Incidental Mutation 'R0233:Robo4'
| ID |
58904 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo4
|
| Ensembl Gene |
ENSMUSG00000032125 |
| Gene Name |
roundabout guidance receptor 4 |
| Synonyms |
Magic roundabout, 1200012D01Rik |
| MMRRC Submission |
038474-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.224)
|
| Stock # |
R0233 (G1)
|
| Quality Score |
212 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
37313198-37325319 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 37313977 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 76
(L76P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150722
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102895]
[ENSMUST00000115046]
[ENSMUST00000115048]
[ENSMUST00000156972]
[ENSMUST00000214185]
|
| AlphaFold |
Q8C310 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102895
AA Change: L76P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000099959
Gene: ENSMUSG00000032125
AA Change: L76P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
748 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
871 |
880 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115046
AA Change: L76P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000110698
Gene: ENSMUSG00000032125
AA Change: L76P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
484 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
546 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
756 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
834 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
925 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115048
|
| SMART Domains |
Protein: ENSMUSP00000110700
Gene: ENSMUSG00000032125
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
695 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
769 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
806 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
887 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000156972
AA Change: L76P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000214185
AA Change: L76P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.4%
|
| Validation Efficiency |
99% (93/94) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
A |
G |
14: 32,385,330 (GRCm39) |
S212P |
probably benign |
Het |
| A730018C14Rik |
A |
C |
12: 112,381,864 (GRCm39) |
|
noncoding transcript |
Het |
| Acsf3 |
A |
G |
8: 123,507,031 (GRCm39) |
Y108C |
probably damaging |
Het |
| Acsl1 |
A |
G |
8: 46,966,606 (GRCm39) |
|
probably benign |
Het |
| Adad1 |
T |
A |
3: 37,139,097 (GRCm39) |
I389N |
possibly damaging |
Het |
| Ankrd27 |
T |
C |
7: 35,300,985 (GRCm39) |
L95P |
probably damaging |
Het |
| Ano5 |
T |
C |
7: 51,185,218 (GRCm39) |
F46S |
possibly damaging |
Het |
| Ap2a1 |
T |
C |
7: 44,565,397 (GRCm39) |
N114S |
probably damaging |
Het |
| Arap1 |
C |
T |
7: 101,049,448 (GRCm39) |
S970L |
possibly damaging |
Het |
| Atad3a |
A |
T |
4: 155,830,524 (GRCm39) |
S525T |
probably damaging |
Het |
| B4galnt1 |
T |
C |
10: 127,006,780 (GRCm39) |
|
probably benign |
Het |
| Bltp1 |
T |
A |
3: 37,002,712 (GRCm39) |
C1552* |
probably null |
Het |
| Cacna2d2 |
A |
T |
9: 107,391,869 (GRCm39) |
I463F |
probably damaging |
Het |
| Casp6 |
T |
A |
3: 129,699,624 (GRCm39) |
N34K |
probably damaging |
Het |
| Ccdc175 |
A |
T |
12: 72,152,650 (GRCm39) |
F752I |
probably benign |
Het |
| Cdhr4 |
A |
G |
9: 107,874,133 (GRCm39) |
I76V |
probably benign |
Het |
| Copa |
T |
C |
1: 171,915,234 (GRCm39) |
|
probably null |
Het |
| Cox11 |
C |
T |
11: 90,535,326 (GRCm39) |
T259I |
probably damaging |
Het |
| Cuzd1 |
C |
A |
7: 130,913,545 (GRCm39) |
K357N |
possibly damaging |
Het |
| Dnah5 |
T |
A |
15: 28,333,216 (GRCm39) |
F2206I |
probably damaging |
Het |
| Dnase2b |
T |
A |
3: 146,288,305 (GRCm39) |
K263N |
probably benign |
Het |
| Dync1h1 |
T |
A |
12: 110,607,414 (GRCm39) |
D2668E |
probably benign |
Het |
| Eno1b |
T |
C |
18: 48,180,806 (GRCm39) |
I328T |
probably benign |
Het |
| Fam124b |
T |
C |
1: 80,190,703 (GRCm39) |
S227G |
probably damaging |
Het |
| Fam13b |
T |
A |
18: 34,581,137 (GRCm39) |
Y675F |
probably damaging |
Het |
| Fgf21 |
T |
A |
7: 45,264,721 (GRCm39) |
M4L |
probably benign |
Het |
| Flg2 |
T |
A |
3: 93,109,104 (GRCm39) |
C377* |
probably null |
Het |
| Foxp2 |
T |
C |
6: 15,409,752 (GRCm39) |
S451P |
probably damaging |
Het |
| Gli2 |
A |
T |
1: 118,763,655 (GRCm39) |
S1499T |
probably damaging |
Het |
| Gm9920 |
A |
T |
15: 54,975,857 (GRCm39) |
|
probably benign |
Het |
| Gpx5 |
T |
A |
13: 21,471,573 (GRCm39) |
D210V |
probably damaging |
Het |
| H2-T5 |
A |
G |
17: 36,478,361 (GRCm39) |
Y224H |
probably benign |
Het |
| Hoxb5 |
T |
A |
11: 96,195,853 (GRCm39) |
S234T |
probably benign |
Het |
| Irf9 |
C |
A |
14: 55,843,551 (GRCm39) |
N140K |
probably benign |
Het |
| Isg20 |
C |
A |
7: 78,566,334 (GRCm39) |
D94E |
probably damaging |
Het |
| Isg20 |
C |
T |
7: 78,564,243 (GRCm39) |
T50M |
probably damaging |
Het |
| Izumo1 |
T |
C |
7: 45,273,592 (GRCm39) |
L115P |
probably damaging |
Het |
| Kdm3b |
G |
A |
18: 34,942,473 (GRCm39) |
E655K |
probably damaging |
Het |
| Kdm5b |
T |
G |
1: 134,532,372 (GRCm39) |
|
probably benign |
Het |
| Kifc3 |
A |
G |
8: 95,828,100 (GRCm39) |
|
probably null |
Het |
| Kpna2 |
T |
C |
11: 106,883,457 (GRCm39) |
S111G |
probably benign |
Het |
| Krt73 |
A |
T |
15: 101,710,451 (GRCm39) |
N94K |
probably benign |
Het |
| Lgmn |
G |
T |
12: 102,366,248 (GRCm39) |
D247E |
probably damaging |
Het |
| Lilra6 |
C |
T |
7: 3,917,935 (GRCm39) |
V70I |
possibly damaging |
Het |
| Lrig3 |
G |
A |
10: 125,849,395 (GRCm39) |
|
probably null |
Het |
| Lrrc4 |
T |
C |
6: 28,829,734 (GRCm39) |
H627R |
probably benign |
Het |
| Macf1 |
G |
A |
4: 123,343,920 (GRCm39) |
|
probably benign |
Het |
| Nat9 |
C |
A |
11: 115,074,234 (GRCm39) |
|
probably null |
Het |
| Nutm2 |
A |
G |
13: 50,621,441 (GRCm39) |
D2G |
probably benign |
Het |
| Or10j3b |
A |
T |
1: 173,043,868 (GRCm39) |
I217F |
probably benign |
Het |
| Or5h23 |
A |
T |
16: 58,906,038 (GRCm39) |
D269E |
probably benign |
Het |
| Or5w8 |
A |
G |
2: 87,688,096 (GRCm39) |
I192M |
probably benign |
Het |
| Parl |
G |
A |
16: 20,106,657 (GRCm39) |
P184L |
probably damaging |
Het |
| Pdzd8 |
A |
T |
19: 59,288,811 (GRCm39) |
M863K |
probably damaging |
Het |
| Phlda3 |
T |
C |
1: 135,694,559 (GRCm39) |
S125P |
probably damaging |
Het |
| Pkd1l3 |
A |
T |
8: 110,377,412 (GRCm39) |
R217* |
probably null |
Het |
| Plekhg5 |
T |
C |
4: 152,196,676 (GRCm39) |
C695R |
probably damaging |
Het |
| Pramel24 |
A |
T |
4: 143,452,633 (GRCm39) |
E21D |
possibly damaging |
Het |
| Prg4 |
T |
C |
1: 150,329,298 (GRCm39) |
|
probably benign |
Het |
| Prkab1 |
A |
G |
5: 116,159,711 (GRCm39) |
|
probably benign |
Het |
| Pyroxd1 |
A |
G |
6: 142,300,356 (GRCm39) |
E162G |
possibly damaging |
Het |
| R3hcc1l |
G |
A |
19: 42,571,360 (GRCm39) |
|
probably null |
Het |
| Rgs12 |
T |
A |
5: 35,187,842 (GRCm39) |
S500T |
probably damaging |
Het |
| Ripor3 |
T |
C |
2: 167,834,518 (GRCm39) |
D299G |
probably damaging |
Het |
| Sbno1 |
T |
C |
5: 124,514,289 (GRCm39) |
Y1302C |
probably damaging |
Het |
| Sec63 |
A |
G |
10: 42,699,904 (GRCm39) |
I655V |
possibly damaging |
Het |
| Serpina11 |
T |
A |
12: 103,946,729 (GRCm39) |
M389L |
probably benign |
Het |
| Sfswap |
C |
A |
5: 129,631,607 (GRCm39) |
P745Q |
possibly damaging |
Het |
| Slc17a3 |
C |
T |
13: 24,039,841 (GRCm39) |
S293F |
probably damaging |
Het |
| Slitrk3 |
C |
T |
3: 72,955,910 (GRCm39) |
S954N |
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 46,222,866 (GRCm39) |
T190A |
probably damaging |
Het |
| Sos2 |
A |
T |
12: 69,664,104 (GRCm39) |
I460N |
probably benign |
Het |
| Spink7 |
T |
A |
18: 62,727,423 (GRCm39) |
I34L |
probably benign |
Het |
| Srbd1 |
A |
G |
17: 86,365,173 (GRCm39) |
S628P |
probably damaging |
Het |
| Srm |
G |
A |
4: 148,677,829 (GRCm39) |
G156S |
probably damaging |
Het |
| Sulf2 |
T |
C |
2: 165,927,589 (GRCm39) |
|
probably benign |
Het |
| Tmc4 |
T |
A |
7: 3,669,866 (GRCm39) |
Y6F |
probably benign |
Het |
| Tmcc2 |
A |
G |
1: 132,288,389 (GRCm39) |
F433L |
probably damaging |
Het |
| Tmprss13 |
T |
G |
9: 45,248,398 (GRCm39) |
|
probably benign |
Het |
| Tnxb |
T |
C |
17: 34,918,007 (GRCm39) |
F2307L |
probably benign |
Het |
| Tsr3 |
A |
G |
17: 25,461,484 (GRCm39) |
E274G |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,725,488 (GRCm39) |
|
probably benign |
Het |
| Tub |
T |
C |
7: 108,628,548 (GRCm39) |
V352A |
possibly damaging |
Het |
| Tubb2a |
A |
G |
13: 34,259,325 (GRCm39) |
I155T |
possibly damaging |
Het |
| Ugt2a2 |
T |
C |
5: 87,622,860 (GRCm39) |
N36S |
probably damaging |
Het |
| Usp13 |
T |
A |
3: 32,969,813 (GRCm39) |
|
probably null |
Het |
| Vmn1r52 |
T |
G |
6: 90,156,593 (GRCm39) |
L120R |
possibly damaging |
Het |
| Vmn2r11 |
A |
T |
5: 109,201,968 (GRCm39) |
S179T |
probably benign |
Het |
| Vwf |
A |
T |
6: 125,663,473 (GRCm39) |
R2805W |
possibly damaging |
Het |
| Wdr7 |
A |
G |
18: 64,037,172 (GRCm39) |
T1199A |
probably benign |
Het |
| Zfp286 |
T |
C |
11: 62,671,219 (GRCm39) |
T285A |
possibly damaging |
Het |
|
| Other mutations in Robo4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Robo4
|
APN |
9 |
37,322,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Robo4
|
APN |
9 |
37,319,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00491:Robo4
|
APN |
9 |
37,317,231 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL00792:Robo4
|
APN |
9 |
37,319,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Robo4
|
APN |
9 |
37,317,296 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01287:Robo4
|
APN |
9 |
37,324,336 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02289:Robo4
|
APN |
9 |
37,319,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02486:Robo4
|
APN |
9 |
37,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02851:Robo4
|
APN |
9 |
37,324,678 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02898:Robo4
|
APN |
9 |
37,319,472 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02965:Robo4
|
APN |
9 |
37,321,765 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03071:Robo4
|
APN |
9 |
37,315,580 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Robo4
|
APN |
9 |
37,315,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Robo4
|
UTSW |
9 |
37,317,106 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Robo4
|
UTSW |
9 |
37,322,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0068:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Robo4
|
UTSW |
9 |
37,316,062 (GRCm39) |
splice site |
probably benign |
|
|
R1005:Robo4
|
UTSW |
9 |
37,319,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Robo4
|
UTSW |
9 |
37,324,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1183:Robo4
|
UTSW |
9 |
37,319,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1254:Robo4
|
UTSW |
9 |
37,322,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1398:Robo4
|
UTSW |
9 |
37,319,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1505:Robo4
|
UTSW |
9 |
37,314,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Robo4
|
UTSW |
9 |
37,314,739 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1834:Robo4
|
UTSW |
9 |
37,324,355 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1899:Robo4
|
UTSW |
9 |
37,315,366 (GRCm39) |
splice site |
probably benign |
|
|
R2203:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2204:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2351:Robo4
|
UTSW |
9 |
37,322,956 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2448:Robo4
|
UTSW |
9 |
37,313,958 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2847:Robo4
|
UTSW |
9 |
37,315,772 (GRCm39) |
nonsense |
probably null |
|
|
R2851:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2852:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2877:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3123:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3124:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3125:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3805:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3806:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3892:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3905:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R3938:Robo4
|
UTSW |
9 |
37,313,313 (GRCm39) |
start gained |
probably benign |
|
|
R4261:Robo4
|
UTSW |
9 |
37,316,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4434:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4435:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4561:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4562:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Robo4
|
UTSW |
9 |
37,316,118 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4695:Robo4
|
UTSW |
9 |
37,314,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Robo4
|
UTSW |
9 |
37,313,856 (GRCm39) |
missense |
probably benign |
|
|
R5000:Robo4
|
UTSW |
9 |
37,319,664 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5056:Robo4
|
UTSW |
9 |
37,316,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5279:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5285:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5347:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5348:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5361:Robo4
|
UTSW |
9 |
37,324,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5403:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5404:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5488:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5489:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5490:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5494:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5629:Robo4
|
UTSW |
9 |
37,319,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5736:Robo4
|
UTSW |
9 |
37,316,093 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5796:Robo4
|
UTSW |
9 |
37,322,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Robo4
|
UTSW |
9 |
37,322,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6178:Robo4
|
UTSW |
9 |
37,316,926 (GRCm39) |
nonsense |
probably null |
|
|
R6189:Robo4
|
UTSW |
9 |
37,314,829 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6365:Robo4
|
UTSW |
9 |
37,322,008 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6528:Robo4
|
UTSW |
9 |
37,315,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6887:Robo4
|
UTSW |
9 |
37,313,363 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7196:Robo4
|
UTSW |
9 |
37,314,001 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7408:Robo4
|
UTSW |
9 |
37,322,277 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7419:Robo4
|
UTSW |
9 |
37,314,105 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7486:Robo4
|
UTSW |
9 |
37,316,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7707:Robo4
|
UTSW |
9 |
37,324,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7839:Robo4
|
UTSW |
9 |
37,322,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8079:Robo4
|
UTSW |
9 |
37,313,931 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8081:Robo4
|
UTSW |
9 |
37,316,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8280:Robo4
|
UTSW |
9 |
37,315,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R8547:Robo4
|
UTSW |
9 |
37,315,674 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8735:Robo4
|
UTSW |
9 |
37,319,577 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8836:Robo4
|
UTSW |
9 |
37,317,130 (GRCm39) |
missense |
unknown |
|
|
R8889:Robo4
|
UTSW |
9 |
37,314,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Robo4
|
UTSW |
9 |
37,315,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Robo4
|
UTSW |
9 |
37,313,206 (GRCm39) |
start gained |
probably benign |
|
|
R9375:Robo4
|
UTSW |
9 |
37,316,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9621:Robo4
|
UTSW |
9 |
37,317,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAGTACAGGAGTCTCTCTTTCCC -3'
(R):5'- TCGTATTTCCCTGGACACAAGCATC -3'
Sequencing Primer
(F):5'- ACAGGAGTCTCTCTTTCCCTCTTAG -3'
(R):5'- AAGCATCTCAGCCTAACTCTG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation