Incidental Mutation 'R0233:Copa'
| ID |
58861 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Copa
|
| Ensembl Gene |
ENSMUSG00000026553 |
| Gene Name |
coatomer protein complex subunit alpha |
| Synonyms |
xenin |
| MMRRC Submission |
038474-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.970)
|
| Stock # |
R0233 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
171910096-171949897 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 171915234 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118179
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000003550]
[ENSMUST00000027833]
[ENSMUST00000027833]
[ENSMUST00000124289]
[ENSMUST00000135192]
[ENSMUST00000140643]
[ENSMUST00000146137]
|
| AlphaFold |
Q8CIE6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000003550
|
| SMART Domains |
Protein: ENSMUSP00000003550
Gene: ENSMUSG00000003458
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
32 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M28
|
254 |
468 |
2.9e-7 |
PFAM |
|
Pfam:Nicastrin
|
273 |
498 |
1.6e-94 |
PFAM |
|
transmembrane domain
|
669 |
691 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000027833
|
| SMART Domains |
Protein: ENSMUSP00000027833
Gene: ENSMUSG00000026553
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
2 |
37 |
2.86e0 |
SMART |
|
WD40
|
40 |
79 |
1.11e-6 |
SMART |
|
WD40
|
82 |
121 |
4.76e-6 |
SMART |
|
WD40
|
124 |
163 |
2.24e-11 |
SMART |
|
WD40
|
194 |
233 |
2.98e-7 |
SMART |
|
WD40
|
238 |
277 |
8.42e-7 |
SMART |
|
WD40
|
280 |
318 |
1.38e1 |
SMART |
|
Pfam:Coatomer_WDAD
|
338 |
776 |
5.4e-144 |
PFAM |
|
Pfam:COPI_C
|
824 |
1233 |
1.4e-190 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000027833
|
| SMART Domains |
Protein: ENSMUSP00000027833
Gene: ENSMUSG00000026553
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
2 |
37 |
2.86e0 |
SMART |
|
WD40
|
40 |
79 |
1.11e-6 |
SMART |
|
WD40
|
82 |
121 |
4.76e-6 |
SMART |
|
WD40
|
124 |
163 |
2.24e-11 |
SMART |
|
WD40
|
194 |
233 |
2.98e-7 |
SMART |
|
WD40
|
238 |
277 |
8.42e-7 |
SMART |
|
WD40
|
280 |
318 |
1.38e1 |
SMART |
|
Pfam:Coatomer_WDAD
|
338 |
776 |
5.4e-144 |
PFAM |
|
Pfam:COPI_C
|
824 |
1233 |
1.4e-190 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124289
|
| SMART Domains |
Protein: ENSMUSP00000118899
Gene: ENSMUSG00000026553
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:WD40
|
1 |
37 |
2e-19 |
BLAST |
|
PDB:4J8G|B
|
1 |
52 |
2e-23 |
PDB |
|
SCOP:d1erja_
|
1 |
52 |
1e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126634
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000135192
|
| SMART Domains |
Protein: ENSMUSP00000118179
Gene: ENSMUSG00000026553
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
2 |
37 |
2.86e0 |
SMART |
|
WD40
|
40 |
79 |
1.11e-6 |
SMART |
|
WD40
|
82 |
121 |
4.76e-6 |
SMART |
|
WD40
|
124 |
163 |
2.24e-11 |
SMART |
|
WD40
|
194 |
233 |
2.98e-7 |
SMART |
|
WD40
|
238 |
277 |
8.42e-7 |
SMART |
|
WD40
|
280 |
318 |
1.38e1 |
SMART |
|
Pfam:Coatomer_WDAD
|
338 |
767 |
1.1e-148 |
PFAM |
|
Pfam:COPI_C
|
815 |
1224 |
3.6e-216 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138407
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140643
|
| SMART Domains |
Protein: ENSMUSP00000119128
Gene: ENSMUSG00000003458
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
32 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191834
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000192810
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142825
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146137
|
| SMART Domains |
Protein: ENSMUSP00000120663
Gene: ENSMUSG00000003458
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
32 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9491 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.4%
|
| Validation Efficiency |
99% (93/94) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(6) : Gene trapped(6)
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
A |
G |
14: 32,385,330 (GRCm39) |
S212P |
probably benign |
Het |
| A730018C14Rik |
A |
C |
12: 112,381,864 (GRCm39) |
|
noncoding transcript |
Het |
| Acsf3 |
A |
G |
8: 123,507,031 (GRCm39) |
Y108C |
probably damaging |
Het |
| Acsl1 |
A |
G |
8: 46,966,606 (GRCm39) |
|
probably benign |
Het |
| Adad1 |
T |
A |
3: 37,139,097 (GRCm39) |
I389N |
possibly damaging |
Het |
| Ankrd27 |
T |
C |
7: 35,300,985 (GRCm39) |
L95P |
probably damaging |
Het |
| Ano5 |
T |
C |
7: 51,185,218 (GRCm39) |
F46S |
possibly damaging |
Het |
| Ap2a1 |
T |
C |
7: 44,565,397 (GRCm39) |
N114S |
probably damaging |
Het |
| Arap1 |
C |
T |
7: 101,049,448 (GRCm39) |
S970L |
possibly damaging |
Het |
| Atad3a |
A |
T |
4: 155,830,524 (GRCm39) |
S525T |
probably damaging |
Het |
| B4galnt1 |
T |
C |
10: 127,006,780 (GRCm39) |
|
probably benign |
Het |
| Bltp1 |
T |
A |
3: 37,002,712 (GRCm39) |
C1552* |
probably null |
Het |
| Cacna2d2 |
A |
T |
9: 107,391,869 (GRCm39) |
I463F |
probably damaging |
Het |
| Casp6 |
T |
A |
3: 129,699,624 (GRCm39) |
N34K |
probably damaging |
Het |
| Ccdc175 |
A |
T |
12: 72,152,650 (GRCm39) |
F752I |
probably benign |
Het |
| Cdhr4 |
A |
G |
9: 107,874,133 (GRCm39) |
I76V |
probably benign |
Het |
| Cox11 |
C |
T |
11: 90,535,326 (GRCm39) |
T259I |
probably damaging |
Het |
| Cuzd1 |
C |
A |
7: 130,913,545 (GRCm39) |
K357N |
possibly damaging |
Het |
| Dnah5 |
T |
A |
15: 28,333,216 (GRCm39) |
F2206I |
probably damaging |
Het |
| Dnase2b |
T |
A |
3: 146,288,305 (GRCm39) |
K263N |
probably benign |
Het |
| Dync1h1 |
T |
A |
12: 110,607,414 (GRCm39) |
D2668E |
probably benign |
Het |
| Eno1b |
T |
C |
18: 48,180,806 (GRCm39) |
I328T |
probably benign |
Het |
| Fam124b |
T |
C |
1: 80,190,703 (GRCm39) |
S227G |
probably damaging |
Het |
| Fam13b |
T |
A |
18: 34,581,137 (GRCm39) |
Y675F |
probably damaging |
Het |
| Fgf21 |
T |
A |
7: 45,264,721 (GRCm39) |
M4L |
probably benign |
Het |
| Flg2 |
T |
A |
3: 93,109,104 (GRCm39) |
C377* |
probably null |
Het |
| Foxp2 |
T |
C |
6: 15,409,752 (GRCm39) |
S451P |
probably damaging |
Het |
| Gli2 |
A |
T |
1: 118,763,655 (GRCm39) |
S1499T |
probably damaging |
Het |
| Gm9920 |
A |
T |
15: 54,975,857 (GRCm39) |
|
probably benign |
Het |
| Gpx5 |
T |
A |
13: 21,471,573 (GRCm39) |
D210V |
probably damaging |
Het |
| H2-T5 |
A |
G |
17: 36,478,361 (GRCm39) |
Y224H |
probably benign |
Het |
| Hoxb5 |
T |
A |
11: 96,195,853 (GRCm39) |
S234T |
probably benign |
Het |
| Irf9 |
C |
A |
14: 55,843,551 (GRCm39) |
N140K |
probably benign |
Het |
| Isg20 |
C |
A |
7: 78,566,334 (GRCm39) |
D94E |
probably damaging |
Het |
| Isg20 |
C |
T |
7: 78,564,243 (GRCm39) |
T50M |
probably damaging |
Het |
| Izumo1 |
T |
C |
7: 45,273,592 (GRCm39) |
L115P |
probably damaging |
Het |
| Kdm3b |
G |
A |
18: 34,942,473 (GRCm39) |
E655K |
probably damaging |
Het |
| Kdm5b |
T |
G |
1: 134,532,372 (GRCm39) |
|
probably benign |
Het |
| Kifc3 |
A |
G |
8: 95,828,100 (GRCm39) |
|
probably null |
Het |
| Kpna2 |
T |
C |
11: 106,883,457 (GRCm39) |
S111G |
probably benign |
Het |
| Krt73 |
A |
T |
15: 101,710,451 (GRCm39) |
N94K |
probably benign |
Het |
| Lgmn |
G |
T |
12: 102,366,248 (GRCm39) |
D247E |
probably damaging |
Het |
| Lilra6 |
C |
T |
7: 3,917,935 (GRCm39) |
V70I |
possibly damaging |
Het |
| Lrig3 |
G |
A |
10: 125,849,395 (GRCm39) |
|
probably null |
Het |
| Lrrc4 |
T |
C |
6: 28,829,734 (GRCm39) |
H627R |
probably benign |
Het |
| Macf1 |
G |
A |
4: 123,343,920 (GRCm39) |
|
probably benign |
Het |
| Nat9 |
C |
A |
11: 115,074,234 (GRCm39) |
|
probably null |
Het |
| Nutm2 |
A |
G |
13: 50,621,441 (GRCm39) |
D2G |
probably benign |
Het |
| Or10j3b |
A |
T |
1: 173,043,868 (GRCm39) |
I217F |
probably benign |
Het |
| Or5h23 |
A |
T |
16: 58,906,038 (GRCm39) |
D269E |
probably benign |
Het |
| Or5w8 |
A |
G |
2: 87,688,096 (GRCm39) |
I192M |
probably benign |
Het |
| Parl |
G |
A |
16: 20,106,657 (GRCm39) |
P184L |
probably damaging |
Het |
| Pdzd8 |
A |
T |
19: 59,288,811 (GRCm39) |
M863K |
probably damaging |
Het |
| Phlda3 |
T |
C |
1: 135,694,559 (GRCm39) |
S125P |
probably damaging |
Het |
| Pkd1l3 |
A |
T |
8: 110,377,412 (GRCm39) |
R217* |
probably null |
Het |
| Plekhg5 |
T |
C |
4: 152,196,676 (GRCm39) |
C695R |
probably damaging |
Het |
| Pramel24 |
A |
T |
4: 143,452,633 (GRCm39) |
E21D |
possibly damaging |
Het |
| Prg4 |
T |
C |
1: 150,329,298 (GRCm39) |
|
probably benign |
Het |
| Prkab1 |
A |
G |
5: 116,159,711 (GRCm39) |
|
probably benign |
Het |
| Pyroxd1 |
A |
G |
6: 142,300,356 (GRCm39) |
E162G |
possibly damaging |
Het |
| R3hcc1l |
G |
A |
19: 42,571,360 (GRCm39) |
|
probably null |
Het |
| Rgs12 |
T |
A |
5: 35,187,842 (GRCm39) |
S500T |
probably damaging |
Het |
| Ripor3 |
T |
C |
2: 167,834,518 (GRCm39) |
D299G |
probably damaging |
Het |
| Robo4 |
T |
C |
9: 37,313,977 (GRCm39) |
L76P |
probably damaging |
Het |
| Sbno1 |
T |
C |
5: 124,514,289 (GRCm39) |
Y1302C |
probably damaging |
Het |
| Sec63 |
A |
G |
10: 42,699,904 (GRCm39) |
I655V |
possibly damaging |
Het |
| Serpina11 |
T |
A |
12: 103,946,729 (GRCm39) |
M389L |
probably benign |
Het |
| Sfswap |
C |
A |
5: 129,631,607 (GRCm39) |
P745Q |
possibly damaging |
Het |
| Slc17a3 |
C |
T |
13: 24,039,841 (GRCm39) |
S293F |
probably damaging |
Het |
| Slitrk3 |
C |
T |
3: 72,955,910 (GRCm39) |
S954N |
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 46,222,866 (GRCm39) |
T190A |
probably damaging |
Het |
| Sos2 |
A |
T |
12: 69,664,104 (GRCm39) |
I460N |
probably benign |
Het |
| Spink7 |
T |
A |
18: 62,727,423 (GRCm39) |
I34L |
probably benign |
Het |
| Srbd1 |
A |
G |
17: 86,365,173 (GRCm39) |
S628P |
probably damaging |
Het |
| Srm |
G |
A |
4: 148,677,829 (GRCm39) |
G156S |
probably damaging |
Het |
| Sulf2 |
T |
C |
2: 165,927,589 (GRCm39) |
|
probably benign |
Het |
| Tmc4 |
T |
A |
7: 3,669,866 (GRCm39) |
Y6F |
probably benign |
Het |
| Tmcc2 |
A |
G |
1: 132,288,389 (GRCm39) |
F433L |
probably damaging |
Het |
| Tmprss13 |
T |
G |
9: 45,248,398 (GRCm39) |
|
probably benign |
Het |
| Tnxb |
T |
C |
17: 34,918,007 (GRCm39) |
F2307L |
probably benign |
Het |
| Tsr3 |
A |
G |
17: 25,461,484 (GRCm39) |
E274G |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,725,488 (GRCm39) |
|
probably benign |
Het |
| Tub |
T |
C |
7: 108,628,548 (GRCm39) |
V352A |
possibly damaging |
Het |
| Tubb2a |
A |
G |
13: 34,259,325 (GRCm39) |
I155T |
possibly damaging |
Het |
| Ugt2a2 |
T |
C |
5: 87,622,860 (GRCm39) |
N36S |
probably damaging |
Het |
| Usp13 |
T |
A |
3: 32,969,813 (GRCm39) |
|
probably null |
Het |
| Vmn1r52 |
T |
G |
6: 90,156,593 (GRCm39) |
L120R |
possibly damaging |
Het |
| Vmn2r11 |
A |
T |
5: 109,201,968 (GRCm39) |
S179T |
probably benign |
Het |
| Vwf |
A |
T |
6: 125,663,473 (GRCm39) |
R2805W |
possibly damaging |
Het |
| Wdr7 |
A |
G |
18: 64,037,172 (GRCm39) |
T1199A |
probably benign |
Het |
| Zfp286 |
T |
C |
11: 62,671,219 (GRCm39) |
T285A |
possibly damaging |
Het |
|
| Other mutations in Copa |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00848:Copa
|
APN |
1 |
171,938,255 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01360:Copa
|
APN |
1 |
171,915,155 (GRCm39) |
splice site |
probably null |
|
|
IGL01434:Copa
|
APN |
1 |
171,947,128 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01744:Copa
|
APN |
1 |
171,940,756 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Copa
|
APN |
1 |
171,946,419 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01988:Copa
|
APN |
1 |
171,945,831 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02059:Copa
|
APN |
1 |
171,927,320 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02123:Copa
|
APN |
1 |
171,939,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02731:Copa
|
APN |
1 |
171,929,785 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL03114:Copa
|
APN |
1 |
171,946,835 (GRCm39) |
nonsense |
probably null |
|
|
P0027:Copa
|
UTSW |
1 |
171,939,515 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
PIT4434001:Copa
|
UTSW |
1 |
171,933,742 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0465:Copa
|
UTSW |
1 |
171,945,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0547:Copa
|
UTSW |
1 |
171,949,254 (GRCm39) |
splice site |
probably benign |
|
|
R0568:Copa
|
UTSW |
1 |
171,939,704 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0628:Copa
|
UTSW |
1 |
171,918,592 (GRCm39) |
splice site |
probably benign |
|
|
R1328:Copa
|
UTSW |
1 |
171,949,258 (GRCm39) |
splice site |
probably benign |
|
|
R1494:Copa
|
UTSW |
1 |
171,931,694 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1728:Copa
|
UTSW |
1 |
171,939,554 (GRCm39) |
missense |
probably benign |
|
|
R1758:Copa
|
UTSW |
1 |
171,931,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Copa
|
UTSW |
1 |
171,939,554 (GRCm39) |
missense |
probably benign |
|
|
R1942:Copa
|
UTSW |
1 |
171,939,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Copa
|
UTSW |
1 |
171,946,524 (GRCm39) |
nonsense |
probably null |
|
|
R2299:Copa
|
UTSW |
1 |
171,949,292 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2518:Copa
|
UTSW |
1 |
171,947,468 (GRCm39) |
missense |
probably benign |
|
|
R2680:Copa
|
UTSW |
1 |
171,948,971 (GRCm39) |
nonsense |
probably null |
|
|
R3080:Copa
|
UTSW |
1 |
171,940,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3160:Copa
|
UTSW |
1 |
171,918,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3161:Copa
|
UTSW |
1 |
171,918,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Copa
|
UTSW |
1 |
171,918,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Copa
|
UTSW |
1 |
171,918,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3973:Copa
|
UTSW |
1 |
171,948,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3975:Copa
|
UTSW |
1 |
171,948,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4031:Copa
|
UTSW |
1 |
171,935,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4155:Copa
|
UTSW |
1 |
171,928,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4227:Copa
|
UTSW |
1 |
171,945,682 (GRCm39) |
intron |
probably benign |
|
|
R4244:Copa
|
UTSW |
1 |
171,938,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4254:Copa
|
UTSW |
1 |
171,929,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4291:Copa
|
UTSW |
1 |
171,919,964 (GRCm39) |
intron |
probably benign |
|
|
R4323:Copa
|
UTSW |
1 |
171,946,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4402:Copa
|
UTSW |
1 |
171,929,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4711:Copa
|
UTSW |
1 |
171,947,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4721:Copa
|
UTSW |
1 |
171,931,841 (GRCm39) |
splice site |
probably benign |
|
|
R4773:Copa
|
UTSW |
1 |
171,932,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4794:Copa
|
UTSW |
1 |
171,946,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Copa
|
UTSW |
1 |
171,919,843 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4953:Copa
|
UTSW |
1 |
171,910,453 (GRCm39) |
unclassified |
probably benign |
|
|
R5139:Copa
|
UTSW |
1 |
171,948,896 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5152:Copa
|
UTSW |
1 |
171,945,628 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5297:Copa
|
UTSW |
1 |
171,940,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Copa
|
UTSW |
1 |
171,932,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5698:Copa
|
UTSW |
1 |
171,946,511 (GRCm39) |
nonsense |
probably null |
|
|
R6283:Copa
|
UTSW |
1 |
171,946,415 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6921:Copa
|
UTSW |
1 |
171,939,491 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6934:Copa
|
UTSW |
1 |
171,938,253 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7009:Copa
|
UTSW |
1 |
171,918,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7194:Copa
|
UTSW |
1 |
171,947,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7348:Copa
|
UTSW |
1 |
171,929,790 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7710:Copa
|
UTSW |
1 |
171,937,411 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7745:Copa
|
UTSW |
1 |
171,939,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7893:Copa
|
UTSW |
1 |
171,947,132 (GRCm39) |
nonsense |
probably null |
|
|
R8168:Copa
|
UTSW |
1 |
171,927,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8273:Copa
|
UTSW |
1 |
171,946,546 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8704:Copa
|
UTSW |
1 |
171,931,693 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8754:Copa
|
UTSW |
1 |
171,935,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8757:Copa
|
UTSW |
1 |
171,947,081 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8759:Copa
|
UTSW |
1 |
171,947,081 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8885:Copa
|
UTSW |
1 |
171,925,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8891:Copa
|
UTSW |
1 |
171,946,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8927:Copa
|
UTSW |
1 |
171,931,737 (GRCm39) |
missense |
probably null |
0.03 |
|
R8928:Copa
|
UTSW |
1 |
171,931,737 (GRCm39) |
missense |
probably null |
0.03 |
|
R8956:Copa
|
UTSW |
1 |
171,937,480 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9063:Copa
|
UTSW |
1 |
171,944,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9295:Copa
|
UTSW |
1 |
171,939,823 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9364:Copa
|
UTSW |
1 |
171,944,831 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9437:Copa
|
UTSW |
1 |
171,931,712 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9673:Copa
|
UTSW |
1 |
171,945,648 (GRCm39) |
missense |
probably benign |
0.11 |
|
T0722:Copa
|
UTSW |
1 |
171,939,515 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1177:Copa
|
UTSW |
1 |
171,933,690 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTGTAGACCCACAGTTACAAAGC -3'
(R):5'- TCAGTGGAGGCCCAAAGAGAGTATC -3'
Sequencing Primer
(F):5'- cacctcagaacaaagcctaac -3'
(R):5'- cccaaagagagtatcacatgcc -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation