Het
Cenpe	A	G	3: 134,952,347 (GRCm39)	T1403A	probably benign	Het
Chd8	C	T	14: 52,457,214 (GRCm39)	G918D	possibly damaging	Het
Csnk1e	T	A	15: 79,304,098 (GRCm39)		probably benign	Het
Dctpp1	A	T	7: 126,856,365 (GRCm39)	I119N	probably damaging	Het
Defb34	T	A	8: 19,173,784 (GRCm39)	F6Y	unknown	Het
Dnai4	T	C	4: 102,930,054 (GRCm39)		probably benign	Het
Dvl1	C	G	4: 155,939,232 (GRCm39)	N248K	probably damaging	Het
Dync1h1	T	C	12: 110,618,181 (GRCm39)		probably benign	Het
Dync2i1	T	C	12: 116,211,910 (GRCm39)	D199G	probably damaging	Het
Eml5	T	A	12: 98,831,738 (GRCm39)	R407W	probably damaging	Het
Epb41l5	T	C	1: 119,551,688 (GRCm39)	D99G	probably damaging	Het
Fat1	A	T	8: 45,504,205 (GRCm39)	N4566I	possibly damaging	Het
Gm21834	T	C	17: 58,049,015 (GRCm39)	E67G	possibly damaging	Het
Gsap	T	A	5: 21,458,949 (GRCm39)		probably null	Het
Guf1	T	C	5: 69,715,923 (GRCm39)	I108T	probably damaging	Het
Hsd3b5	T	C	3: 98,526,720 (GRCm39)	D242G	probably damaging	Het
Kcna7	A	G	7: 45,059,114 (GRCm39)	D467G	probably null	Het
Lars1	A	G	18: 42,375,849 (GRCm39)		probably benign	Het
Lrrc56	A	T	7: 140,786,366 (GRCm39)	D248V	probably damaging	Het
Map3k14	T	A	11: 103,133,117 (GRCm39)	E27V	possibly damaging	Het
Med12l	G	A	3: 58,945,123 (GRCm39)	W116*	probably null	Het
Mgll	A	G	6: 88,702,799 (GRCm39)	R33G	probably damaging	Het
Mmp13	A	G	9: 7,280,221 (GRCm39)	S384G	possibly damaging	Het
Nalcn	C	T	14: 123,607,444 (GRCm39)	C675Y	probably benign	Het
Nrxn1	A	G	17: 91,396,117 (GRCm39)	L13P	unknown	Het
Ocstamp	A	G	2: 165,239,772 (GRCm39)	V138A	probably damaging	Het
Or12e8	T	G	2: 87,188,026 (GRCm39)	Y79*	probably null	Het
Or2z8	T	A	8: 72,812,006 (GRCm39)	S161T	possibly damaging	Het
Or4a68	A	G	2: 89,270,482 (GRCm39)	V47A	possibly damaging	Het
Or4f7	T	C	2: 111,645,056 (GRCm39)	N5S	probably damaging	Het
Or5p51	A	G	7: 107,444,323 (GRCm39)	S206P	possibly damaging	Het
Or9i1b	T	G	19: 13,896,808 (GRCm39)	C141W	probably damaging	Het
Patj	T	C	4: 98,569,472 (GRCm39)		probably benign	Het
Pcdhb22	A	G	18: 37,651,780 (GRCm39)	I83V	probably benign	Het
Pclo	A	G	5: 14,719,670 (GRCm39)	E1269G	unknown	Het
Plagl2	T	C	2: 153,077,973 (GRCm39)	T3A	probably benign	Het
Plcb1	C	T	2: 135,136,831 (GRCm39)	P309S	possibly damaging	Het
Pld3	A	T	7: 27,239,000 (GRCm39)	L175Q	possibly damaging	Het
Prrx1	A	G	1: 163,075,974 (GRCm39)		probably benign	Het
Psap	T	G	10: 60,135,345 (GRCm39)		probably benign	Het
Ptgfr	G	A	3: 151,540,839 (GRCm39)	T223M	probably damaging	Het
Reep2	A	T	18: 34,973,824 (GRCm39)	I6F	probably benign	Het
Rraga	A	G	4: 86,494,454 (GRCm39)	E100G	probably benign	Het
Rrm2b	T	C	15: 37,931,889 (GRCm39)	D37G	probably benign	Het
Rtl1	T	C	12: 109,559,153 (GRCm39)	I895M	probably damaging	Het
Ryr1	G	A	7: 28,774,034 (GRCm39)	A2445V	probably damaging	Het
Sbf1	C	T	15: 89,186,532 (GRCm39)	D898N	possibly damaging	Het
Sh3d19	G	A	3: 86,022,213 (GRCm39)	V548I	possibly damaging	Het
Shf	C	A	2: 122,199,116 (GRCm39)		probably benign	Het
Sipa1l3	T	C	7: 29,086,676 (GRCm39)	E638G	probably damaging	Het
Slc13a3	G	T	2: 165,253,807 (GRCm39)	P449T	probably damaging	Het
Slc2a13	C	T	15: 91,234,215 (GRCm39)	V374I	possibly damaging	Het
Slc4a7	T	C	14: 14,794,059 (GRCm38)		probably null	Het
Slc7a2	T	A	8: 41,361,568 (GRCm39)	S414T	probably benign	Het
Slc9c1	A	G	16: 45,393,719 (GRCm39)	E554G	probably benign	Het
Smad2	T	C	18: 76,433,064 (GRCm39)	I332T	probably damaging	Het
Snrnp40	C	T	4: 130,256,451 (GRCm39)	P59S	probably damaging	Het
Sorcs2	A	T	5: 36,222,777 (GRCm39)	I154N	probably damaging	Het
Sort1	G	A	3: 108,255,946 (GRCm39)	G631S	probably damaging	Het
Sox10	T	C	15: 79,043,586 (GRCm39)	D149G	possibly damaging	Het
Spn	C	T	7: 126,735,380 (GRCm39)	V376M	possibly damaging	Het
Tacc2	A	G	7: 130,179,239 (GRCm39)	D9G	probably damaging	Het
Tapt1	T	G	5: 44,334,448 (GRCm39)	L514F	possibly damaging	Het
Tcf3	A	G	10: 80,249,168 (GRCm39)	L480P	probably damaging	Het
Tenm4	G	C	7: 96,423,227 (GRCm39)	G637A	probably damaging	Het
Tex14	T	A	11: 87,411,525 (GRCm39)	N950K	probably benign	Het
Tgfbrap1	T	G	1: 43,098,289 (GRCm39)	H497P	probably benign	Het
Tnfrsf18	A	T	4: 156,110,986 (GRCm39)	Y48F	possibly damaging	Het
Ttn	A	G	2: 76,593,571 (GRCm39)		probably benign	Het
Ugt2b34	C	G	5: 87,041,591 (GRCm39)		probably null	Het
Vldlr	A	G	19: 27,215,663 (GRCm39)	D220G	possibly damaging	Het
Vmn1r33	A	T	6: 66,589,121 (GRCm39)	Y144*	probably null	Het
Xrcc4	T	C	13: 90,140,594 (GRCm39)	E205G	possibly damaging	Het

Other mutations in Tnxb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Tnxb	APN	17	34,904,603 (GRCm39)	missense	probably damaging	1.00
IGL00424:Tnxb	APN	17	34,933,666 (GRCm39)	missense	probably damaging	1.00
IGL00486:Tnxb	APN	17	34,911,356 (GRCm39)	missense	probably damaging	1.00
IGL00952:Tnxb	APN	17	34,932,102 (GRCm39)	missense	probably damaging	1.00
IGL00974:Tnxb	APN	17	34,937,707 (GRCm39)	critical splice donor site	probably null
IGL01017:Tnxb	APN	17	34,912,782 (GRCm39)	missense	probably damaging	0.98
IGL01082:Tnxb	APN	17	34,933,584 (GRCm39)	missense	probably damaging	0.97
IGL01397:Tnxb	APN	17	34,933,647 (GRCm39)	missense	probably damaging	0.99
IGL01473:Tnxb	APN	17	34,904,675 (GRCm39)	missense	probably damaging	0.99
IGL01642:Tnxb	APN	17	34,937,488 (GRCm39)	missense	probably damaging	1.00
IGL01774:Tnxb	APN	17	34,907,813 (GRCm39)	missense	probably damaging	1.00
IGL01971:Tnxb	APN	17	34,891,271 (GRCm39)	missense	probably damaging	1.00
IGL02016:Tnxb	APN	17	34,891,249 (GRCm39)	missense	probably damaging	0.98
IGL02160:Tnxb	APN	17	34,933,719 (GRCm39)	missense	probably benign	0.01
IGL02473:Tnxb	APN	17	34,936,736 (GRCm39)	missense	probably damaging	1.00
IGL02666:Tnxb	APN	17	34,903,913 (GRCm39)	missense	probably benign	0.20
IGL02831:Tnxb	APN	17	34,922,545 (GRCm39)	missense	possibly damaging	0.93
IGL02838:Tnxb	APN	17	34,908,606 (GRCm39)	missense	possibly damaging	0.74
IGL02965:Tnxb	APN	17	34,928,628 (GRCm39)	missense	possibly damaging	0.93
IGL03155:Tnxb	APN	17	34,932,569 (GRCm39)	missense	probably damaging	1.00
IGL03194:Tnxb	APN	17	34,914,921 (GRCm39)	nonsense	probably null
IGL03215:Tnxb	APN	17	34,911,499 (GRCm39)	missense	possibly damaging	0.66
IGL03256:Tnxb	APN	17	34,907,694 (GRCm39)	missense	probably damaging	1.00
BB008:Tnxb	UTSW	17	34,907,672 (GRCm39)	missense	probably damaging	1.00
BB018:Tnxb	UTSW	17	34,907,672 (GRCm39)	missense	probably damaging	1.00
E0370:Tnxb	UTSW	17	34,897,917 (GRCm39)	missense	probably damaging	1.00
R0006:Tnxb	UTSW	17	34,901,266 (GRCm39)	missense	probably benign	0.07
R0049:Tnxb	UTSW	17	34,928,542 (GRCm39)	missense	possibly damaging	0.93
R0050:Tnxb	UTSW	17	34,892,299 (GRCm39)	missense	probably damaging	1.00
R0233:Tnxb	UTSW	17	34,918,007 (GRCm39)	missense	probably benign	0.32
R0233:Tnxb	UTSW	17	34,918,007 (GRCm39)	missense	probably benign	0.32
R0311:Tnxb	UTSW	17	34,935,958 (GRCm39)	missense	probably damaging	0.97
R0326:Tnxb	UTSW	17	34,917,153 (GRCm39)	missense	probably benign	0.32
R0387:Tnxb	UTSW	17	34,902,548 (GRCm39)	missense	probably benign	0.30
R0396:Tnxb	UTSW	17	34,890,707 (GRCm39)	missense	probably damaging	1.00
R0511:Tnxb	UTSW	17	34,937,219 (GRCm39)	missense	probably damaging	0.96
R0540:Tnxb	UTSW	17	34,890,892 (GRCm39)	missense	probably damaging	1.00
R0563:Tnxb	UTSW	17	34,935,921 (GRCm39)	missense	probably benign	0.05
R0575:Tnxb	UTSW	17	34,936,180 (GRCm39)	missense	possibly damaging	0.91
R0586:Tnxb	UTSW	17	34,891,118 (GRCm39)	missense	probably damaging	1.00
R0607:Tnxb	UTSW	17	34,890,892 (GRCm39)	missense	probably damaging	1.00
R0622:Tnxb	UTSW	17	34,937,703 (GRCm39)	missense	probably damaging	1.00
R0709:Tnxb	UTSW	17	34,908,328 (GRCm39)	missense	probably damaging	1.00
R0898:Tnxb	UTSW	17	34,889,719 (GRCm39)	missense	probably damaging	1.00
R0970:Tnxb	UTSW	17	34,917,917 (GRCm39)	missense	possibly damaging	0.85
R0972:Tnxb	UTSW	17	34,904,117 (GRCm39)	missense	probably damaging	1.00
R1118:Tnxb	UTSW	17	34,904,017 (GRCm39)	missense	probably damaging	1.00
R1119:Tnxb	UTSW	17	34,904,017 (GRCm39)	missense	probably damaging	1.00
R1226:Tnxb	UTSW	17	34,907,903 (GRCm39)	missense	probably damaging	1.00
R1296:Tnxb	UTSW	17	34,890,551 (GRCm39)	missense	probably damaging	1.00
R1297:Tnxb	UTSW	17	34,929,140 (GRCm39)	missense	probably damaging	0.96
R1349:Tnxb	UTSW	17	34,929,267 (GRCm39)	missense	possibly damaging	0.67
R1356:Tnxb	UTSW	17	34,914,446 (GRCm39)	missense	possibly damaging	0.53
R1372:Tnxb	UTSW	17	34,929,267 (GRCm39)	missense	possibly damaging	0.67
R1521:Tnxb	UTSW	17	34,930,477 (GRCm39)	missense	probably damaging	1.00
R1522:Tnxb	UTSW	17	34,937,612 (GRCm39)	missense	probably damaging	1.00
R1532:Tnxb	UTSW	17	34,929,804 (GRCm39)	missense	probably damaging	1.00
R1735:Tnxb	UTSW	17	34,936,944 (GRCm39)	missense	probably damaging	1.00
R1778:Tnxb	UTSW	17	34,902,548 (GRCm39)	missense	probably benign	0.30
R1802:Tnxb	UTSW	17	34,922,863 (GRCm39)	missense	probably damaging	0.98
R1824:Tnxb	UTSW	17	34,911,307 (GRCm39)	nonsense	probably null
R1838:Tnxb	UTSW	17	34,897,884 (GRCm39)	missense	probably damaging	0.96
R1863:Tnxb	UTSW	17	34,889,848 (GRCm39)	missense	probably damaging	1.00
R1865:Tnxb	UTSW	17	34,922,431 (GRCm39)	nonsense	probably null
R1867:Tnxb	UTSW	17	34,890,821 (GRCm39)	missense	probably damaging	1.00
R1883:Tnxb	UTSW	17	34,908,539 (GRCm39)	missense	probably benign	0.01
R1884:Tnxb	UTSW	17	34,908,539 (GRCm39)	missense	probably benign	0.01
R1889:Tnxb	UTSW	17	34,914,799 (GRCm39)	missense	probably damaging	0.97
R1969:Tnxb	UTSW	17	34,898,055 (GRCm39)	missense	probably benign	0.20
R1989:Tnxb	UTSW	17	34,912,859 (GRCm39)	missense	probably damaging	1.00
R1989:Tnxb	UTSW	17	34,902,351 (GRCm39)	missense	probably benign	0.08
R1991:Tnxb	UTSW	17	34,901,225 (GRCm39)	missense	probably damaging	1.00
R1991:Tnxb	UTSW	17	34,890,878 (GRCm39)	missense	probably damaging	1.00
R1992:Tnxb	UTSW	17	34,890,878 (GRCm39)	missense	probably damaging	1.00
R2001:Tnxb	UTSW	17	34,911,553 (GRCm39)	missense	possibly damaging	0.82
R2018:Tnxb	UTSW	17	34,890,724 (GRCm39)	missense	probably benign	0.04
R2030:Tnxb	UTSW	17	34,937,443 (GRCm39)	missense	probably damaging	1.00
R2037:Tnxb	UTSW	17	34,918,179 (GRCm39)	missense	probably damaging	1.00
R2103:Tnxb	UTSW	17	34,901,225 (GRCm39)	missense	probably damaging	1.00
R2116:Tnxb	UTSW	17	34,891,201 (GRCm39)	missense	probably damaging	1.00
R2206:Tnxb	UTSW	17	34,928,391 (GRCm39)	missense	possibly damaging	0.86
R2207:Tnxb	UTSW	17	34,928,391 (GRCm39)	missense	possibly damaging	0.86
R2215:Tnxb	UTSW	17	34,923,114 (GRCm39)	missense	possibly damaging	0.93
R2413:Tnxb	UTSW	17	34,937,252 (GRCm39)	missense	probably damaging	0.99
R2680:Tnxb	UTSW	17	34,922,594 (GRCm39)	missense	possibly damaging	0.51
R2910:Tnxb	UTSW	17	34,891,424 (GRCm39)	missense	probably damaging	1.00
R2984:Tnxb	UTSW	17	34,897,636 (GRCm39)	nonsense	probably null
R3120:Tnxb	UTSW	17	34,911,329 (GRCm39)	missense	possibly damaging	0.86
R3429:Tnxb	UTSW	17	34,922,561 (GRCm39)	missense	probably damaging	0.98
R3429:Tnxb	UTSW	17	34,891,605 (GRCm39)	nonsense	probably null
R3552:Tnxb	UTSW	17	34,937,695 (GRCm39)	missense	probably damaging	1.00
R3698:Tnxb	UTSW	17	34,909,407 (GRCm39)	critical splice donor site	probably null
R3720:Tnxb	UTSW	17	34,931,938 (GRCm39)	missense	possibly damaging	0.95
R3841:Tnxb	UTSW	17	34,917,897 (GRCm39)	missense	possibly damaging	0.72
R3848:Tnxb	UTSW	17	34,909,369 (GRCm39)	missense	possibly damaging	0.82
R3886:Tnxb	UTSW	17	34,937,885 (GRCm39)	missense	probably damaging	1.00
R4074:Tnxb	UTSW	17	34,890,845 (GRCm39)	missense	probably benign	0.22
R4159:Tnxb	UTSW	17	34,930,491 (GRCm39)	missense	probably damaging	0.99
R4160:Tnxb	UTSW	17	34,930,491 (GRCm39)	missense	probably damaging	0.99
R4161:Tnxb	UTSW	17	34,930,491 (GRCm39)	missense	probably damaging	0.99
R4181:Tnxb	UTSW	17	34,928,428 (GRCm39)	missense	possibly damaging	0.93
R4210:Tnxb	UTSW	17	34,929,951 (GRCm39)	missense	possibly damaging	0.84
R4275:Tnxb	UTSW	17	34,917,205 (GRCm39)	missense	probably damaging	0.98
R4329:Tnxb	UTSW	17	34,912,838 (GRCm39)	missense	probably damaging	1.00
R4394:Tnxb	UTSW	17	34,897,636 (GRCm39)	nonsense	probably null
R4395:Tnxb	UTSW	17	34,897,636 (GRCm39)	nonsense	probably null
R4397:Tnxb	UTSW	17	34,897,636 (GRCm39)	nonsense	probably null
R4540:Tnxb	UTSW	17	34,922,309 (GRCm39)	missense	possibly damaging	0.86
R4673:Tnxb	UTSW	17	34,891,514 (GRCm39)	missense	probably damaging	0.99
R4719:Tnxb	UTSW	17	34,908,394 (GRCm39)	missense	probably damaging	1.00
R4725:Tnxb	UTSW	17	34,918,041 (GRCm39)	missense	probably damaging	0.99
R4753:Tnxb	UTSW	17	34,914,909 (GRCm39)	missense	possibly damaging	0.71
R4777:Tnxb	UTSW	17	34,890,917 (GRCm39)	missense	probably damaging	1.00
R4837:Tnxb	UTSW	17	34,936,981 (GRCm39)	missense	probably damaging	0.98
R4898:Tnxb	UTSW	17	34,914,566 (GRCm39)	missense	possibly damaging	0.95
R4938:Tnxb	UTSW	17	34,932,606 (GRCm39)	missense	probably damaging	1.00
R5044:Tnxb	UTSW	17	34,936,457 (GRCm39)	missense	probably damaging	1.00
R5100:Tnxb	UTSW	17	34,929,902 (GRCm39)	missense	probably damaging	0.99
R5223:Tnxb	UTSW	17	34,923,052 (GRCm39)	missense	possibly damaging	0.51
R5269:Tnxb	UTSW	17	34,922,582 (GRCm39)	missense	possibly damaging	0.95
R5333:Tnxb	UTSW	17	34,909,205 (GRCm39)	missense	probably damaging	1.00
R5454:Tnxb	UTSW	17	34,928,599 (GRCm39)	missense	possibly damaging	0.71
R5470:Tnxb	UTSW	17	34,935,947 (GRCm39)	missense	probably null	1.00
R5475:Tnxb	UTSW	17	34,908,567 (GRCm39)	missense	probably damaging	1.00
R5574:Tnxb	UTSW	17	34,929,998 (GRCm39)	missense	probably benign
R5596:Tnxb	UTSW	17	34,907,778 (GRCm39)	missense	probably damaging	1.00
R5599:Tnxb	UTSW	17	34,909,179 (GRCm39)	missense	probably benign	0.22
R5599:Tnxb	UTSW	17	34,909,176 (GRCm39)	missense	probably damaging	1.00
R5615:Tnxb	UTSW	17	34,902,392 (GRCm39)	missense	probably damaging	1.00
R5620:Tnxb	UTSW	17	34,936,504 (GRCm39)	nonsense	probably null
R5625:Tnxb	UTSW	17	34,904,185 (GRCm39)	missense	probably benign	0.30
R5734:Tnxb	UTSW	17	34,917,884 (GRCm39)	missense	possibly damaging	0.53
R5896:Tnxb	UTSW	17	34,891,126 (GRCm39)	missense	probably damaging	1.00
R5961:Tnxb	UTSW	17	34,937,609 (GRCm39)	missense	probably damaging	1.00
R5974:Tnxb	UTSW	17	34,904,681 (GRCm39)	missense	probably damaging	1.00
R6091:Tnxb	UTSW	17	34,929,338 (GRCm39)	missense	probably damaging	0.98
R6134:Tnxb	UTSW	17	34,890,986 (GRCm39)	missense	probably damaging	0.96
R6325:Tnxb	UTSW	17	34,911,398 (GRCm39)	missense	probably damaging	1.00
R6358:Tnxb	UTSW	17	34,897,968 (GRCm39)	missense	probably damaging	0.98
R6362:Tnxb	UTSW	17	34,913,362 (GRCm39)	missense	probably damaging	1.00
R6432:Tnxb	UTSW	17	34,936,891 (GRCm39)	missense	probably damaging	1.00
R6461:Tnxb	UTSW	17	34,890,872 (GRCm39)	missense	probably damaging	1.00
R6467:Tnxb	UTSW	17	34,912,898 (GRCm39)	missense	probably damaging	1.00
R6476:Tnxb	UTSW	17	34,909,166 (GRCm39)	missense	probably damaging	0.98
R6477:Tnxb	UTSW	17	34,938,513 (GRCm39)	missense	probably damaging	1.00
R6631:Tnxb	UTSW	17	34,937,222 (GRCm39)	missense	probably damaging	1.00
R6774:Tnxb	UTSW	17	34,928,606 (GRCm39)	nonsense	probably null
R6787:Tnxb	UTSW	17	34,929,710 (GRCm39)	missense	probably benign	0.02
R6805:Tnxb	UTSW	17	34,917,127 (GRCm39)	missense	possibly damaging	0.93
R6860:Tnxb	UTSW	17	34,932,131 (GRCm39)	missense	probably damaging	0.99
R6883:Tnxb	UTSW	17	34,937,493 (GRCm39)	missense	probably damaging	1.00
R7049:Tnxb	UTSW	17	34,936,242 (GRCm39)	critical splice donor site	probably null
R7107:Tnxb	UTSW	17	34,890,314 (GRCm39)	missense	unknown
R7172:Tnxb	UTSW	17	34,914,994 (GRCm39)	missense	probably damaging	1.00
R7206:Tnxb	UTSW	17	34,923,075 (GRCm39)	missense	possibly damaging	0.71
R7219:Tnxb	UTSW	17	34,898,039 (GRCm39)	missense	probably benign	0.08
R7237:Tnxb	UTSW	17	34,901,170 (GRCm39)	missense	possibly damaging	0.82
R7257:Tnxb	UTSW	17	34,935,475 (GRCm39)	missense	probably benign	0.44
R7269:Tnxb	UTSW	17	34,914,428 (GRCm39)	missense	probably damaging	1.00
R7302:Tnxb	UTSW	17	34,897,875 (GRCm39)	missense	probably benign	0.41
R7372:Tnxb	UTSW	17	34,936,228 (GRCm39)	missense	possibly damaging	0.72
R7384:Tnxb	UTSW	17	34,937,492 (GRCm39)	missense	probably damaging	1.00
R7447:Tnxb	UTSW	17	34,937,444 (GRCm39)	missense	probably damaging	1.00
R7449:Tnxb	UTSW	17	34,922,335 (GRCm39)	missense	possibly damaging	0.93
R7480:Tnxb	UTSW	17	34,934,747 (GRCm39)	missense	probably damaging	0.96
R7506:Tnxb	UTSW	17	34,934,665 (GRCm39)	missense	possibly damaging	0.89
R7586:Tnxb	UTSW	17	34,935,382 (GRCm39)	missense	probably damaging	0.98
R7688:Tnxb	UTSW	17	34,890,880 (GRCm39)	missense	probably benign	0.23
R7690:Tnxb	UTSW	17	34,908,501 (GRCm39)	missense	probably damaging	1.00
R7690:Tnxb	UTSW	17	34,908,494 (GRCm39)	missense	probably benign	0.03
R7732:Tnxb	UTSW	17	34,913,254 (GRCm39)	missense	probably damaging	1.00
R7735:Tnxb	UTSW	17	34,890,398 (GRCm39)	missense	unknown
R7760:Tnxb	UTSW	17	34,931,911 (GRCm39)	missense	probably damaging	0.96
R7874:Tnxb	UTSW	17	34,930,417 (GRCm39)	missense	probably damaging	1.00
R7909:Tnxb	UTSW	17	34,911,428 (GRCm39)	missense	probably benign	0.02
R7922:Tnxb	UTSW	17	34,933,577 (GRCm39)	missense	probably damaging	1.00
R7931:Tnxb	UTSW	17	34,907,672 (GRCm39)	missense	probably damaging	1.00
R7949:Tnxb	UTSW	17	34,936,103 (GRCm39)	missense	probably damaging	1.00
R7953:Tnxb	UTSW	17	34,929,077 (GRCm39)	missense	probably benign	0.03
R7953:Tnxb	UTSW	17	34,928,509 (GRCm39)	missense	possibly damaging	0.86
R7977:Tnxb	UTSW	17	34,929,194 (GRCm39)	missense	possibly damaging	0.92
R7985:Tnxb	UTSW	17	34,935,984 (GRCm39)	critical splice donor site	probably null
R7987:Tnxb	UTSW	17	34,929,194 (GRCm39)	missense	possibly damaging	0.92
R8040:Tnxb	UTSW	17	34,935,532 (GRCm39)	missense	probably damaging	1.00
R8053:Tnxb	UTSW	17	34,923,153 (GRCm39)	missense	probably damaging	0.98
R8074:Tnxb	UTSW	17	34,922,955 (GRCm39)	missense	probably benign	0.32
R8089:Tnxb	UTSW	17	34,891,763 (GRCm39)	missense	unknown
R8169:Tnxb	UTSW	17	34,918,181 (GRCm39)	missense	possibly damaging	0.96
R8348:Tnxb	UTSW	17	34,929,102 (GRCm39)	missense	possibly damaging	0.92
R8352:Tnxb	UTSW	17	34,908,381 (GRCm39)	missense	probably damaging	1.00
R8362:Tnxb	UTSW	17	34,931,946 (GRCm39)	missense	probably damaging	0.99
R8452:Tnxb	UTSW	17	34,908,381 (GRCm39)	missense	probably damaging	1.00
R8527:Tnxb	UTSW	17	34,907,634 (GRCm39)	missense	probably damaging	1.00
R8754:Tnxb	UTSW	17	34,934,882 (GRCm39)	missense	probably damaging	1.00
R8813:Tnxb	UTSW	17	34,938,136 (GRCm39)	missense	probably damaging	1.00
R8936:Tnxb	UTSW	17	34,904,646 (GRCm39)	missense	probably damaging	1.00
R8986:Tnxb	UTSW	17	34,897,646 (GRCm39)	missense	possibly damaging	0.66
R9001:Tnxb	UTSW	17	34,922,410 (GRCm39)	missense	probably benign	0.32
R9215:Tnxb	UTSW	17	34,891,564 (GRCm39)	missense	unknown
R9226:Tnxb	UTSW	17	34,904,766 (GRCm39)	missense	probably damaging	1.00
R9276:Tnxb	UTSW	17	34,929,134 (GRCm39)	missense	possibly damaging	0.60
R9279:Tnxb	UTSW	17	34,898,088 (GRCm39)	missense	possibly damaging	0.46
R9363:Tnxb	UTSW	17	34,917,294 (GRCm39)	missense	possibly damaging	0.93
R9367:Tnxb	UTSW	17	34,931,993 (GRCm39)	missense	probably damaging	1.00
R9494:Tnxb	UTSW	17	34,904,796 (GRCm39)	missense	probably damaging	1.00
R9606:Tnxb	UTSW	17	34,914,578 (GRCm39)	missense	possibly damaging	0.82
R9650:Tnxb	UTSW	17	34,930,629 (GRCm39)	missense	probably damaging	0.99
R9677:Tnxb	UTSW	17	34,917,878 (GRCm39)	missense	possibly damaging	0.93
R9690:Tnxb	UTSW	17	34,936,171 (GRCm39)	missense	probably damaging	1.00
R9761:Tnxb	UTSW	17	34,903,987 (GRCm39)	missense	probably benign	0.32
X0004:Tnxb	UTSW	17	34,922,389 (GRCm39)	missense	possibly damaging	0.71
X0010:Tnxb	UTSW	17	34,890,908 (GRCm39)	missense	probably damaging	1.00
X0019:Tnxb	UTSW	17	34,913,163 (GRCm39)	missense	possibly damaging	0.51
X0063:Tnxb	UTSW	17	34,922,482 (GRCm39)	missense	probably damaging	0.98
X0064:Tnxb	UTSW	17	34,913,006 (GRCm39)	missense	probably damaging	1.00
Z1177:Tnxb	UTSW	17	34,937,700 (GRCm39)	missense	probably damaging	0.99
Z1177:Tnxb	UTSW	17	34,902,305 (GRCm39)	missense	probably damaging	1.00
Z1177:Tnxb	UTSW	17	34,890,740 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TTTCGTCCCCAAACCTCAGACAGG -3'
(R):5'- ATTCCCAAATCAGGTCGAGGCCAG -3'

Sequencing Primer
(F):5'- CCTGGGTGAACTGACAGTGAC -3'
(R):5'- CAAAAGAGAGCTGTGCATTCTCTG -3'

Posted On

2013-07-11